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The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase.

Sala K, Corbetta A, Minici C, Tonoli D, Murray DH, Cammarota E, Ribolla L, Ramella M, Fesce R, Mazza D, Degano M, de Curtis I.

Sci Rep. 2019 Sep 19;9(1):13530. doi: 10.1038/s41598-019-49630-y.


The Rac3 GTPase in Neuronal Development, Neurodevelopmental Disorders, and Cancer.

de Curtis I.

Cells. 2019 Sep 11;8(9). pii: E1063. doi: 10.3390/cells8091063. Review.


Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.

Pennucci R, Gucciardi I, de Curtis I.

PLoS One. 2019 Aug 1;14(8):e0220496. doi: 10.1371/journal.pone.0220496. eCollection 2019.


A Method to Culture GABAergic Interneurons Derived from the Medial Ganglionic Eminence.

Franchi SA, Macco R, Astro V, Tonoli D, Savino E, Valtorta F, Sala K, Botta M, de Curtis I.

Front Cell Neurosci. 2018 Jan 8;11:423. doi: 10.3389/fncel.2017.00423. eCollection 2017.


Identification of a membrane-less compartment regulating invadosome function and motility.

Sala K, Raimondi A, Tonoli D, Tacchetti C, de Curtis I.

Sci Rep. 2018 Jan 18;8(1):1164. doi: 10.1038/s41598-018-19447-2.


Novel role of Rac-Mid1 signaling in medial cerebellar development.

Nakamura T, Ueyama T, Ninoyu Y, Sakaguchi H, Choijookhuu N, Hishikawa Y, Kiyonari H, Kohta M, Sakahara M, de Curtis I, Kohmura E, Hisa Y, Aiba A, Saito N.

Development. 2017 May 15;144(10):1863-1875. doi: 10.1242/dev.147900.


Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.

Franchi SA, Astro V, Macco R, Tonoli D, Barnier JV, Botta M, de Curtis I.

Front Cell Neurosci. 2016 Dec 21;10:289. doi: 10.3389/fncel.2016.00289. eCollection 2016.


Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.

Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR.

Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877.


Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnover.

Astro V, Tonoli D, Chiaretti S, Badanai S, Sala K, Zerial M, de Curtis I.

Sci Rep. 2016 Sep 23;6:33653. doi: 10.1038/srep33653.


Role of Liprins in the Regulation of Tumor Cell Motility and Invasion.

Chiaretti S, de Curtis I.

Curr Cancer Drug Targets. 2016;16(3):238-48. Review.


Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells.

Chiaretti S, Astro V, Chiricozzi E, de Curtis I.

Biol Cell. 2016 Mar;108(3):65-75. doi: 10.1111/boc.201500063. Epub 2016 Feb 5.


Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.

Pennucci R, Talpo F, Astro V, Montinaro V, Morè L, Cursi M, Castoldi V, Chiaretti S, Bianchi V, Marenna S, Cambiaghi M, Tonoli D, Leocani L, Biella G, D'Adamo P, de Curtis I.

Cereb Cortex. 2016 Feb;26(2):873-890. doi: 10.1093/cercor/bhv274. Epub 2015 Nov 17.


Plasma membrane-associated platforms: dynamic scaffolds that organize membrane-associated events.

Astro V, de Curtis I.

Sci Signal. 2015 Mar 10;8(367):re1. doi: 10.1126/scisignal.aaa3312. Review.


Roles of Rac1 and Rac3 GTPases during the development of cortical and hippocampal GABAergic interneurons.

de Curtis I.

Front Cell Neurosci. 2014 Sep 25;8:307. doi: 10.3389/fncel.2014.00307. eCollection 2014. Review.


Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.

Astro V, Chiaretti S, Magistrati E, Fivaz M, de Curtis I.

J Cell Sci. 2014 Sep 1;127(Pt 17):3862-76. doi: 10.1242/jcs.155663. Epub 2014 Jun 30.


Reduction in parvalbumin-positive interneurons and inhibitory input in the cortex of mice with experimental autoimmune encephalomyelitis.

Falco A, Pennucci R, Brambilla E, de Curtis I.

