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Items: 1 to 50 of 144

1.

Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures.

Vangoor VR, Reschke CR, Senthilkumar K, van de Haar LL, de Wit M, Giuliani G, Broekhoven MH, Morris G, Engel T, Brennan GP, Conroy RM, van Rijen PC, Gosselaar PH, Schorge S, Schaapveld RQJ, Henshall DC, De Graan PNE, Pasterkamp RJ.

J Neurosci. 2019 Jun 26;39(26):5064-5079. doi: 10.1523/JNEUROSCI.3014-18.2019. Epub 2019 Apr 23.

PMID:
31015341
2.

Hyperthermia-induced seizures followed by repetitive stress are associated with age-dependent changes in specific aspects of the mouse stress system.

Umeoka EHL, Robinson EJ, Turimella SL, van Campen JS, Motta-Teixeira LC, Sarabdjitsingh RA, Garcia-Cairasco N, Braun K, de Graan PN, Joëls M.

J Neuroendocrinol. 2019 Apr;31(4):e12697. doi: 10.1111/jne.12697. Epub 2019 Mar 20.

PMID:
30773738
3.

Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice.

van Campen JS, Hessel EVS, Bohmbach K, Rizzi G, Lucassen PJ, Lakshmi Turimella S, Umeoka EHL, Meerhoff GF, Braun KPJ, de Graan PNE, Joëls M.

Front Endocrinol (Lausanne). 2018 Jan 26;9:3. doi: 10.3389/fendo.2018.00003. eCollection 2018.

4.

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

Hessel EV, van Lith HA, Wolterink-Donselaar IG, de Wit M, Groot Koerkamp MJ, Holstege FC, Kas MJ, Fernandes C, de Graan PN.

Eur J Neurosci. 2016 Dec;44(11):2950-2957. doi: 10.1111/ejn.13420.

PMID:
27690330
5.

Expression Profiling after Prolonged Experimental Febrile Seizures in Mice Suggests Structural Remodeling in the Hippocampus.

Jongbloets BC, van Gassen KL, Kan AA, Olde Engberink AH, de Wit M, Wolterink-Donselaar IG, Groot Koerkamp MJ, van Nieuwenhuizen O, Holstege FC, de Graan PN.

PLoS One. 2015 Dec 18;10(12):e0145247. doi: 10.1371/journal.pone.0145247. eCollection 2015.

6.

Identification of Srp9 as a febrile seizure susceptibility gene.

Hessel EV, de Wit M, Wolterink-Donselaar IG, Karst H, de Graaff E, van Lith HA, de Bruijn E, de Sonnaville S, Verbeek NE, Lindhout D, de Kovel CG, Koeleman BP, van Kempen M, Brilstra E, Cuppen E, Loos M, Spijker SS, Kan AA, Baars SE, van Rijen PC, Gosselaar PH, Groot Koerkamp MJ, Holstege FC, van Duijn C, Vergeer J, Moll HA, Taubøll E, Heuser K, Ramakers GM, Pasterkamp RJ, van Nieuwenhuizen O, Hoogenraad CC, Kas MJ, de Graan PN.

Ann Clin Transl Neurol. 2014 Apr;1(4):239-50. doi: 10.1002/acn3.48. Epub 2014 Mar 12.

7.

Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.

van der Hel WS, Hessel EV, Bos IW, Mulder SD, Verlinde SA, van Eijsden P, de Graan PN.

Eur J Neurosci. 2014 Dec;40(12):3711-9. doi: 10.1111/ejn.12756. Epub 2014 Oct 28.

PMID:
25350774
8.

Antenatal glucocorticoid treatment affects hippocampal development in mice.

Noorlander CW, Tijsseling D, Hessel EV, de Vries WB, Derks JB, Visser GH, de Graan PN.

PLoS One. 2014 Jan 22;9(1):e85671. doi: 10.1371/journal.pone.0085671. eCollection 2014.

9.

Early life stress in epilepsy: a seizure precipitant and risk factor for epileptogenesis.

van Campen JS, Jansen FE, de Graan PN, Braun KP, Joels M.

Epilepsy Behav. 2014 Sep;38:160-71. doi: 10.1016/j.yebeh.2013.09.029. Epub 2013 Oct 19. Review.

PMID:
24144618
10.

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A.

