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Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases.

Madzharova E, Kastl P, Sabino F, Auf dem Keller U.

Int J Mol Sci. 2019 Jun 24;20(12). pii: E3077. doi: 10.3390/ijms20123077. Review.


Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening.

Kalogeropoulos K, Treschow AF, Auf dem Keller U, Escalante T, Rucavado A, Gutiérrez JM, Laustsen AH, Workman CT.

Toxins (Basel). 2019 Mar 19;11(3). pii: E170. doi: 10.3390/toxins11030170.


Exploring Extracellular Matrix Degradomes by TMT-TAILS N-Terminomics.

Madzharova E, Sabino F, Auf dem Keller U.

Methods Mol Biol. 2019;1944:115-126. doi: 10.1007/978-1-4939-9095-5_8.


Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress.

Seltmann K, Meyer M, Sulcova J, Kockmann T, Wehkamp U, Weidinger S, Auf dem Keller U, Werner S.

Sci Transl Med. 2018 May 9;10(440). pii: eaao4650. doi: 10.1126/scitranslmed.aao4650.


Comparative Degradomics of Porcine and Human Wound Exudates Unravels Biomarker Candidates for Assessment of Wound Healing Progression in Trauma Patients.

Sabino F, Egli FE, Savickas S, Holstein J, Kaspar D, Rollmann M, Kizhakkedathu JN, Pohlemann T, Smola H, Auf dem Keller U.

J Invest Dermatol. 2018 Feb;138(2):413-422. doi: 10.1016/j.jid.2017.08.032. Epub 2017 Sep 9.


Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.

Bachofner M, Speicher T, Bogorad RL, Muzumdar S, Derrer CP, Hürlimann F, Böhm F, Nanni P, Kockmann T, Kachaylo E, Meyer M, Padrissa-Altés S, Graf R, Anderson DG, Koteliansky V, Auf dem Keller U, Werner S.

Dev Cell. 2017 Sep 25;42(6):616-625.e8. doi: 10.1016/j.devcel.2017.07.025. Epub 2017 Sep 7.


Targeted degradomics in protein terminomics and protease substrate discovery.

Savickas S, Auf dem Keller U.

Biol Chem. 2017 Dec 20;399(1):47-54. doi: 10.1515/hsz-2017-0187. Review.


Time-Resolved Analysis of Matrix Metalloproteinase Substrates in Complex Samples.

Schlage P, Egli FE, Auf dem Keller U.

Methods Mol Biol. 2017;1579:185-198. doi: 10.1007/978-1-4939-6863-3_9.


Body Fluid Degradomics and Characterization of Basic N-Terminome.

Sabino F, Hermes O, Auf dem Keller U.

Methods Enzymol. 2017;585:177-199. doi: 10.1016/bs.mie.2016.09.018. Epub 2016 Oct 19.


TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM.

Cell Rep. 2016 Aug 9;16(6):1762-1773. doi: 10.1016/j.celrep.2016.06.086. Epub 2016 Jul 28.


Autocrine and Paracrine Regulation of Keratinocyte Proliferation through a Novel Nrf2-IL-36γ Pathway.

Kurinna S, Muzumdar S, Köhler UA, Kockmann T, Auf dem Keller U, Schäfer M, Werner S.

J Immunol. 2016 Jun 1;196(11):4663-70. doi: 10.4049/jimmunol.1501447. Epub 2016 Apr 25.


Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun.


Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions.

Schlage P, Kockmann T, Sabino F, Kizhakkedathu JN, Auf dem Keller U.

Mol Cell Proteomics. 2015 Dec;14(12):3234-46. doi: 10.1074/mcp.M115.053520. Epub 2015 Oct 16.


Monitoring matrix metalloproteinase activity at the epidermal-dermal interface by SILAC-iTRAQ-TAILS.

Schlage P, Kockmann T, Kizhakkedathu JN, auf dem Keller U.

Proteomics. 2015 Jul;15(14):2491-502. doi: 10.1002/pmic.201400627. Epub 2015 May 15.


Proteomic approaches to uncover MMP function.

Schlage P, auf dem Keller U.

Matrix Biol. 2015 May-Jul;44-46:232-8. doi: 10.1016/j.matbio.2015.01.003. Epub 2015 Jan 17. Review.


Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes.

Sollberger G, Strittmatter GE, Grossi S, Garstkiewicz M, Auf dem Keller U, French LE, Beer HD.

