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Items: 1 to 50 of 73

1.

Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection.

Burdet C, Sayah-Jeanne S, Nguyen TT, Hugon P, Sablier-Gallis F, Saint-Lu N, Corbel T, Ferreira S, Pulse M, Weiss W, Andremont A, Mentré F, de Gunzburg J.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00925-18. doi: 10.1128/AAC.00925-18. Print 2018 Oct.

2.

Protection of the Human Gut Microbiome From Antibiotics.

de Gunzburg J, Ghozlane A, Ducher A, Le Chatelier E, Duval X, Ruppé E, Armand-Lefevre L, Sablier-Gallis F, Burdet C, Alavoine L, Chachaty E, Augustin V, Varastet M, Levenez F, Kennedy S, Pons N, Mentré F, Andremont A.

J Infect Dis. 2018 Jan 30;217(4):628-636. doi: 10.1093/infdis/jix604.

3.

Protection of Hamsters from Mortality by Reducing Fecal Moxifloxacin Concentration with DAV131A in a Model of Moxifloxacin-Induced Clostridium difficile Colitis.

Burdet C, Sayah-Jeanne S, Nguyen TT, Miossec C, Saint-Lu N, Pulse M, Weiss W, Andremont A, Mentré F, de Gunzburg J.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00543-17. doi: 10.1128/AAC.00543-17. Print 2017 Oct.

4.

Removal of antibiotics in wastewater by enzymatic treatment with fungal laccase - Degradation of compounds does not always eliminate toxicity.

Becker D, Varela Della Giustina S, Rodriguez-Mozaz S, Schoevaart R, Barceló D, de Cazes M, Belleville MP, Sanchez-Marcano J, de Gunzburg J, Couillerot O, Völker J, Oehlmann J, Wagner M.

Bioresour Technol. 2016 Nov;219:500-509. doi: 10.1016/j.biortech.2016.08.004. Epub 2016 Aug 4.

PMID:
27521787
5.

Mathematical modeling of bacterial kinetics to predict the impact of antibiotic colonic exposure and treatment duration on the amount of resistant enterobacteria excreted.

Nguyen TT, Guedj J, Chachaty E, de Gunzburg J, Andremont A, Mentré F.

PLoS Comput Biol. 2014 Sep 11;10(9):e1003840. doi: 10.1371/journal.pcbi.1003840. eCollection 2014 Sep.

6.

Targeted adsorption of molecules in the colon with the novel adsorbent-based medicinal product, DAV132: A proof of concept study in healthy subjects.

de Gunzburg J, Ducher A, Modess C, Wegner D, Oswald S, Dressman J, Augustin V, Feger C, Andremont A, Weitschies W, Siegmund W.

J Clin Pharmacol. 2015 Jan;55(1):10-6. doi: 10.1002/jcph.359. Epub 2014 Jul 16.

PMID:
25042595
7.

Identification of new transformation products during enzymatic treatment of tetracycline and erythromycin antibiotics at laboratory scale by an on-line turbulent flow liquid-chromatography coupled to a high resolution mass spectrometer LTQ-Orbitrap.

Llorca M, Rodríguez-Mozaz S, Couillerot O, Panigoni K, de Gunzburg J, Bayer S, Czaja R, Barceló D.

Chemosphere. 2015 Jan;119:90-98. doi: 10.1016/j.chemosphere.2014.05.072. Epub 2014 Jun 24.

PMID:
24972175
8.

Oral DAV131, a charcoal-based adsorbent, inhibits intestinal colonization by β-lactam-resistant Klebsiella pneumoniae in cefotaxime-treated mice.

Grall N, Massias L, Nguyen TT, Sayah-Jeanne S, Ducrot N, Chachaty E, de Gunzburg J, Andremont A.

Antimicrob Agents Chemother. 2013 Nov;57(11):5423-5. doi: 10.1128/AAC.00039-13. Epub 2013 Aug 19.

9.

Correlation between fecal concentrations of ciprofloxacin and fecal counts of resistant Enterobacteriaceae in piglets treated with ciprofloxacin: toward new means to control the spread of resistance?

Nguyen TT, Chachaty E, Huy C, Cambier C, de Gunzburg J, Mentré F, Andremont A.

Antimicrob Agents Chemother. 2012 Sep;56(9):4973-5. doi: 10.1128/AAC.06402-11. Epub 2012 Jul 2.

10.

Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis.

Dao VT, Dupuy AG, Gavet O, Caron E, de Gunzburg J.

J Cell Sci. 2009 Aug 15;122(Pt 16):2996-3004. doi: 10.1242/jcs.041301. Epub 2009 Jul 28.

11.

Dissecting activation of the PAK1 kinase at protrusions in living cells.

Parrini MC, Camonis J, Matsuda M, de Gunzburg J.

J Biol Chem. 2009 Sep 4;284(36):24133-43. doi: 10.1074/jbc.M109.015271. Epub 2009 Jul 1.

12.

Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway.

