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Items: 46

1.

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh).

Veerman CC, Mengarelli I, Koopman CD, Wilders R, van Amersfoorth SC, Bakker D, Wolswinkel R, Hababa M, de Boer TP, Guan K, Milnes J, Lodder EM, Bakkers J, Verkerk AO, Bezzina CR.

Dis Model Mech. 2019 Jul 9;12(7). pii: dmm037994. doi: 10.1242/dmm.037994.

2.

The influence of hERG1a and hERG1b isoforms on drug safety screening in iPSC-CMs.

Goversen B, Jonsson MK, van den Heuvel NH, Rijken R, Vos MA, van Veen TA, de Boer TP.

Prog Biophys Mol Biol. 2019 Feb 27. pii: S0079-6107(18)30263-3. doi: 10.1016/j.pbiomolbio.2019.02.003. [Epub ahead of print] Review.

PMID:
30826123
3.

Flotillins in the intercalated disc are potential modulators of cardiac excitability.

Kessler EL, van Stuijvenberg L, van Bavel JJA, van Bennekom J, Zwartsen A, Rivaud MR, Vink A, Efimov IR, Postma AV, van Tintelen JP, Remme CA, Vos MA, Banning A, de Boer TP, Tikkanen R, van Veen TAB.

J Mol Cell Cardiol. 2019 Jan;126:86-95. doi: 10.1016/j.yjmcc.2018.11.007. Epub 2018 Nov 17.

PMID:
30452906
4.

Using Light to Endow Stem-Cell-Derived Cardiomyocytes With Virtual IK1 Conductances.

de Boer TP.

Biophys J. 2018 Dec 4;115(11):2079-2080. doi: 10.1016/j.bpj.2018.10.019. Epub 2018 Oct 30. No abstract available.

PMID:
30442328
5.

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis.

van Opbergen CJM, Koopman CD, Kok BJM, Knöpfel T, Renninger SL, Orger MB, Vos MA, van Veen TAB, Bakkers J, de Boer TP.

Theranostics. 2018 Sep 9;8(17):4750-4764. doi: 10.7150/thno.26108. eCollection 2018.

6.

Cardiac Ca2+ signalling in zebrafish: Translation of findings to man.

van Opbergen CJM, van der Voorn SM, Vos MA, de Boer TP, van Veen TAB.

Prog Biophys Mol Biol. 2018 Oct;138:45-58. doi: 10.1016/j.pbiomolbio.2018.05.002. Epub 2018 May 7. Review.

PMID:
29746887
7.

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

Beattie KA, Hill AP, Bardenet R, Cui Y, Vandenberg JI, Gavaghan DJ, de Boer TP, Mirams GR.

J Physiol. 2018 May 15;596(10):1813-1828. doi: 10.1113/JP275733. Epub 2018 Apr 17.

8.

A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time.

Goversen B, Becker N, Stoelzle-Feix S, Obergrussberger A, Vos MA, van Veen TAB, Fertig N, de Boer TP.

Front Physiol. 2018 Jan 19;8:1094. doi: 10.3389/fphys.2017.01094. eCollection 2017.

9.

Action potential contour and inter-species differences.

de Boer TP, Stengl M.

Europace. 2018 Sep 1;20(9):1395-1396. doi: 10.1093/europace/eux308. No abstract available.

PMID:
29096032
10.

The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on IK1.

Goversen B, van der Heyden MAG, van Veen TAB, de Boer TP.

Pharmacol Ther. 2018 Mar;183:127-136. doi: 10.1016/j.pharmthera.2017.10.001. Epub 2017 Oct 3. Review.

11.

Cardiac optogenetics: using light to monitor cardiac physiology.

Koopman CD, Zimmermann WH, Knöpfel T, de Boer TP.

Basic Res Cardiol. 2017 Aug 31;112(5):56. doi: 10.1007/s00395-017-0645-y. Review.

12.

eSolv, a CellML-based simulation front-end for online teaching.

de Boer TP, van der Werf S, Hennekam B, Nickerson DP, Garny A, Gerbrands M, Bouwmeester RAM, Rozendal AP, Torfs E, van Rijen HVM.

