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Items: 1 to 50 of 53

1.

Metabolic and Functional Heterogeneity in Pancreatic β Cells.

Da Silva Xavier G, Rutter GA.

J Mol Biol. 2020 Mar 6;432(5):1395-1406. doi: 10.1016/j.jmb.2019.08.005. Epub 2019 Aug 13. Review.

PMID:
31419404
2.

Convolutional neural networks for reconstruction of undersampled optical projection tomography data applied to in vivo imaging of zebrafish.

Davis SPX, Kumar S, Alexandrov Y, Bhargava A, da Silva Xavier G, Rutter GA, Frankel P, Sahai E, Flaxman S, French PMW, McGinty J.

J Biophotonics. 2019 Dec;12(12):e201900128. doi: 10.1002/jbio.201900128. Epub 2019 Aug 29.

3.

Correction: Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion.

Nguyen-Tu MS, da Silva Xavier G, Leclerc I, Rutter GA.

J Biol Chem. 2018 Nov 23;293(47):18420. doi: 10.1074/jbc.AAC118.006541. No abstract available.

4.

Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity.

Kimura T, Obata A, Shimoda M, Shimizu I, da Silva Xavier G, Okauchi S, Hirukawa H, Kohara K, Mune T, Moriuchi S, Hiraoka A, Tamura K, Chikazawa G, Ishida A, Yoshitaka H, Rutter GA, Kaku K, Kaneto H.

Sci Rep. 2018 Jul 13;8(1):10644. doi: 10.1038/s41598-018-28849-1.

5.

Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion.

Nguyen-Tu MS, da Silva Xavier G, Leclerc I, Rutter GA.

J Biol Chem. 2018 Sep 7;293(36):14178-14189. doi: 10.1074/jbc.RA118.003613. Epub 2018 Jul 2. Erratum in: J Biol Chem. 2018 Nov 23;293(47):18420.

6.

Neuronatin regulates pancreatic β cell insulin content and secretion.

Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ.

J Clin Invest. 2018 Aug 1;128(8):3369-3381. doi: 10.1172/JCI120115. Epub 2018 Jul 9.

7.

Mouse models of peripheral metabolic disease.

da Silva Xavier G, Hodson DJ.

Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):299-315. doi: 10.1016/j.beem.2018.03.009. Epub 2018 Mar 31. Review.

PMID:
29779583
8.

The Cells of the Islets of Langerhans.

Da Silva Xavier G.

J Clin Med. 2018 Mar 12;7(3). pii: E54. doi: 10.3390/jcm7030054. Review.

9.

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.

Fletcher RS, Ratajczak J, Doig CL, Oakey LA, Callingham R, Da Silva Xavier G, Garten A, Elhassan YS, Redpath P, Migaud ME, Philp A, Brenner C, Canto C, Lavery GG.

Mol Metab. 2017 May 29;6(8):819-832. doi: 10.1016/j.molmet.2017.05.011. eCollection 2017 Aug.

10.

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.

da Silva Xavier G, Mondragon A, Mourougavelou V, Cruciani-Guglielmacci C, Denom J, Herrera PL, Magnan C, Rutter GA.

Diabetologia. 2017 Jun;60(6):1043-1050. doi: 10.1007/s00125-017-4242-2. Epub 2017 Mar 25.

11.

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.

Semplici F, Mondragon A, Macintyre B, Madeyski-Bengston K, Persson-Kry A, Barr S, Ramne A, Marley A, McGinty J, French P, Soedling H, Yokosuka R, Gaitan J, Lang J, Migrenne-Li S, Philippe E, Herrera PL, Magnan C, da Silva Xavier G, Rutter GA.

Diabetologia. 2016 Sep;59(9):1938-47. doi: 10.1007/s00125-016-4025-1. Epub 2016 Jun 24.

12.

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.

Sun G, da Silva Xavier G, Gorman T, Priest C, Solomou A, Hodson DJ, Foretz M, Viollet B, Herrera PL, Parker H, Reimann F, Gribble FM, Migrenne S, Magnan C, Marley A, Rutter GA.

Mol Metab. 2015 Jan 31;4(4):277-86. doi: 10.1016/j.molmet.2015.01.006. eCollection 2015 Apr.

13.

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

Mitchell RK, Mondragon A, Chen L, Mcginty JA, French PM, Ferrer J, Thorens B, Hodson DJ, Rutter GA, Da Silva Xavier G.

Hum Mol Genet. 2015 Mar 1;24(5):1390-9. doi: 10.1093/hmg/ddu553. Epub 2014 Oct 29.

14.

Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression.

Zatyka M, Da Silva Xavier G, Bellomo EA, Leadbeater W, Astuti D, Smith J, Michelangeli F, Rutter GA, Barrett TG.

