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Towards a theoretical clarification of biomimetics using conceptual tools from engineering design.

Drack M, Limpinsel M, de Bruyn G, Nebelsick JH, Betz O.

Bioinspir Biomim. 2017 Dec 13;13(1):016007. doi: 10.1088/1748-3190/aa967c.


Safety and immunogenicity of Clostridium difficile toxoid vaccine in Japanese adults.

Matsuoka O, Patel DM, Sasaki S, Oka H, Sasaki T, Pietrobon PJ, Laot T, Bouckenooghe A, Menezes J, de Bruyn G.

Hum Vaccin Immunother. 2018 Feb 1;14(2):322-328. doi: 10.1080/21645515.2017.1395538. Epub 2017 Dec 6.


Defining the optimal formulation and schedule of a candidate toxoid vaccine against Clostridium difficile infection: A randomized Phase 2 clinical trial.

de Bruyn G, Saleh J, Workman D, Pollak R, Elinoff V, Fraser NJ, Lefebvre G, Martens M, Mills RE, Nathan R, Trevino M, van Cleeff M, Foglia G, Ozol-Godfrey A, Patel DM, Pietrobon PJ, Gesser R; H-030-012 Clinical Investigator Study Team.

Vaccine. 2016 Apr 27;34(19):2170-8. doi: 10.1016/j.vaccine.2016.03.028. Epub 2016 Mar 21.


Transient Increase in Herpes Simplex Virus Type 2 (HSV-2)-Associated Genital Ulcers Following Initiation of Antiretroviral Therapy in HIV/HSV-2-Coinfected Individuals.

Fife KH, Mugwanya K, Thomas KK, Baeten JM, Celum C, Bukusi E, de Bruyn G, Mujugira A, Vwalika B, Wald A, Lingappa JR; Partners in Prevention HSV/HIV Transmission Study Team.

J Infect Dis. 2016 May 15;213(10):1573-8. doi: 10.1093/infdis/jiv765. Epub 2015 Dec 23.


WAVEFORM WINDOW #32: 14 and 6 Hz Positive Spikes: A Normal Variant that Could be Mistaken as Epileptiform.

Eber C, de Bruyn G, Knight EM.

Neurodiagn J. 2015 Sep;55(3):204-10. No abstract available.


Sexual communication self-efficacy, hegemonic masculine norms and condom use among heterosexual couples in South Africa.

Leddy A, Chakravarty D, Dladla S, de Bruyn G, Darbes L.

AIDS Care. 2016;28(2):228-33. doi: 10.1080/09540121.2015.1080792. Epub 2015 Sep 7.


The tuberculosis vaccine H4:IC31 is safe and induces a persistent polyfunctional CD4 T cell response in South African adults: A randomized controlled trial.

Geldenhuys H, Mearns H, Miles DJ, Tameris M, Hokey D, Shi Z, Bennett S, Andersen P, Kromann I, Hoff ST, Hanekom WA, Mahomed H, Hatherill M, Scriba TJ; H4:IC31 Trial Study Group, van Rooyen M, Bruce McClain J, Ryall R, de Bruyn G; H4:IC31 Trial Study Groupa.

Vaccine. 2015 Jul 9;33(30):3592-9. doi: 10.1016/j.vaccine.2015.05.036. Epub 2015 Jun 3.


Plasma cytokine levels and risk of HIV type 1 (HIV-1) transmission and acquisition: a nested case-control study among HIV-1-serodiscordant couples.

Kahle EM, Bolton M, Hughes JP, Donnell D, Celum C, Lingappa JR, Ronald A, Cohen CR, de Bruyn G, Fong Y, Katabira E, McElrath MJ, Baeten JM; Partners in Prevention HSV/HIV Transmission Study Team.

J Infect Dis. 2015 May 1;211(9):1451-60. doi: 10.1093/infdis/jiu621. Epub 2014 Nov 10.


Frequent genital HSV-2 shedding among women during labor in Soweto, South Africa.

Perti T, Nyati M, Gray G, De Bruyn G, Selke S, Magaret A, Huang ML, Velaphi S, Corey L, Wald A.

Infect Dis Obstet Gynecol. 2014;2014:258291. doi: 10.1155/2014/258291. Epub 2014 May 20.


CD4 counts and viral loads of newly diagnosed HIV-infected individuals: implications for treatment as prevention.

Govender S, Otwombe K, Essien T, Panchia R, de Bruyn G, Mohapi L, Gray G, Martinson N.

