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Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction.

Pomatto LCD, Dill T, Carboneau B, Levan S, Kato J, Mercken EM, Pearson KJ, Bernier M, de Cabo R.

Free Radic Biol Med. 2020 Jan 14. pii: S0891-5849(19)32365-2. doi: 10.1016/j.freeradbiomed.2020.01.005. [Epub ahead of print]


A Central Role for the Gasotransmitter H2S in Aging.

de Cabo R, Diaz-Ruiz A.

Cell Metab. 2020 Jan 7;31(1):10-12. doi: 10.1016/j.cmet.2019.11.015. Epub 2019 Dec 5.


A toolbox for the longitudinal assessment of healthspan in aging mice.

Bellantuono I, de Cabo R, Ehninger D, Di Germanio C, Lawrie A, Miller J, Mitchell SJ, Navas-Enamorado I, Potter PK, Tchkonia T, Trejo JL, Lamming DW.

Nat Protoc. 2020 Jan 8. doi: 10.1038/s41596-019-0256-1. [Epub ahead of print]


Effects of Intermittent Fasting on Health, Aging, and Disease.

de Cabo R, Mattson MP.

N Engl J Med. 2019 Dec 26;381(26):2541-2551. doi: 10.1056/NEJMra1905136. Review. No abstract available. Erratum in: N Engl J Med. 2020 Jan 16;382(3):298.


Measuring biological aging in humans: A quest.

Ferrucci L, Gonzalez-Freire M, Fabbri E, Simonsick E, Tanaka T, Moore Z, Salimi S, Sierra F, de Cabo R.

Aging Cell. 2019 Dec 12:e13080. doi: 10.1111/acel.13080. [Epub ahead of print] Review.


Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice.

Wahl D, Gokarn R, Mitchell SJ, Solon-Biet SM, Cogger VC, Simpson SJ, Le Couteur DG, de Cabo R.

Nutr Healthy Aging. 2019 Sep 23;5(2):111-117. doi: 10.3233/NHA-180059.


Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.

Stekovic S, Hofer SJ, Tripolt N, Aon MA, Royer P, Pein L, Stadler JT, Pendl T, Prietl B, Url J, Schroeder S, Tadic J, Eisenberg T, Magnes C, Stumpe M, Zuegner E, Bordag N, Riedl R, Schmidt A, Kolesnik E, Verheyen N, Springer A, Madl T, Sinner F, de Cabo R, Kroemer G, Obermayer-Pietsch B, Dengjel J, Sourij H, Pieber TR, Madeo F.

Cell Metab. 2019 Sep 3;30(3):462-476.e5. doi: 10.1016/j.cmet.2019.07.016. Epub 2019 Aug 27.


Maternally expressed gene 3 in metabolic programming.

Hamilton S, de Cabo R, Bernier M.

Biochim Biophys Acta Gene Regul Mech. 2019 Jul 1:194396. doi: 10.1016/j.bbagrm.2019.06.007. [Epub ahead of print] Review.


Pomalidomide Reduces Ischemic Brain Injury in Rodents.

Tsai YR, Tweedie D, Navas-Enamorado I, Scerba MT, Chang CF, Lai JH, Wu JC, Chen YH, Kang SJ, Hoffer BJ, de Cabo R, Greig NH, Chiang YH, Chen KY.

Cell Transplant. 2019 Apr;28(4):439-450. doi: 10.1177/0963689719850078. Epub 2019 May 16.


Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.

Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L.

J Am Geriatr Soc. 2019 Aug;67(8):1559-1564. doi: 10.1111/jgs.15928. Epub 2019 May 2.


Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions.

Palliyaguru DL, Moats JM, Di Germanio C, Bernier M, de Cabo R.

Mech Ageing Dev. 2019 Jun;180:42-48. doi: 10.1016/j.mad.2019.03.005. Epub 2019 Mar 26. Review.


Loss of miR-451a enhances SPARC production during myogenesis.

Munk R, Martindale JL, Yang X, Yang JH, Grammatikakis I, Di Germanio C, Mitchell SJ, de Cabo R, Lehrmann E, Zhang Y, Becker KG, Raz V, Gorospe M, Abdelmohsen K, Panda AC.

PLoS One. 2019 Mar 29;14(3):e0214301. doi: 10.1371/journal.pone.0214301. eCollection 2019.


Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.

Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R.

J Am Geriatr Soc. 2019 Mar;67(3):428-433. doi: 10.1111/jgs.15788. Epub 2019 Jan 29.


Of Aging Mice and Men: Gait Speed Decline Is a Translatable Trait, With Species-Specific Underlying Properties.

Bair WN, Petr M, Alfaras I, Mitchell SJ, Bernier M, Ferrucci L, Studenski SA, De Cabo R.