Adv Physiol Educ. 2017 Sep 1;41(3):425-427. doi: 10.1152/advan.00127.2016. No abstract available.

13.

The concept of triple wavefront fusion during biventricular pacing: Using the EGM to produce the best acute hemodynamic improvement in CRT.

Ter Horst IAH, Bogaard MD, Tuinenburg AE, Mast TP, de Boer TP, Doevendans PAFM, Meine M.

Pacing Clin Electrophysiol. 2017 Jul;40(7):873-882. doi: 10.1111/pace.13118. Epub 2017 Jun 16.

PMID:
28543106
14.

Commentary: Reciprocal Modulation of IK1-INa Extends Excitability in Cardiac Ventricular Cells.

Goversen B, de Boer TP, van der Heyden MA.

Front Physiol. 2016 Dec 23;7:647. doi: 10.3389/fphys.2016.00647. eCollection 2016. No abstract available.

15.

Perpetuation of torsade de pointes in heterogeneous hearts: competing foci or re-entry?

Vandersickel N, de Boer TP, Vos MA, Panfilov AV.

J Physiol. 2016 Dec 1;594(23):6865-6878. doi: 10.1113/JP271728. Epub 2016 Mar 4.

16.

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

Johnstone RH, Chang ETY, Bardenet R, de Boer TP, Gavaghan DJ, Pathmanathan P, Clayton RH, Mirams GR.

J Mol Cell Cardiol. 2016 Jul;96:49-62. doi: 10.1016/j.yjmcc.2015.11.018. Epub 2015 Dec 2.

17.

A 2015 focus on preventing drug-induced arrhythmias.

Bossu A, van der Heyden MA, de Boer TP, Vos MA.

Expert Rev Cardiovasc Ther. 2016;14(2):245-53. doi: 10.1586/14779072.2016.1116940. Epub 2015 Nov 26. Review.

PMID:
26560188
18.

Arrhythmogenic Remodeling in Murine Models of Deoxycorticosterone Acetate-Salt-Induced and 5/6-Subtotal Nephrectomy-Salt-Induced Cardiorenal Disease.

Fontes MS, Papazova DA, van Koppen A, de Jong S, Korte SM, Bongartz LG, Nguyen TQ, Bierhuizen MF, de Boer TP, van Veen TA, Verhaar MC, Joles JA, van Rijen HV.

Cardiorenal Med. 2015 Jun;5(3):208-18. doi: 10.1159/000430475. Epub 2015 Jun 5.

19.

Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator.

Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S, Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH.

Circ Res. 2015 Aug 14;117(5):401-12. doi: 10.1161/CIRCRESAHA.117.306143. Epub 2015 Jun 15.

PMID:
26078285
20.

Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy.

Fontes MS, Raaijmakers AJ, van Doorn T, Kok B, Nieuwenhuis S, van der Nagel R, Vos MA, de Boer TP, van Rijen HV, Bierhuizen MF.

PLoS One. 2014 Jan 31;9(1):e87226. doi: 10.1371/journal.pone.0087226. eCollection 2014.

21.

Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.

Takanari H, Nalos L, Stary-Weinzinger A, de Git KC, Varkevisser R, Linder T, Houtman MJ, Peschar M, de Boer TP, Tidwell RR, Rook MB, Vos MA, van der Heyden MA.

Cardiovasc Res. 2013 Jul 1;99(1):203-14. doi: 10.1093/cvr/cvt103. Epub 2013 Apr 25.

PMID:
23625347
22.

Cardiac ion channel trafficking defects and drugs.

de Git KC, de Boer TP, Vos MA, van der Heyden MA.

Pharmacol Ther. 2013 Jul;139(1):24-31. doi: 10.1016/j.pharmthera.2013.03.008. Epub 2013 Apr 2. Review.

PMID:
23558293
23.

Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion Channel.

Houtman MJ, Takanari H, Kok BG, van Eck M, Montagne DR, Vos MA, de Boer TP, van der Heyden MA.

