Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 49

1.

Development of a Novel Ex-vivo 3D Model to Screen Amoebicidal Activity on Infected Tissue.

Guzmán-Delgado NE, Carranza-Torres IE, García-Davis S, Rivera G, Morán-Martínez J, Betancourt-Martínez ND, Groothuis GMM, de Graaf IAM, Carranza-Rosales P.

Sci Rep. 2019 Jun 10;9(1):8396. doi: 10.1038/s41598-019-44899-5.

2.

Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study.

Bigaeva E, Bomers JJM, Biel C, Mutsaers HAM, de Graaf IAM, Boersema M, Olinga P.

Toxicol In Vitro. 2019 Sep;59:312-321. doi: 10.1016/j.tiv.2019.05.024. Epub 2019 May 31.

3.

Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter.

Li M, Vokral I, Evers B, de Graaf IAM, de Jager MH, Groothuis GMM.

Eur J Pharm Sci. 2018 Aug 30;121:65-73. doi: 10.1016/j.ejps.2018.05.005. Epub 2018 May 9. No abstract available.

PMID:
29751102
4.

On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent.

Spreckelmeyer S, Estrada-Ortiz N, Prins GGH, van der Zee M, Gammelgaard B, Stürup S, de Graaf IAM, Groothuis GMM, Casini A.

Metallomics. 2017 Dec 1;9(12):1786-1795. doi: 10.1039/c7mt00271h. Epub 2017 Nov 6.

PMID:
29104982
5.

Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study.

Estrada-Ortiz N, Guarra F, de Graaf IAM, Marchetti L, de Jager MH, Groothuis GMM, Gabbiani C, Casini A.

ChemMedChem. 2017 Sep 7;12(17):1429-1435. doi: 10.1002/cmdc.201700316. Epub 2017 Aug 29.

PMID:
28741878
6.

Rat precision-cut liver slices predict drug-induced cholestatic injury.

Starokozhko V, Greupink R, van de Broek P, Soliman N, Ghimire S, de Graaf IAM, Groothuis GMM.

Arch Toxicol. 2017 Oct;91(10):3403-3413. doi: 10.1007/s00204-017-1960-7. Epub 2017 Apr 8.

7.

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.

Li M, de Graaf IA, van de Steeg E, de Jager MH, Groothuis GM.

Toxicol In Vitro. 2017 Apr;40:26-33. doi: 10.1016/j.tiv.2016.12.002. Epub 2016 Dec 7.

PMID:
27939799
8.

P-gp activity and inhibition in the different regions of human intestine ex vivo.

Li M, de Graaf IA, de Jager MH, Groothuis GM.

Biopharm Drug Dispos. 2017 Mar;38(2):127-138. doi: 10.1002/bdd.2047. Epub 2016 Nov 14.

PMID:
27757966
9.

An integrative view of cisplatin-induced renal and cardiac toxicities: Molecular mechanisms, current treatment challenges and potential protective measures.

Dugbartey GJ, Peppone LJ, de Graaf IA.

Toxicology. 2016 Sep 14;371:58-66. doi: 10.1016/j.tox.2016.10.001. Epub 2016 Oct 4. Review.

10.

Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.

Moser J, Heeringa P, Jongman RM, Zwiers PJ, Niemarkt AE, Yan R, de Graaf IA, Li R, Ravasz Regan E, Kümpers P, Aird WC, van Nieuw Amerongen GP, Zijlstra JG, Molema G, van Meurs M.

J Immunol. 2016 Jun 1;196(11):4681-91. doi: 10.4049/jimmunol.1501819. Epub 2016 Apr 29.

11.

The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices.

Li M, de Graaf IA, Siissalo S, de Jager MH, van Dam A, Groothuis GM.

Drug Metab Dispos. 2016 May;44(5):683-91. doi: 10.1124/dmd.115.068684. Epub 2016 Mar 1.

PMID:
26932816
12.

Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research.

Li M, de Graaf IA, Groothuis GM.

Expert Opin Drug Metab Toxicol. 2016;12(2):175-90. doi: 10.1517/17425255.2016.1125882. Epub 2016 Jan 9. Review.

PMID:
26750630
13.

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group.

Muenzner JK, Rehm T, Biersack B, Casini A, de Graaf IA, Worawutputtapong P, Noor A, Kempe R, Brabec V, Kasparkova J, Schobert R.

J Med Chem. 2015 Aug 13;58(15):6283-92. doi: 10.1021/acs.jmedchem.5b00896. Epub 2015 Jul 29.

PMID:
26182125
14.

Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.

Li M, de Graaf IA, de Jager MH, Groothuis GM.

Toxicol In Vitro. 2015 Aug;29(5):1070-8. doi: 10.1016/j.tiv.2015.04.011. Epub 2015 Apr 25.

PMID:
25917215
15.

Precision-cut rat, mouse, and human intestinal slices as novel models for the early-onset of intestinal fibrosis.