Exp Brain Res. 2014 Jul;232(7):2439-49. doi: 10.1007/s00221-014-3944-7. Epub 2014 Apr 26.


Identification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation.

Totaro A, Astro V, Tonoli D, de Curtis I.

PLoS One. 2014 Apr 3;9(4):e93199. doi: 10.1371/journal.pone.0093199. eCollection 2014.


Rac-GTPases Regulate Microtubule Stability and Axon Growth of Cortical GABAergic Interneurons.

Tivodar S, Kalemaki K, Kounoupa Z, Vidaki M, Theodorakis K, Denaxa M, Kessaris N, de Curtis I, Pachnis V, Karagogeos D.

Cereb Cortex. 2015 Sep;25(9):2370-82. doi: 10.1093/cercor/bhu037. Epub 2014 Mar 13.


Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.

Vaghi V, Pennucci R, Talpo F, Corbetta S, Montinaro V, Barone C, Croci L, Spaiardi P, Consalez GG, Biella G, de Curtis I.

Cereb Cortex. 2014 May;24(5):1247-58. doi: 10.1093/cercor/bhs402. Epub 2012 Dec 20.


Cell surface dynamics - how Rho GTPases orchestrate the interplay between the plasma membrane and the cortical cytoskeleton.

de Curtis I, Meldolesi J.

J Cell Sci. 2012 Oct 1;125(Pt 19):4435-44. doi: 10.1242/jcs.108266. Epub 2012 Oct 23. Review.


Biochemical and functional characterisation of αPIX, a specific regulator of axonal and dendritic branching in hippocampal neurons.

Totaro A, Tavano S, Filosa G, Gärtner A, Pennucci R, Santambrogio P, Bachi A, Dotti CG, de Curtis I.

Biol Cell. 2012 Sep;104(9):533-52. doi: 10.1111/boc.201100060. Epub 2012 Jun 22.


Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus.

Pennucci R, Tavano S, Tonoli D, Gualdoni S, de Curtis I.

PLoS One. 2011;6(9):e24819. doi: 10.1371/journal.pone.0024819. Epub 2011 Sep 20.


Biochemical and functional characterization of the interaction between liprin-α1 and GIT1: implications for the regulation of cell motility.

Asperti C, Astro V, Pettinato E, Paris S, Bachi A, de Curtis I.

PLoS One. 2011;6(6):e20757. doi: 10.1371/journal.pone.0020757. Epub 2011 Jun 13.


Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development.

Basso V, Corbetta S, Gualdoni S, Tonoli D, Poliani PL, Sanvito F, Doglioni C, Mondino A, de Curtis I.

Eur J Immunol. 2011 May;41(5):1410-9. doi: 10.1002/eji.201040892. Epub 2011 Apr 15.


Host-pathogen interactions: cheating the host by making new connections.

de Curtis I.

Curr Biol. 2011 Mar 8;21(5):R192-4. doi: 10.1016/j.cub.2011.01.041.


Liprin-α1 regulates breast cancer cell invasion by affecting cell motility, invadopodia and extracellular matrix degradation.

Astro V, Asperti C, Cangi MG, Doglioni C, de Curtis I.

Oncogene. 2011 Apr 14;30(15):1841-9. doi: 10.1038/onc.2010.562. Epub 2010 Dec 13. Erratum in: Oncogene. 2011 Apr 14;30(15):1850. Cangi, G [corrected to Cangi, M G].


Function of liprins in cell motility.

de Curtis I.

Exp Cell Res. 2011 Jan 1;317(1):1-8. doi: 10.1016/j.yexcr.2010.09.014. Epub 2010 Sep 25. Review.


Liprin-alpha1 affects the distribution of low-affinity beta1 integrins and stabilizes their permanence at the cell surface.

Asperti C, Pettinato E, de Curtis I.

Exp Cell Res. 2010 Apr 1;316(6):915-26. doi: 10.1016/j.yexcr.2010.01.017. Epub 2010 Jan 22.


The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells.

Gavina M, Za L, Molteni R, Pardi R, de Curtis I.

Biol Cell. 2010 Jan 14;102(4):231-44. doi: 10.1042/BC20090074.


Liprin-alpha1 promotes cell spreading on the extracellular matrix by affecting the distribution of activated integrins.