Front Physiol. 2012 Jan 30;3:9. doi: 10.3389/fphys.2012.00009. eCollection 2012.

24.

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Jonsson MK, Vos MA, Mirams GR, Duker G, Sartipy P, de Boer TP, van Veen TA.

J Mol Cell Cardiol. 2012 May;52(5):998-1008. doi: 10.1016/j.yjmcc.2012.02.002. Epub 2012 Feb 14.

PMID:
22353256
25.

Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.

Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA.

Br J Pharmacol. 2012 Jan;165(2):467-78. doi: 10.1111/j.1476-5381.2011.01558.x.

26.

Carvedilol inhibits Kir2.3 channels by interference with PIP₂-channel interaction.

Ferrer T, Ponce-Balbuena D, López-Izquierdo A, Aréchiga-Figueroa IA, de Boer TP, van der Heyden MA, Sánchez-Chapula JA.

Eur J Pharmacol. 2011 Oct 1;668(1-2):72-7. doi: 10.1016/j.ejphar.2011.05.067. Epub 2011 Jun 6.

PMID:
21663737
27.

Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.

Boulaksil M, Jungschleger JG, Antoons G, Houtman MJ, de Boer TP, Wilders R, Beekman JD, Maessen JG, van der Hulst FF, van der Heyden MA, van Veen TA, van Rijen HV, de Bakker JM, Vos MA.

Circ Arrhythm Electrophysiol. 2011 Aug;4(4):566-76. doi: 10.1161/CIRCEP.110.958991. Epub 2011 May 27.

PMID:
21622813
28.

Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1.

Nalos L, de Boer TP, Houtman MJ, Rook MB, Vos MA, van der Heyden MA.

Eur J Pharmacol. 2011 Feb 10;652(1-3):96-103. doi: 10.1016/j.ejphar.2010.10.093. Epub 2010 Nov 27.

PMID:
21114988
29.

Hyperpolarization induces differentiation in human cardiomyocyte progenitor cells.

van Vliet P, de Boer TP, van der Heyden MA, El Tamer MK, Sluijter JP, Doevendans PA, Goumans MJ.

Stem Cell Rev Rep. 2010 Jun;6(2):178-85. doi: 10.1007/s12015-010-9142-5.

PMID:
20354915
30.

The mammalian K(IR)2.x inward rectifier ion channel family: expression pattern and pathophysiology.

de Boer TP, Houtman MJ, Compier M, van der Heyden MA.

Acta Physiol (Oxf). 2010 Jul 1;199(3):243-56. doi: 10.1111/j.1748-1716.2010.02108.x. Epub 2010 Mar 13. Review.

PMID:
20331539
31.

Foetal and adult cardiomyocyte progenitor cells have different developmental potential.

van Vliet P, Smits AM, de Boer TP, Korfage TH, Metz CH, Roccio M, van der Heyden MA, van Veen TA, Sluijter JP, Doevendans PA, Goumans MJ.

J Cell Mol Med. 2010 Apr;14(4):861-70. doi: 10.1111/j.1582-4934.2010.01053.x. Epub 2010 Mar 8.

32.

The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.

de Boer TP, Nalos L, Stary A, Kok B, Houtman MJ, Antoons G, van Veen TA, Beekman JD, de Groot BL, Opthof T, Rook MB, Vos MA, van der Heyden MA.

Br J Pharmacol. 2010 Apr;159(7):1532-41. doi: 10.1111/j.1476-5381.2010.00658.x. Epub 2010 Feb 24.

33.

Myocardial tissue slices: organotypic pseudo-2D models for cardiac research & development.

de Boer TP, Camelliti P, Ravens U, Kohl P.

Future Cardiol. 2009 Sep;5(5):425-30. doi: 10.2217/fca.09.32. Review. No abstract available.

34.

Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype.

de Boer TP, van Veen TA, Jonsson MK, Kok BG, Metz CH, Sluijter JP, Doevendans PA, de Bakker JM, Goumans MJ, van der Heyden MA.