Pham BT, van Haaften WT, Oosterhuis D, Nieken J, de Graaf IA, Olinga P.

Physiol Rep. 2015 Apr;3(4). pii: e12323. doi: 10.14814/phy2.12323.

16.

Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity.

Daum S, Chekhun VF, Todor IN, Lukianova NY, Shvets YV, Sellner L, Putzker K, Lewis J, Zenz T, de Graaf IA, Groothuis GM, Casini A, Zozulia O, Hampel F, Mokhir A.

J Med Chem. 2015 Feb 26;58(4):2015-24. doi: 10.1021/jm5019548. Epub 2015 Feb 9.

PMID:
25633601
17.

Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo.

Niu X, de Graaf IA, van de Vegte D, Langelaar-Makkinje M, Sekine S, Groothuis GM.

Toxicol In Vitro. 2015 Feb;29(1):168-75.

PMID:
25450747
18.

Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats.

Niu X, de Graaf IA, van der Bij HA, Groothuis GM.

Toxicol In Vitro. 2014 Oct;28(7):1296-305. doi: 10.1016/j.tiv.2014.06.010. Epub 2014 Jul 8.

PMID:
25014874
19.

Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.

Niu X, de Graaf IA, Langelaar-Makkinje M, Horvatovich P, Groothuis GM.

Arch Toxicol. 2015 Jan;89(1):107-19. doi: 10.1007/s00204-014-1242-6. Epub 2014 Apr 26.

PMID:
24770551
20.

Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine.

Siissalo S, de Waard H, de Jager MH, Hayeshi R, Frijlink HW, Hinrichs WL, Dinter-Heidorn H, van Dam A, Proost JH, Groothuis GM, de Graaf IA.

Drug Metab Dispos. 2013 Aug;41(8):1557-65. doi: 10.1124/dmd.112.049585. Epub 2013 Jun 3.

PMID:
23733277
21.

Bilitranslocase is involved in the uptake of bromosulfophthalein in rat and human liver.

Terdoslavich M, de Graaf IA, Proost JH, Cocolo A, Passamonti S, Groothuis GM.

Drug Metab Lett. 2012 Sep 1;6(3):165-73.

PMID:
23470127
22.

Analysis of gene expression changes to elucidate the mechanism of chilling injury in precision-cut liver slices.

Guan N, Blomsma SA, Fahy GM, Groothuis GM, de Graaf IA.

Toxicol In Vitro. 2013 Mar;27(2):890-9. doi: 10.1016/j.tiv.2012.10.009. Epub 2012 Oct 27.

PMID:
23111282
23.

Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices.

Niu X, de Graaf IA, Groothuis GM.

Xenobiotica. 2013 Jan;43(1):73-83. doi: 10.3109/00498254.2012.729870. Epub 2012 Oct 30. Review.

PMID:
23106567
24.

Cryopreservation of precision-cut tissue slices.

Fahy GM, Guan N, de Graaf IA, Tan Y, Griffin L, Groothuis GM.

Xenobiotica. 2013 Jan;43(1):113-32. doi: 10.3109/00498254.2012.728300. Epub 2012 Oct 30. Review.

PMID:
23106534
25.

Effects of cryoprotectant addition and washout methods on the viability of precision-cut liver slices.

Guan N, Blomsma SA, van Midwoud PM, Fahy GM, Groothuis GM, de Graaf IA.

Cryobiology. 2012 Dec;65(3):179-87. doi: 10.1016/j.cryobiol.2012.05.011. Epub 2012 Jun 18.

PMID:
22722061
26.

Precision-cut intestinal slices as in vitro tool for studies on drug metabolism.

Groothuis GM, de Graaf IA.

Curr Drug Metab. 2013 Jan;14(1):112-9. Review.

PMID:
22497569
27.

Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4.

Wittgen HG, van den Heuvel JJ, van den Broek PH, Siissalo S, Groothuis GM, de Graaf IA, Koenderink JB, Russel FG.

Drug Metab Dispos. 2012 Jun;40(6):1076-9. doi: 10.1124/dmd.111.044438. Epub 2012 Mar 12.

PMID:
22415933
28.

On-line HPLC analysis system for metabolism and inhibition studies in precision-cut liver slices.

van Midwoud PM, Janssen J, Merema MT, de Graaf IA, Groothuis GM, Verpoorte E.

Anal Chem. 2011 Jan 1;83(1):84-91. doi: 10.1021/ac1018638. Epub 2010 Dec 3.

PMID:
21128611
29.

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.

de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM.

Nat Protoc. 2010 Sep;5(9):1540-51. doi: 10.1038/nprot.2010.111. Epub 2010 Aug 19.

PMID:
20725069
30.

Reduced ischemia-reoxygenation injury in rat intestine after luminal preservation with a tailored solution.

Roskott AM, Nieuwenhuijs VB, Leuvenink HG, Dijkstra G, Ottens P, de Jager MH, Gonalves Dias Pereira P, Fidler V, Groothuis GM, Ploeg RJ, de Graaf IA.

