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Items: 1 to 50 of 73


A deep neural network to assess spontaneous pain from mouse facial expressions.

Tuttle AH, Molinaro MJ, Jethwa JF, Sotocinal SG, Prieto JC, Styner MA, Mogil JS, Zylka MJ.

Mol Pain. 2018 Jan-Dec;14:1744806918763658. doi: 10.1177/1744806918763658.


Toward a conceptual framework for early brain and behavior development in autism.

Piven J, Elison JT, Zylka MJ.

Mol Psychiatry. 2018 Jan;23(1):165. doi: 10.1038/mp.2017.212. Epub 2017 Oct 17.


Toward a conceptual framework for early brain and behavior development in autism.

Piven J, Elison JT, Zylka MJ.

Mol Psychiatry. 2017 Oct;22(10):1385-1394. doi: 10.1038/mp.2017.131. Epub 2017 Jul 25. Review. Erratum in: Mol Psychiatry. 2018 Jan;23 (1):165.


Enhanced Nociception in Angelman Syndrome Model Mice.

McCoy ES, Taylor-Blake B, Aita M, Simon JM, Philpot BD, Zylka MJ.

J Neurosci. 2017 Oct 18;37(42):10230-10239. doi: 10.1523/JNEUROSCI.1018-17.2017. Epub 2017 Sep 20.


The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.

Yi JJ, Paranjape SR, Walker MP, Choudhury R, Wolter JM, Fragola G, Emanuele MJ, Major MB, Zylka MJ.

J Biol Chem. 2017 Jul 28;292(30):12503-12515. doi: 10.1074/jbc.M117.788448. Epub 2017 May 30.


The Troubled Touch of Autism.

Tuttle AH, Bartsch VB, Zylka MJ.

Cell. 2016 Jul 14;166(2):273-274. doi: 10.1016/j.cell.2016.06.054.


Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.

Mabb AM, Simon JM, King IF, Lee HM, An LK, Philpot BD, Zylka MJ.

PLoS One. 2016 May 27;11(5):e0156439. doi: 10.1371/journal.pone.0156439. eCollection 2016.


Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.

Pearson BL, Simon JM, McCoy ES, Salazar G, Fragola G, Zylka MJ.

Nat Commun. 2016 Mar 31;7:11173. doi: 10.1038/ncomms11173.


GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility.

Judson MC, Wallace ML, Sidorov MS, Burette AC, Gu B, van Woerden GM, King IF, Han JE, Zylka MJ, Elgersma Y, Weinberg RJ, Philpot BD.

Neuron. 2016 Apr 6;90(1):56-69. doi: 10.1016/j.neuron.2016.02.040. Epub 2016 Mar 24.


Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact.

Ehlen JC, Jones KA, Pinckney L, Gray CL, Burette S, Weinberg RJ, Evans JA, Brager AJ, Zylka MJ, Paul KN, Philpot BD, DeBruyne JP.

J Neurosci. 2015 Oct 7;35(40):13587-98. doi: 10.1523/JNEUROSCI.2194-15.2015.


An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A.

Yi JJ, Berrios J, Newbern JM, Snider WD, Philpot BD, Hahn KM, Zylka MJ.

Cell. 2015 Aug 13;162(4):795-807. doi: 10.1016/j.cell.2015.06.045. Epub 2015 Aug 6.


Sex, drugs and pain control.

Brings VE, Zylka MJ.

Nat Neurosci. 2015 Aug;18(8):1059-60. doi: 10.1038/nn.4057. No abstract available.


Gene length matters in neurons.

Zylka MJ, Simon JM, Philpot BD.

Neuron. 2015 Apr 22;86(2):353-5. doi: 10.1016/j.neuron.2015.03.059.


Lipid kinases as therapeutic targets for chronic pain.

Loo L, Wright BD, Zylka MJ.

Pain. 2015 Apr;156 Suppl 1:S2-10. doi: 10.1097/01.j.pain.0000460345.92588.4b. Review.


Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C.

Wright BD, Simpson C, Stashko M, Kireev D, Hull-Ryde EA, Zylka MJ, Janzen WP.