Kasperaviciute D, Catarino CB, Matarin M, Leu C, Novy J, Tostevin A, Leal B, Hessel EV, Hallmann K, Hildebrand MS, Dahl HH, Ryten M, Trabzuni D, Ramasamy A, Alhusaini S, Doherty CP, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Zumsteg D, Duncan S, Kälviäinen RK, Eriksson KJ, Kantanen AM, Pandolfo M, Gruber-Sedlmayr U, Schlachter K, Reinthaler EM, Stogmann E, Zimprich F, Théâtre E, Smith C, O'Brien TJ, Meng Tan K, Petrovski S, Robbiano A, Paravidino R, Zara F, Striano P, Sperling MR, Buono RJ, Hakonarson H, Chaves J, Costa PP, Silva BM, da Silva AM, de Graan PN, Koeleman BP, Becker A, Schoch S, von Lehe M, Reif PS, Rosenow F, Becker F, Weber Y, Lerche H, Rössler K, Buchfelder M, Hamer HM, Kobow K, Coras R, Blumcke I, Scheffer IE, Berkovic SF, Weale ME; UK Brain Expression Consortium, Delanty N, Depondt C, Cavalleri GL, Kunz WS, Sisodiya SM.

Brain. 2013 Oct;136(Pt 10):3140-50. doi: 10.1093/brain/awt233. Epub 2013 Sep 6.

11.

Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines.

Kan AA, de Jager W, de Wit M, Heijnen C, van Zuiden M, Ferrier C, van Rijen P, Gosselaar P, Hessel E, van Nieuwenhuizen O, de Graan PN.

J Neuroinflammation. 2012 Aug 30;9:207. doi: 10.1186/1742-2094-9-207.

12.

In vivo MRS and histochemistry of status epilepticus-induced hippocampal pathology in a juvenile model of temporal lobe epilepsy.

van der Hel WS, van Eijsden P, Bos IW, de Graaf RA, Behar KL, van Nieuwenhuizen O, de Graan PN, Braun KP.

NMR Biomed. 2013 Feb;26(2):132-40. doi: 10.1002/nbm.2828. Epub 2012 Jul 16.

PMID:
22806932
13.

Mapping an X-linked locus that influences heat-induced febrile seizures in mice.

Hessel EV, van Lith HA, Wolterink-Donselaar IG, de Wit M, Hendrickx DA, Kas MJ, de Graan PN.

Epilepsia. 2012 Aug;53(8):1399-410. doi: 10.1111/j.1528-1167.2012.03575.x. Epub 2012 Jul 10.

14.

Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6.

Nelson TE, Olde Engberink A, Hernandez R, Puro A, Huitron-Resendiz S, Hao C, De Graan PN, Gruol DL.

Brain Behav Immun. 2012 Aug;26(6):959-71. doi: 10.1016/j.bbi.2012.05.005. Epub 2012 May 17.

15.

Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response.

Kan AA, van Erp S, Derijck AA, de Wit M, Hessel EV, O'Duibhir E, de Jager W, Van Rijen PC, Gosselaar PH, de Graan PN, Pasterkamp RJ.

Cell Mol Life Sci. 2012 Sep;69(18):3127-45. doi: 10.1007/s00018-012-0992-7. Epub 2012 Apr 26.

16.

Prolonged increase in rat hippocampal chemokine signalling after status epilepticus.

Kan AA, van der Hel WS, Kolk SM, Bos IW, Verlinde SA, van Nieuwenhuizen O, de Graan PN.

J Neuroimmunol. 2012 Apr;245(1-2):15-22. doi: 10.1016/j.jneuroim.2012.01.012. Epub 2012 Feb 20.

17.

Chronic exposure to the chemokine CCL3 enhances neuronal network activity in rat hippocampal cultures.

Kuijpers M, van Gassen KL, de Graan PN, Gruol D.

J Neuroimmunol. 2010 Dec 15;229(1-2):73-80. doi: 10.1016/j.jneuroim.2010.07.004. Epub 2010 Aug 1.

18.

Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures.

Notenboom RG, Ramakers GM, Kamal A, Spruijt BM, de Graan PN.

Eur J Neurosci. 2010 Sep;32(5):749-58. doi: 10.1111/j.1460-9568.2010.07321.x. Epub 2010 Jul 16.

PMID:
20646062
19.

Hippocampal distribution of vesicular glutamate transporter 1 in patients with temporal lobe epilepsy.

van der Hel WS, Verlinde SA, Meijer DH, de Wit M, Rensen MG, van Gassen KL, van Rijen PC, van Veelen CW, de Graan PN.

Epilepsia. 2009 Jul;50(7):1717-28. doi: 10.1111/j.1528-1167.2009.02054.x. Epub 2009 Apr 6.

20.

Hippocampal Nabeta3 expression in patients with temporal lobe epilepsy.

van Gassen KL, de Wit M, van Kempen M, van der Hel WS, van Rijen PC, Jackson AP, Lindhout D, de Graan PN.

Epilepsia. 2009 Apr;50(4):957-62. doi: 10.1111/j.1528-1167.2008.02015.x. Epub 2009 Jan 26.