J Gerontol A Biol Sci Med Sci. 2019 Aug 16;74(9):1413-1416. doi: 10.1093/gerona/glz015.


Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG.

Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.


Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice.

Cortassa S, Caceres V, Tocchetti CG, Bernier M, de Cabo R, Paolocci N, Sollott SJ, Aon MA.

J Physiol. 2018 Nov 21. doi: 10.1113/JP276824. [Epub ahead of print]


A time to fast.

Di Francesco A, Di Germanio C, Bernier M, de Cabo R.

Science. 2018 Nov 16;362(6416):770-775. doi: 10.1126/science.aau2095. Review.


Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells.

Bodogai M, O'Connell J, Kim K, Kim Y, Moritoh K, Chen C, Gusev F, Vaughan K, Shulzhenko N, Mattison JA, Lee-Chang C, Chen W, Carlson O, Becker KG, Gurung M, Morgun A, White J, Meade T, Perdue K, Mack M, Ferrucci L, Trinchieri G, de Cabo R, Rogaev E, Egan J, Wu J, Biragyn A.

Sci Transl Med. 2018 Nov 14;10(467). pii: eaat4271. doi: 10.1126/scitranslmed.aat4271.


Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype.

Wang M, Zhang L, Zhu W, Zhang J, Kim SH, Wang Y, Ni L, Telljohann R, Monticone RE, McGraw K, Liu L, de Cabo R, Lakatta EG.

J Am Heart Assoc. 2018 Sep 18;7(18):e009112. doi: 10.1161/JAHA.118.009112. Erratum in: J Am Heart Assoc. 2018 Nov 20;7(22):e004303.


Yo-Yo Dieting is Better than None.

Di Germanio C, Di Francesco A, Bernier M, de Cabo R.

Obesity (Silver Spring). 2018 Nov;26(11):1673. doi: 10.1002/oby.22335. No abstract available.


Carbotoxicity-Noxious Effects of Carbohydrates.

Kroemer G, López-Otín C, Madeo F, de Cabo R.

Cell. 2018 Oct 18;175(3):605-614. doi: 10.1016/j.cell.2018.07.044. Review.


Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.

Mitchell SJ, Bernier M, Mattison JA, Aon MA, Kaiser TA, Anson RM, Ikeno Y, Anderson RM, Ingram DK, de Cabo R.

Cell Metab. 2019 Jan 8;29(1):221-228.e3. doi: 10.1016/j.cmet.2018.08.011. Epub 2018 Sep 6.


Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats.

Mach J, Huizer-Pajkos A, Cogger VC, McKenzie C, Le Couteur DG, Jones BE, de Cabo R, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):332. doi: 10.1093/gerona/gly160. No abstract available.


Sirt1 protects from K-Ras-driven lung carcinogenesis.

Costa-Machado LF, Martín-Hernández R, Sanchez-Luengo MÁ, Hess K, Vales-Villamarin C, Barradas M, Lynch C, de la Nava D, Diaz-Ruiz A, de Cabo R, Cañamero M, Martinez L, Sanchez-Carbayo M, Herranz D, Serrano M, Fernandez-Marcos PJ.

EMBO Rep. 2018 Sep;19(9). pii: e43879. doi: 10.15252/embr.201643879. Epub 2018 Jul 18.


The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle.

Gutiérrez-Casado E, Khraiwesh H, López-Domínguez JA, Montero-Guisado J, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, González-Reyes JA, Villalba JM.

J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):760-769. doi: 10.1093/gerona/gly161.


Future directions of resveratrol research.

Wahl D, Bernier M, Simpson SJ, de Cabo R, Le Couteur DG.

Nutr Healthy Aging. 2018 Jun 15;4(4):287-290. doi: 10.3233/NHA-170035. Review.


Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.

Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863. doi: 10.1093/gerona/glx177.


Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1.

Diaz-Ruiz A, Di Francesco A, Carboneau BA, Levan SR, Pearson KJ, Price NL, Ward TM, Bernier M, de Cabo R, Mercken EM.

J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):155-162. doi: 10.1093/gerona/gly112.


Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction.

Diaz-Ruiz A, Lanasa M, Garcia J, Mora H, Fan F, Martin-Montalvo A, Di Francesco A, Calvo-Rubio M, Salvador-Pascual A, Aon MA, Fishbein KW, Pearson KJ, Villalba JM, Navas P, Bernier M, de Cabo R.

Aging Cell. 2018 Aug;17(4):e12767. doi: 10.1111/acel.12767. Epub 2018 Apr 28.


Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.

Gokarn R, Solon-Biet SM, Cogger VC, Cooney GJ, Wahl D, McMahon AC, Mitchell JR, Mitchell SJ, Hine C, de Cabo R, Raubenheimer D, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1618-1625. doi: 10.1093/gerona/gly065.


Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.


Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C.