Hatzoglou A, Ader I, Splingard A, Flanders J, Saade E, Leroy I, Traver S, Aresta S, de Gunzburg J.

Mol Biol Cell. 2007 Apr;18(4):1242-52. Epub 2007 Jan 31.

13.

Biochemical and structural characterization of the gem GTPase.

Splingard A, Ménétrey J, Perderiset M, Cicolari J, Regazzoni K, Hamoudi F, Cabanié L, El Marjou A, Wells A, Houdusse A, de Gunzburg J.

J Biol Chem. 2007 Jan 19;282(3):1905-15. Epub 2006 Nov 15.

14.

Spatiotemporal regulation of the Pak1 kinase.

Parrini MC, Matsuda M, de Gunzburg J.

Biochem Soc Trans. 2005 Aug;33(Pt 4):646-8. Review.

PMID:
16042564
15.

Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.

Dupuy AG, L'Hoste S, Cherfils J, Camonis J, Gaudriault G, de Gunzburg J.

Oncogene. 2005 Jun 30;24(28):4509-20.

PMID:
15856025
16.

Protein interaction mapping: a Drosophila case study.

Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V, Maire S, Brun C, Jacq B, Arpin M, Bellaiche Y, Bellusci S, Benaroch P, Bornens M, Chanet R, Chavrier P, Delattre O, Doye V, Fehon R, Faye G, Galli T, Girault JA, Goud B, de Gunzburg J, Johannes L, Junier MP, Mirouse V, Mukherjee A, Papadopoulo D, Perez F, Plessis A, Rossé C, Saule S, Stoppa-Lyonnet D, Vincent A, White M, Legrain P, Wojcik J, Camonis J, Daviet L.

Genome Res. 2005 Mar;15(3):376-84. Epub 2005 Feb 14.

17.

Subcellular localization of A and B Nm23/NDPK subunits.

Bosnar MH, De Gunzburg J, Bago R, Brecević L, Weber I, Pavelić J.

Exp Cell Res. 2004 Aug 1;298(1):275-84.

PMID:
15242782
18.

The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling.

Traver S, Splingard A, Gaudriault G, De Gunzburg J.

Biochem J. 2004 May 1;379(Pt 3):627-32.

19.

Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.

Leprince C, Le Scolan E, Meunier B, Fraisier V, Brandon N, De Gunzburg J, Camonis J.

J Cell Sci. 2003 May 15;116(Pt 10):1937-48. Epub 2003 Mar 26.

20.

Xenopus H-RasV12 promotes entry into meiotic M phase and cdc2 activation independently of Mos and p42(MAPK).

Dupré A, Suziedelis K, Valuckaite R, de Gunzburg J, Ozon R, Jessus C, Haccard O.

Oncogene. 2002 Sep 19;21(42):6425-33.

21.

A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases.

Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J.

Biochem J. 2002 Oct 1;367(Pt 1):57-65.

22.

Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells.

Cambot M, Aresta S, Kahn-Perlès B, de Gunzburg J, Roméo PH.

Blood. 2002 May 1;99(9):3293-301.

23.

The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases.

Nancy V, Callebaut I, El Marjou A, de Gunzburg J.

J Biol Chem. 2002 Apr 26;277(17):15076-84. Epub 2002 Jan 10.

24.

Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.

Rihet S, Vielh P, Camonis J, Goud B, Chevillard S, de Gunzburg J.

J Cancer Res Clin Oncol. 2001 Dec;127(12):733-8.

PMID:
11768613
25.

A novel group IIA phospholipase A2 interacts with v-Src oncoprotein from RSV-transformed hamster cells.

Mizenina O, Musatkina E, Yanushevich Y, Rodina A, Krasilnikov M, de Gunzburg J, Camonis JH, Tavitian A, Tatosyan A.

J Biol Chem. 2001 Sep 7;276(36):34006-12. Epub 2001 Jun 26.

26.
27.

RUN domains: a new family of domains involved in Ras-like GTPase signaling.

Callebaut I, de Gunzburg J, Goud B, Mornon JP.

Trends Biochem Sci. 2001 Feb;26(2):79-83.

PMID:
11166556
28.

RGS14, a GTPase-activating protein for Gialpha, attenuates Gialpha- and G13alpha-mediated signaling pathways.

Cho H, Kozasa T, Takekoshi K, De Gunzburg J, Kehrl JH.

Mol Pharmacol. 2000 Sep;58(3):569-76.

PMID:
10953050
29.

Proteins of the Ras pathway as novel potential anticancer therapeutic targets.

de Gunzburg J.

Cell Biol Toxicol. 1999;15(6):345-58. Review.

PMID:
10811529
30.

Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location.

El Ghouzzi V, Legeai-Mallet L, Aresta S, Benoist C, Munnich A, de Gunzburg J, Bonaventure J.

Hum Mol Genet. 2000 Mar 22;9(5):813-9.

PMID:
10749989
31.

Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.

Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J.

J Biol Chem. 1999 Mar 26;274(13):8737-45.

32.