Transplantation. 2010 Sep 27;90(6):622-9. doi: 10.1097/TP.0b013e3181ebf796.

PMID:
20689496
31.

Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study.

Asgeirsdóttir SA, Talman EG, de Graaf IA, Kamps JA, Satchell SC, Mathieson PW, Ruiters MH, Molema G.

J Control Release. 2010 Jan 25;141(2):241-51. doi: 10.1016/j.jconrel.2009.09.008. Epub 2009 Sep 18.

PMID:
19766679
32.

Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function.

van Meurs M, Kurniati NF, Wulfert FM, Asgeirsdottir SA, de Graaf IA, Satchell SC, Mathieson PW, Jongman RM, Kümpers P, Zijlstra JG, Heeringa P, Molema G.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F272-81. doi: 10.1152/ajprenal.00137.2009. Epub 2009 Jun 10.

33.

Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro.

van de Kerkhof EG, de Graaf IA, Ungell AL, Groothuis GM.

Drug Metab Dispos. 2008 Mar;36(3):604-13. Epub 2007 Dec 19.

PMID:
18094037
34.

In vitro methods to study intestinal drug metabolism.

van de Kerkhof EG, de Graaf IA, Groothuis GM.

Curr Drug Metab. 2007 Oct;8(7):658-75. Review.

PMID:
17979654
35.

Induction of phase I and II drug metabolism in rat small intestine and colon in vitro.

van de Kerkhof EG, de Graaf IA, de Jager MH, Groothuis GM.

Drug Metab Dispos. 2007 Jun;35(6):898-907. Epub 2007 Mar 7.

PMID:
17344336
36.

Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification.

de Graaf IA, Draaisma AL, Schoeman O, Fahy GM, Groothuis GM, Koster HJ.

Cryobiology. 2007 Feb;54(1):1-12. Epub 2006 Dec 12.

PMID:
17166492
37.

Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

van de Kerkhof EG, Ungell AL, Sjöberg AK, de Jager MH, Hilgendorf C, de Graaf IA, Groothuis GM.

Drug Metab Dispos. 2006 Nov;34(11):1893-902. Epub 2006 Aug 16.

PMID:
16914511
38.

Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.

de Graaf IA, de Kanter R, de Jager MH, Camacho R, Langenkamp E, van de Kerkhof EG, Groothuis GM.

Drug Metab Dispos. 2006 Apr;34(4):591-9. Epub 2006 Jan 13.

PMID:
16415126
39.

Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.

van de Kerkhof EG, de Graaf IA, de Jager MH, Meijer DK, Groothuis GM.

Drug Metab Dispos. 2005 Nov;33(11):1613-20. Epub 2005 Jul 28.

PMID:
16051733
40.

A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies.

de Kanter R, Tuin A, van de Kerkhof E, Martignoni M, Draaisma AL, de Jager MH, de Graaf IA, Meijer DK, Groothuis GM.

J Pharmacol Toxicol Methods. 2005 Jan-Feb;51(1):65-72.

PMID:
15596116
41.

Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon.

De Kanter R, Monshouwer M, Draaisma AL, De Jager MH, de Graaf IA, Proost JH, Meijer DK, Groothuis GM.

Xenobiotica. 2004 Mar;34(3):229-41.

PMID:
15204696
42.

Cryopreservation of precision-cut tissue slices for application in drug metabolism research.

de Graaf IA, Koster HJ.

Toxicol In Vitro. 2003 Feb;17(1):1-17. Review.

PMID:
12537957
43.
44.

Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism.

De Graaf IA, Van Meijeren CE, Pektaş F, Koster HJ.

Drug Metab Dispos. 2002 Oct;30(10):1129-36.

PMID:
12228190
45.

Water crystallization within rat precision-cut liver slices in relation to their viability.

de Graaf IA, Koster HJ.

Cryobiology. 2001 Nov;43(3):224-37.

PMID:
11888216
46.
47.

Assessment of some critical factors in the freezing technique for the cryopreservation of precision-cut rat liver slices.

Maas WJ, de Graaf IA, Schoen ED, Koster HJ, van de Sandt JJ, Groten JP.

Cryobiology. 2000 May;40(3):250-63.

PMID:
10860624
48.

Intercellular communication and cell proliferation in precision-cut rat liver slices: effect of medium composition and DDT.

de Graaf IA, Tajima O, Groten JP, Wolterbeek AP.

Cancer Lett. 2000 Jun 1;154(1):53-62.

PMID:
10799739
49.

Paraquat Exposure of Knapsack Spray Operators on Banana Plantations in Costa Rica.

Van Wendel de Joode BN, De Graaf IAM, Wesseling C, Kromhout H.

Int J Occup Environ Health. 1996 Oct;2(4):294-304.

PMID:
9933884

Supplemental Content

Loading ...
Support Center