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Specificity Protein 7 Is Required for Proliferation and Differentiation of Ameloblasts and Odontoblasts.

Bae JM, Clarke JC, Rashid H, Adhami MD, McCullough K, Scott JS, Chen H, Sinha KM, de Crombrugghe B, Javed A.

J Bone Miner Res. 2018 Jun;33(6):1126-1140. doi: 10.1002/jbmr.3401. Epub 2018 Mar 24.


Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.

Li IMH, Horwell AL, Chu G, de Crombrugghe B, Bou-Gharios G.

Methods Mol Biol. 2017;1627:139-161. doi: 10.1007/978-1-4939-7113-8_10.


A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6.

Yasuda H, Oh CD, Chen D, de Crombrugghe B, Kim JH.

J Biol Chem. 2017 Jan 13;292(2):528-538. doi: 10.1074/jbc.M116.758425. Epub 2016 Nov 23.


SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc.

Oh CD, Yasuda H, Zhao W, Henry SP, Zhang Z, Xue M, de Crombrugghe B, Chen D.

Sci Rep. 2016 Jul 20;6:29916. doi: 10.1038/srep29916.


Correction: SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters.

Oh CD, Lu Y, Liang S, Mori-Akiyama Y, Chen D, de Crombrugghe B, Yasuda H.

PLoS One. 2015 Nov 12;10(11):e0143156. doi: 10.1371/journal.pone.0143156. eCollection 2015. No abstract available.


Chondrocytes Directly Transform into Bone Cells in Mandibular Condyle Growth.

Jing Y, Zhou X, Han X, Jing J, von der Mark K, Wang J, de Crombrugghe B, Hinton RJ, Feng JQ.

J Dent Res. 2015 Dec;94(12):1668-75. doi: 10.1177/0022034515598135. Epub 2015 Sep 4.


Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation.

Chen Q, Zhang L, de Crombrugghe B, Krahe R.

FASEB J. 2015 Jun;29(6):2555-65. doi: 10.1096/fj.14-258970. Epub 2015 Mar 6.


Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation.

Chen Q, Sinha K, Deng JM, Yasuda H, Krahe R, Behringer RR, de Crombrugghe B.

J Bone Miner Res. 2015 Sep;30(9):1608-17. doi: 10.1002/jbmr.2494. Epub 2015 Jun 11.


Osterix regulates tooth root formation in a site-specific manner.

Kim TH, Bae CH, Lee JC, Kim JE, Yang X, de Crombrugghe B, Cho ES.

J Dent Res. 2015 Mar;94(3):430-8. doi: 10.1177/0022034514565647. Epub 2015 Jan 7.


Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice.

Zhou X, von der Mark K, Henry S, Norton W, Adams H, de Crombrugghe B.

PLoS Genet. 2014 Dec 4;10(12):e1004820. doi: 10.1371/journal.pgen.1004820. eCollection 2014 Dec.


Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells.

Coşkun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK.

Cell Rep. 2014 Oct 23;9(2):581-90. doi: 10.1016/j.celrep.2014.09.013. Epub 2014 Oct 9.


SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters.

Oh CD, Lu Y, Liang S, Mori-Akiyama Y, Chen D, de Crombrugghe B, Yasuda H.

PLoS One. 2014 Sep 17;9(9):e107577. doi: 10.1371/journal.pone.0107577. eCollection 2014. Erratum in: PLoS One. 2015;10(11):e0143156.


Sp7 and Runx2 molecular complex synergistically regulate expression of target genes.

Rashid H, Ma C, Chen H, Wang H, Hassan MQ, Sinha K, de Crombrugghe B, Javed A.

Connect Tissue Res. 2014 Aug;55 Suppl 1:83-7. doi: 10.3109/03008207.2014.923872.


E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein.

Hattori T, Kishino T, Stephen S, Eberspaecher H, Maki S, Takigawa M, de Crombrugghe B, Yasuda H.

J Biol Chem. 2013 Dec 6;288(49):35138-48. doi: 10.1074/jbc.M113.486795. Epub 2013 Oct 23.


Persistent low level of osterix accelerates interleukin-6 production and impairs regeneration after tissue injury.

Baek WY, Park SY, Kim YH, Lee MA, Kwon TH, Park KM, de Crombrugghe B, Kim JE.

PLoS One. 2013 Jul 26;8(7):e69859. doi: 10.1371/journal.pone.0069859. Print 2013.


Structural insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor osterix and gene repression.

Tao Y, Wu M, Zhou X, Yin W, Hu B, de Crombrugghe B, Sinha KM, Zang J.

J Biol Chem. 2013 Jun 7;288(23):16430-7. doi: 10.1074/jbc.M112.446849. Epub 2013 Apr 24.


Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro.

Sonnylal S, Xu S, Jones H, Tam A, Sreeram VR, Ponticos M, Norman J, Agrawal P, Abraham D, de Crombrugghe B.

J Cell Sci. 2013 May 15;126(Pt 10):2164-75. doi: 10.1242/jcs.111302. Epub 2013 Mar 22.


Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix.

Chen Q, Liu W, Sinha KM, Yasuda H, de Crombrugghe B.

PLoS One. 2013;8(3):e58104. doi: 10.1371/journal.pone.0058104. Epub 2013 Mar 5.


Osterix is required for cranial neural crest-derived craniofacial bone formation.

Baek WY, Kim YJ, de Crombrugghe B, Kim JE.

Biochem Biophys Res Commun. 2013 Mar 1;432(1):188-92. doi: 10.1016/j.bbrc.2012.12.138. Epub 2013 Jan 9.


The postnatal role of Sox9 in cartilage.

Henry SP, Liang S, Akdemir KC, de Crombrugghe B.

J Bone Miner Res. 2012 Dec;27(12):2511-25. doi: 10.1002/jbmr.1696.


Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx.

Zhang C, Dai H, de Crombrugghe B.

Biochem Biophys Res Commun. 2012 Apr 20;420(4):782-6. doi: 10.1016/j.bbrc.2012.03.073. Epub 2012 Mar 20.


β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.

Beyer C, Schramm A, Akhmetshina A, Dees C, Kireva T, Gelse K, Sonnylal S, de Crombrugghe B, Taketo MM, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2012 May;71(5):761-7. doi: 10.1136/annrheumdis-2011-200568. Epub 2012 Feb 10.


Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification.

Oh JH, Park SY, de Crombrugghe B, Kim JE.

Biochem Biophys Res Commun. 2012 Feb 24;418(4):634-40. doi: 10.1016/j.bbrc.2012.01.064. Epub 2012 Jan 21.


Genetic evidence for the vital function of Osterix in cementogenesis.

Cao Z, Zhang H, Zhou X, Han X, Ren Y, Gao T, Xiao Y, de Crombrugghe B, Somerman MJ, Feng JQ.

J Bone Miner Res. 2012 May;27(5):1080-92. doi: 10.1002/jbmr.1552.


Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.

Renard E, Porée B, Chadjichristos C, Kypriotou M, Maneix L, Bigot N, Legendre F, Ollitrault D, De Crombrugghe B, Malléin-Gérin F, Moslemi S, Demoor M, Boumediene K, Galéra P.

J Mol Med (Berl). 2012 Jun;90(6):649-66. doi: 10.1007/s00109-011-0842-3. Epub 2012 Jan 4.


Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts.

Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, Zhang C.

J Biol Chem. 2012 Jan 13;287(3):1671-8. doi: 10.1074/jbc.M111.288472. Epub 2011 Nov 22.


Attenuation of expression of extracellular matrix genes with siRNAs to Sparc and Ctgf in skin fibroblasts of CTGF transgenic mice.

Wang JC, Sonnylal S, Arnett FC, De Crombrugghe B, Zhou X.

Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):595-601.


Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors.

Dancer JY, Henry SP, Bondaruk J, Lee S, Ayala AG, de Crombrugghe B, Czerniak B.

Hum Pathol. 2010 Dec;41(12):1788-93. doi: 10.1016/j.humpath.2010.06.008.


Sclerostin is a direct target of osteoblast-specific transcription factor osterix.

Yang F, Tang W, So S, de Crombrugghe B, Zhang C.

Biochem Biophys Res Commun. 2010 Oct 1;400(4):684-8. doi: 10.1016/j.bbrc.2010.08.128. Epub 2010 Sep 8.


Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons.

Soeda T, Deng JM, de Crombrugghe B, Behringer RR, Nakamura T, Akiyama H.

Genesis. 2010 Nov;48(11):635-44. doi: 10.1002/dvg.20667. Epub 2010 Oct 7.


Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice.

Zhou X, Zhang Z, Feng JQ, Dusevich VM, Sinha K, Zhang H, Darnay BG, de Crombrugghe B.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12919-24. doi: 10.1073/pnas.0912855107. Epub 2010 Jul 6.


The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template.

Coustry F, Oh CD, Hattori T, Maity SN, de Crombrugghe B, Yasuda H.

Nucleic Acids Res. 2010 Oct;38(18):6018-28. doi: 10.1093/nar/gkq417. Epub 2010 May 19.


Identification of SOX9 interaction sites in the genome of chondrocytes.