J Invest Dermatol. 2015 May;135(5):1395-1404. doi: 10.1038/jid.2014.551. Epub 2015 Jan 6.


In vivo assessment of protease dynamics in cutaneous wound healing by degradomics analysis of porcine wound exudates.

Sabino F, Hermes O, Egli FE, Kockmann T, Schlage P, Croizat P, Kizhakkedathu JN, Smola H, auf dem Keller U.

Mol Cell Proteomics. 2015 Feb;14(2):354-70. doi: 10.1074/mcp.M114.043414. Epub 2014 Dec 16.


Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis.

Bellac CL, Dufour A, Krisinger MJ, Loonchanta A, Starr AE, Auf dem Keller U, Lange PF, Goebeler V, Kappelhoff R, Butler GS, Burtnick LD, Conway EM, Roberts CR, Overall CM.

Cell Rep. 2014 Oct 23;9(2):618-32. doi: 10.1016/j.celrep.2014.09.006. Epub 2014 Oct 9.


Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.

Schlage P, Egli FE, Nanni P, Wang LW, Kizhakkedathu JN, Apte SS, auf dem Keller U.

Mol Cell Proteomics. 2014 Feb;13(2):580-93. doi: 10.1074/mcp.M113.035139. Epub 2013 Nov 26.


Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation.

auf dem Keller U, Prudova A, Eckhard U, Fingleton B, Overall CM.

Sci Signal. 2013 Jan 15;6(258):rs2. doi: 10.1126/scisignal.2003512.


The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C.

Cell Mol Life Sci. 2013 Jan;70(2):309-33. doi: 10.1007/s00018-012-1106-2. Epub 2012 Sep 1.


Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening.

Lieder F, Reisen F, Geppert T, Sollberger G, Beer HD, auf dem Keller U, Schäfer M, Detmar M, Schneider G, Werner S.

J Biol Chem. 2012 Sep 21;287(39):33001-13. Epub 2012 Jul 31.


Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates.

Kleifeld O, Doucet A, Prudova A, auf dem Keller U, Gioia M, Kizhakkedathu JN, Overall CM.

Nat Protoc. 2011 Sep 22;6(10):1578-611. doi: 10.1038/nprot.2011.382.


Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites.

Schilling O, auf dem Keller U, Overall CM.

Biol Chem. 2011 Nov;392(11):1031-7. doi: 10.1515/BC.2011.158.


Wound degradomics - current status and future perspectives.

Hermes O, Schlage P, auf dem Keller U.

Biol Chem. 2011 Nov;392(11):949-54. doi: 10.1515/BC.2011.092. Epub 2011 Aug 5. Review.


Nematotoxicity of Marasmius oreades agglutinin (MOA) depends on glycolipid binding and cysteine protease activity.

Wohlschlager T, Butschi A, Zurfluh K, Vonesch SC, auf dem Keller U, Gehrig P, Bleuler-Martinez S, Hengartner MO, Aebi M, Künzler M.

J Biol Chem. 2011 Sep 2;286(35):30337-43. doi: 10.1074/jbc.M111.258202. Epub 2011 Jul 8.


Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.

Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM.

Mol Cell Proteomics. 2011 Sep;10(9):M111.009233. doi: 10.1074/mcp.M111.009233. Epub 2011 Jun 21.


Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.

Jefferson T, Čaušević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C.

J Biol Chem. 2011 Aug 5;286(31):27741-50. doi: 10.1074/jbc.M111.252718. Epub 2011 Jun 6.


Protease specificity profiling by tandem mass spectrometry using proteome-derived peptide libraries.

Schilling O, auf dem Keller U, Overall CM.

Methods Mol Biol. 2011;753:257-72. doi: 10.1007/978-1-61779-148-2_17.


Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, Overall CM, Minchinton A, Pacchiano F, Carta F, Scozzafava A, Touisni N, Winum JY, Supuran CT, Dedhar S.

Cancer Res. 2011 May 1;71(9):3364-76. doi: 10.1158/0008-5472.CAN-10-4261. Epub 2011 Mar 17. Erratum in: Cancer Res. 2011 Jul 1;71(13):4733. Cancer Res. 2011 Jun 15;71(12):4325.


Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry.

Schilling O, Huesgen PF, Barré O, Auf dem Keller U, Overall CM.

Nat Protoc. 2011 Jan;6(1):111-20. doi: 10.1038/nprot.2010.178. Epub 2011 Jan 6.


Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

auf dem Keller U, Bellac CL, Li Y, Lou Y, Lange PF, Ting R, Harwig C, Kappelhoff R, Dedhar S, Adam MJ, Ruth TJ, Bénard F, Perrin DM, Overall CM.

Cancer Res. 2010 Oct 1;70(19):7562-9. doi: 10.1158/0008-5472.CAN-10-1584. Epub 2010 Aug 20.


Nrf2: a central regulator of UV protection in the epidermis.

Schäfer M, Dütsch S, auf dem Keller U, Werner S.

Cell Cycle. 2010 Aug 1;9(15):2917-8. doi: 10.4161/cc.9.15.12701. Epub 2010 Aug 16. No abstract available.


Proteomic techniques and activity-based probes for the system-wide study of proteolysis.

auf dem Keller U, Schilling O.

Biochimie. 2010 Nov;92(11):1705-14. doi: 10.1016/j.biochi.2010.04.027. Epub 2010 May 20. Review.


Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis.

Schäfer M, Dütsch S, auf dem Keller U, Navid F, Schwarz A, Johnson DA, Johnson JA, Werner S.

Genes Dev. 2010 May 15;24(10):1045-58. doi: 10.1101/gad.568810.


Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics.

Prudova A, auf dem Keller U, Butler GS, Overall CM.

Mol Cell Proteomics. 2010 May;9(5):894-911. doi: 10.1074/mcp.M000050-MCP201. Epub 2010 Mar 20.


A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products.

auf dem Keller U, Prudova A, Gioia M, Butler GS, Overall CM.

Mol Cell Proteomics. 2010 May;9(5):912-27. doi: 10.1074/mcp.M000032-MCP201. Epub 2010 Mar 20.


Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products.

Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM.

Nat Biotechnol. 2010 Mar;28(3):281-8. doi: 10.1038/nbt.1611. Epub 2010 Mar 7.


Analysis of the degradome with the CLIP-CHIP microarray.

Kappelhoff R, Auf dem Keller U, Overall CM.

Methods Mol Biol. 2010;622:175-93. doi: 10.1007/978-1-60327-299-5_10.


Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.

Lou Y, Preobrazhenska O, auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S.

Dev Dyn. 2008 Oct;237(10):2755-68. doi: 10.1002/dvdy.21658.


Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice.

Ting R, Harwig C, auf dem Keller U, McCormick S, Austin P, Overall CM, Adam MJ, Ruth TJ, Perrin DM.

J Am Chem Soc. 2008 Sep 10;130(36):12045-55. doi: 10.1021/ja802734t. Epub 2008 Aug 14.


Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.

Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, Thiery J, Kan YW, Werner S.

EMBO J. 2008 Jan 9;27(1):212-23. Epub 2007 Dec 6.


Protease research in the era of systems biology.

auf dem Keller U, Doucet A, Overall CM.

Biol Chem. 2007 Nov;388(11):1159-62. Review.


Roles and mechanisms of action of the Nrf2 transcription factor in skin morphogenesis, wound repair and skin cancer.

Beyer TA, Auf dem Keller U, Braun S, Schäfer M, Werner S.

Cell Death Differ. 2007 Jul;14(7):1250-4. Epub 2007 Mar 23. Review. No abstract available.


Reactive oxygen species and their detoxification in healing skin wounds.

auf dem Keller U, Kümin A, Braun S, Werner S.

J Investig Dermatol Symp Proc. 2006 Sep;11(1):106-11. Review.


Electrophilic chemicals but not UV irradiation or reactive oxygen species activate Nrf2 in keratinocytes in vitro and in vivo.

Durchdewald M, Beyer TA, Johnson DA, Johnson JA, Werner S, auf dem Keller U.

J Invest Dermatol. 2007 Mar;127(3):646-53. Epub 2006 Sep 28.


Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing.

auf dem Keller U, Huber M, Beyer TA, Kümin A, Siemes C, Braun S, Bugnon P, Mitropoulos V, Johnson DA, Johnson JA, Hohl D, Werner S.

Mol Cell Biol. 2006 May;26(10):3773-84.


Fibroblast growth factors in epithelial repair and cytoprotection.

Braun S, auf dem Keller U, Steiling H, Werner S.

Philos Trans R Soc Lond B Biol Sci. 2004 May 29;359(1445):753-7. Review.


Meeting report: growth factors in development, repair and disease.

Braun S, auf dem Keller U, Beer HD, Krampert M, Müller M, Werner S, Dickson C, Werner S.

Eur J Cell Biol. 2002 Jul;81(7):375-82. No abstract available.


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