PLoS One. 2014 Mar 4;9(3):e90754. doi: 10.1371/journal.pone.0090754. eCollection 2014.


Multiple levels of influence in predicting sexual activity and condom use among adolescents in Soweto, Johannesburg, South Africa.

Dietrich J, Sikkema K, Otwombe KN, Sanchez A, Nkala B, de Bruyn G, Van Der Watt M, Gray GE.

J HIV AIDS Soc Serv. 2013 Jul 1;12(3-4):404-423. No abstract available.


Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans.

Bigham AW, Mackelprang RD, Celum C, De Bruyn G, Beima-Sofie K, John-Stewart G, Ronald A, Mugo NR, Buckingham K, Bamshad MJ, Mullins JI, McElrath MJ, Lingappa JR.

J Acquir Immune Defic Syndr. 2014 Jun 1;66(2):127-34. doi: 10.1097/QAI.0000000000000113.


Unreported antiretroviral use by HIV-1-infected participants enrolling in a prospective research study.

Kahle EM, Kashuba A, Baeten JM, Fife KH, Celum C, Mujugira A, Essex M, De Bruyn G, Wald A, Donnell D, John-Stewart G, Delany-Moretlwe S, Mugo NR, Farquhar C, Lingappa JR; Partners in Prevention HSVHIV Transmission Study Team.

J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):e90-4. doi: 10.1097/QAI.0b013e3182a2db02. No abstract available.


Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans.

Mackelprang RD, Bigham AW, Celum C, de Bruyn G, Beima-Sofie K, John-Stewart G, Ronald A, Mugo NR, Buckingham KJ, Bamshad MJ, Mullins JI, McElrath MJ, Lingappa JR.

J Infect Dis. 2014 May 15;209(10):1623-7. doi: 10.1093/infdis/jit807. Epub 2013 Dec 10.


Intimate partner violence and condom and diaphragm nonadherence among women in an HIV prevention trial in southern Africa.

Kacanek D, Bostrom A, Montgomery ET, Ramjee G, de Bruyn G, Blanchard K, Rock A, Mtetwa S, van der Straten A; MIRA Team.

J Acquir Immune Defic Syndr. 2013 Dec 1;64(4):400-8. doi: 10.1097/QAI.0b013e3182a6b0be.


Daily acyclovir to decrease herpes simplex virus type 2 (HSV-2) transmission from HSV-2/HIV-1 coinfected persons: a randomized controlled trial.

Mujugira A, Magaret AS, Celum C, Baeten JM, Lingappa JR, Morrow RA, Fife KH, Delany-Moretlwe S, de Bruyn G, Bukusi EA, Karita E, Kapiga S, Corey L, Wald A; Partners in Prevention HSV/HIV Transmission Study Team.

J Infect Dis. 2013 Nov 1;208(9):1366-74. doi: 10.1093/infdis/jit333. Epub 2013 Jul 30.


Oral and injectable contraception use and risk of HIV acquisition among women in sub-Saharan Africa.

McCoy SI, Zheng W, Montgomery ET, Blanchard K, van der Straten A, de Bruyn G, Padian NS.

AIDS. 2013 Mar 27;27(6):1001-9. doi: 10.1097/QAD.0b013e32835da401.


Identification and characterisation of vaginal lactobacilli from South African women.

Pendharkar S, Magopane T, Larsson PG, de Bruyn G, Gray GE, Hammarström L, Marcotte H.

BMC Infect Dis. 2013 Jan 26;13:43. doi: 10.1186/1471-2334-13-43.


Incidence of cytological abnormalities within 24 months of a normal cervical smear in Soweto, South Africa.

Adam Y, McIntyre JA, De Bruyn G.

S Afr Med J. 2012 Nov 22;103(1):34-9. doi: 10.7196/samj.6124.


Mortality in members of HIV-1 serodiscordant couples in Africa and implications for antiretroviral therapy initiation: results of analyses from a multicenter randomized trial.

de Bruyn G, Magaret A, Baeten JM, Lingappa JR, Ndase P, Celum C, Wald A; Partners in Prevention HSV/HIV Transmission Study Team.

BMC Infect Dis. 2012 Oct 30;12:277. doi: 10.1186/1471-2334-12-277.


HIV testing and counseling leads to immediate consistent condom use among South African stable HIV-discordant couples.

Rosenberg NE, Pettifor AE, De Bruyn G, Westreich D, Delany-Moretlwe S, Behets F, Maman S, Coetzee D, Kamupira M, Miller WC.