Oh CD, Maity SN, Lu JF, Zhang J, Liang S, Coustry F, de Crombrugghe B, Yasuda H.

PLoS One. 2010 Apr 9;5(4):e10113. doi: 10.1371/journal.pone.0010113.


Attenuation of fibrosis in vitro and in vivo with SPARC siRNA.

Wang JC, Lai S, Guo X, Zhang X, de Crombrugghe B, Sonnylal S, Arnett FC, Zhou X.

Arthritis Res Ther. 2010;12(2):R60. doi: 10.1186/ar2973. Epub 2010 Apr 1.


Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

Sonnylal S, Shi-Wen X, Leoni P, Naff K, Van Pelt CS, Nakamura H, Leask A, Abraham D, Bou-Gharios G, de Crombrugghe B.

Arthritis Rheum. 2010 May;62(5):1523-32. doi: 10.1002/art.27382.


SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification.

Hattori T, Müller C, Gebhard S, Bauer E, Pausch F, Schlund B, Bösl MR, Hess A, Surmann-Schmitt C, von der Mark H, de Crombrugghe B, von der Mark K.

Development. 2010 Mar;137(6):901-11. doi: 10.1242/dev.045203.


Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance.

Baek WY, de Crombrugghe B, Kim JE.

Bone. 2010 Apr;46(4):920-8. doi: 10.1016/j.bone.2009.12.007. Epub 2009 Dec 21.


Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closure.

Martinez-Ferrer M, Afshar-Sherif AR, Uwamariya C, de Crombrugghe B, Davidson JM, Bhowmick NA.

Am J Pathol. 2010 Jan;176(1):98-107. doi: 10.2353/ajpath.2010.090283. Epub 2009 Dec 3.


Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase.

Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B.

EMBO J. 2010 Jan 6;29(1):68-79. doi: 10.1038/emboj.2009.332. Epub 2009 Nov 19.


Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage.

Henry SP, Jang CW, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B.

Genesis. 2009 Dec;47(12):805-14. doi: 10.1002/dvg.20564.


Regulation of bone formation and remodeling by G-protein-coupled receptor 48.

Luo J, Zhou W, Zhou X, Li D, Weng J, Yi Z, Cho SG, Li C, Yi T, Wu X, Li XY, de Crombrugghe B, Höök M, Liu M.

Development. 2009 Aug;136(16):2747-56. doi: 10.1242/dev.033571. Epub 2009 Jul 15.


Joint formation requires muscle formation and contraction.

Yasuda H, de Crombrugghe B.

Dev Cell. 2009 May;16(5):625-6. doi: 10.1016/j.devcel.2009.05.003.


Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix.

Baek WY, Lee MA, Jung JW, Kim SY, Akiyama H, de Crombrugghe B, Kim JE.

J Bone Miner Res. 2009 Jun;24(6):1055-65. doi: 10.1359/jbmr.081248.


Cthrc1 is a positive regulator of osteoblastic bone formation.

Kimura H, Kwan KM, Zhang Z, Deng JM, Darnay BG, Behringer RR, Nakamura T, de Crombrugghe B, Akiyama H.

PLoS One. 2008 Sep 9;3(9):e3174. doi: 10.1371/journal.pone.0003174.


Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter.

Gebhard S, Hattori T, Bauer E, Schlund B, Bösl MR, de Crombrugghe B, von der Mark K.

Matrix Biol. 2008 Oct;27(8):693-9. doi: 10.1016/j.matbio.2008.07.001. Epub 2008 Jul 12.


Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix.

Zhang C, Cho K, Huang Y, Lyons JP, Zhou X, Sinha K, McCrea PD, de Crombrugghe B.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6936-41. doi: 10.1073/pnas.0710831105. Epub 2008 May 5.


Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.

Hattori T, Coustry F, Stephens S, Eberspaecher H, Takigawa M, Yasuda H, de Crombrugghe B.

Nucleic Acids Res. 2008 May;36(9):3011-24. doi: 10.1093/nar/gkn150. Epub 2008 Apr 4.


The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells.

Cao Y, Jia SF, Chakravarty G, de Crombrugghe B, Kleinerman ES.

Mol Cancer Res. 2008 Jan;6(1):119-26. doi: 10.1158/1541-7786.MCR-07-0090.


SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.

Mori-Akiyama Y, van den Born M, van Es JH, Hamilton SR, Adams HP, Zhang J, Clevers H, de Crombrugghe B.

Gastroenterology. 2007 Aug;133(2):539-46. Epub 2007 May 21.


Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation.

Kimura H, Akiyama H, Nakamura T, de Crombrugghe B.

Biochem Biophys Res Commun. 2007 May 18;356(4):935-41. Epub 2007 Mar 22.

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