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Items: 1 to 50 of 428

1.

The Landscape of Atypical and Eukaryotic Protein Kinases.

Kanev GK, de Graaf C, de Esch IJP, Leurs R, Würdinger T, Westerman BA, Kooistra AJ.

Trends Pharmacol Sci. 2019 Nov;40(11):818-832. doi: 10.1016/j.tips.2019.09.002. Epub 2019 Oct 31. Review.

2.

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells.

Brinkmann K, Ng AP, de Graaf CA, Di Rago L, Hyland CD, Morelli E, Rautela J, Huntington ND, Strasser A, Alexander WS, Herold MJ.

Cell Death Differ. 2019 Oct 7. doi: 10.1038/s41418-019-0430-6. [Epub ahead of print]

PMID:
31591473
3.

Modulators of CXCR4 and CXCR7/ACKR3 function.

Adlere I, Caspar B, Arimont M, Dekkers S, Visser K, Stuijt J, de Graaf C, Stocks M, Kellam B, Briddon S, Wijtmans M, de Esch I, Hill S, Leurs R.

Mol Pharmacol. 2019 Sep 23. pii: mol.119.117663. doi: 10.1124/mol.119.117663. [Epub ahead of print]

4.

Theoretical studies on the energy structures and optical properties of copper cysteamine - a novel sensitizer.

Alias M, Alkhaldi ND, Reguero M, Ma L, Zhang J, de Graaf C, Huda MN, Chen W.

Phys Chem Chem Phys. 2019 Oct 7;21(37):21084-21093. doi: 10.1039/c9cp04392f. Epub 2019 Sep 17.

PMID:
31528957
5.

Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.

O'Brien A, Andrews SP, Baig AH, Bortolato A, Brown AJH, Brown GA, Brown SH, Christopher JA, Congreve M, Cooke RM, De Graaf C, Errey JC, Fieldhouse C, Jazayeri A, Marshall FH, Mason JS, Mobarec JC, Okrasa K, Steele KN, Southall SM, Teobald I, Watson SP, Weir M.

Bioorg Med Chem Lett. 2019 Oct 15;29(20):126611. doi: 10.1016/j.bmcl.2019.08.015. Epub 2019 Aug 9.

PMID:
31447084
6.

Baby's first bites: a randomized controlled trial to assess the effects of vegetable-exposure and sensitive feeding on vegetable acceptance, eating behavior and weight gain in infants and toddlers.

van der Veek SMC, de Graaf C, de Vries JHM, Jager G, Vereijken CMJL, Weenen H, van Winden N, van Vliet MS, Schultink JM, de Wild VWT, Janssen S, Mesman J.

BMC Pediatr. 2019 Aug 1;19(1):266. doi: 10.1186/s12887-019-1627-z.

7.

Multiple vs Single Target Vegetable Exposure to Increase Young Children's Vegetable Intake.

Poelman AAM, Delahunty CM, Broch M, de Graaf C.

J Nutr Educ Behav. 2019 Sep;51(8):985-992. doi: 10.1016/j.jneb.2019.06.009. Epub 2019 Jul 23.

PMID:
31345677
8.

Colouring perception: Package colour cues affect neural responses to sweet dairy drinks in reward and inhibition related regions.

Tijssen IOJM, Smeets PAM, Goedegebure RPG, Zandstra EH, de Graaf C, Jager G.

Appetite. 2019 Nov 1;142:104378. doi: 10.1016/j.appet.2019.104378. Epub 2019 Jul 18.

PMID:
31326440
9.

Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine.

Bosma R, Wang Z, Kooistra AJ, Bushby N, Kuhne S, van den Bor J, Waring MJ, de Graaf C, de Esch IJ, Vischer HF, Sheppard RJ, Wijtmans M, Leurs R.

J Med Chem. 2019 Jul 25;62(14):6630-6644. doi: 10.1021/acs.jmedchem.9b00447. Epub 2019 Jul 5.

10.

Chemokine receptor crystal structures: what can be learnt from them?

Arimont M, Hoffmann C, de Graaf C, Leurs R.

