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Triskelion channels might bring Star Wars to the global problem of hypertension.

Beech DJ.

Cell Calcium. 2019 Jan;77:77-78. doi: 10.1016/j.ceca.2018.12.005. Epub 2018 Dec 11.


Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory.

Lepannetier S, Gualdani R, Tempesta S, Schakman O, Seghers F, Kreis A, Yerna X, Slimi A, de Clippele M, Tajeddine N, Voets T, Bon RS, Beech DJ, Tissir F, Gailly P.

Front Cell Neurosci. 2018 Sep 14;12:318. doi: 10.3389/fncel.2018.00318. eCollection 2018.


Piezo1 channels are mechanosensors in human fetoplacental endothelial cells.

Morley LC, Shi J, Gaunt HJ, Hyman AJ, Webster PJ, Williams C, Forbes K, Walker JJ, Simpson NAB, Beech DJ.

Mol Hum Reprod. 2018 Oct 1;24(10):510-520. doi: 10.1093/molehr/gay033.


TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.

Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote SJ, Christmann M, Waldmann H, Abbas SK, Beech DJ, Vasudev NS.

Oncotarget. 2018 Jul 3;9(51):29634-29643. doi: 10.18632/oncotarget.25659. eCollection 2018 Jul 3.


ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension.

Rode B, Bailey MA, Marthan R, Beech DJ, Guibert C.

Physiology (Bethesda). 2018 Jul 1;33(4):261-268. doi: 10.1152/physiol.00016.2018.


Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease.

Minard A, Bauer CC, Wright DJ, Rubaiy HN, Muraki K, Beech DJ, Bon RS.

Cells. 2018 Jun 1;7(6). pii: E52. doi: 10.3390/cells7060052. Review.


Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels.

Rubaiy HN, Ludlow MJ, Siems K, Norman K, Foster R, Wolf D, Beutler JA, Beech DJ.

Br J Pharmacol. 2018 Jun 2. doi: 10.1111/bph.14379. [Epub ahead of print]


Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin.

Pedicini L, Miteva KT, Hawley V, Gaunt HJ, Appleby HL, Cubbon RM, Marszalek K, Kearney MT, Beech DJ, McKeown L.

Sci Rep. 2018 May 15;8(1):7569. doi: 10.1038/s41598-018-25853-3.


Correspondence: Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing.

Thakore P, Brain SD, Beech DJ.

Nat Commun. 2018 Mar 23;9(1):1245. doi: 10.1038/s41467-017-02703-w. No abstract available.


Piezo channel mechanisms in health and disease.

Beech DJ, Xiao B.

J Physiol. 2018 Mar 15;596(6):965-967. doi: 10.1113/JP274395. No abstract available.


Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation.

Evans EL, Cuthbertson K, Endesh N, Rode B, Blythe NM, Hyman AJ, Hall SJ, Gaunt HJ, Ludlow MJ, Foster R, Beech DJ.

Br J Pharmacol. 2018 May;175(10):1744-1759. doi: 10.1111/bph.14188. Epub 2018 Apr 6.


Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.

Rubaiy HN, Seitz T, Hahn S, Choidas A, Habenberger P, Klebl B, Dinkel K, Nussbaumer P, Waldmann H, Christmann M, Beech DJ.

Br J Pharmacol. 2018 Mar;175(5):830-839. doi: 10.1111/bph.14128. Epub 2018 Jan 25.


Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells.

Muraki K, Ohnishi K, Takezawa A, Suzuki H, Hatano N, Muraki Y, Hamzah N, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Beech DJ.

Sci Rep. 2017 Dec 5;7(1):16988. doi: 10.1038/s41598-017-17303-3.


Endothelial Piezo1 channels as sensors of exercise.

Beech DJ.

J Physiol. 2018 Mar 15;596(6):979-984. doi: 10.1113/JP274396. Epub 2018 Jan 9.


Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ.

Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3.


Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Watt NT, Gage MC, Patel PA, Viswambharan H, Sukumar P, Galloway S, Yuldasheva NY, Imrie H, Walker AMN, Griffin KJ, Makava N, Skromna A, Bridge K, Beech DJ, Schurmans S, Wheatcroft SB, Kearney MT, Cubbon RM.

Diabetes. 2017 Nov;66(11):2808-2821. doi: 10.2337/db17-0062. Epub 2017 Aug 22.


Piezo1 Channels in Vascular Development and the Sensing of Shear Stress.

Hyman AJ, Tumova S, Beech DJ.

Curr Top Membr. 2017;79:37-57. doi: 10.1016/bs.ctm.2016.11.001. Epub 2017 Jan 10. Review.


Pico145 - powerful new tool for TRPC1/4/5 channels.

Rubaiy HN, Ludlow MJ, Bon RS, Beech DJ.

Channels (Austin). 2017 Sep 3;11(5):362-364. doi: 10.1080/19336950.2017.1317485. Epub 2017 Apr 11. No abstract available.


Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.

Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ.

J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21.


AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells.

Webster PJ, Littlejohns AT, Gaunt HJ, Prasad KR, Beech DJ, Burke DA.

Cell Cycle. 2017;16(22):2176-2182. doi: 10.1080/15384101.2017.1301329. Epub 2017 Nov 9.


Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.

Webster PJ, Littlejohns AT, Gaunt HJ, Young RS, Rode B, Ritchie JE, Stead LF, Harrison S, Droop A, Martin HL, Tomlinson DC, Hyman AJ, Appleby HL, Boxall S, Bruns AF, Li J, Prasad RK, Lodge JPA, Burke DA, Beech DJ.

Oncotarget. 2017 Jun 27;8(26):42288-42299. doi: 10.18632/oncotarget.15039.


Hospital-based, Multidisciplinary, youth mentoring and medical exposure program positively influences and reinforces health care career choice: "The Reach One Each One Program early Experience".

Danner OK, Lokko C, Mobley F, Dansby M, Maze M, Bradley B, Williams E, Matthews LR, Harrington E, Mack L, Clark C, Wilson K, Beech D, Heron S, Childs E.

Am J Surg. 2017 Apr;213(4):611-616. doi: 10.1016/j.amjsurg.2016.12.002. Epub 2016 Dec 14.


Leptin-Notch signaling axis is involved in pancreatic cancer progression.

Harbuzariu A, Rampoldi A, Daley-Brown DS, Candelaria P, Harmon TL, Lipsey CC, Beech DJ, Quarshie A, Ilies GO, Gonzalez-Perez RR.

Oncotarget. 2017 Jan 31;8(5):7740-7752. doi: 10.18632/oncotarget.13946.


Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.

Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood N, Walker AM, Skromna A, Makova N, Galloway S, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft SB, Cubbon RM, Kearney MT.

Circ Res. 2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.309678. Epub 2016 Dec 5.


(-)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase.

Ludlow MJ, Gaunt HJ, Rubaiy HN, Musialowski KE, Blythe NM, Vasudev NS, Muraki K, Beech DJ.

J Biol Chem. 2017 Jan 13;292(2):723-731. doi: 10.1074/jbc.M116.755678. Epub 2016 Nov 14.


Non-selective cationic channels in chemical and physical stress.

Beech DJ.

J Physiol. 2016 Aug 1;594(15):4139. doi: 10.1113/JP270937. No abstract available.


Implementing the Prospective Surveillance Model (PSM) of Rehabilitation for Breast Cancer Patients with 1-Year Postoperative Follow-up, a Prospective, Observational Study.

Lai L, Binkley J, Jones V, Kirkpatrick S, Furbish C, Stratford P, Thompson W, Sidhu A, Farley C, Okoli J, Beech D, Gabram S.

Ann Surg Oncol. 2016 Oct;23(10):3379-84. doi: 10.1245/s10434-016-5315-z. Epub 2016 Jun 22.


Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics.

Gaunt HJ, Vasudev NS, Beech DJ.

Eur Biophys J. 2016 Oct;45(7):611-620. Epub 2016 Jun 11. Review.


CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition.

Kapur N, Mir H, Clark Iii CE, Krishnamurti U, Beech DJ, Lillard JW, Singh S.

Br J Cancer. 2016 Jun 14;114(12):1343-51. doi: 10.1038/bjc.2016.113. Epub 2016 May 5.


Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites.

Desai A, Xu J, Aysola K, Akinbobuyi O, White M, Reddy VE, Okoli J, Clark C, Partridge EE, Childs E, Beech DJ, Rice MV, Reddy E, Rao VN.

J Gynecol Res. 2015;1(1). pii: 103. Epub 2015 Apr 24.


Natural and synthetic flavonoid modulation of TRPC5 channels.

Naylor J, Minard A, Gaunt HJ, Amer MS, Wilson LA, Migliore M, Cheung SY, Rubaiy HN, Blythe NM, Musialowski KE, Ludlow MJ, Evans WD, Green BL, Yang H, You Y, Li J, Fishwick CW, Muraki K, Beech DJ, Bon RS.

Br J Pharmacol. 2016 Feb;173(3):562-74. doi: 10.1111/bph.13387. Epub 2016 Jan 13.


Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.

Li J, Bruns AF, Hou B, Rode B, Webster PJ, Bailey MA, Appleby HL, Moss NK, Ritchie JE, Yuldasheva NY, Tumova S, Quinney M, McKeown L, Taylor H, Prasad KR, Burke D, O'Regan D, Porter KE, Foster R, Kearney MT, Beech DJ.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1987-94. doi: 10.1161/ATVBAHA.115.305969. Epub 2015 Jul 9.


(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.

Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S, Seitz T, Ziegler S, Christmann M, Beech DJ, Waldmann H.

