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Items: 37


Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.

Deuring JJ, Li M, Cao W, Chen S, Wang W, de Haar C, van der Woude CJ, Peppelenbosch M.

PLoS One. 2019 Oct 3;14(10):e0221924. doi: 10.1371/journal.pone.0221924. eCollection 2019.


Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation.

Rakhshandehroo M, van Eijkeren RJ, Gabriel TL, de Haar C, Gijzel SMW, Hamers N, Ferraz MJ, Aerts JMFG, Schipper HS, van Eijk M, Boes M, Kalkhoven E.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1157-1167. doi: 10.1016/j.bbalip.2019.04.016. Epub 2019 Apr 30.


Cord-Blood-Stem-Cell-Derived Conventional Dendritic Cells Specifically Originate from CD115-Expressing Precursors.

Plantinga M, de Haar CG, Dünnebach E, van den Beemt DAMH, Bloemenkamp KWM, Mokry M, Boelens JJ, Nierkens S.

Cancers (Basel). 2019 Feb 5;11(2). pii: E181. doi: 10.3390/cancers11020181.


Dendritic Cells.

Plantinga M, de Haar C, Nierkens S.

In: Verhoeckx K, Cotter P, López-Expósito I, Kleiveland C, Lea T, Mackie A, Requena T, Swiatecka D, Wichers H, editors. The Impact of Food Bioactives on Health: in vitro and ex vivo models [Internet]. Cham (CH): Springer; 2015. Chapter 17.


Analysis of SHIP1 expression and activity in Crohn's disease patients.

Somasundaram R, Fernandes S, Deuring JJ, de Haar C, Kuipers EJ, Vogelaar L, Middleton FA, van der Woude CJ, Peppelenbosch MP, Kerr WG, Fuhler GM.

PLoS One. 2017 Aug 2;12(8):e0182308. doi: 10.1371/journal.pone.0182308. eCollection 2017.


Fatigue in patients with inflammatory bowel disease is associated with distinct differences in immune parameters.

Vogelaar L, de Haar C, Aerts BR, Peppelenbosch MP, Timman R, Hanssen BE, van der Woude CJ.

Clin Exp Gastroenterol. 2017 May 2;10:83-90. doi: 10.2147/CEG.S123942. eCollection 2017.


Generation of a cord blood-derived Wilms Tumor 1 dendritic cell vaccine for AML patients treated with allogeneic cord blood transplantation.

de Haar C, Plantinga M, Blokland NJ, van Til NP, Flinsenberg TW, Van Tendeloo VF, Smits EL, Boon L, Spel L, Boes M, Boelens JJ, Nierkens S.

Oncoimmunology. 2015 May 27;4(11):e1023973. eCollection 2015 Nov.


Cognate CD4 T-cell licensing of dendritic cells heralds anti-cytomegalovirus CD8 T-cell immunity after human allogeneic umbilical cord blood transplantation.

Flinsenberg TW, Spel L, Jansen M, Koning D, de Haar C, Plantinga M, Scholman R, van Loenen MM, Nierkens S, Boon L, van Baarle D, Heemskerk MH, Boelens JJ, Boes M.

J Virol. 2015 Jan 15;89(2):1058-69. doi: 10.1128/JVI.01850-14. Epub 2014 Nov 5.


CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein.

Rakhshandehroo M, Gijzel SM, Siersbæk R, Broekema MF, de Haar C, Schipper HS, Boes M, Mandrup S, Kalkhoven E.

J Biol Chem. 2014 Aug 8;289(32):22128-39. doi: 10.1074/jbc.M114.551242. Epub 2014 Jun 25.


Dendritic Cell Therapy in an Allogeneic-Hematopoietic Cell Transplantation Setting: An Effective Strategy toward Better Disease Control?

Plantinga M, de Haar C, Nierkens S, Boelens JJ.

Front Immunol. 2014 May 19;5:218. doi: 10.3389/fimmu.2014.00218. eCollection 2014. Review.


Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease.