Hum Mol Genet. 2015 Feb 1;24(3):814-27. doi: 10.1093/hmg/ddu499. Epub 2014 Sep 30.

15.

Divergent effects of liraglutide, exendin-4, and sitagliptin on beta-cell mass and indicators of pancreatitis in a mouse model of hyperglycaemia.

Mondragon A, Davidsson D, Kyriakoudi S, Bertling A, Gomes-Faria R, Cohen P, Rothery S, Chabosseau P, Rutter GA, da Silva Xavier G.

PLoS One. 2014 Aug 13;9(8):e104873. doi: 10.1371/journal.pone.0104873. eCollection 2014.

16.

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion.

Locke JM, da Silva Xavier G, Dawe HR, Rutter GA, Harries LW.

Diabetologia. 2014 Jan;57(1):122-8. doi: 10.1007/s00125-013-3089-4. Epub 2013 Oct 23.

17.

Animal models of GWAS-identified type 2 diabetes genes.

da Silva Xavier G, Bellomo EA, McGinty JA, French PM, Rutter GA.

J Diabetes Res. 2013;2013:906590. doi: 10.1155/2013/906590. Epub 2013 Apr 11. Review.

18.

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.

da Silva Xavier G, Mondragon A, Sun G, Chen L, McGinty JA, French PM, Rutter GA.

Diabetologia. 2012 Oct;55(10):2667-2676. doi: 10.1007/s00125-012-2600-7. Epub 2012 Jun 21.

19.

An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes.

Locke JM, Da Silva Xavier G, Rutter GA, Harries LW.

Diabetologia. 2011 Dec;54(12):3078-82. doi: 10.1007/s00125-011-2290-6. Epub 2011 Sep 14. Erratum in: Diabetologia. 2011 Dec;54(12):3170.

20.

miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1).

Pullen TJ, da Silva Xavier G, Kelsey G, Rutter GA.

Mol Cell Biol. 2011 Aug;31(15):3182-94. doi: 10.1128/MCB.01433-10. Epub 2011 Jun 6.

21.

Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).

Meur G, Qian Q, da Silva Xavier G, Pullen TJ, Tsuboi T, McKinnon C, Fletcher L, Tavaré JM, Hughes S, Johnson P, Rutter GA.

J Biol Chem. 2011 Apr 15;286(15):13647-56. doi: 10.1074/jbc.M110.204248. Epub 2011 Feb 18.

22.

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion.

da Silva Xavier G, Farhan H, Kim H, Caxaria S, Johnson P, Hughes S, Bugliani M, Marselli L, Marchetti P, Birzele F, Sun G, Scharfmann R, Rutter J, Siniakowicz K, Weir G, Parker H, Reimann F, Gribble FM, Rutter GA.

Diabetologia. 2011 Apr;54(4):819-27. doi: 10.1007/s00125-010-2010-7. Epub 2010 Dec 23.

23.

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells.

Dominguez V, Raimondi C, Somanath S, Bugliani M, Loder MK, Edling CE, Divecha N, da Silva-Xavier G, Marselli L, Persaud SJ, Turner MD, Rutter GA, Marchetti P, Falasca M, Maffucci T.

J Biol Chem. 2011 Feb 11;286(6):4216-25. doi: 10.1074/jbc.M110.200295. Epub 2010 Dec 2.

24.

ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells.

da Silva Xavier G, Sun G, Qian Q, Rutter GA, Leclerc I.

Biochem Biophys Res Commun. 2010 Nov 12;402(2):252-7. doi: 10.1016/j.bbrc.2010.10.010. Epub 2010 Oct 8.

25.

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.

An R, da Silva Xavier G, Semplici F, Vakhshouri S, Hao HX, Rutter J, Pagano MA, Meggio F, Pinna LA, Rutter GA.

Biochem Biophys Res Commun. 2010 Aug 20;399(2):155-61. doi: 10.1016/j.bbrc.2010.07.035. Epub 2010 Jul 15.

26.

Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.

Sun G, Tarasov AI, McGinty J, McDonald A, da Silva Xavier G, Gorman T, Marley A, French PM, Parker H, Gribble F, Reimann F, Prendiville O, Carzaniga R, Viollet B, Leclerc I, Rutter GA.

Diabetologia. 2010 May;53(5):924-36. doi: 10.1007/s00125-010-1692-1. Epub 2010 Mar 11.

27.

Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells.

Voronina SG, Barrow SL, Simpson AW, Gerasimenko OV, da Silva Xavier G, Rutter GA, Petersen OH, Tepikin AV.

Gastroenterology. 2010 May;138(5):1976-87. doi: 10.1053/j.gastro.2010.01.037. Epub 2010 Jan 25.

28.

Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells.

