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Items: 30

1.

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells.

Olbrich T, Vega-Sendino M, Murga M, de Carcer G, Malumbres M, Ortega S, Ruiz S, Fernandez-Capetillo O.

Cell Rep. 2019 Jul 16;28(3):597-604.e4. doi: 10.1016/j.celrep.2019.06.060.

2.

The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?

de Cárcer G.

Genes (Basel). 2019 Mar 11;10(3). pii: E208. doi: 10.3390/genes10030208. Review.

3.

Plk1 overexpression induces chromosomal instability and suppresses tumor development.

de Cárcer G, Venkateswaran SV, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, Montañés P, Sanclemente M, Escobar B, de Martino A, McGranahan N, Malumbres M, Sotillo R.

Nat Commun. 2018 Aug 1;9(1):3012. doi: 10.1038/s41467-018-05429-5.

4.

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.

de Cárcer G, Wachowicz P, Martínez-Martínez S, Oller J, Méndez-Barbero N, Escobar B, González-Loyola A, Takaki T, El Bakkali A, Cámara JA, Jiménez-Borreguero LJ, Bustelo XR, Cañamero M, Mulero F, de Los Ángeles Sevilla M, Montero MJ, Redondo JM, Malumbres M.

Nat Med. 2017 Aug;23(8):964-974. doi: 10.1038/nm.4364. Epub 2017 Jul 10.

PMID:
28692064
5.

Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies.

Wachowicz P, Fernández-Miranda G, Marugán C, Escobar B, de Cárcer G.

Bioessays. 2016 Jul;38 Suppl 1:S96-S106. doi: 10.1002/bies.201670908.

PMID:
27417127
6.

Aurora A drives early signalling and vesicle dynamics during T-cell activation.

Blas-Rus N, Bustos-Morán E, Pérez de Castro I, de Cárcer G, Borroto A, Camafeita E, Jorge I, Vázquez J, Alarcón B, Malumbres M, Martín-Cófreces NB, Sánchez-Madrid F.

Nat Commun. 2016 Apr 19;7:11389. doi: 10.1038/ncomms11389.

7.

Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.

González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez Á, de Cárcer G, Pérez de Castro I, Earnshaw WC, Malumbres M.

Mol Cell Biol. 2015 Oct;35(20):3566-78. doi: 10.1128/MCB.01286-14. Epub 2015 Aug 3.

8.

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice.

Trakala M, Partida D, Salazar-Roa M, Maroto M, Wachowicz P, de Cárcer G, Malumbres M.

Blood. 2015 Oct 1;126(14):1707-14. doi: 10.1182/blood-2015-03-634402. Epub 2015 Jul 16.

PMID:
26185128
9.

A centrosomal route for cancer genome instability.

de Cárcer G, Malumbres M.

Nat Cell Biol. 2014 Jun;16(6):504-6. doi: 10.1038/ncb2978.

PMID:
24875738
10.

Low dose of amino-modified nanoparticles induces cell cycle arrest.

Kim JA, Åberg C, de Cárcer G, Malumbres M, Salvati A, Dawson KA.

ACS Nano. 2013 Sep 24;7(9):7483-94. doi: 10.1021/nn403126e. Epub 2013 Aug 19.

PMID:
23941353
11.

HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.

Elorza A, Soro-Arnáiz I, Meléndez-Rodríguez F, Rodríguez-Vaello V, Marsboom G, de Cárcer G, Acosta-Iborra B, Albacete-Albacete L, Ordóñez A, Serrano-Oviedo L, Giménez-Bachs JM, Vara-Vega A, Salinas A, Sánchez-Prieto R, Martín del Río R, Sánchez-Madrid F, Malumbres M, Landázuri MO, Aragonés J.

Mol Cell. 2012 Dec 14;48(5):681-91. doi: 10.1016/j.molcel.2012.09.017. Epub 2012 Oct 25.

12.

From Plk1 to Plk5: functional evolution of polo-like kinases.

de Cárcer G, Manning G, Malumbres M.

Cell Cycle. 2011 Jul 15;10(14):2255-62. Epub 2011 Jul 15. Review.