Mol Pharmacol. 2019 Jul 2. pii: mol.119.117168. doi: 10.1124/mol.119.117168. [Epub ahead of print]

11.

Understanding Ligand Binding Selectivity in a Prototypical GPCR Family.

Mattedi G, Deflorian F, Mason JS, de Graaf C, Gervasio FL.

J Chem Inf Model. 2019 Jun 24;59(6):2830-2836. doi: 10.1021/acs.jcim.9b00298. Epub 2019 Jun 4.

PMID:
31125224
12.

Corrigendum to "Time of on-scene resuscitation in out of-hospital cardiac arrest patients transported without return of spontaneous circulation" [Resuscitation 138 (2019) 235-242].

de Graaf C, Beesems SG, Koster RW.

Resuscitation. 2019 Jul;140:223. doi: 10.1016/j.resuscitation.2019.05.003. Epub 2019 May 18. No abstract available.

PMID:
31100212
13.

Time of on-scene resuscitation in out of-hospital cardiac arrest patients transported without return of spontaneous circulation.

de Graaf C, Beesems SG, Koster RW.

Resuscitation. 2019 May;138:235-242. doi: 10.1016/j.resuscitation.2019.03.030. Epub 2019 Mar 27. Erratum in: Resuscitation. 2019 Jul;140:223.

PMID:
30928502
14.

Age, gender, ethnicity and eating capability influence oral processing behaviour of liquid, semi-solid and solid foods differently.

Ketel EC, Aguayo-Mendoza MG, de Wijk RA, de Graaf C, Piqueras-Fiszman B, Stieger M.

Food Res Int. 2019 May;119:143-151. doi: 10.1016/j.foodres.2019.01.048. Epub 2019 Jan 22.

PMID:
30884642
15.

How Does the Redox State of Polyoxovanadates Influence the Collective Behavior in Solution? A Case Study with [I@V18O42] q- ( q = 3, 5, 7, 11, and 13).

Solé-Daura A, Notario-Estévez A, Carbó JJ, Poblet JM, de Graaf C, Monakhov KY, López X.

Inorg Chem. 2019 Mar 18;58(6):3881-3894. doi: 10.1021/acs.inorgchem.8b03508. Epub 2019 Mar 4.

PMID:
30830759
16.

A systematic review of practices to promote vegetable acceptance in the first three years of life.

Barends C, Weenen H, Warren J, Hetherington MM, de Graaf C, de Vries JHM.

Appetite. 2019 Jun 1;137:174-197. doi: 10.1016/j.appet.2019.02.003. Epub 2019 Feb 19. Review.

PMID:
30794819
17.

Trends in the Bond Multiplicity of Cr2, Cr3, and Cr2M (M = Zn, Ni, Fe, Mn) Complexes Extracted from Multiconfigurational Wave Functions.

Spivak M, López X, de Graaf C.

J Phys Chem A. 2019 Feb 28;123(8):1538-1547. doi: 10.1021/acs.jpca.8b10124. Epub 2019 Feb 13.

PMID:
30702886
18.

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.

Adlere I, Sun S, Zarca A, Roumen L, Gozelle M, Viciano CP, Caspar B, Arimont M, Bebelman JP, Briddon SJ, Hoffmann C, Hill SJ, Smit MJ, Vischer HF, Wijtmans M, de Graaf C, de Esch IJP, Leurs R.

Eur J Med Chem. 2019 Jan 15;162:631-649. doi: 10.1016/j.ejmech.2018.10.060. Epub 2018 Oct 30.

PMID:
30476826
19.

Brain Responses to Anticipation and Consumption of Beer with and without Alcohol.

Smeets PAM, de Graaf C.

Chem Senses. 2019 Jan 1;44(1):51-60. doi: 10.1093/chemse/bjy071.

PMID:
30423017
20.

Addressing Multiple Resistive States of Polyoxovanadates: Conductivity as a Function of Individual Molecular Redox States.

Linnenberg O, Moors M, Notario-Estévez A, López X, de Graaf C, Peter S, Baeumer C, Waser R, Monakhov KY.

