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Heat shock proteins create a signature to predict the clinical outcome in breast cancer.

Klimczak M, Biecek P, Zylicz A, Zylicz M.

Sci Rep. 2019 May 17;9(1):7507. doi: 10.1038/s41598-019-43556-1.


Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness.

Olszewski MB, Pruszko M, Snaar-Jagalska E, Zylicz A, Zylicz M.

Int J Oncol. 2019 Apr;54(4):1168-1182. doi: 10.3892/ijo.2019.4723. Epub 2019 Feb 22.


Function, evolution, and structure of J-domain proteins.

Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, Pulido P, Ramos C, De Los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young JC, Zimmermann R, Zylicz A, Zylicz M, Craig EA, Marszalek J.

Cell Stress Chaperones. 2019 Jan;24(1):7-15. doi: 10.1007/s12192-018-0948-4. Epub 2018 Nov 26.


Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.

Donzelli S, Milano E, Pruszko M, Sacconi A, Masciarelli S, Iosue I, Melucci E, Gallo E, Terrenato I, Mottolese M, Zylicz M, Zylicz A, Fazi F, Blandino G, Fontemaggi G.

Breast Cancer Res. 2018 Jun 19;20(1):59. doi: 10.1186/s13058-018-0990-2.


Zebrafish as experimental model to establish the contribution of mutant p53 and ID4 to breast cancer angiogenesis in vivo.

Pruszko M, Milano E, Zylicz A, Zylicz M, Blandino G, Fontemaggi G.

J Thorac Dis. 2018 Mar;10(3):E231-E233. doi: 10.21037/jtd.2018.03.86. No abstract available.


Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action.

Wawrzynow B, Zylicz A, Zylicz M.

Biochim Biophys Acta Rev Cancer. 2018 Apr;1869(2):161-174. doi: 10.1016/j.bbcan.2017.12.004. Epub 2018 Jan 31. Review.


Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation.

Tracz-Gaszewska Z, Klimczak M, Biecek P, Herok M, Kosinski M, Olszewski MB, Czerwińska P, Wiech M, Wiznerowicz M, Zylicz A, Zylicz M, Wawrzynow B.

Oncotarget. 2017 Jun 30;8(47):82123-82143. doi: 10.18632/oncotarget.18899. eCollection 2017 Oct 10.


The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1.

Pruszko M, Milano E, Forcato M, Donzelli S, Ganci F, Di Agostino S, De Panfilis S, Fazi F, Bates DO, Bicciato S, Zylicz M, Zylicz A, Blandino G, Fontemaggi G.

EMBO Rep. 2017 Aug;18(8):1331-1351. doi: 10.15252/embr.201643370. Epub 2017 Jun 26.


Research centres: Spread excellence across Europe.

Żylicz M.

Nature. 2015 Jan 22;517(7535):438. doi: 10.1038/517438a. No abstract available.


Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.

Wiech M, Olszewski MB, Tracz-Gaszewska Z, Wawrzynow B, Zylicz M, Zylicz A.

PLoS One. 2012;7(12):e51426. doi: 10.1371/journal.pone.0051426. Epub 2012 Dec 12. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/5f4c812a-79d4-44eb-9890-6a8de45c303b.


Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms.

Zubrienė A, Gutkowska M, Matulienė J, Chaleckis R, Michailovienė V, Voroncova A, Venclovas C, Zylicz A, Zylicz M, Matulis D.

Biophys Chem. 2010 Nov;152(1-3):153-63. doi: 10.1016/j.bpc.2010.09.003. Epub 2010 Oct 12.


ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein.

Walerych D, Gutkowska M, Klejman MP, Wawrzynow B, Tracz Z, Wiech M, Zylicz M, Zylicz A.

J Biol Chem. 2010 Oct 15;285(42):32020-8. doi: 10.1074/jbc.M110.112110. Epub 2010 Aug 5.


Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions.