J Mol Cell Cardiol. 2010 Jan;48(1):254-60. doi: 10.1016/j.yjmcc.2009.05.004. Epub 2009 May 19.

PMID:
19460390
35.

Rewiring the heart: stem cell therapy to restore normal cardiac excitability and conduction.

Blank AC, van Veen TA, Jonsson MK, Zelen JS, Strengers JL, de Boer TP, van der Heyden MA.

Curr Stem Cell Res Ther. 2009 Jan;4(1):23-33. Review.

PMID:
19149627
36.

Adrenergic regulation of conduction velocity in cultures of immature cardiomyocytes.

de Boer TP, van Rijen HV, van der Heyden MA, de Bakker JM, van Veen TA.

Neth Heart J. 2008;16(3):106-9.

37.

Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.

Jansen JA, de Boer TP, Wolswinkel R, van Veen TA, Vos MA, van Rijen HV, van der Heyden MA.

Biochem Biophys Res Commun. 2008 Mar 14;367(3):687-92. doi: 10.1016/j.bbrc.2007.12.168. Epub 2008 Jan 7.

PMID:
18182162
38.

Cardiomyocytes from human and mouse embryonic stem cells.

Mummery C, van der Heyden MA, de Boer TP, Passier R, Ward D, van den Brink S, van Rooijen M, van de Stolpe A.

Methods Mol Med. 2007;140:249-72.

PMID:
18085213
39.

TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro.

Goumans MJ, de Boer TP, Smits AM, van Laake LW, van Vliet P, Metz CH, Korfage TH, Kats KP, Hochstenbach R, Pasterkamp G, Verhaar MC, van der Heyden MA, de Kleijn D, Mummery CL, van Veen TA, Sluijter JP, Doevendans PA.

Stem Cell Res. 2007 Nov;1(2):138-49. doi: 10.1016/j.scr.2008.02.003. Epub 2008 Mar 12.

40.

Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes.

de Boer TP, van Rijen HV, Van der Heyden MA, Kok B, Opthof T, Vos MA, Jongsma HJ, de Bakker JM, van Veen TA.

Circ J. 2007 Jun;71(6):973-81.

41.

Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor.

de Boer TP, van Veen TA, Bierhuizen MF, Kok B, Rook MB, Boonen KJ, Vos MA, Doevendans PA, de Bakker JM, van der Heyden MA.

Differentiation. 2007 Mar;75(3):208-18.

PMID:
17359298
42.

Cloning, embryonic expression, and functional characterization of two novel connexins from Xenopus laevis.

de Boer TP, Kok B, Roël G, van Veen TA, Destrée OH, Rook MB, Vos MA, de Bakker JM, van der Heyden MA.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):855-62. Epub 2006 Aug 31.

PMID:
16950205
43.

Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir2.1 expressing cells.

de Boer TP, van Veen TA, Houtman MJ, Jansen JA, van Amersfoorth SC, Doevendans PA, Vos MA, van der Heyden MA.

Med Biol Eng Comput. 2006 Jul;44(7):537-42. Epub 2006 Apr 20.

PMID:
16937189
44.

Pro-arrhythmogenic potential of immature cardiomyocytes is triggered by low coupling and cluster size.

de Boer TP, van der Heyden MA, Rook MB, Wilders R, Broekstra R, Kok B, Vos MA, de Bakker JM, van Veen TA.

Cardiovasc Res. 2006 Sep 1;71(4):704-14. Epub 2006 Jun 6.

PMID:
16824499
45.

Xenopus connexins: how frogs bridge the gap.

de Boer TP, van der Heyden MA.

Differentiation. 2005 Sep;73(7):330-40. Review.

PMID:
16219037
46.

Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis.

De Boer TP, Kok B, Neuteboom KI, Spieker N, De Graaf J, Destrée OH, Rook MB, Van Veen TA, Jongsma HJ, Vos MA, De Bakker JM, Van Der Heyden MA.

Dev Dyn. 2005 Jul;233(3):864-71.

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