Specific inhibition of phorbol ester-stimulated phospholipase D by Clostridium sordellii lethal toxin and Clostridium difficile toxin B-1470 in HEK-293 cells. Restoration by Ral GTPases.

Schmidt M, Voss M, Thiel M, Bauer B, Grannass A, Tapp E, Cool RH, de Gunzburg J, von Eichel-Streiber C, Jakobs KH.

J Biol Chem. 1998 Mar 27;273(13):7413-22.

33.

Exclusion of five subunits of cGMP phosphodiesterase in Leber's congenital amaurosis.

Perrault I, Châtelin S, Nancy V, Rozet JM, Gerber S, Ghazi I, Souied E, Dufier JL, Munnich A, de Gunzburg J, Kaplan J.

Hum Genet. 1998 Mar;102(3):322-6.

PMID:
9544846
34.

Identification of a specific effector of the small GTP-binding protein Rap2.

Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J.

Eur J Biochem. 1998 Mar 1;252(2):290-8.

35.

Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I.

EMBO J. 1997 Sep 15;16(18):5582-91.

36.

Getting more from the two-hybrid system: N-terminal fusions to LexA are efficient and sensitive baits for two-hybrid studies.

Béranger F, Aresta S, de Gunzburg J, Camonis J.

Nucleic Acids Res. 1997 May 15;25(10):2035-6.

37.

cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36.

Ershova G, Derré J, Chételin S, Nancy V, Berger R, Kaplan J, Munnich A, de Gunzburg J.

Cytogenet Cell Genet. 1997;79(1-2):139-41. No abstract available.

PMID:
9533031
38.

[Isoprenylated proteins and cell proliferation: regulators and effectors of Ras proteins].

de Gunzburg J.

C R Seances Soc Biol Fil. 1997;191(2):195-210. Review. French.

PMID:
9255347
39.

Expression of the TSC2 product tuberin and its target Rap1 in normal human tissues.

Wienecke R, Maize JC Jr, Reed JA, de Gunzburg J, Yeung RS, DeClue JE.

Am J Pathol. 1997 Jan;150(1):43-50.

40.

Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.

Wienecke R, Maize JC Jr, Shoarinejad F, Vass WC, Reed J, Bonifacino JS, Resau JH, de Gunzburg J, Yeung RS, DeClue JE.

Oncogene. 1996 Sep 5;13(5):913-23.

PMID:
8806680
41.

Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

Popoff MR, Chaves-Olarte E, Lemichez E, von Eichel-Streiber C, Thelestam M, Chardin P, Cussac D, Antonny B, Chavrier P, Flatau G, Giry M, de Gunzburg J, Boquet P.

J Biol Chem. 1996 Apr 26;271(17):10217-24.

42.

Ultrastructural localization of the small GTP-binding protein Rap1 in human platelets and megakaryocytes.

Berger G, Quarck R, Tenza D, Levy-Toledano S, de Gunzburg J, Cramer EM.

Br J Haematol. 1994 Oct;88(2):372-82.

PMID:
7803284
43.

Phosphorylation of Rap1GAP during the cell cycle.

Janoueix-Lerosey I, Fontenay M, Tobelem G, Tavitian A, Polakis P, de Gunzburg J.

Biochem Biophys Res Commun. 1994 Jul 29;202(2):967-75.

PMID:
8048970
44.

Purification and characterization of smooth muscle cell caveolae.

Chang WJ, Ying YS, Rothberg KG, Hooper NM, Turner AJ, Gambliel HA, De Gunzburg J, Mumby SM, Gilman AG, Anderson RG.

J Cell Biol. 1994 Jul;126(1):127-38.

45.

Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase.

Beranger F, Cadwallader K, Porfiri E, Powers S, Evans T, de Gunzburg J, Hancock JF.

J Biol Chem. 1994 May 6;269(18):13637-43.

46.

Evidence for Rap1 in vascular smooth muscle cells. Regulation of their expression by platelet-derived growth factor BB.

Quarck R, Bryckaert M, Magnier C, Corvazier E, Bredoux R, de Gunzburg J, Fontenay M, Tobelem G, Enouf J.

FEBS Lett. 1994 Apr 4;342(2):159-64.

47.
48.

Abnormal cAMP-induced phosphorylation of rap 1 protein in grey platelet syndrome platelets.

Enouf J, Corvazier E, Papp B, Quarck R, Magnier C, Kovàcs T, Bredoux R, Lévy-Tolédano S, de Gunzburg J, Wuytack F, et al.

Br J Haematol. 1994 Feb;86(2):338-46.

PMID:
8199024
49.

Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines.

Magnier C, Bredoux R, Kovacs T, Quarck R, Papp B, Corvazier E, de Gunzburg J, Enouf J.

Biochem J. 1994 Jan 15;297 ( Pt 2):343-50.

50.

The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization.

Beranger F, Paterson H, Powers S, de Gunzburg J, Hancock JF.

Mol Cell Biol. 1994 Jan;14(1):744-58.

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