Asperti C, Astro V, Totaro A, Paris S, de Curtis I.

J Cell Sci. 2009 Sep 15;122(Pt 18):3225-32. doi: 10.1242/jcs.054155. Epub 2009 Aug 18.


Essential role of Rac1 and Rac3 GTPases in neuronal development.

Corbetta S, Gualdoni S, Ciceri G, Monari M, Zuccaro E, Tybulewicz VL, de Curtis I.

FASEB J. 2009 May;23(5):1347-57. doi: 10.1096/fj.08-121574. Epub 2009 Jan 6.


Functions of Rac GTPases during neuronal development.

de Curtis I.

Dev Neurosci. 2008;30(1-3):47-58. Review.


Identification of an intramolecular interaction important for the regulation of GIT1 functions.

Totaro A, Paris S, Asperti C, de Curtis I.

Mol Biol Cell. 2007 Dec;18(12):5124-38. Epub 2007 Sep 26.


Hyperactivity and novelty-induced hyperreactivity in mice lacking Rac3.

Corbetta S, D'Adamo P, Gualdoni S, Braschi C, Berardi N, de Curtis I.

Behav Brain Res. 2008 Jan 25;186(2):246-55. Epub 2007 Aug 22.


Normal levels of Rac1 are important for dendritic but not axonal development in hippocampal neurons.

Gualdoni S, Albertinazzi C, Corbetta S, Valtorta F, de Curtis I.

Biol Cell. 2007 Aug;99(8):455-64.


betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1.

Za L, Albertinazzi C, Paris S, Gagliani M, Tacchetti C, de Curtis I.

J Cell Sci. 2006 Jul 1;119(Pt 13):2654-66.


Assay and properties of the GIT1/p95-APP1 ARFGAP.

de Curtis I, Paris S.

Methods Enzymol. 2005;404:267-78.


Characterization of the endogenous GIT1-betaPIX complex, and identification of its association to membranes.

Botrugno OA, Paris S, Za L, Gualdoni S, Cattaneo A, Bachi A, de Curtis I.

Eur J Cell Biol. 2006 Jan;85(1):35-46. Epub 2005 Nov 8.


Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia.

Cho YJ, Zhang B, Kaartinen V, Haataja L, de Curtis I, Groffen J, Heisterkamp N.

Mol Cell Biol. 2005 Jul;25(13):5777-85.


Generation and characterization of Rac3 knockout mice.

Corbetta S, Gualdoni S, Albertinazzi C, Paris S, Croci L, Consalez GG, de Curtis I.

Mol Cell Biol. 2005 Jul;25(13):5763-76.


EphA4, RhoB and the molecular development of feather buds are maintained by the integrity of the actin cytoskeleton.

McKinnell IW, Makarenkova H, de Curtis I, Turmaine M, Patel K.

Dev Biol. 2004 Jun 1;270(1):94-105.


ADP-ribosylation factor 6 and a functional PIX/p95-APP1 complex are required for Rac1B-mediated neurite outgrowth.

Albertinazzi C, Za L, Paris S, de Curtis I.

Mol Biol Cell. 2003 Apr;14(4):1295-307.


Analysis of the subcellular distribution of avian p95-APP2, an ARF-GAP orthologous to mammalian paxillin kinase linker.

Paris S, Za L, Sporchia B, de Curtis I.

Int J Biochem Cell Biol. 2002 Jul;34(7):826-37.


Cell migration: GAPs between membrane traffic and the cytoskeleton.

de Curtis I.

EMBO Rep. 2001 Apr;2(4):277-81. Review.


p95-APP1 links membrane transport to Rac-mediated reorganization of actin.

Di Cesare A, Paris S, Albertinazzi C, Dariozzi S, Andersen J, Mann M, Longhi R, de Curtis I.

Nat Cell Biol. 2000 Aug;2(8):521-30.


Estradiol induces differential neuronal phenotypes by activating estrogen receptor alpha or beta.

Patrone C, Pollio G, Vegeto E, Enmark E, de Curtis I, Gustafsson JA, Maggi A.

Endocrinology. 2000 May;141(5):1839-45.


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