13.

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.

de Cárcer G, Escobar B, Higuero AM, García L, Ansón A, Pérez G, Mollejo M, Manning G, Meléndez B, Abad-Rodríguez J, Malumbres M.

Mol Cell Biol. 2011 Mar;31(6):1225-39. doi: 10.1128/MCB.00607-10. Epub 2011 Jan 18.

14.

Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.

Manchado E, Guillamot M, de Cárcer G, Eguren M, Trickey M, García-Higuera I, Moreno S, Yamano H, Cañamero M, Malumbres M.

Cancer Cell. 2010 Dec 14;18(6):641-54. doi: 10.1016/j.ccr.2010.10.028.

15.

Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin.

Muñoz IG, Yébenes H, Zhou M, Mesa P, Serna M, Park AY, Bragado-Nilsson E, Beloso A, de Cárcer G, Malumbres M, Robinson CV, Valpuesta JM, Montoya G.

Nat Struct Mol Biol. 2011 Jan;18(1):14-9. doi: 10.1038/nsmb.1971. Epub 2010 Dec 12.

PMID:
21151115
16.

Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation.

Escobar B, de Cárcer G, Fernández-Miranda G, Cascón A, Bravo-Cordero JJ, Montoya MC, Robledo M, Cañamero M, Malumbres M.

Cancer Res. 2010 Nov 15;70(22):9349-59. doi: 10.1158/0008-5472.CAN-09-4491. Epub 2010 Sep 22.

17.

RINGO C is required to sustain the spindle-assembly checkpoint.

Mourón S, de Cárcer G, Seco E, Fernández-Miranda G, Malumbres M, Nebreda AR.

J Cell Sci. 2010 Aug 1;123(Pt 15):2586-95. doi: 10.1242/jcs.059964. Epub 2010 Jul 6.

18.

TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis.

Muñoz P, Blanco R, de Carcer G, Schoeftner S, Benetti R, Flores JM, Malumbres M, Blasco MA.

Mol Cell Biol. 2009 Mar;29(6):1608-25. doi: 10.1128/MCB.01339-08. Epub 2009 Jan 5.

19.

Emerging cancer therapeutic opportunities by inhibiting mitotic kinases.

Pérez de Castro I, de Cárcer G, Montoya G, Malumbres M.

Curr Opin Pharmacol. 2008 Aug;8(4):375-83. doi: 10.1016/j.coph.2008.06.013. Epub 2008 Jul 30. Review.

PMID:
18644252
20.

Targeting cell cycle kinases for cancer therapy.

de Cárcer G, Pérez de Castro I, Malumbres M.

Curr Med Chem. 2007;14(9):969-85. Review.

PMID:
17439397
21.

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.

García-Alvarez B, de Cárcer G, Ibañez S, Bragado-Nilsson E, Montoya G.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3107-12. Epub 2007 Feb 16.

22.

A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy.

Pérez de Castro I, de Cárcer G, Malumbres M.

Carcinogenesis. 2007 May;28(5):899-912. Epub 2007 Jan 27. Review.

PMID:
17259655
23.
24.

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability.

de Cárcer G, do Carmo Avides M, Lallena MJ, Glover DM, González C.

EMBO J. 2001 Jun 1;20(11):2878-84.

25.

The functional organization of the nucleolus in proliferating plant cells.

Medina FJ, Cerdido A, de Cárcer G.

Eur J Histochem. 2000;44(2):117-31. Review.

PMID:
10968360
26.

The N-terminal 209-aa domain of high molecular-weight 4.1R isoforms abrogates 4.1R targeting to the nucleus.

Luque CM, Lallena MJ, Pérez-Ferreiro CM, de Isidro Y, De Cárcer G, Alonso MA, Correas I.

Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14925-30.

28.

Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT.

Mol Cell Biol. 1998 May;18(5):3069-80.

30.

Protein 4.1 is a component of the nuclear matrix of mammalian cells.

de Cárcer G, Lallena MJ, Correas I.

Biochem J. 1995 Dec 15;312 ( Pt 3):871-7.

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