J Biomol Screen. 2015 Jun;20(5):655-62. doi: 10.1177/1087057114564057. Epub 2014 Dec 22.


Topoisomerase 1 inhibition reversibly impairs synaptic function.

Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17290-5. doi: 10.1073/pnas.1413204111. Epub 2014 Nov 17.


Zylka et al. reply.

Zylka MJ, Philpot BD, King IF.

Nature. 2014 Aug 7;512(7512):E2. doi: 10.1038/nature13584. No abstract available.


Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice.

Huang HS, Yoon BJ, Brooks S, Bakal R, Berrios J, Larsen RS, Wallace ML, Han JE, Chung EH, Zylka MJ, Philpot BD.

PLoS One. 2014 May 23;9(5):e98383. doi: 10.1371/journal.pone.0098383. eCollection 2014.


The lipid kinase PIP5K1C regulates pain signaling and sensitization.

Wright BD, Loo L, Street SE, Ma A, Taylor-Blake B, Stashko MA, Jin J, Janzen WP, Frye SV, Zylka MJ.

Neuron. 2014 May 21;82(4):836-47. doi: 10.1016/j.neuron.2014.04.006.


Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling.

Rittiner JE, Brings VE, Zylka MJ.

Mol Pharmacol. 2014 May;85(5):800-10. doi: 10.1124/mol.113.091280. Epub 2014 Mar 7.


Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons.

Coutinho-Budd JC, Snider SB, Fitzpatrick BJ, Rittiner JE, Zylka MJ.

J Negat Results Biomed. 2013 Sep 8;12:13. doi: 10.1186/1477-5751-12-13.


Topoisomerases facilitate transcription of long genes linked to autism.

King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ.

Nature. 2013 Sep 5;501(7465):58-62. doi: 10.1038/nature12504. Epub 2013 Aug 28.


Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.

Street SE, Kramer NJ, Walsh PL, Taylor-Blake B, Yadav MC, King IF, Vihko P, Wightman RM, Millán JL, Zylka MJ.

J Neurosci. 2013 Jul 3;33(27):11314-22. doi: 10.1523/JNEUROSCI.0133-13.2013.


Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold.

McCoy ES, Taylor-Blake B, Street SE, Pribisko AL, Zheng J, Zylka MJ.

Neuron. 2013 Apr 10;78(1):138-51. doi: 10.1016/j.neuron.2013.01.030. Epub 2013 Mar 21.


Photochemical activation of TRPA1 channels in neurons and animals.

Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT.

Nat Chem Biol. 2013 Apr;9(4):257-63. doi: 10.1038/nchembio.1183. Epub 2013 Feb 10.


High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase.

McCoy ES, Lea WA, Mott BT, Maloney DJ, Jadhav A, Simeonov A, Zylka MJ.

J Biomol Screen. 2013 Apr;18(4):481-9. doi: 10.1177/1087057112468613. Epub 2012 Nov 27.


Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.

Hurt JK, Coleman JL, Fitzpatrick BJ, Taylor-Blake B, Bridges AS, Vihko P, Zylka MJ.

PLoS One. 2012;7(10):e48562. doi: 10.1371/journal.pone.0048562. Epub 2012 Oct 31.


Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.

Korboukh I, Hull-Ryde EA, Rittiner JE, Randhawa AS, Coleman J, Fitzpatrick BJ, Setola V, Janzen WP, Frye SV, Zylka MJ, Jin J.

J Med Chem. 2012 Jul 26;55(14):6467-77. doi: 10.1021/jm3004834. Epub 2012 Jul 16.


CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.

McCoy ES, Taylor-Blake B, Zylka MJ.

PLoS One. 2012;7(5):e36355. doi: 10.1371/journal.pone.0036355. Epub 2012 May 1.


The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently.

Coutinho-Budd J, Ghukasyan V, Zylka MJ, Polleux F.

J Cell Sci. 2012 Jul 15;125(Pt 14):3390-401. doi: 10.1242/jcs.098962. Epub 2012 Mar 30.