J Am Chem Soc. 2018 Dec 5;140(48):16635-16640. doi: 10.1021/jacs.8b08780. Epub 2018 Nov 27.

PMID:
30418764
21.

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans.

Choi J, Baldwin TM, Wong M, Bolden JE, Fairfax KA, Lucas EC, Cole R, Biben C, Morgan C, Ramsay KA, Ng AP, Kauppi M, Corcoran LM, Shi W, Wilson N, Wilson MJ, Alexander WS, Hilton DJ, de Graaf CA.

Nucleic Acids Res. 2019 Jan 8;47(D1):D780-D785. doi: 10.1093/nar/gky1020.

22.

Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data.

Vass M, Podlewska S, de Esch IJP, Bojarski AJ, Leurs R, Kooistra AJ, de Graaf C.

J Med Chem. 2019 Apr 25;62(8):3784-3839. doi: 10.1021/acs.jmedchem.8b00836. Epub 2018 Nov 27.

PMID:
30351004
23.

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry.

Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, Van Loy T, Smit MJ, Schols D.

Biochem Pharmacol. 2018 Dec;158:402-412. doi: 10.1016/j.bcp.2018.10.015. Epub 2018 Oct 17.

PMID:
30342024
24.

Evaluation of dietary taste patterns as assessed by FFQ against 24-h recalls and biomarkers of exposure.

van Langeveld AWB, Teo PS, Mars M, Feskens EJM, de Graaf C, de Vries JHM.

Eur J Clin Nutr. 2019 Jan;73(1):132-140. doi: 10.1038/s41430-018-0300-1. Epub 2018 Sep 25.

PMID:
30254242
25.

Sweetness but not sourness enhancement increases acceptance of cucumber and green capsicum purees in children.

van Stokkom VL, Poelman AAM, de Graaf C, van Kooten O, Stieger M.

Appetite. 2018 Dec 1;131:100-107. doi: 10.1016/j.appet.2018.08.034. Epub 2018 Sep 11.

PMID:
30213749
26.

Effect of Taste Enhancement on Consumer Acceptance of Pureed Cucumber and Green Capsicum.

van Stokkom VL, de Graaf C, van Kooten O, Stieger M.

J Food Sci. 2018 Oct;83(10):2578-2585. doi: 10.1111/1750-3841.14325. Epub 2018 Sep 4.

PMID:
30178873
27.

Modulation of event-related potentials to food cues upon sensory-specific satiety.

Zoon HFA, Ohla K, de Graaf C, Boesveldt S.

Physiol Behav. 2018 Nov 1;196:126-134. doi: 10.1016/j.physbeh.2018.08.020. Epub 2018 Aug 30.

PMID:
30172720
28.

Identification and detection of protein markers to differentiate between forensically relevant body fluids.

de Beijer RP, de Graaf C, van Weert A, van Leeuwen TG, Aalders MCG, van Dam A.

Forensic Sci Int. 2018 Sep;290:196-206. doi: 10.1016/j.forsciint.2018.07.013. Epub 2018 Jul 24.

PMID:
30071450
29.

The magnetic fingerprint of dithiazolyl-based molecule magnets.

Francese T, Ribas-Arino J, Novoa JJ, Havenith RWA, Broer R, de Graaf C, Deumal M.

Phys Chem Chem Phys. 2018 Aug 8;20(31):20406-20416. doi: 10.1039/c8cp03173h.

PMID:
30042990
30.

Altered neural responsivity to food cues in relation to food preferences, but not appetite-related hormone concentrations after RYGB-surgery.

Zoon HFA, de Bruijn SEM, Smeets PAM, de Graaf C, Janssen IMC, Schijns W, Aarts EO, Jager G, Boesveldt S.

Behav Brain Res. 2018 Nov 1;353:194-202. doi: 10.1016/j.bbr.2018.07.016. Epub 2018 Jul 21.

31.

Exacting Responses: Lack of Endocrine Cephalic Phase Responses Upon Oro-Sensory Exposure.