J Acquir Immune Defic Syndr. 2013 Feb 1;62(2):226-33. doi: 10.1097/QAI.0b013e31827971ca.


Partner characteristics predicting HIV-1 set point in sexually acquired HIV-1 among African seroconverters.

Lingappa JR, Thomas KK, Hughes JP, Baeten JM, Wald A, Farquhar C, de Bruyn G, Fife KH, Campbell MS, Kapiga S, Mullins JI, Celum C; Partners in Prevention HSV/HIV Transmission Study Team.

AIDS Res Hum Retroviruses. 2013 Jan;29(1):164-71.


Discrepancies in diagnosis of incident HIV infection between antibody- and DNA-based tests in a phase III prevention trial in southern Africa.

Montgomery ET, van der Pol B, van der Straten A, Ramjee G, de Bruyn G, Chipato T, Blanchard K, Padian NS; MIRA Team.

Int J STD AIDS. 2012 Sep;23(9):649-52. doi: 10.1258/ijsa.2009.009124.


Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cells.

Riou C, Treurnicht F, Abrahams MR, Mlisana K, Liu MK, Goonetilleke N, Koup R, Roederer M, Abdool Karim S, de Bruyn G, Williamson C, Gray CM, Burgers WA; CAPRISA 002 Study Team.

J Immunol. 2012 Oct 15;189(8):3838-47. doi: 10.4049/jimmunol.1201488. Epub 2012 Sep 10.


Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1.

Mackelprang RD, Baeten JM, Donnell D, Celum C, Farquhar C, de Bruyn G, Essex M, McElrath MJ, Nakku-Joloba E, Lingappa JR; Partners in Prevention HSV/HIV Transmission Study Team.

J Infect Dis. 2012 Oct;206(8):1299-308. Epub 2012 Aug 27.


"Group sex" parties and other risk patterns: A qualitative study about the perceptions of sexual behaviors and attitudes of adolescents in Soweto, South Africa.

Dietrich J, Khunwane M, Laher F, de Bruyn G, Sikkema KJ, Gray G.

Vulnerable Child Youth Stud. 2011 Sep 1;6(3):244-254. Epub 2011 Aug 23.


Congenital glucose-galactose malabsorption: a novel deletion within the SLC5A1 gene.

Vallaeys L, Van Biervliet S, De Bruyn G, Loeys B, Moring AS, Van Deynse E, Cornette L.

Eur J Pediatr. 2013 Mar;172(3):409-11. doi: 10.1007/s00431-012-1802-9. Epub 2012 Jul 29.


Increased regression and decreased incidence of human papillomavirus-related cervical lesions among HIV-infected women on HAART.

Adler DH, Kakinami L, Modisenyane T, Tshabangu N, Mohapi L, De Bruyn G, Martinson NA, Omar T.

AIDS. 2012 Aug 24;26(13):1645-52.


Pregnancy incidence and correlates during the HVTN 503 Phambili HIV vaccine trial conducted among South African women.

Latka MH, Fielding K, Gray GE, Bekker LG, Nchabeleng M, Mlisana K, Nielson T, Roux S, Mkhize B, Mathebula M, Naicker N, de Bruyn G, Kublin J, Churchyard GJ; HVTN 503 Phambili study team.

PLoS One. 2012;7(4):e31387. doi: 10.1371/journal.pone.0031387. Epub 2012 Apr 19.


Specificity of four laboratory approaches for cross-sectional HIV incidence determination: analysis of samples from adults with known nonrecent HIV infection from five African countries.

Laeyendecker O, Brookmeyer R, Mullis CE, Donnell D, Lingappa J, Celum C, Baeten JM, Campbell MS, Essex M, de Bruyn G, Farquhar C, Quinn TC, Eshleman SH; Partners in Prevention HSV/HIV Transmission Study Team.

AIDS Res Hum Retroviruses. 2012 Oct;28(10):1177-83.


Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples.

Hughes JP, Baeten JM, Lingappa JR, Magaret AS, Wald A, de Bruyn G, Kiarie J, Inambao M, Kilembe W, Farquhar C, Celum C; Partners in Prevention HSV/HIV Transmission Study Team.

J Infect Dis. 2012 Feb 1;205(3):358-65. doi: 10.1093/infdis/jir747. Epub 2012 Jan 11.


Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.

Lingappa JR, Petrovski S, Kahle E, Fellay J, Shianna K, McElrath MJ, Thomas KK, Baeten JM, Celum C, Wald A, de Bruyn G, Mullins JI, Nakku-Joloba E, Farquhar C, Essex M, Donnell D, Kiarie J, Haynes B, Goldstein D; Partners in Prevention HSV/HIV Transmission Study Team.

