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Of aging mice and men: gait speed decline is a translatable trait, with species-specific underlying properties.

Bair WN, Petr M, Alfaras I, Mitchell SJ, Bernier M, Ferrucci L, Studenski SA, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2019 Jan 14. doi: 10.1093/gerona/glz015. [Epub ahead of print]


Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG.

Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.


Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice.

Cortassa S, Caceres V, Tocchetti CG, Bernier M, de Cabo R, Paolocci N, Sollott SJ, Aon MA.

J Physiol. 2018 Nov 21. doi: 10.1113/JP276824. [Epub ahead of print]


A time to fast.

Di Francesco A, Di Germanio C, Bernier M, de Cabo R.

Science. 2018 Nov 16;362(6416):770-775. doi: 10.1126/science.aau2095. Review.


Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells.

Bodogai M, O'Connell J, Kim K, Kim Y, Moritoh K, Chen C, Gusev F, Vaughan K, Shulzhenko N, Mattison JA, Lee-Chang C, Chen W, Carlson O, Becker KG, Gurung M, Morgun A, White J, Meade T, Perdue K, Mack M, Ferrucci L, Trinchieri G, de Cabo R, Rogaev E, Egan J, Wu J, Biragyn A.

Sci Transl Med. 2018 Nov 14;10(467). pii: eaat4271. doi: 10.1126/scitranslmed.aat4271.


Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype.

Wang M, Zhang L, Zhu W, Zhang J, Kim SH, Wang Y, Ni L, Telljohann R, Monticone RE, McGraw K, Liu L, de Cabo R, Lakatta EG.

J Am Heart Assoc. 2018 Sep 18;7(18):e009112. doi: 10.1161/JAHA.118.009112. Erratum in: J Am Heart Assoc. 2018 Nov 20;7(22):e004303.


Yo-Yo Dieting is Better than None.

Di Germanio C, Di Francesco A, Bernier M, de Cabo R.

Obesity (Silver Spring). 2018 Nov;26(11):1673. doi: 10.1002/oby.22335. No abstract available.


Carbotoxicity-Noxious Effects of Carbohydrates.

Kroemer G, López-Otín C, Madeo F, de Cabo R.

Cell. 2018 Oct 18;175(3):605-614. doi: 10.1016/j.cell.2018.07.044. Review.


Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.

Mitchell SJ, Bernier M, Mattison JA, Aon MA, Kaiser TA, Anson RM, Ikeno Y, Anderson RM, Ingram DK, de Cabo R.

Cell Metab. 2019 Jan 8;29(1):221-228.e3. doi: 10.1016/j.cmet.2018.08.011. Epub 2018 Sep 6.


Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats.

Mach J, Huizer-Pajkos A, Cogger VC, McKenzie C, Le Couteur DG, Jones BE, de Cabo R, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2018 Aug 25. doi: 10.1093/gerona/gly160. [Epub ahead of print] No abstract available.


Sirt1 protects from K-Ras-driven lung carcinogenesis.

Costa-Machado LF, Martín-Hernández R, Sanchez-Luengo MÁ, Hess K, Vales-Villamarin C, Barradas M, Lynch C, de la Nava D, Diaz-Ruiz A, de Cabo R, Cañamero M, Martinez L, Sanchez-Carbayo M, Herranz D, Serrano M, Fernandez-Marcos PJ.

EMBO Rep. 2018 Sep;19(9). pii: e43879. doi: 10.15252/embr.201643879. Epub 2018 Jul 18.


The impact of aging, calorie restriction and dietary fat on mitochondrial ultrastructure, dynamics and autophagy markers in mouse skeletal muscle.

Gutiérrez-Casado E, Khraiwesh H, López-Domínguez JA, Montero-Guisado J, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, González-Reyes JA, Villalba JM.

J Gerontol A Biol Sci Med Sci. 2018 Jul 13. doi: 10.1093/gerona/gly161. [Epub ahead of print]


Future directions of resveratrol research.

Wahl D, Bernier M, Simpson SJ, de Cabo R, Le Couteur DG.

Nutr Healthy Aging. 2018 Jun 15;4(4):287-290. doi: 10.3233/NHA-170035. Review.


Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.

Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863. doi: 10.1093/gerona/glx177.


Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1.

Diaz-Ruiz A, Di Francesco A, Carboneau BA, Levan SR, Pearson KJ, Price NL, Ward TM, Bernier M, de Cabo R, Mercken EM.

J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):155-162. doi: 10.1093/gerona/gly112.


Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction.