21.

Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures.

van Gassen KL, van der Hel WS, Hakvoort TB, Lamers WH, de Graan PN.

Genes Brain Behav. 2009 Apr;8(3):290-5. doi: 10.1111/j.1601-183X.2008.00471.x. Epub 2008 Dec 17.

22.

Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility.

Hessel EV, van Gassen KL, Wolterink-Donselaar IG, Stienen PJ, Fernandes C, Brakkee JH, Kas MJ, de Graan PN.

Genes Brain Behav. 2009 Mar;8(2):248-55. doi: 10.1111/j.1601-183X.2008.00466.x.

23.

High-resolution genetic mapping of mammalian motor activity levels in mice.

Kas MJ, de Mooij-van Malsen JG, de Krom M, van Gassen KL, van Lith HA, Olivier B, Oppelaar H, Hendriks J, de Wit M, Groot Koerkamp MJ, Holstege FC, van Oost BA, de Graan PN.

Genes Brain Behav. 2009 Feb;8(1):13-22. doi: 10.1111/j.1601-183X.2008.00435.x. Epub 2008 Aug 21.

24.

Characterization of febrile seizures and febrile seizure susceptibility in mouse inbred strains.

van Gassen KL, Hessel EV, Ramakers GM, Notenboom RG, Wolterink-Donselaar IG, Brakkee JH, Godschalk TC, Qiao X, Spruijt BM, van Nieuwenhuizen O, de Graan PN.

Genes Brain Behav. 2008 Jul;7(5):578-86. doi: 10.1111/j.1601-183X.2008.00393.x.

25.

Possible role of the innate immunity in temporal lobe epilepsy.

van Gassen KL, de Wit M, Koerkamp MJ, Rensen MG, van Rijen PC, Holstege FC, Lindhout D, de Graan PN.

Epilepsia. 2008 Jun;49(6):1055-65. Epub 2007 Dec 11.

26.

Prenatal corticosteroid exposure affects hippocampal plasticity and reduces lifespan.

Noorlander CW, Visser GH, Ramakers GM, Nikkels PG, de Graan PN.

Dev Neurobiol. 2008 Feb 1;68(2):237-46.

27.

Chronic interleukin-6 alters the level of synaptic proteins in hippocampus in culture and in vivo.

Vereyken EJ, Bajova H, Chow S, de Graan PN, Gruol DL.

Eur J Neurosci. 2007 Jun;25(12):3605-16.

PMID:
17610580
28.

Ontogeny of hippocampal corticosteroid receptors: effects of antenatal glucocorticoids in human and mouse.

Noorlander CW, De Graan PN, Middeldorp J, Van Beers JJ, Visser GH.

J Comp Neurol. 2006 Dec 20;499(6):924-32.

PMID:
17072842
29.

Persistent changes in action potential broadening and the slow afterhyperpolarization in rat CA1 pyramidal cells after febrile seizures.

Kamal A, Notenboom RG, de Graan PN, Ramakers GM.

Eur J Neurosci. 2006 Apr;23(8):2230-4.

PMID:
16630069
30.

Increased glutamine synthetase but normal EAAT2 expression in platelets of ALS patients.

Bos IW, Hoogland G, Meine Jansen CF, Willigen Gv, Spierenburg HA, van den Berg LH, de Graan PN.

Neurochem Int. 2006 Mar;48(4):306-11. Epub 2006 Jan 19.

PMID:
16426705
31.

Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients.

Notenboom RG, Hampson DR, Jansen GH, van Rijen PC, van Veelen CW, van Nieuwenhuizen O, de Graan PN.

Brain. 2006 Jan;129(Pt 1):96-107. Epub 2005 Nov 25.

PMID:
16311265
32.

Thrombin-stimulated glutamate uptake in human platelets is predominantly mediated by the glial glutamate transporter EAAT2.

Hoogland G, Bos IW, Kupper F, van Willigen G, Spierenburg HA, van Nieuwenhuizen O, de Graan PN.

Neurochem Int. 2005 Dec;47(7):499-506.

PMID:
16137792
33.

The chemokine CCL2 modulates Ca2+ dynamics and electrophysiological properties of cultured cerebellar Purkinje neurons.

van Gassen KL, Netzeband JG, de Graan PN, Gruol DL.

Eur J Neurosci. 2005 Jun;21(11):2949-57.

PMID:
15978006
34.

Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsy.

van der Hel WS, Notenboom RG, Bos IW, van Rijen PC, van Veelen CW, de Graan PN.

Neurology. 2005 Jan 25;64(2):326-33.

PMID:
15668432
35.