PLoS One. 2011;6(12):e28632. doi: 10.1371/journal.pone.0028632. Epub 2011 Dec 12.


Optimal uses of antiretrovirals for prevention in HIV-1 serodiscordant heterosexual couples in South Africa: a modelling study.

Hallett TB, Baeten JM, Heffron R, Barnabas R, de Bruyn G, Cremin Í, Delany S, Garnett GP, Gray G, Johnson L, McIntyre J, Rees H, Celum C.

PLoS Med. 2011 Nov;8(11):e1001123. doi: 10.1371/journal.pmed.1001123. Epub 2011 Nov 15.


Male circumcision for HIV prevention: current evidence and implementation in sub-Saharan Africa.

Wamai RG, Morris BJ, Bailis SA, Sokal D, Klausner JD, Appleton R, Sewankambo N, Cooper DA, Bongaarts J, de Bruyn G, Wodak AD, Banerjee J.

J Int AIDS Soc. 2011 Oct 20;14:49. doi: 10.1186/1758-2652-14-49. Review.


Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial.

Eshleman SH, Hudelson SE, Redd AD, Wang L, Debes R, Chen YQ, Martens CA, Ricklefs SM, Selig EJ, Porcella SF, Munshaw S, Ray SC, Piwowar-Manning E, McCauley M, Hosseinipour MC, Kumwenda J, Hakim JG, Chariyalertsak S, de Bruyn G, Grinsztejn B, Kumarasamy N, Makhema J, Mayer KH, Pilotto J, Santos BR, Quinn TC, Cohen MS, Hughes JP.

J Infect Dis. 2011 Dec 15;204(12):1918-26. doi: 10.1093/infdis/jir651. Epub 2011 Oct 11.


Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study.

Heffron R, Donnell D, Rees H, Celum C, Mugo N, Were E, de Bruyn G, Nakku-Joloba E, Ngure K, Kiarie J, Coombs RW, Baeten JM; Partners in Prevention HSV/HIV Transmission Study Team.

Lancet Infect Dis. 2012 Jan;12(1):19-26. doi: 10.1016/S1473-3099(11)70247-X. Epub 2011 Oct 3. Erratum in: Lancet Infect Dis. 2012 Feb;12(2):98.


Hydrops fetalis and pulmonary lymphangiectasia due to FOXC2 mutation: an autosomal dominant hereditary lymphedema syndrome with variable expression.

de Bruyn G, Casaer A, Devolder K, Van Acker G, Logghe H, Devriendt K, Cornette L.

Eur J Pediatr. 2012 Mar;171(3):447-50. doi: 10.1007/s00431-011-1557-8. Epub 2011 Sep 15.


Antiretroviral therapy refusal among newly diagnosed HIV-infected adults.

Katz IT, Essien T, Marinda ET, Gray GE, Bangsberg DR, Martinson NA, De Bruyn G.

AIDS. 2011 Nov 13;25(17):2177-81. doi: 10.1097/QAD.0b013e32834b6464.


Prevention of HIV-1 infection with early antiretroviral therapy.

Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole SV, Mehendale S, Chariyalertsak S, Santos BR, Mayer KH, Hoffman IF, Eshleman SH, Piwowar-Manning E, Wang L, Makhema J, Mills LA, de Bruyn G, Sanne I, Eron J, Gallant J, Havlir D, Swindells S, Ribaudo H, Elharrar V, Burns D, Taha TE, Nielsen-Saines K, Celentano D, Essex M, Fleming TR; HPTN 052 Study Team.

N Engl J Med. 2011 Aug 11;365(6):493-505. doi: 10.1056/NEJMoa1105243. Epub 2011 Jul 18.


Willingness to participate in biomedical HIV prevention studies after the HVTN 503/Phambili trial: a survey conducted among adolescents in Soweto, South Africa.

Otwombe KN, Sikkema KJ, Dietrich J, de Bruyn G, van der Watt M, Gray GE.

J Acquir Immune Defic Syndr. 2011 Oct 1;58(2):211-8. doi: 10.1097/QAI.0b013e31822b7702.


Impact of learning HIV status on contraceptive use in the MIRA trial.

Blanchard K, Holt K, Bostrom A, van der Straten A, Ramjee G, de Bruyn G, Chipato T, Montgomery ET, Padian NS.