Parikh K, Zhou L, Somasundaram R, Fuhler GM, Deuring JJ, Blokzijl T, Regeling A, Kuipers EJ, Weersma RK, Nuij VJ, Alves M, Vogelaar L, Visser L, de Haar C, Krishnadath KK, van der Woude CJ, Dijkstra G, Faber KN, Peppelenbosch MP.

Sci Transl Med. 2014 Apr 23;6(233):233ra53. doi: 10.1126/scitranslmed.3006763.


Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease.

Deuring JJ, Fuhler GM, Konstantinov SR, Peppelenbosch MP, Kuipers EJ, de Haar C, van der Woude CJ.

Gut. 2014 Jul;63(7):1081-91. doi: 10.1136/gutjnl-2012-303527. Epub 2013 Aug 20.


The cell biology of the intestinal epithelium and its relation to inflammatory bowel disease.

Deuring JJ, de Haar C, Kuipers EJ, Peppelenbosch MP, van der Woude CJ.

Int J Biochem Cell Biol. 2013 Apr;45(4):798-806. doi: 10.1016/j.biocel.2012.12.020. Epub 2013 Jan 3. Review.


STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis.

Li Y, Deuring J, Peppelenbosch MP, Kuipers EJ, de Haar C, van der Woude CJ.

Mol Med. 2012 Dec 20;18:1412-9. doi: 10.2119/molmed.2012.00277.


CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.

Tamoutounour S, Henri S, Lelouard H, de Bovis B, de Haar C, van der Woude CJ, Woltman AM, Reyal Y, Bonnet D, Sichien D, Bain CC, Mowat AM, Reis e Sousa C, Poulin LF, Malissen B, Guilliams M.

Eur J Immunol. 2012 Dec;42(12):3150-66. doi: 10.1002/eji.201242847. Epub 2012 Oct 17.


IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer.

Li Y, Deuring J, Peppelenbosch MP, Kuipers EJ, de Haar C, van der Woude CJ.

Carcinogenesis. 2012 Oct;33(10):1889-96. doi: 10.1093/carcin/bgs214. Epub 2012 Jun 27.


SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer.

Li Y, de Haar C, Peppelenbosch MP, van der Woude CJ.

Cytokine Growth Factor Rev. 2012 Jun;23(3):127-38. doi: 10.1016/j.cytogfr.2012.04.005. Epub 2012 May 15. Review.


Increased suppressor of cytokine signaling-3 expression predicts mucosal relapse in ulcerative colitis.

Li Y, Nuij VJ, Baars JE, Biermann K, Kuipers EJ, Peppelenbosch MP, de Haar C, Janneke van der Woude C.

Inflamm Bowel Dis. 2013 Jan;19(1):132-40. doi: 10.1002/ibd.22992.


Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing.

Rieder F, Karrasch T, Ben-Horin S, Schirbel A, Ehehalt R, Wehkamp J, de Haar C, Velin D, Latella G, Scaldaferri F, Rogler G, Higgins P, Sans M.

J Crohns Colitis. 2012 Apr;6(3):373-85. doi: 10.1016/j.crohns.2011.11.009. Epub 2011 Dec 11. Review.


Predictors of dose escalation of adalimumab in a prospective cohort of Crohn's disease patients.

Bultman E, de Haar C, van Liere-Baron A, Verhoog H, West RL, Kuipers EJ, Zelinkova Z, van der Woude CJ.

Aliment Pharmacol Ther. 2012 Feb;35(3):335-41. doi: 10.1111/j.1365-2036.2011.04946.x. Epub 2011 Dec 22.


Psychoeducation for patients with a psychotic disorder: effects on knowledge and coping.

Bossema ER, de Haar CA, Westerhuis W, Beenackers BP, Blom BC, Appels MC, van Oeveren CJ.

Prim Care Companion CNS Disord. 2011;13(4). pii: PCC.10m01116. doi: 10.4088/PCC.10m01116.


New insights into the role of STAT3 in IBD.

Li Y, de Haar C, Peppelenbosch MP, van der Woude CJ.

Inflamm Bowel Dis. 2012 Jun;18(6):1177-83. doi: 10.1002/ibd.21884. Epub 2011 Oct 12. Review.


Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding.

