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Items: 29

1.

'2A-Like' Signal Sequences Mediating Translational Recoding: A Novel Form of Dual Protein Targeting.

Roulston C, Luke GA, de Felipe P, Ruan L, Cope J, Nicholson J, Sukhodub A, Tilsner J, Ryan MD.

Traffic. 2016 Aug;17(8):923-39. doi: 10.1111/tra.12411. Epub 2016 Jun 2.

2.

Lost in translation: The biogenesis of non-LTR retrotransposon proteins.

Luke GA, Roulston C, Odon V, de Felipe P, Sukhodub A, Ryan MD.

Mob Genet Elements. 2013 Nov 1;3(6):e27525. Epub 2013 Dec 13.

3.

The committee for advanced therapies' of the European Medicines Agency reflection paper on management of clinical risks deriving from insertional mutagenesis.

Aiuti A, Cossu G, de Felipe P, Galli MC, Narayanan G, Renner M, Stahlbom A, Schneider CK, Voltz-Girolt C.

Hum Gene Ther Clin Dev. 2013 Jun;24(2):47-54. doi: 10.1089/humc.2013.119.

PMID:
23862696
4.

APE-type non-LTR retrotransposons of multicellular organisms encode virus-like 2A oligopeptide sequences, which mediate translational recoding during protein synthesis.

Odon V, Luke GA, Roulston C, de Felipe P, Ruan L, Escuin-Ordinas H, Brown JD, Ryan MD, Sukhodub A.

Mol Biol Evol. 2013 Aug;30(8):1955-65. doi: 10.1093/molbev/mst102. Epub 2013 May 31.

5.

Genome organization and translation products of Providence virus: insight into a unique tetravirus.

Walter CT, Pringle FM, Nakayinga R, de Felipe P, Ryan MD, Ball LA, Dorrington RA.

J Gen Virol. 2010 Nov;91(Pt 11):2826-35. doi: 10.1099/vir.0.023796-0. Epub 2010 Aug 11.

PMID:
20702652
6.

2A to the fore - research, technology and applications.

Luke G, Escuin H, De Felipe P, Ryan M.

Biotechnol Genet Eng Rev. 2010;26:223-60. Review.

PMID:
21415883
7.

Inhibition of 2A-mediated 'cleavage' of certain artificial polyproteins bearing N-terminal signal sequences.

de Felipe P, Luke GA, Brown JD, Ryan MD.

Biotechnol J. 2010 Feb;5(2):213-23. doi: 10.1002/biot.200900134.

8.

Dissection of a co-translational nascent chain separation event.

Doronina VA, de Felipe P, Wu C, Sharma P, Sachs MS, Ryan MD, Brown JD.

Biochem Soc Trans. 2008 Aug;36(Pt 4):712-6. doi: 10.1042/BST0360712.

PMID:
18631146
9.

Site-specific release of nascent chains from ribosomes at a sense codon.

Doronina VA, Wu C, de Felipe P, Sachs MS, Ryan MD, Brown JD.

Mol Cell Biol. 2008 Jul;28(13):4227-39. doi: 10.1128/MCB.00421-08. Epub 2008 May 5.

10.

Occurrence, function and evolutionary origins of '2A-like' sequences in virus genomes.

Luke GA, de Felipe P, Lukashev A, Kallioinen SE, Bruno EA, Ryan MD.

J Gen Virol. 2008 Apr;89(Pt 4):1036-42. doi: 10.1099/vir.0.83428-0.

11.

Expression of heterologous genes in oncolytic adenoviruses using picornaviral 2A sequences that trigger ribosome skipping.

Funston GM, Kallioinen SE, de Felipe P, Ryan MD, Iggo RD.

J Gen Virol. 2008 Feb;89(Pt 2):389-96. doi: 10.1099/vir.0.83444-0.

PMID:
18198369
12.

Molecular analysis of yogurt containing Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus in human intestinal microbiota.

García-Albiach R, Pozuelo de Felipe MJ, Angulo S, Morosini MI, Bravo D, Baquero F, del Campo R.

Am J Clin Nutr. 2008 Jan;87(1):91-6. Erratum in: Am J Clin Nutr. 2008 Jun;87(6):1969. José, María [corrected to Pozuelo de Felipe, María José]; de Felipe, Pozuelo [corrected to Pozuelo de Felipe, María José].