J Fam Plann Reprod Health Care. 2011 Oct;37(4):204-8. doi: 10.1136/jfprhc-2011-0109. Epub 2011 Jul 11.


Determinants of differential HIV incidence among women in three southern African locations.

Mavedzenge SN, Weiss HA, Montgomery ET, Blanchard K, de Bruyn G, Ramjee G, Chipato T, Padian NS, Van Der Straten A.

J Acquir Immune Defic Syndr. 2011 Sep 1;58(1):89-99. doi: 10.1097/QAI.0b013e3182254038.


International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations.

Barouch DH, Kik SV, Weverling GJ, Dilan R, King SL, Maxfield LF, Clark S, Ng'ang'a D, Brandariz KL, Abbink P, Sinangil F, de Bruyn G, Gray GE, Roux S, Bekker LG, Dilraj A, Kibuuka H, Robb ML, Michael NL, Anzala O, Amornkul PN, Gilmour J, Hural J, Buchbinder SP, Seaman MS, Dolin R, Baden LR, Carville A, Mansfield KG, Pau MG, Goudsmit J.

Vaccine. 2011 Jul 18;29(32):5203-9. doi: 10.1016/j.vaccine.2011.05.025. Epub 2011 May 25.


Contraception use and effectiveness among women in a trial of the diaphragm for HIV prevention.

Blanchard K, Bostrom A, Montgomery E, van der Straten A, Lince N, de Bruyn G, Grossman D, Chipato T, Ramjee G, Padian N.

Contraception. 2011 Jun;83(6):556-63. doi: 10.1016/j.contraception.2010.10.018. Epub 2011 Jan 26.


Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study.

Gray GE, Allen M, Moodie Z, Churchyard G, Bekker LG, Nchabeleng M, Mlisana K, Metch B, de Bruyn G, Latka MH, Roux S, Mathebula M, Naicker N, Ducar C, Carter DK, Puren A, Eaton N, McElrath MJ, Robertson M, Corey L, Kublin JG; HVTN 503/Phambili study team.

Lancet Infect Dis. 2011 Jul;11(7):507-15. doi: 10.1016/S1473-3099(11)70098-6. Epub 2011 May 11. Erratum in: Lancet Infect Dis. 2011 Jul;11(7):495.


Changes in sexual risk behavior before and after HIV seroconversion in Southern African women enrolled in a HIV prevention trial.

Venkatesh KK, de Bruyn G, Mayer KH, Cheng H, Blanchard K, Ramjee G, Chipato T, Triche EW, Padian NS, van der Straten A.

J Acquir Immune Defic Syndr. 2011 Aug 15;57(5):435-41. doi: 10.1097/QAI.0b013e318220379b.


The relative contribution of viral and bacterial sexually transmitted infections on HIV acquisition in southern African women in the Methods for Improving Reproductive Health in Africa study.

Venkatesh KK, van der Straten A, Cheng H, Montgomery ET, Lurie MN, Chipato T, Ramjee G, Blanchard K, Padian NS, Mayer KH, de Bruyn G.

Int J STD AIDS. 2011 Apr;22(4):218-24. doi: 10.1258/ijsa.2010.010385.


Sexual risk behaviors among HIV-infected South African men and women with their partners in a primary care program: implications for couples-based prevention.

Venkatesh KK, de Bruyn G, Lurie MN, Modisenyane T, Triche EW, Gray GE, Welte A, Martinson NA.

AIDS Behav. 2012 Jan;16(1):139-50. doi: 10.1007/s10461-011-9941-y.


The effect of the vaginal diaphragm and lubricant gel on acquisition of HSV-2.

de Bruyn G, Shiboski S, van der Straten A, Blanchard K, Chipato T, Ramjee G, Montgomery E, Padian N; MIRA Team.

Sex Transm Infect. 2011 Jun;87(4):301-5. doi: 10.1136/sti.2010.047142. Epub 2011 Mar 29.


Performance of the Focus HerpeSelect-2 enzyme immunoassay for the detection of herpes simplex virus type 2 antibodies in seven African countries.

Mujugira A, Morrow RA, Celum C, Lingappa J, Delany-Moretlwe S, Fife KH, Heffron R, De Bruyn G, Homawoo B, Karita E, Mugo N, Vwalika B, Baeten JM; Partners in Prevention HSV/HIV Transmission Study Team.

Sex Transm Infect. 2011 Apr;87(3):238-41. doi: 10.1136/sti.2010.047415. Epub 2011 Feb 9.

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