Noordeen NA, Khera TK, Sun G, Longbottom ER, Pullen TJ, da Silva Xavier G, Rutter GA, Leclerc I.

Diabetes. 2010 Jan;59(1):153-60. doi: 10.2337/db08-0868. Epub 2009 Oct 15.

29.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. doi: 10.2337/db09-0551. Epub 2009 Jun 19.

30.

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells.

da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA.

Diabetes. 2009 Apr;58(4):894-905. doi: 10.2337/db08-1187. Epub 2009 Jan 23.

31.

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells.

Loder MK, da Silva Xavier G, McDonald A, Rutter GA.

Biochem Soc Trans. 2008 Jun;36(Pt 3):357-9. doi: 10.1042/BST0360357.

PMID:
18481957
32.

ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile.

Barrow SL, Voronina SG, da Silva Xavier G, Chvanov MA, Longbottom RE, Gerasimenko OV, Petersen OH, Rutter GA, Tepikin AV.

Pflugers Arch. 2008 Mar;455(6):1025-39. Epub 2007 Oct 20.

PMID:
17952455
33.

Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress.

Zatyka M, Ricketts C, da Silva Xavier G, Minton J, Fenton S, Hofmann-Thiel S, Rutter GA, Barrett TG.

Hum Mol Genet. 2008 Jan 15;17(2):190-200. Epub 2007 Oct 18.

34.

Glucose is necessary for embryonic pancreatic endocrine cell differentiation.

Guillemain G, Filhoulaud G, Da Silva-Xavier G, Rutter GA, Scharfmann R.

J Biol Chem. 2007 May 18;282(20):15228-37. Epub 2007 Mar 21.

35.

Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells.

An R, da Silva Xavier G, Hao HX, Semplici F, Rutter J, Rutter GA.

Biochem Soc Trans. 2006 Nov;34(Pt 5):791-3.

PMID:
17052199
36.

Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.

Rencurel F, Foretz M, Kaufmann MR, Stroka D, Looser R, Leclerc I, da Silva Xavier G, Rutter GA, Viollet B, Meyer UA.

Mol Pharmacol. 2006 Dec;70(6):1925-34. Epub 2006 Sep 20.

PMID:
16988011
37.

ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells.

da Silva Xavier G, Rutter GA, Diraison F, Andreolas C, Leclerc I.

J Lipid Res. 2006 Nov;47(11):2482-91. Epub 2006 Aug 4.

38.

Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells.

Reimann F, Williams L, da Silva Xavier G, Rutter GA, Gribble FM.

Diabetologia. 2004 Sep;47(9):1592-601. Epub 2004 Sep 9.

PMID:
15365617
39.

Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose.

da Silva Xavier G, Rutter J, Rutter GA.

Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8319-24. Epub 2004 May 17.

40.

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.

41.

Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6).

Guillemain G, Da Silva Xavier G, Rafiq I, Leturque A, Rutter GA.

Biochem J. 2004 Feb 15;378(Pt 1):219-27.

42.

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing.

Da Silva Xavier G, Qian Q, Cullen PJ, Rutter GA.

Biochem J. 2004 Jan 1;377(Pt 1):149-58. Erratum in: Biochem J. 2004 Nov 1;383(Pt. 3):599.

43.

5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics.

Tsuboi T, da Silva Xavier G, Leclerc I, Rutter GA.

J Biol Chem. 2003 Dec 26;278(52):52042-51. Epub 2003 Oct 7.

44.

Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis.

Rutter GA, Da Silva Xavier G, Leclerc I.

Biochem J. 2003 Oct 1;375(Pt 1):1-16. Review.

45.

Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression.

da Silva Xavier G, Leclerc I, Varadi A, Tsuboi T, Moule SK, Rutter GA.

Biochem J. 2003 May 1;371(Pt 3):761-74.

46.

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells.

Tsuboi T, da Silva Xavier G, Holz GG, Jouaville LS, Thomas AP, Rutter GA.

Biochem J. 2003 Jan 15;369(Pt 2):287-99.

47.

Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 beta-cells.

Andreolas C, da Silva Xavier G, Diraison F, Zhao C, Varadi A, Lopez-Casillas F, Ferré P, Foufelle F, Rutter GA.

Diabetes. 2002 Aug;51(8):2536-45.

48.

AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?

Leclerc I, da Silva Xavier G, Rutter GA.

Prog Nucleic Acid Res Mol Biol. 2002;71:69-90. Review.

PMID:
12102561
49.

Role of AMP-activated protein kinase in the regulation of gene transcription.

Leclerc I, Viollet B, da Silva Xavier G, Kahn A, Rutter GA.

Biochem Soc Trans. 2002 Apr;30(2):307-11. Review.

PMID:
12023870
50.

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