Walerych D, Olszewski MB, Gutkowska M, Helwak A, Zylicz M, Zylicz A.

Oncogene. 2009 Dec 3;28(48):4284-94. doi: 10.1038/onc.2009.281. Epub 2009 Sep 14.


Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery.

Narayan V, Eckert M, Zylicz A, Zylicz M, Ball KL.

J Biol Chem. 2009 Sep 18;284(38):25889-99. doi: 10.1074/jbc.M109.019505. Epub 2009 Jun 5.


Mathematical modeling of heat shock protein synthesis in response to temperature change.

Szymańska Z, Zylicz M.

J Theor Biol. 2009 Aug 7;259(3):562-9. doi: 10.1016/j.jtbi.2009.03.021. Epub 2009 Mar 25.


How I became a biochemist.

Zylicz M.

IUBMB Life. 2008 Apr;60(4):245-8. doi: 10.1002/iub.73. No abstract available.


MDM2 chaperones the p53 tumor suppressor.

Wawrzynow B, Zylicz A, Wallace M, Hupp T, Zylicz M.

J Biol Chem. 2007 Nov 9;282(45):32603-12. Epub 2007 Sep 11.


High guanine and cytosine content increases mRNA levels in mammalian cells.

Kudla G, Lipinski L, Caffin F, Helwak A, Zylicz M.

PLoS Biol. 2006 Jun;4(6):e180. Epub 2006 May 23.


[Regulatory cells: their development, mechanisms and effects of action, and their potential use in transplantation].

Zylicz M, Bocian K, Korczak-Kowalska G.

Postepy Hig Med Dosw (Online). 2005;59:160-71. Review. Polish.


Hsp90 chaperones wild-type p53 tumor suppressor protein.

Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A, Zylicz M.

J Biol Chem. 2004 Nov 19;279(47):48836-45. Epub 2004 Sep 9.


MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC).

Dworakowska D, Jassem E, Jassem J, Peters B, Dziadziuszko R, Zylicz M, Jakóbkiewicz-Banecka J, Kobierska-Gulida G, Szymanowska A, Skokowski J, Roessner A, Schneider-Stock R.

Lung Cancer. 2004 Mar;43(3):285-95.


P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.

Jassem J, Jassem E, Jakóbkiewicz-Banecka J, Rzyman W, Badzio A, Dziadziuszko R, Kobierska-Gulida G, Szymanowska A, Skrzypski M, Zylicz M.

Cancer. 2004 May 1;100(9):1951-60.


Dropping habilitation would aid progress in Poland.

Zylicz M.

Nature. 2004 Feb 19;427(6976):677. No abstract available.


[P53 and P16 gene mutations in non-small cell lung cancer].

Jassem E, Ramlau R, Dziadziuszko R, Szymanowska A, Jakóbkiewicz J, Lamperska K, Kobierska G, Skokowski J, Dyszkiewicz W, Mackiewicz A, Zylicz M, Jassem J.

Pneumonol Alergol Pol. 2002;70(1-2):64-70. Polish.


Types and localisation of p53 gene mutations: a report on 332 non-small cell lung cancer patients.

Jassem E, Nikliński J, Rosell R, Niklińska W, Jakóbkiewicz J, Monzo M, Chyczewski L, Kobierska G, Skokowski J, Zylicz M, Jassem J.

Lung Cancer. 2001 Dec;34 Suppl 2:S47-51.


Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

King FW, Wawrzynow A, Höhfeld J, Zylicz M.

EMBO J. 2001 Nov 15;20(22):6297-305.


Insights into the function of Hsp70 chaperones.

Zylicz M, Wawrzynow A.

IUBMB Life. 2001 May;51(5):283-7. Review. No abstract available.


Hsp70 interactions with the p53 tumour suppressor protein.

Zylicz M, King FW, Wawrzynow A.

EMBO J. 2001 Sep 3;20(17):4634-8. Review. No abstract available.


Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.