In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat.

van Eijsden P, Notenboom RG, Wu O, de Graan PN, van Nieuwenhuizen O, Nicolay K, Braun KP.

Brain Res. 2004 Dec 24;1030(1):11-8.

PMID:
15567333
36.

Differential localization of hamartin and tuberin and increased S6 phosphorylation in a tuber.

Jansen FE, Notenboom RG, Nellist M, Goedbloed MA, Halley DJ, de Graan PN, van Nieuwenhuizen O.

Neurology. 2004 Oct 12;63(7):1293-5.

PMID:
15477556
37.

Alternative splicing of glutamate transporter EAAT2 RNA in neocortex and hippocampus of temporal lobe epilepsy patients.

Hoogland G, van Oort RJ, Proper EA, Jansen GH, van Rijen PC, van Veelen CW, van Nieuwenhuizen O, Troost D, de Graan PN.

Epilepsy Res. 2004 Apr-May;59(2-3):75-82.

PMID:
15246112
38.

Synaptosomal glutamate and GABA transport in patients with temporal lobe epilepsy.

Hoogland G, Spierenburg HA, van Veelen CW, van Rijen PC, van Huffelen AC, de Graan PN.

J Neurosci Res. 2004 Jun 15;76(6):881-90.

PMID:
15160399
39.

Distribution of glutamate transporters in the human placenta.

Noorlander CW, de Graan PN, Nikkels PG, Schrama LH, Visser GH.

Placenta. 2004 Jul;25(6):489-95.

PMID:
15135231
40.

Group I metabotropic glutamate receptors regulate the frequency-response function of hippocampal CA1 synapses for the induction of LTP and LTD.

van Dam EJ, Kamal A, Artola A, de Graan PN, Gispen WH, Ramakers GM.

Eur J Neurosci. 2004 Jan;19(1):112-8.

PMID:
14750969
41.

Cells over-expressing EAAT2 protect motoneurons from excitotoxic death in vitro.

Wisman LA, van Muiswinkel FL, de Graan PN, Hol EM, Bär PR.

Neuroreport. 2003 Oct 27;14(15):1967-70.

PMID:
14561930
42.

Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms.

Hol EM, Roelofs RF, Moraal E, Sonnemans MA, Sluijs JA, Proper EA, de Graan PN, Fischer DF, van Leeuwen FW.

Mol Psychiatry. 2003 Sep;8(9):786-96.

PMID:
12931206
43.

Calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3.

van Dalen JJ, Gerendasy DD, de Graan PN, Schrama LH, Gruol DL.

Eur J Neurosci. 2003 Jul;18(1):13-22.

PMID:
12859333
44.

N-methyl-D-aspartate-induced long-term depression is associated with a decrease in postsynaptic protein kinase C substrate phosphorylation in rat hippocampal slices.

van Dam EJ, Ruiter B, Kamal A, Ramakers GM, Gispen WH, de Graan PN.

Neurosci Lett. 2002 Mar 8;320(3):129-32.

PMID:
11852179
45.

Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy.

Proper EA, Hoogland G, Kappen SM, Jansen GH, Rensen MG, Schrama LH, van Veelen CW, van Rijen PC, van Nieuwenhuizen O, Gispen WH, de Graan PN.

Brain. 2002 Jan;125(Pt 1):32-43.

PMID:
11834591
46.

Glutamate transporters alterations in the reorganizing dentate gyrus are associated with progressive seizure activity in chronic epileptic rats.

Gorter JA, Van Vliet EA, Proper EA, De Graan PN, Ghijsen WE, Lopes Da Silva FH, Aronica E.

J Comp Neurol. 2002 Jan 21;442(4):365-77.

PMID:
11793340
47.

A grading system for hippocampal sclerosis based on the degree of hippocampal mossy fiber sprouting.

Proper EA, Jansen GH, van Veelen CW, van Rijen PC, Gispen WH, de Graan PN.

Acta Neuropathol. 2001 Apr;101(4):405-9.

PMID:
11355312
48.
49.

Activation of pre- and postsynaptic protein kinase C during tetraethylammonium-induced long-term potentiation in the CA1 field of the hippocampus.

Ramakers GM, Pasinelli P, van Beest M, van der Slot A, Gispen WH, De Graan PN.

Neurosci Lett. 2000 May 26;286(1):53-6.

PMID:
10822151
50.

Glutamate and gamma-aminobutyric acid content and release of synaptosomes from temporal lobe epilepsy patients.

Hoogland G, Hens JJ, De Wit M, van Veelen CW, van Huffelen AC, Gispen WH, de Graan PN.

J Neurosci Res. 2000 Jun 1;60(5):686-95.

PMID:
10820440

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