Cell Rep. 2018 Feb 20;22(8):2133-2145. doi: 10.1016/j.celrep.2018.01.074.


Intermittent mTOR Inhibition Reverses Kidney Aging in Old Rats.

Di Francesco A, Diaz-Ruiz A, de Cabo R, Bernier M.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):843-844. doi: 10.1093/gerona/gly023. No abstract available.


α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice.

Maxwell N, Castro RW, Sutherland NM, Vaughan KL, Szarowicz MD, de Cabo R, Mattison JA, Valdez G.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12726. Epub 2018 Feb 4.


Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging.

Gonzalez-Freire M, Scalzo P, D'Agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, de Cabo R, Ferrucci L.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12725. Epub 2018 Jan 21.


Redox modulation of NQO1.

Siegel D, Dehn DD, Bokatzian SS, Quinn K, Backos DS, Di Francesco A, Bernier M, Reisdorph N, de Cabo R, Ross D.

PLoS One. 2018 Jan 3;13(1):e0190717. doi: 10.1371/journal.pone.0190717. eCollection 2018.


Aged interleukin-10tm1Cgn chronically inflamed mice have substantially reduced fat mass, metabolic rate, and adipokines.

Westbrook RM, Yang HL, Langdon JM, Roy CN, Kim JA, Choudhury PP, Xue QL, di Francesco A, de Cabo R, Walston J.

PLoS One. 2017 Dec 21;12(12):e0186811. doi: 10.1371/journal.pone.0186811. eCollection 2017.


Caloric Restriction Research: New Perspectives on the Biology of Aging.

Anderson RM, Le Couteur DG, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):1-3. doi: 10.1093/gerona/glx212. No abstract available.


Health benefits of late-onset metformin treatment every other week in mice.

Alfaras I, Mitchell SJ, Mora H, Lugo DR, Warren A, Navas-Enamorado I, Hoffmann V, Hine C, Mitchell JR, Le Couteur DG, Cogger VC, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2017 Nov 20;3:16. doi: 10.1038/s41514-017-0018-7. eCollection 2017.


Sex and Aging.

Le Couteur DG, Anderson RM, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):139-140. doi: 10.1093/gerona/glx221. No abstract available.


Breaking the Ceiling of Human Maximal Life span.

Ben-Haim MS, Kanfi Y, Mitchell SJ, Maoz N, Vaughan KL, Amariglio N, Lerrer B, de Cabo R, Rechavi G, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1465-1471. doi: 10.1093/gerona/glx219.


Stem Cell Transplantation for Frailty.

Le Couteur DG, Anderson RM, Newman AB, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1503-1504. doi: 10.1093/gerona/glx158. Review. No abstract available.


Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies.

Vaughan KL, Kaiser T, Peaden R, Anson RM, de Cabo R, Mattison JA.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):48-53. doi: 10.1093/gerona/glx088. Erratum in: J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1207.


Hexokinases link DJ-1 to the PINK1/parkin pathway.

Hauser DN, Mamais A, Conti MM, Primiani CT, Kumaran R, Dillman AA, Langston RG, Beilina A, Garcia JH, Diaz-Ruiz A, Bernier M, Fiesel FC, Hou X, Springer W, Li Y, de Cabo R, Cookson MR.

Mol Neurodegener. 2017 Sep 29;12(1):70. doi: 10.1186/s13024-017-0212-x.


Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.

Wahl D, Coogan SC, Solon-Biet SM, de Cabo R, Haran JB, Raubenheimer D, Cogger VC, Mattson MP, Simpson SJ, Le Couteur DG.

Clin Interv Aging. 2017 Sep 8;12:1419-1428. doi: 10.2147/CIA.S145247. eCollection 2017. Review.


Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R.

NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017.


Calorie restriction in rodents: Caveats to consider.

Ingram DK, de Cabo R.

Ageing Res Rev. 2017 Oct;39:15-28. doi: 10.1016/j.arr.2017.05.008. Epub 2017 Jun 10. Review.


Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.

Fernández-Del-Río L, Nag A, Gutiérrez Casado E, Ariza J, Awad AM, Joseph AI, Kwon O, Verdin E, de Cabo R, Schneider C, Torres JZ, Burón MI, Clarke CF, Villalba JM.

Free Radic Biol Med. 2017 Sep;110:176-187. doi: 10.1016/j.freeradbiomed.2017.06.006. Epub 2017 Jun 9.


A Comparison of Two Mouse Frailty Assessment Tools.

Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett SE, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):904-909. doi: 10.1093/gerona/glx009.


Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.

Navas-Enamorado I, Bernier M, Brea-Calvo G, de Cabo R.

Ageing Res Rev. 2017 Aug;37:39-52. doi: 10.1016/j.arr.2017.04.005. Epub 2017 May 6. Review. No abstract available.

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