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Items: 1 to 50 of 122

1.

Neutrophils: New insights and open questions.

Ley K, Hoffman HM, Kubes P, Cassatella MA, Zychlinsky A, Hedrick CC, Catz SD.

Sci Immunol. 2018 Dec 7;3(30). pii: eaat4579. doi: 10.1126/sciimmunol.aat4579. Epub 2018 Dec 7. Review.

PMID:
30530726
2.

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.

Sollberger G, Choidas A, Burn GL, Habenberger P, Di Lucrezia R, Kordes S, Menninger S, Eickhoff J, Nussbaumer P, Klebl B, Krüger R, Herzig A, Zychlinsky A.

Sci Immunol. 2018 Aug 24;3(26). pii: eaar6689. doi: 10.1126/sciimmunol.aar6689.

PMID:
30143555
3.

The role of neutrophil extracellular traps in rheumatic diseases.

Apel F, Zychlinsky A, Kenny EF.

Nat Rev Rheumatol. 2018 Aug;14(8):467-475. doi: 10.1038/s41584-018-0039-z. Review.

PMID:
29930301
4.

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization.

Sollberger G, Tilley DO, Zychlinsky A.

Dev Cell. 2018 Mar 12;44(5):542-553. doi: 10.1016/j.devcel.2018.01.019. Review.

PMID:
29533770
5.

The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species.

Virreira Winter S, Zychlinsky A.

J Biol Chem. 2018 Mar 30;293(13):4893-4900. doi: 10.1074/jbc.RA117.001105. Epub 2018 Feb 6.

6.

Copper Regulates the Canonical NLRP3 Inflammasome.

Deigendesch N, Zychlinsky A, Meissner F.

J Immunol. 2018 Mar 1;200(5):1607-1617. doi: 10.4049/jimmunol.1700712. Epub 2018 Jan 22.

PMID:
29358279
7.

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.

Amulic B, Knackstedt SL, Abu Abed U, Deigendesch N, Harbort CJ, Caffrey BE, Brinkmann V, Heppner FL, Hinds PW, Zychlinsky A.

Dev Cell. 2017 Nov 20;43(4):449-462.e5. doi: 10.1016/j.devcel.2017.10.013. Epub 2017 Nov 2.

8.

Diverse stimuli engage different neutrophil extracellular trap pathways.

Kenny EF, Herzig A, Krüger R, Muth A, Mondal S, Thompson PR, Brinkmann V, Bernuth HV, Zychlinsky A.

Elife. 2017 Jun 2;6. pii: e24437. doi: 10.7554/eLife.24437.

9.

Tetrahydroisoquinolines: New Inhibitors of Neutrophil Extracellular Trap (NET) Formation.

Martinez NE, Zimmermann TJ, Goosmann C, Alexander T, Hedberg C, Ziegler S, Zychlinsky A, Waldmann H.

Chembiochem. 2017 May 18;18(10):888-893. doi: 10.1002/cbic.201600650. Epub 2017 Mar 31.

PMID:
28240414
10.

Immunodetection of NETs in Paraffin-Embedded Tissue.

Brinkmann V, Abu Abed U, Goosmann C, Zychlinsky A.

Front Immunol. 2016 Nov 22;7:513. eCollection 2016.

11.

Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression.

Sollberger G, Amulic B, Zychlinsky A.

PLoS One. 2016 Jun 16;11(6):e0157454. doi: 10.1371/journal.pone.0157454. eCollection 2016.

12.

Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity.

Virreira Winter S, Zychlinsky A, Bardoel BW.

Sci Rep. 2016 Apr 12;6:24242. doi: 10.1038/srep24242.

13.

Beyond the grave: When is cell death critical for immunity to infection?

Stephenson HN, Herzig A, Zychlinsky A.

Curr Opin Immunol. 2016 Feb;38:59-66. doi: 10.1016/j.coi.2015.11.004. Epub 2015 Dec 10. Review.

PMID:
26682763
14.

Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis.

Harbort CJ, Soeiro-Pereira PV, von Bernuth H, Kaindl AM, Costa-Carvalho BT, Condino-Neto A, Reichenbach J, Roesler J, Zychlinsky A, Amulic B.

Blood. 2015 Dec 24;126(26):2842-51. doi: 10.1182/blood-2015-05-645424. Epub 2015 Oct 21.

15.

Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis--A Pilot Study.

Maier A, Deigendesch N, Müller K, Weishaupt JH, Krannich A, Röhle R, Meissner F, Molawi K, Münch C, Holm T, Meyer R, Meyer T, Zychlinsky A.

PLoS One. 2015 Oct 7;10(10):e0139684. doi: 10.1371/journal.pone.0139684. eCollection 2015.

16.

Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity.

Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC.

Infect Immun. 2015 Sep;83(9):3648-56. doi: 10.1128/IAI.00545-15. Epub 2015 Jul 6.