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. doi: 10.1002/anie.201411511. Epub 2015 Feb 23.


TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death.

Manna PT, Munsey TS, Abuarab N, Li F, Asipu A, Howell G, Sedo A, Yang W, Naylor J, Beech DJ, Jiang LH, Sivaprasadarao A.

Biochem J. 2015 Mar 15;466(3):537-46. doi: 10.1042/BJ20140747.


Endothelial Piezo1: life depends on it.

Li J, Hou B, Beech DJ.

Channels (Austin). 2015;9(1):1-2. doi: 10.4161/19336950.2014.986623. No abstract available.


Expression of a long variant of CRACR2A that belongs to the Rab GTPase protein family in endothelial cells.

Wilson LA, McKeown L, Tumova S, Li J, Beech DJ.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):398-402. doi: 10.1016/j.bbrc.2014.11.095. Epub 2014 Dec 2.


TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia.

Ye M, Yang W, Ainscough JF, Hu XP, Li X, Sedo A, Zhang XH, Zhang X, Chen Z, Li XM, Beech DJ, Sivaprasadarao A, Luo JH, Jiang LH.

Cell Death Dis. 2014 Nov 27;5:e1541. doi: 10.1038/cddis.2014.494.


Piezo1 integration of vascular architecture with physiological force.

Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ.

Nature. 2014 Nov 13;515(7526):279-282. doi: 10.1038/nature13701. Epub 2014 Aug 10.


Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.

Cubbon RM, Yuldasheva NY, Viswambharan H, Mercer BN, Baliga V, Stephen SL, Askham J, Sukumar P, Skromna A, Mughal RS, Walker AM, Bruns A, Bailey MA, Galloway S, Imrie H, Gage MC, Rakobowchuk M, Li J, Porter KE, Ponnambalam S, Wheatcroft SB, Beech DJ, Kearney MT.

Stem Cells. 2014 Oct;32(10):2714-23. doi: 10.1002/stem.1766.


Mitochondrial DNA mutations and cognition: a case-series report.

Inczedy-Farkas G, Trampush JW, Perczel Forintos D, Beech D, Andrejkovics M, Varga Z, Remenyi V, Bereznai B, Gal A, Molnar MJ.

Arch Clin Neuropsychol. 2014 Jun;29(4):315-21. doi: 10.1093/arclin/acu016. Epub 2014 Apr 28.


Marjolin's ulcer of a primarily grafted burn.

Johnson P, Brookins S, Beech D, Ternovits C, Burnette R.

J Natl Med Assoc. 2013 Summer;105(2):192-5. No abstract available.


Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor.

Jin X, Shah S, Liu Y, Zhang H, Lees M, Fu Z, Lippiat JD, Beech DJ, Sivaprasadarao A, Baldwin SA, Zhang H, Gamper N.

Sci Signal. 2013 Aug 27;6(290):ra73. doi: 10.1126/scisignal.2004184.


In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold?

Bon RS, Beech DJ.

Br J Pharmacol. 2013 Oct;170(3):459-74. doi: 10.1111/bph.12274. Review.


A differential role of macrophage TRPM2 channels in Ca²⁺ signaling and cell death in early responses to H₂O₂.

Zou J, Ainscough JF, Yang W, Sedo A, Yu SP, Mei ZZ, Sivaprasadarao A, Beech DJ, Jiang LH.

Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C61-9. doi: 10.1152/ajpcell.00390.2012. Epub 2013 Apr 17.


Generation of antibodies that are externally acting isoform-specific inhibitors of ion channels.

Naylor J, Beech DJ.

Methods Mol Biol. 2013;998:245-56. doi: 10.1007/978-1-62703-351-0_19.


Situs inversus.

Atanda A, Chambers T, Beech DJ.

Tenn Med. 2013 Jan;106(1):33-4.


A tailored prostate cancer education intervention for low-income African Americans: impact on knowledge and screening.

Ukoli FA, Patel K, Hargreaves M, Beard K, Moton PJ, Bragg R, Beech D, Davis R.

J Health Care Poor Underserved. 2013 Feb;24(1):311-31. doi: 10.1353/hpu.2013.0033.


Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.

Sukumar P, Viswambharan H, Imrie H, Cubbon RM, Yuldasheva N, Gage M, Galloway S, Skromna A, Kandavelu P, Santos CX, Gatenby VK, Smith J, Beech DJ, Wheatcroft SB, Channon KM, Shah AM, Kearney MT.

Diabetes. 2013 Jun;62(6):2130-4. doi: 10.2337/db12-1294. Epub 2013 Jan 24.


Triple Negative Breast Cancer - An Overview.

Aysola K, Desai A, Welch C, Xu J, Qin Y, Reddy V, Matthews R, Owens C, Okoli J, Beech DJ, Piyathilake CJ, Reddy SP, Rao VN.

Hereditary Genet. 2013;2013(Suppl 2). pii: 001.

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