Lasschuijt MP, Mars M, de Graaf C, Smeets PAM.

Front Endocrinol (Lausanne). 2018 Jun 13;9:332. doi: 10.3389/fendo.2018.00332. eCollection 2018.

32.

Altered neural inhibition responses to food cues after Roux-en-Y Gastric Bypass.

Zoon HFA, de Bruijn SEM, Jager G, Smeets PAM, de Graaf C, Janssen IMC, Schijns W, Deden L, Boesveldt S.

Biol Psychol. 2018 Sep;137:34-41. doi: 10.1016/j.biopsycho.2018.06.005. Epub 2018 Jun 23.

PMID:
29944963
33.

PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors.

Pang SHM, de Graaf CA, Hilton DJ, Huntington ND, Carotta S, Wu L, Nutt SL.

Front Immunol. 2018 Jun 11;9:1264. doi: 10.3389/fimmu.2018.01264. eCollection 2018.

34.

Decoding the role of encapsulated ions in the electronic and magnetic properties of mixed-valence polyoxovanadate capsules {X@V22O54} (X = ClO4-, SCN-, VO2F2-): a combined theoretical approach.

Notario-Estévez A, Kozłowski P, Linnenberg O, de Graaf C, López X, Monakhov KY.

Phys Chem Chem Phys. 2018 Jul 14;20(26):17847-17858. doi: 10.1039/c8cp02669f. Epub 2018 Jun 20.

PMID:
29923560
35.

Deactivation of Excited States in Transition-Metal Complexes: Insight from Computational Chemistry.

Sousa C, Alías M, Domingo A, de Graaf C.

Chemistry. 2019 Jan 24;25(5):1152-1164. doi: 10.1002/chem.201801990. Epub 2018 Nov 19. Review.

PMID:
29882615
36.

Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation.

Marsman C, Lafouresse F, Liao Y, Baldwin TM, Mielke LA, Hu Y, Mack M, Hertzog PJ, de Graaf CA, Shi W, Groom JR.

Immunol Cell Biol. 2018 Nov;96(10):1083-1094. doi: 10.1111/imcb.12173. Epub 2018 Jun 25.

PMID:
29870118
37.

Sensory analysis of characterising flavours: evaluating tobacco product odours using an expert panel.

Krüsemann EJZ, Lasschuijt MP, de Graaf C, de Wijk RA, Punter PH, van Tiel L, Cremers JWJM, van de Nobelen S, Boesveldt S, Talhout R.

Tob Control. 2019 Mar;28(2):152-160. doi: 10.1136/tobaccocontrol-2017-054152. Epub 2018 May 23.

38.

Dietary taste patterns by sex and weight status in the Netherlands.

van Langeveld AWB, Teo PS, de Vries JHM, Feskens EJM, de Graaf C, Mars M.

Br J Nutr. 2018 May;119(10):1195-1206. doi: 10.1017/S0007114518000715.

PMID:
29759103
39.

Transcriptional profiling of eosinophil subsets in interleukin-5 transgenic mice.

Fairfax KA, Bolden JE, Robinson AJ, Lucas EC, Baldwin TM, Ramsay KA, Cole R, Hilton DJ, de Graaf CA.

J Leukoc Biol. 2018 Jul;104(1):195-204. doi: 10.1002/JLB.6MA1117-451R. Epub 2018 May 14.

40.

Just add water: Effects of added gastric distention by water on gastric emptying and satiety related brain activity.

Camps G, Veit R, Mars M, de Graaf C, Smeets PA.

Appetite. 2018 Aug 1;127:195-202. doi: 10.1016/j.appet.2018.04.023. Epub 2018 May 3.

PMID:
29730186
41.

Dynamic tuneable G protein-coupled receptor monomer-dimer populations.

Dijkman PM, Castell OK, Goddard AD, Munoz-Garcia JC, de Graaf C, Wallace MI, Watts A.

Nat Commun. 2018 Apr 27;9(1):1710. doi: 10.1038/s41467-018-03727-6.

42.