Secretion and N-linked glycosylation are required for prostatic acid phosphatase catalytic and antinociceptive activity.

Hurt JK, Fitzpatrick BJ, Norris-Drouin J, Zylka MJ.

PLoS One. 2012;7(2):e32741. doi: 10.1371/journal.pone.0032741. Epub 2012 Feb 28.


AMP is an adenosine A1 receptor agonist.

Rittiner JE, Korboukh I, Hull-Ryde EA, Jin J, Janzen WP, Frye SV, Zylka MJ.

J Biol Chem. 2012 Feb 17;287(8):5301-9. doi: 10.1074/jbc.M111.291666. Epub 2012 Jan 3.


Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.

Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD.

Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726.


PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine.

Street SE, Walsh PL, Sowa NA, Taylor-Blake B, Guillot TS, Vihko P, Wightman RM, Zylka MJ.

Mol Pain. 2011 Oct 19;7:80. doi: 10.1186/1744-8069-7-80.


Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes.

Mabb AM, Judson MC, Zylka MJ, Philpot BD.

Trends Neurosci. 2011 Jun;34(6):293-303. doi: 10.1016/j.tins.2011.04.001. Epub 2011 May 17. Review.


NT5E mutations and arterial calcifications.

Zylka MJ, Sowa NA.

N Engl J Med. 2011 Apr 21;364(16):1579; author reply 1579-80. doi: 10.1056/NEJMc1102515. No abstract available.


Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors.

Gray SJ, Foti SB, Schwartz JW, Bachaboina L, Taylor-Blake B, Coleman J, Ehlers MD, Zylka MJ, McCown TJ, Samulski RJ.

Hum Gene Ther. 2011 Sep;22(9):1143-53. doi: 10.1089/hum.2010.245. Epub 2011 Jun 1.


Pain-relieving prospects for adenosine receptors and ectonucleotidases.

Zylka MJ.

Trends Mol Med. 2011 Apr;17(4):188-96. doi: 10.1016/j.molmed.2010.12.006. Epub 2011 Jan 13. Review.


Emerging roles for ectonucleotidases in pain-sensing neurons.

Street SE, Zylka MJ.

Neuropsychopharmacology. 2011 Jan;36(1):358. doi: 10.1038/npp.2010.141. No abstract available.


Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate.

Sowa NA, Street SE, Vihko P, Zylka MJ.

J Neurosci. 2010 Aug 4;30(31):10282-93. doi: 10.1523/JNEUROSCI.2162-10.2010.


Needling adenosine receptors for pain relief.

Zylka MJ.

Nat Neurosci. 2010 Jul;13(7):783-4. doi: 10.1038/nn0710-783. No abstract available.


A high throughput assay to identify small molecule modulators of prostatic acid phosphatase.

Larsen RS, Zylka MJ, Scott JE.

Curr Chem Genomics. 2009 Jun 16;3:42-9. doi: 10.2174/1875397300903010042.


Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits.

Sowa NA, Taylor-Blake B, Zylka MJ.

J Neurosci. 2010 Feb 10;30(6):2235-44. doi: 10.1523/JNEUROSCI.5324-09.2010.


Prostatic acid phosphatase is expressed in peptidergic and nonpeptidergic nociceptive neurons of mice and rats.

Taylor-Blake B, Zylka MJ.

PLoS One. 2010 Jan 13;5(1):e8674. doi: 10.1371/journal.pone.0008674.


Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons.

Wang H, Zylka MJ.

J Neurosci. 2009 Oct 21;29(42):13202-9. doi: 10.1523/JNEUROSCI.3248-09.2009.


Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors.

Rau KK, McIlwrath SL, Wang H, Lawson JJ, Jankowski MP, Zylka MJ, Anderson DJ, Koerber HR.

J Neurosci. 2009 Jul 1;29(26):8612-9. doi: 10.1523/JNEUROSCI.1057-09.2009.


Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.

Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9075-80. doi: 10.1073/pnas.0901507106. Epub 2009 May 18. Erratum in: Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11424.

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