Deuring JJ, de Haar C, Koelewijn CL, Kuipers EJ, Peppelenbosch MP, van der Woude CJ.

Biochem J. 2012 Jan 1;441(1):87-93. doi: 10.1042/BJ20111281.


Impeded protein folding and function in active inflammatory bowel disease.

Deuring JJ, Peppelenbosch MP, Kuipers EJ, van der Woude CJ, de Haar C.

Biochem Soc Trans. 2011 Aug;39(4):1107-11. doi: 10.1042/BST0391107. Review.


Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.

Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9927-32. doi: 10.1073/pnas.1019037108. Epub 2011 May 31.


Role of defective autophagia and the intestinal flora in Crohn disease.

Regeling A, Somasundaram R, de Haar C, van der Woude CJ, Braat H, Peppelenbosch MP.

Self Nonself. 2010 Oct-Dec;1(4):323-327. doi: 10.4161/self.1.4.13990. Review.


Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

Buschard K, Hansen AK, Jensen K, Lindenbergh-Kortleve DJ, de Ruiter LF, Krohn TC, Hufeldt MR, Vogensen FK, Aasted B, Osterbye T, Roep BO, de Haar C, Nieuwenhuis EE.

PLoS One. 2011 Apr 1;6(4):e17931. doi: 10.1371/journal.pone.0017931.


High intra-uterine exposure to infliximab following maternal anti-TNF treatment during pregnancy.

Zelinkova Z, de Haar C, de Ridder L, Pierik MJ, Kuipers EJ, Peppelenbosch MP, van der Woude CJ.

Aliment Pharmacol Ther. 2011 May;33(9):1053-8. doi: 10.1111/j.1365-2036.2011.04617.x. Epub 2011 Mar 1.


Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis.

Li Y, de Haar C, Chen M, Deuring J, Gerrits MM, Smits R, Xia B, Kuipers EJ, van der Woude CJ.

Gut. 2010 Feb;59(2):227-35. doi: 10.1136/gut.2009.184176. Epub 2009 Nov 18.


T-cell regulation of neutrophil infiltrate at the early stages of a murine colitis model.

van Lierop PP, de Haar C, Lindenbergh-Kortleve DJ, Simons-Oosterhuis Y, van Rijt LS, Lambrecht BN, Escher JC, Samsom JN, Nieuwenhuis EE.

Inflamm Bowel Dis. 2010 Mar;16(3):442-51. doi: 10.1002/ibd.21073.


Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity.

de Haar C, Kool M, Hassing I, Bol M, Lambrecht BN, Pieters R.

J Allergy Clin Immunol. 2008 May;121(5):1246-54. doi: 10.1016/j.jaci.2008.01.010. Epub 2008 Mar 4.


Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice.

de Haar C, Hassing I, Bol M, Bleumink R, Pieters R.

Clin Exp Allergy. 2006 Nov;36(11):1469-79.


Ultrafine carbon black particles cause early airway inflammation and have adjuvant activity in a mouse allergic airway disease model.

de Haar C, Hassing I, Bol M, Bleumink R, Pieters R.

Toxicol Sci. 2005 Oct;87(2):409-18. Epub 2005 Jul 13.


Particulate matter inflammation and receptor sensitivity are target cell specific.

Veronesi B, de Haar C, Roy J, Oortgiesen M.

Inhal Toxicol. 2002 Feb;14(2):159-83.


The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells.

Veronesi B, de Haar C, Lee L, Oortgiesen M.

Toxicol Appl Pharmacol. 2002 Feb 1;178(3):144-54.


Coadministration of antigen and particles optimally stimulates the immune response in an intranasal administration model in mice.

van Zijverden M, de Haar C, van Beelen A, van Loveren H, Penninks A, Pieters R.

Toxicol Appl Pharmacol. 2001 Dec 15;177(3):174-8.


Diesel exhaust, carbon black, and silica particles display distinct Th1/Th2 modulating activity.

van Zijverden M, van der Pijl A, Bol M, van Pinxteren FA, de Haar C, Penninks AH, van Loveren H, Pieters R.

Toxicol Appl Pharmacol. 2000 Oct 15;168(2):131-9.


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