17.

A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis.

Metzler KD, Goosmann C, Lubojemska A, Zychlinsky A, Papayannopoulos V.

Cell Rep. 2014 Aug 7;8(3):883-96. doi: 10.1016/j.celrep.2014.06.044. Epub 2014 Jul 24.

18.

The balancing act of neutrophils.

Bardoel BW, Kenny EF, Sollberger G, Zychlinsky A.

Cell Host Microbe. 2014 May 14;15(5):526-36. doi: 10.1016/j.chom.2014.04.011. Review.

19.

IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis.

Brotcke Zumsteg A, Goosmann C, Brinkmann V, Morona R, Zychlinsky A.

Cell Host Microbe. 2014 Apr 9;15(4):435-45. doi: 10.1016/j.chom.2014.03.001.

20.

Induction and quantification of neutrophil extracellular traps.

Gonzalez AS, Bardoel BW, Harbort CJ, Zychlinsky A.

Methods Mol Biol. 2014;1124:307-18. doi: 10.1007/978-1-62703-845-4_20.

PMID:
24504961
21.

O-antigen protects gram-negative bacteria from histone killing.

Chaput C, Spindler E, Gill RT, Zychlinsky A.

PLoS One. 2013 Aug 8;8(8):e71097. doi: 10.1371/journal.pone.0071097. eCollection 2013.

22.

A proposed role for neutrophil extracellular traps in cancer immunoediting.

Berger-Achituv S, Brinkmann V, Abed UA, Kühn LI, Ben-Ezra J, Elhasid R, Zychlinsky A.

Front Immunol. 2013 Mar 6;4:48. doi: 10.3389/fimmu.2013.00048. eCollection 2013.

23.

Automatic quantification of in vitro NET formation.

Brinkmann V, Goosmann C, Kühn LI, Zychlinsky A.

Front Immunol. 2013 Jan 9;3:413. doi: 10.3389/fimmu.2012.00413. eCollection 2012.

24.

Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages.

Senerovic L, Tsunoda SP, Goosmann C, Brinkmann V, Zychlinsky A, Meissner F, Kolbe M.

Cell Death Dis. 2012 Sep 6;3:e384. doi: 10.1038/cddis.2012.124.

25.

Neutrophil extracellular traps: is immunity the second function of chromatin?

Brinkmann V, Zychlinsky A.

J Cell Biol. 2012 Sep 3;198(5):773-83. doi: 10.1083/jcb.201203170. Review.

26.

Neutrophil function: from mechanisms to disease.

Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A.

Annu Rev Immunol. 2012;30:459-89. doi: 10.1146/annurev-immunol-020711-074942. Epub 2012 Jan 3. Review.

PMID:
22224774
27.

Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy.

Papayannopoulos V, Staab D, Zychlinsky A.

PLoS One. 2011;6(12):e28526. doi: 10.1371/journal.pone.0028526. Epub 2011 Dec 9.

28.

Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst.

Talà A, Monaco C, Nagorska K, Exley RM, Corbett A, Zychlinsky A, Alifano P, Tang CM.

Mol Microbiol. 2011 Sep;81(5):1330-42. doi: 10.1111/j.1365-2958.2011.07766.x. Epub 2011 Jul 20.

29.

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.

Hakkim A, Fuchs TA, Martinez NE, Hess S, Prinz H, Zychlinsky A, Waldmann H.

Nat Chem Biol. 2011 Feb;7(2):75-7. doi: 10.1038/nchembio.496. Epub 2010 Dec 19.

PMID:
21170021
30.

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps.

Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A.

J Cell Biol. 2010 Nov 1;191(3):677-91. doi: 10.1083/jcb.201006052. Epub 2010 Oct 25.

31.

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity.

Metzler KD, Fuchs TA, Nauseef WM, Reumaux D, Roesler J, Schulze I, Wahn V, Papayannopoulos V, Zychlinsky A.

Blood. 2011 Jan 20;117(3):953-9. doi: 10.1182/blood-2010-06-290171. Epub 2010 Oct 25.

32.

Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.

Meissner F, Molawi K, Zychlinsky A.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13046-50. doi: 10.1073/pnas.1002396107. Epub 2010 Jun 28.

33.

Protein refolding is required for assembly of the type three secretion needle.

Poyraz O, Schmidt H, Seidel K, Delissen F, Ader C, Tenenboim H, Goosmann C, Laube B, Thünemann AF, Zychlinsky A, Baldus M, Lange A, Griesinger C, Kolbe M.

Nat Struct Mol Biol. 2010 Jul;17(7):788-92. doi: 10.1038/nsmb.1822. Epub 2010 Jun 13.

PMID:
20543831
34.

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease.

Meissner F, Seger RA, Moshous D, Fischer A, Reichenbach J, Zychlinsky A.

