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Items: 37


Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats.

Kimbrough A, Kononoff J, Simpson S, Kallupi M, Sedighim S, Palomino K, Conlisk D, Momper JD, de Guglielmo G, George O.

Psychopharmacology (Berl). 2020 Feb 29. doi: 10.1007/s00213-020-05479-y. [Epub ahead of print]


Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats.

de Guglielmo G, Kallupi M, Sedighim S, Newman AH, George O.

Front Behav Neurosci. 2020 Jan 14;13:292. doi: 10.3389/fnbeh.2019.00292. eCollection 2019.


Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats.

Kallupi M, Carrette LLG, Kononoff J, Solberg Woods LC, Palmer AA, Schweitzer P, George O, de Guglielmo G.

Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2140-2148. doi: 10.1073/pnas.1915143117. Epub 2020 Jan 13.


Increases in compulsivity, inflammation, and neural injury in HIV transgenic rats with escalated methamphetamine self-administration under extended-access conditions.

de Guglielmo G, Fu Y, Chen J, Larrosa E, Hoang I, Kawamura T, Lorrai I, Zorman B, Bryant J, George O, Sumazin P, Lefebvre C, Repunte-Canonigo V, Sanna PP.

Brain Res. 2020 Jan 1;1726:146502. doi: 10.1016/j.brainres.2019.146502. Epub 2019 Oct 9.


Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food.

Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, Zorrilla EP.

Neuropsychopharmacology. 2020 Mar;45(4):579-588. doi: 10.1038/s41386-019-0538-x. Epub 2019 Oct 8.


Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder?

Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, de Guglielmo G, Hoang I, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP.

Alcohol Alcohol. 2019 Jan 9;54(5):497-502. doi: 10.1093/alcalc/agz054.


Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood.

Kallupi M, de Guglielmo G, Larrosa E, George O.

Eur Neuropsychopharmacol. 2019 Nov;29(11):1227-1234. doi: 10.1016/j.euroneuro.2019.08.299. Epub 2019 Aug 26.


Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats.

Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C.

Alcohol Clin Exp Res. 2019 Oct;43(10):2079-2089. doi: 10.1111/acer.14177. Epub 2019 Aug 30.


National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies.

Cates HM, Benca-Bachman CE, de Guglielmo G, Schoenrock SA, Shu C, Kallupi M.

Genes Brain Behav. 2019 Jul;18(6):e12577. doi: 10.1111/gbb.12577. Epub 2019 May 17. Review.


Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats.

de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O.

Nat Commun. 2019 Mar 18;10(1):1238. doi: 10.1038/s41467-019-09183-0.


Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood.

Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O.

Sci Rep. 2018 Sep 17;8(1):13893. doi: 10.1038/s41598-018-31921-5.


Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.

Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O.

eNeuro. 2018 Jul 2;5(3). pii: ENEURO.0153-18.2018. doi: 10.1523/ENEURO.0153-18.2018. eCollection 2018 May-Jun.


Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats.

de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O.

Pharmacol Biochem Behav. 2018 Apr;167:36-41. doi: 10.1016/j.pbb.2018.03.001. Epub 2018 Mar 2.


Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats.

Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF.

Psychopharmacology (Berl). 2018 Apr;235(4):1131-1140. doi: 10.1007/s00213-018-4830-y. Epub 2018 Jan 21.


CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure.

Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O.

Alcohol Clin Exp Res. 2017 Nov;41(11):1886-1895. doi: 10.1111/acer.13484. Epub 2017 Sep 22.


Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats.

de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O.

J Pharmacol Exp Ther. 2017 Sep;362(3):378-384. doi: 10.1124/jpet.117.241042. Epub 2017 Jun 23.


Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption.

Kallupi M, Shen Q, de Guglielmo G, Yasuda D, Journigan VB, Zaveri NT, Ciccocioppo R.

Addict Biol. 2018 Mar;23(2):585-595. doi: 10.1111/adb.12513. Epub 2017 Jun 21.


Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms.

Varodayan FP, de Guglielmo G, Logrip ML, George O, Roberto M.

J Neurosci. 2017 Apr 26;37(17):4593-4603. doi: 10.1523/JNEUROSCI.3721-16.2017. Epub 2017 Mar 31.


Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration.

de Guglielmo G, Kallupi M, Cole MD, George O.

Psychopharmacology (Berl). 2017 Jul;234(13):2009-2018. doi: 10.1007/s00213-017-4608-7. Epub 2017 Mar 24.


Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE.

J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16.


High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats.

Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O.

Neuropsychopharmacology. 2017 Aug;42(9):1850-1859. doi: 10.1038/npp.2016.270. Epub 2016 Dec 5.


Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents.

de Guglielmo G, Kallupi M, Scuppa G, Demopulos G, Gaitanaris G, Ciccocioppo R.

Psychopharmacology (Berl). 2017 Jan;234(2):223-234. doi: 10.1007/s00213-016-4452-1. Epub 2016 Oct 6.


Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence.

de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O.

J Neurosci. 2016 Sep 7;36(36):9446-53. doi: 10.1523/JNEUROSCI.1395-16.2016.


Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction.

Kallupi M, Scuppa G, de Guglielmo G, Calò G, Weiss F, Statnick MA, Rorick-Kehn LM, Ciccocioppo R.

Neuropsychopharmacology. 2017 Feb;42(3):695-706. doi: 10.1038/npp.2016.171. Epub 2016 Aug 26.


A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits.

Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO.

Front Neurosci. 2015 Dec 24;9:487. doi: 10.3389/fnins.2015.00487. eCollection 2015.


Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S.

Ubaldi M, Giordano A, Severi I, Li H, Kallupi M, de Guglielmo G, Ruggeri B, Stopponi S, Ciccocioppo R, Cannella N.

Biol Psychiatry. 2016 Mar 15;79(6):452-62. doi: 10.1016/j.biopsych.2015.04.021. Epub 2015 May 2.


Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking.

Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O.

J Neurosci. 2015 Apr 15;35(15):6241-53. doi: 10.1523/JNEUROSCI.3302-14.2015. Erratum in: J Neurosci. 2015 Aug 5;35(31):11169.


PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.

de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R.

Neuropsychopharmacology. 2015 Mar;40(4):1052. doi: 10.1038/npp.2014.305. No abstract available.


PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.

de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R.

Neuropsychopharmacology. 2015 Mar;40(4):927-37. doi: 10.1038/npp.2014.268. Epub 2014 Sep 14. Erratum in: Neuropsychopharmacology. 2015 Mar;40(4):1052.


Analgesic tolerance to morphine is regulated by PPARγ.

de Guglielmo G, Kallupi M, Scuppa G, Stopponi S, Demopulos G, Gaitanaris G, Ciccocioppo R.

Br J Pharmacol. 2014 Dec;171(23):5407-16. doi: 10.1111/bph.12851.


MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats.

de Guglielmo G, Martin-Fardon R, Teshima K, Ciccocioppo R, Weiss F.

Addict Biol. 2015 Jul;20(4):643-51. doi: 10.1111/adb.12157. Epub 2014 Jun 16.


Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors.

Ciccocioppo R, de Guglielmo G, Hansson AC, Ubaldi M, Kallupi M, Cruz MT, Oleata CS, Heilig M, Roberto M.

J Neurosci. 2014 Jan 8;34(2):363-72. doi: 10.1523/JNEUROSCI.2400-13.2014.


Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats.

Stopponi S, de Guglielmo G, Somaini L, Cippitelli A, Cannella N, Kallupi M, Ubaldi M, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R.

Alcohol Clin Exp Res. 2013 Aug;37(8):1351-60. doi: 10.1111/acer.12091. Epub 2013 Mar 29.


Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat.

Kallupi M, de Guglielmo G, Cannella N, Li HW, Caló G, Guerrini R, Ubaldi M, Renger JJ, Uebele VN, Ciccocioppo R.

Psychopharmacology (Berl). 2013 Mar;226(2):347-55. doi: 10.1007/s00213-012-2910-y. Epub 2012 Nov 13.


Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat.

de Guglielmo G, Cippitelli A, Somaini L, Gerra G, Li H, Stopponi S, Ubaldi M, Kallupi M, Ciccocioppo R.

Addict Biol. 2013 Jul;18(4):644-53. doi: 10.1111/j.1369-1600.2012.00468.x. Epub 2012 Jun 27.


Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat.

Stopponi S, Somaini L, Cippitelli A, de Guglielmo G, Kallupi M, Cannella N, Gerra G, Massi M, Ciccocioppo R.

Psychopharmacology (Berl). 2012 Mar;220(1):87-96. doi: 10.1007/s00213-011-2457-3. Epub 2011 Sep 2.


Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.

Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh J, Tauscher JT, Hunt SP, Hommer D, Heilig M.

Alcohol. 2009 Nov;43(7):491-8. doi: 10.1016/j.alcohol.2009.08.003. Review.

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