Structural insights into serotonin receptor ligands polypharmacology.

Podlewska S, Kafel R, Lacivita E, Satała G, Kooistra AJ, Vass M, de Graaf C, Leopoldo M, Bojarski AJ, Mordalski S.

Eur J Med Chem. 2018 May 10;151:797-814. doi: 10.1016/j.ejmech.2018.04.010. Epub 2018 Apr 6.

PMID:
29679900
43.

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.

Blaazer AR, Singh AK, de Heuvel E, Edink E, Orrling KM, Veerman JJN, van den Bergh T, Jansen C, Balasubramaniam E, Mooij WJ, Custers H, Sijm M, Tagoe DNA, Kalejaiye TD, Munday JC, Tenor H, Matheeussen A, Wijtmans M, Siderius M, de Graaf C, Maes L, de Koning HP, Bailey DS, Sterk GJ, de Esch IJP, Brown DG, Leurs R.

J Med Chem. 2018 May 10;61(9):3870-3888. doi: 10.1021/acs.jmedchem.7b01670. Epub 2018 May 1.

44.

Identification of a Siglec-F+ granulocyte-macrophage progenitor.

Bolden JE, Lucas EC, Zhou G, O'Sullivan JA, de Graaf CA, McKenzie MD, Di Rago L, Baldwin TM, Shortt J, Alexander WS, Bochner BS, Ritchie ME, Hilton DJ, Fairfax KA.

J Leukoc Biol. 2018 Jul;104(1):123-133. doi: 10.1002/JLB.1MA1217-475R. Epub 2018 Apr 12.

45.

Chemical Diversity in the G Protein-Coupled Receptor Superfamily.

Vass M, Kooistra AJ, Yang D, Stevens RC, Wang MW, de Graaf C.

Trends Pharmacol Sci. 2018 May;39(5):494-512. doi: 10.1016/j.tips.2018.02.004. Epub 2018 Mar 22. Review.

PMID:
29576399
46.

Sweet taste exposure and the subsequent acceptance and preference for sweet taste in the diet: systematic review of the published literature.

Appleton KM, Tuorila H, Bertenshaw EJ, de Graaf C, Mela DJ.

Am J Clin Nutr. 2018 Mar 1;107(3):405-419. doi: 10.1093/ajcn/nqx031.

PMID:
29566187
47.

The efficacy of daily snack replacement with oligofructose-enriched granola bars in overweight and obese adults: a 12-week randomised controlled trial.

Pol K, de Graaf C, Meyer D, Mars M.

Br J Nutr. 2018 May;119(9):1076-1086. doi: 10.1017/S0007114518000211. Epub 2018 Mar 1.

PMID:
29490721
48.

Taste and smell perception and quality of life during and after systemic therapy for breast cancer.

de Vries YC, Boesveldt S, Kelfkens CS, Posthuma EE, van den Berg MMGA, de Kruif JTCM, Haringhuizen A, Sommeijer DW, Buist N, Grosfeld S, de Graaf C, van Laarhoven HWM, Kampman E, Winkels RM.

Breast Cancer Res Treat. 2018 Jul;170(1):27-34. doi: 10.1007/s10549-018-4720-3. Epub 2018 Feb 23.

49.

Indirect vs direct assessment of gastric emptying: A randomized crossover trial comparing C-isotope breath analysis and MRI.

Camps G, Mars M, Witteman BJM, de Graaf C, Smeets PAM.

Neurogastroenterol Motil. 2018 Jul;30(7):e13317. doi: 10.1111/nmo.13317. Epub 2018 Feb 23.

PMID:
29473700
50.

Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology.

Hauwert NJ, Mocking TAM, Da Costa Pereira D, Kooistra AJ, Wijnen LM, Vreeker GCM, Verweij EWE, De Boer AH, Smit MJ, De Graaf C, Vischer HF, de Esch IJP, Wijtmans M, Leurs R.

J Am Chem Soc. 2018 Mar 28;140(12):4232-4243. doi: 10.1021/jacs.7b11422. Epub 2018 Mar 14.

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