PMID:
18175741
13.

L1Tc non-LTR retrotransposons from Trypanosoma cruzi contain a functional viral-like self-cleaving 2A sequence in frame with the active proteins they encode.

Heras SR, Thomas MC, García-Canadas M, de Felipe P, García-Pérez JL, Ryan MD, López MC.

Cell Mol Life Sci. 2006 Jun;63(12):1449-60.

PMID:
16767356
14.

Self-processing polyproteins: a strategy for co-expression of multiple proteins in plants.

Luke GA, De Felipe P, Cowton VM, Hughes LE, Halpin C, Ryan MD.

Biotechnol Genet Eng Rev. 2006;23:239-52. Review. No abstract available.

PMID:
22530510
15.

E unum pluribus: multiple proteins from a self-processing polyprotein.

de Felipe P, Luke GA, Hughes LE, Gani D, Halpin C, Ryan MD.

Trends Biotechnol. 2006 Feb;24(2):68-75. Epub 2005 Dec 27. Review.

PMID:
16380176
16.

Skipping the co-expression problem: the new 2A "CHYSEL" technology.

de Felipe P.

Genet Vaccines Ther. 2004 Sep 13;2(1):13.

17.

Targeting of proteins derived from self-processing polyproteins containing multiple signal sequences.

de Felipe P, Ryan MD.

Traffic. 2004 Aug;5(8):616-26. Erratum in: Traffic. 2004 Nov;5(11):904.

18.

Construction and characterization of pentacistronic retrovirus vectors.

de Felipe P, Izquierdo M.

J Gen Virol. 2003 May;84(Pt 5):1281-5.

PMID:
12692295
19.

Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide.

de Felipe P, Hughes LE, Ryan MD, Brown JD.

J Biol Chem. 2003 Mar 28;278(13):11441-8. Epub 2003 Jan 8.

20.

Polycistronic viral vectors.

de Felipe P.

Curr Gene Ther. 2002 Sep;2(3):355-78. Review.

PMID:
12189721
21.

Integrating retroviral cassette extends gene delivery of HSV-1 expression vectors to dividing cells.

de Felipe P, Izquierdo M, Wandosell F, Lim F.

Biotechniques. 2001 Aug;31(2):394-402, 404-5.

22.

Tricistronic and tetracistronic retroviral vectors for gene transfer.

De Felipe P, Izquierdo M.

Hum Gene Ther. 2000 Sep 1;11(13):1921-31.

PMID:
10986564
23.

Cancer gene therapy by thyroid hormone-mediated expression of toxin genes.

Martín V, Cortés ML, de Felipe P, Farsetti A, Calcaterra NB, Izquierdo M.

Cancer Res. 2000 Jun 15;60(12):3218-24.

24.

Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy.

de Felipe P, Martín V, Cortés ML, Ryan M, Izquierdo M.

Gene Ther. 1999 Feb;6(2):198-208.

25.

Successful use of a plant gene in the treatment of cancer in vivo.

Cortés ML, de Felipe P, Martín V, Hughes MA, Izquierdo M.

Gene Ther. 1998 Nov;5(11):1499-507.

26.

Gene therapy in brain tumours: implications of the size of glioblastoma on its curability.

Izquierdo M, Cortés ML, Martín V, de Felipe P, Izquierdo JM, Pérez-Higueras A, Paz JF, Isla A, Blázquez MG.

Acta Neurochir Suppl. 1997;68:111-7.

PMID:
9233425
27.

Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy.

Izquierdo M, Martín V, de Felipe P, Izquierdo JM, Pérez-Higueras A, Cortés ML, Paz JF, Isla A, Blázquez MG.

Gene Ther. 1996 Jun;3(6):491-5.

PMID:
8789798
28.

[Gene therapy of glioblastomas].

Izquierdo M, Martín V, de Felipe P, Izquierdo JM, Pérez-Higueras A, Cortés ML, Paz JF, Isla A, Blázquez MG.

Rev Neurol. 1996 Mar;24(127):325-8. Spanish. No abstract available.

PMID:
8742401
29.

Long-term rat survival after malignant brain tumor regression by retroviral gene therapy.

Izquierdo M, Cortés M, de Felipe P, Martín V, Díez-Guerra J, Talavera A, Perez-Higueras A.

Gene Ther. 1995 Jan;2(1):66-9.

PMID:
7712334

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