Banecki B, Wawrzynow A, Puzewicz J, Georgopoulos C, Zylicz M.

J Biol Chem. 2001 Jun 1;276(22):18843-8. Epub 2001 Mar 13.


DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction.

Genevaux P, Wawrzynow A, Zylicz M, Georgopoulos C, Kelley WL.

J Biol Chem. 2001 Mar 16;276(11):7906-12. Epub 2000 Dec 5.


Role of bacterial chaperones in DNA replication.

Konieczny I, Zylicz M.

Genet Eng (N Y). 1999;21:95-111. Review.


Recognition, targeting, and hydrolysis of the lambda O replication protein by the ClpP/ClpX protease.

Gonciarz-Swiatek M, Wawrzynow A, Um SJ, Learn BA, McMacken R, Kelley WL, Georgopoulos C, Sliekers O, Zylicz M.

J Biol Chem. 1999 May 14;274(20):13999-4005.


Formation of the preprimosome protects lambda O from RNA transcription-dependent proteolysis by ClpP/ClpX.

Zylicz M, Liberek K, Wawrzynow A, Georgopoulos C.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15259-63.


Purification and biochemical properties of Saccharomyces cerevisiae Mdj1p, the mitochondrial DnaJ homologue.

Deloche O, Liberek K, Zylicz M, Georgopoulos C.

J Biol Chem. 1997 Nov 7;272(45):28539-44.


Structure-function analysis of the Escherichia coli GrpE heat shock protein.

Wu B, Wawrzynow A, Zylicz M, Georgopoulos C.

EMBO J. 1996 Sep 16;15(18):4806-16.


The Clp ATPases define a novel class of molecular chaperones.

Wawrzynow A, Banecki B, Zylicz M.

Mol Microbiol. 1996 Sep;21(5):895-9. Review.


Structure-function analysis of the zinc finger region of the DnaJ molecular chaperone.

Banecki B, Liberek K, Wall D, Wawrzynów A, Georgopoulos C, Bertoli E, Tanfani F, Zylicz M.

J Biol Chem. 1996 Jun 21;271(25):14840-8.


Real time kinetics of the DnaK/DnaJ/GrpE molecular chaperone machine action.

Banecki B, Zylicz M.

J Biol Chem. 1996 Mar 15;271(11):6137-43.


ATP hydrolysis is required for the DnaJ-dependent activation of DnaK chaperone for binding to both native and denatured protein substrates.

Wawrzynów A, Banecki B, Wall D, Liberek K, Georgopoulos C, Zylicz M.

J Biol Chem. 1995 Aug 18;270(33):19307-11.


Calf thymus Hsc70 protein protects and reactivates prokaryotic and eukaryotic enzymes.

Ziemienowicz A, Zylicz M, Floth C, Hübscher U.

J Biol Chem. 1995 Jun 30;270(26):15479-84.


The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.

Wawrzynow A, Wojtkowiak D, Marszalek J, Banecki B, Jonsen M, Graves B, Georgopoulos C, Zylicz M.

EMBO J. 1995 May 1;14(9):1867-77.


Both the Escherichia coli chaperone systems, GroEL/GroES and DnaK/DnaJ/GrpE, can reactivate heat-treated RNA polymerase. Different mechanisms for the same activity.

Ziemienowicz A, Skowyra D, Zeilstra-Ryalls J, Fayet O, Georgopoulos C, Zylicz M.

J Biol Chem. 1993 Dec 5;268(34):25425-31.


The Escherichia coli chaperones involved in DNA replication.

Zylicz M.

Philos Trans R Soc Lond B Biol Sci. 1993 Mar 29;339(1289):271-7; discussion 277-8. Review.


Structural and functional relationships in DnaK and DnaK756 heat-shock proteins from Escherichia coli.

Banecki B, Zylicz M, Bertoli E, Tanfani F.

J Biol Chem. 1992 Dec 15;267(35):25051-8.

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