Blood. 2010 Sep 2;116(9):1570-3. doi: 10.1182/blood-2010-01-264218. Epub 2010 May 21.

35.

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.

Hakkim A, Fürnrohr BG, Amann K, Laube B, Abed UA, Brinkmann V, Herrmann M, Voll RE, Zychlinsky A.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9813-8. doi: 10.1073/pnas.0909927107. Epub 2010 May 3.

36.

Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion.

Eilers B, Mayer-Scholl A, Walker T, Tang C, Weinrauch Y, Zychlinsky A.

Cell Microbiol. 2010 Aug;12(8):1134-43. doi: 10.1111/j.1462-5822.2010.01459.x. Epub 2010 Mar 12.

PMID:
20331641
37.

Neutrophil extracellular traps: how to generate and visualize them.

Brinkmann V, Laube B, Abu Abed U, Goosmann C, Zychlinsky A.

J Vis Exp. 2010 Feb 24;(36). pii: 1724. doi: 10.3791/1724.

38.

Sepsis: the dark side of histones.

Chaput C, Zychlinsky A.

Nat Med. 2009 Nov;15(11):1245-6. doi: 10.1038/nm1109-1245. No abstract available.

PMID:
19893552
39.

Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans.

Urban CF, Ermert D, Schmid M, Abu-Abed U, Goosmann C, Nacken W, Brinkmann V, Jungblut PR, Zychlinsky A.

PLoS Pathog. 2009 Oct;5(10):e1000639. doi: 10.1371/journal.ppat.1000639. Epub 2009 Oct 30.

40.

NETs: a new strategy for using old weapons.

Papayannopoulos V, Zychlinsky A.

Trends Immunol. 2009 Nov;30(11):513-21. doi: 10.1016/j.it.2009.07.011. Epub 2009 Aug 21. Review.

PMID:
19699684
41.

Restoration of NET formation by gene therapy in CGD controls aspergillosis.

Bianchi M, Hakkim A, Brinkmann V, Siler U, Seger RA, Zychlinsky A, Reichenbach J.

Blood. 2009 Sep 24;114(13):2619-22. doi: 10.1182/blood-2009-05-221606. Epub 2009 Jun 18.

42.

IpaB-IpgC interaction defines binding motif for type III secretion translocator.

Lunelli M, Lokareddy RK, Zychlinsky A, Kolbe M.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9661-6. doi: 10.1073/pnas.0812900106. Epub 2009 May 28.

43.

Mouse neutrophil extracellular traps in microbial infections.

Ermert D, Urban CF, Laube B, Goosmann C, Zychlinsky A, Brinkmann V.

J Innate Immun. 2009;1(3):181-93. doi: 10.1159/000205281. Epub 2009 Feb 26.

44.

Fungal and bacterial killing by neutrophils.

Ermert D, Zychlinsky A, Urban C.

Methods Mol Biol. 2009;470:293-312. doi: 10.1007/978-1-59745-204-5_21.

PMID:
19089391
45.

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock.

Meissner F, Molawi K, Zychlinsky A.

Nat Immunol. 2008 Aug;9(8):866-72. doi: 10.1038/ni.1633. Epub 2008 Jul 6.

PMID:
18604212
46.

A Toll-like receptor 2-integrin beta3 complex senses bacterial lipopeptides via vitronectin.

Gerold G, Abu Ajaj K, Bienert M, Laws HJ, Zychlinsky A, de Diego JL.

Nat Immunol. 2008 Jul;9(7):761-8. doi: 10.1038/ni.1618. Epub 2008 May 30.

PMID:
18516040
47.

Sensing, presenting, and regulating PAMPs.

de Diego JL, Gerold G, Zychlinsky A.

Ernst Schering Found Symp Proc. 2007;(3):83-95. Review.

PMID:
18510100
48.

The capsule sensitizes Streptococcus pneumoniae to alpha-defensins human neutrophil proteins 1 to 3.

Beiter K, Wartha F, Hurwitz R, Normark S, Zychlinsky A, Henriques-Normark B.

Infect Immun. 2008 Aug;76(8):3710-6. doi: 10.1128/IAI.01748-07. Epub 2008 May 12.

49.

Single residue determines the specificity of neutrophil elastase for Shigella virulence factors.

Averhoff P, Kolbe M, Zychlinsky A, Weinrauch Y.

J Mol Biol. 2008 Apr 4;377(4):1053-66. doi: 10.1016/j.jmb.2007.12.034. Epub 2007 Dec 23.

PMID:
18295791
50.

Shigella flexneri phagosomal escape is independent of invasion.

Paetzold S, Lourido S, Raupach B, Zychlinsky A.

Infect Immun. 2007 Oct;75(10):4826-30. Epub 2007 Jul 30.

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