Diaz-Ruiz A, Lanasa M, Garcia J, Mora H, Fan F, Martin-Montalvo A, Di Francesco A, Calvo-Rubio M, Salvador-Pascual A, Aon MA, Fishbein KW, Pearson KJ, Villalba JM, Navas P, Bernier M, de Cabo R.

Aging Cell. 2018 Apr 28:e12767. doi: 10.1111/acel.12767. [Epub ahead of print]


Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.

Gokarn R, Solon-Biet SM, Cogger VC, Cooney GJ, Wahl D, McMahon AC, Mitchell JR, Mitchell SJ, Hine C, de Cabo R, Raubenheimer D, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1618-1625. doi: 10.1093/gerona/gly065.


Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.


Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C.

Cell Rep. 2018 Feb 20;22(8):2133-2145. doi: 10.1016/j.celrep.2018.01.074.


Intermittent mTOR Inhibition Reverses Kidney Aging in Old Rats.

Di Francesco A, Diaz-Ruiz A, de Cabo R, Bernier M.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):843-844. doi: 10.1093/gerona/gly023. No abstract available.


α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice.

Maxwell N, Castro RW, Sutherland NM, Vaughan KL, Szarowicz MD, de Cabo R, Mattison JA, Valdez G.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12726. Epub 2018 Feb 4.


Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging.

Gonzalez-Freire M, Scalzo P, D'Agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, de Cabo R, Ferrucci L.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12725. Epub 2018 Jan 21.


Redox modulation of NQO1.

Siegel D, Dehn DD, Bokatzian SS, Quinn K, Backos DS, Di Francesco A, Bernier M, Reisdorph N, de Cabo R, Ross D.

PLoS One. 2018 Jan 3;13(1):e0190717. doi: 10.1371/journal.pone.0190717. eCollection 2018.


Aged interleukin-10tm1Cgn chronically inflamed mice have substantially reduced fat mass, metabolic rate, and adipokines.

Westbrook RM, Yang HL, Langdon JM, Roy CN, Kim JA, Choudhury PP, Xue QL, di Francesco A, de Cabo R, Walston J.

PLoS One. 2017 Dec 21;12(12):e0186811. doi: 10.1371/journal.pone.0186811. eCollection 2017.


Caloric Restriction Research: New Perspectives on the Biology of Aging.

Anderson RM, Le Couteur DG, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):1-3. doi: 10.1093/gerona/glx212. No abstract available.


Health benefits of late-onset metformin treatment every other week in mice.

Alfaras I, Mitchell SJ, Mora H, Lugo DR, Warren A, Navas-Enamorado I, Hoffmann V, Hine C, Mitchell JR, Le Couteur DG, Cogger VC, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2017 Nov 20;3:16. doi: 10.1038/s41514-017-0018-7. eCollection 2017.


Sex and Aging.

Le Couteur DG, Anderson RM, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):139-140. doi: 10.1093/gerona/glx221. No abstract available.


Breaking the Ceiling of Human Maximal Life span.

Ben-Haim MS, Kanfi Y, Mitchell SJ, Maoz N, Vaughan KL, Amariglio N, Lerrer B, de Cabo R, Rechavi G, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1465-1471. doi: 10.1093/gerona/glx219.


Stem Cell Transplantation for Frailty.

Le Couteur DG, Anderson RM, Newman AB, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1503-1504. doi: 10.1093/gerona/glx158. No abstract available.


Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies.

Vaughan KL, Kaiser T, Peaden R, Anson RM, de Cabo R, Mattison JA.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):48-53. doi: 10.1093/gerona/glx088. Erratum in: J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1207.


Hexokinases link DJ-1 to the PINK1/parkin pathway.

Hauser DN, Mamais A, Conti MM, Primiani CT, Kumaran R, Dillman AA, Langston RG, Beilina A, Garcia JH, Diaz-Ruiz A, Bernier M, Fiesel FC, Hou X, Springer W, Li Y, de Cabo R, Cookson MR.

Mol Neurodegener. 2017 Sep 29;12(1):70. doi: 10.1186/s13024-017-0212-x.


Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.

Wahl D, Coogan SC, Solon-Biet SM, de Cabo R, Haran JB, Raubenheimer D, Cogger VC, Mattson MP, Simpson SJ, Le Couteur DG.

Clin Interv Aging. 2017 Sep 8;12:1419-1428. doi: 10.2147/CIA.S145247. eCollection 2017. Review.


Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R.

NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017.


Calorie restriction in rodents: Caveats to consider.

Ingram DK, de Cabo R.

Ageing Res Rev. 2017 Oct;39:15-28. doi: 10.1016/j.arr.2017.05.008. Epub 2017 Jun 10. Review.


Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.

Fernández-Del-Río L, Nag A, Gutiérrez Casado E, Ariza J, Awad AM, Joseph AI, Kwon O, Verdin E, de Cabo R, Schneider C, Torres JZ, Burón MI, Clarke CF, Villalba JM.

Free Radic Biol Med. 2017 Sep;110:176-187. doi: 10.1016/j.freeradbiomed.2017.06.006. Epub 2017 Jun 9.


A Comparison of Two Mouse Frailty Assessment Tools.

Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett SE, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):904-909. doi: 10.1093/gerona/glx009.


Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.

Navas-Enamorado I, Bernier M, Brea-Calvo G, de Cabo R.

Ageing Res Rev. 2017 Aug;37:39-52. doi: 10.1016/j.arr.2017.04.005. Epub 2017 May 6. No abstract available.


Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial.

McDermott MM, Leeuwenburgh C, Guralnik JM, Tian L, Sufit R, Zhao L, Criqui MH, Kibbe MR, Stein JH, Lloyd-Jones D, Anton SD, Polonsky TS, Gao Y, de Cabo R, Ferrucci L.

JAMA Cardiol. 2017 Aug 1;2(8):902-907. doi: 10.1001/jamacardio.2017.0538.


SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.

Razi S, Cogger VC, Kennerson M, Benson VL, McMahon AC, Blyth FM, Handelsman DJ, Seibel MJ, Hirani V, Naganathan V, Waite L, de Cabo R, Cumming RG, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):870-876. doi: 10.1093/gerona/glx018.


The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL.

Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26.


Caloric restriction improves health and survival of rhesus monkeys.

Mattison JA, Colman RJ, Beasley TM, Allison DB, Kemnitz JW, Roth GS, Ingram DK, Weindruch R, de Cabo R, Anderson RM.

Nat Commun. 2017 Jan 17;8:14063. doi: 10.1038/ncomms14063.


Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G.

Cell Metab. 2017 Jan 10;25(1):218. doi: 10.1016/j.cmet.2016.12.003. No abstract available.


Spermidine to the rescue for an aging heart.

de Cabo R, Navas P.

Nat Med. 2016 Dec 6;22(12):1389-1390. doi: 10.1038/nm.4243. No abstract available.


Amniotic Epithelial Cells: A New Tool to Combat Aging and Age-Related Diseases?

Di Germanio C, Bernier M, de Cabo R, Barboni B.

Front Cell Dev Biol. 2016 Nov 22;4:135. eCollection 2016.


Involvement of c-Jun N-Terminal Kinase in TNF-α-Driven Remodeling.

Eurlings IM, Reynaert NL, van de Wetering C, Aesif SW, Mercken EM, de Cabo R, van der Velden JL, Janssen-Heininger YM, Wouters EF, Dentener MA.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):393-401. doi: 10.1165/rcmb.2015-0195OC.


Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function.

Swomley AM, Triplett JC, Keeney JT, Warrier G, Pearson KJ, Mattison JA, de Cabo R, Cai J, Klein JB, Butterfield DA.

J Nutr Biochem. 2017 Jan;39:169-179. doi: 10.1016/j.jnutbio.2016.10.006. Epub 2016 Oct 13.


Animal models of frailty: current applications in clinical research.

Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE.

Clin Interv Aging. 2016 Oct 26;11:1519-1529. eCollection 2016. Review.


The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct.

Ucer S, Iyer S, Kim HN, Han L, Rutlen C, Allison K, Thostenson JD, de Cabo R, Jilka RL, O'Brien C, Almeida M, Manolagas SC.

J Bone Miner Res. 2017 Mar;32(3):560-574. doi: 10.1002/jbmr.3014. Epub 2016 Nov 3.


Conditioned medium derived from rat amniotic epithelial cells confers protection against inflammation, cancer, and senescence.

Di Germanio C, Bernier M, Petr M, Mattioli M, Barboni B, de Cabo R.

Oncotarget. 2016 Jun 28;7(26):39051-39064. doi: 10.18632/oncotarget.9694.


Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.

Di Francesco A, Di Germanio C, Panda AC, Huynh P, Peaden R, Navas-Enamorado I, Bastian P, Lehrmann E, Diaz-Ruiz A, Ross D, Siegel D, Martindale JL, Bernier M, Gorospe M, Abdelmohsen K, de Cabo R.

Free Radic Biol Med. 2016 Oct;99:225-233. doi: 10.1016/j.freeradbiomed.2016.08.005. Epub 2016 Aug 8.

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