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Items: 1 to 50 of 73

1.

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.

Ackermann M, Kempf H, Hetzel M, Hesse C, Hashtchin AR, Brinkert K, Schott JW, Haake K, Kühnel MP, Glage S, Figueiredo C, Jonigk D, Sewald K, Schambach A, Wronski S, Moritz T, Martin U, Zweigerdt R, Munder A, Lachmann N.

Nat Commun. 2018 Nov 30;9(1):5088. doi: 10.1038/s41467-018-07570-7.

2.

Corrigendum to "Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice" Journal of Molecular and Cellular Cardiology 122 (2018) 114-124.

Froese N, Wang H, Zwadlo C, Wang Y, Grund A, Gigina A, Hofmann M, Kilian K, Scharf G, Korf-Klingebiel M, Melchert A, Signorini MER, Halloin C, Zweigerdt R, Martin U, Gruh I, Wollert KC, Geffers R, Bauersachs J, Heineke J.

J Mol Cell Cardiol. 2018 Dec;125:205. doi: 10.1016/j.yjmcc.2018.11.003. Epub 2018 Nov 7. No abstract available.

PMID:
30414408
3.

Paracrine mechanisms in early differentiation of human pluripotent stem cells: Insights from a mathematical model.

Gaspari E, Franke A, Robles-Diaz D, Zweigerdt R, Roeder I, Zerjatke T, Kempf H.

Stem Cell Res. 2018 Oct;32:1-7. doi: 10.1016/j.scr.2018.07.025. Epub 2018 Aug 18.

4.

Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice.

Froese N, Wang H, Zwadlo C, Wang Y, Grund A, Gigina A, Hofmann M, Kilian K, Scharf G, Korf-Klingebiel M, Melchert A, Signorini MER, Halloin C, Zweigerdt R, Martin U, Gruh I, Wollert KC, Geffers R, Bauersachs J, Heineke J.

J Mol Cell Cardiol. 2018 Sep;122:114-124. doi: 10.1016/j.yjmcc.2018.08.011. Epub 2018 Aug 14. Erratum in: J Mol Cell Cardiol. 2018 Dec;125:205.

PMID:
30118791
5.

Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.

Eicke D, Baigger A, Schulze K, Latham SL, Halloin C, Zweigerdt R, Guzman CA, Blasczyk R, Figueiredo C.

Sci Rep. 2018 Jul 5;8(1):10146. doi: 10.1038/s41598-018-28459-x.

6.

Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis.

Wolling H, Konze SA, Höfer A, Erdmann J, Pich A, Zweigerdt R, Buettner FFR.

Proteomics. 2018 Jul;18(14):e1800102. doi: 10.1002/pmic.201800102. Epub 2018 Jun 27.

PMID:
29905012
7.

Solubilization and renaturation of biologically active human bone morphogenetic protein-4 from inclusion bodies.

Gieseler GM, Ekramzadeh K, Nölle V, Malysheva S, Kempf H, Beutel S, Zweigerdt R, Martin U, Rinas U, Scheper T, Pepelanova I.

Biotechnol Rep (Amst). 2018 Apr 4;18:e00249. doi: 10.1016/j.btre.2018.e00249. eCollection 2018 Jun.

8.

A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device.

Christoffersson J, Meier F, Kempf H, Schwanke K, Coffee M, Beilmann M, Zweigerdt R, Mandenius CF.

Bioengineering (Basel). 2018 May 4;5(2). pii: E36. doi: 10.3390/bioengineering5020036.

9.

Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture.

Olmer R, Engels L, Usman A, Menke S, Malik MNH, Pessler F, Göhring G, Bornhorst D, Bolten S, Abdelilah-Seyfried S, Scheper T, Kempf H, Zweigerdt R, Martin U.

Stem Cell Reports. 2018 May 8;10(5):1657-1672. doi: 10.1016/j.stemcr.2018.03.017. Epub 2018 Apr 19.

10.

Laser bioprinting of human induced pluripotent stem cells-the effect of printing and biomaterials on cell survival, pluripotency, and differentiation.

Koch L, Deiwick A, Franke A, Schwanke K, Haverich A, Zweigerdt R, Chichkov B.

Biofabrication. 2018 Apr 25;10(3):035005. doi: 10.1088/1758-5090/aab981.

PMID:
29578448
11.

Expansion of functional personalized cells with specific transgene combinations.

Lipps C, Klein F, Wahlicht T, Seiffert V, Butueva M, Zauers J, Truschel T, Luckner M, Köster M, MacLeod R, Pezoldt J, Hühn J, Yuan Q, Müller PP, Kempf H, Zweigerdt R, Dittrich-Breiholz O, Pufe T, Beckmann R, Drescher W, Riancho J, Sañudo C, Korff T, Opalka B, Rebmann V, Göthert JR, Alves PM, Ott M, Schucht R, Hauser H, Wirth D, May T.

Nat Commun. 2018 Mar 8;9(1):994. doi: 10.1038/s41467-018-03408-4.

12.

Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms.

Iorga B, Schwanke K, Weber N, Wendland M, Greten S, Piep B, Dos Remedios CG, Martin U, Zweigerdt R, Kraft T, Brenner B.

Front Physiol. 2018 Jan 19;8:1111. doi: 10.3389/fphys.2017.01111. eCollection 2017.

13.

Differential Expression of Cholinergic System Components in Human Induced Pluripotent Stem Cells, Bone Marrow-Derived Multipotent Stromal Cells, and Induced Pluripotent Stem Cell-Derived Multipotent Stromal Cells.

Weist R, Flörkemeier T, Roger Y, Franke A, Schwanke K, Zweigerdt R, Martin U, Willbold E, Hoffmann A.

Stem Cells Dev. 2018 Feb 1;27(3):166-183. doi: 10.1089/scd.2017.0162. Epub 2018 Jan 3.

PMID:
29205106
14.

Scalable Cardiac Differentiation of Pluripotent Stem Cells Using Specific Growth Factors and Small Molecules.

Kempf H, Zweigerdt R.

Adv Biochem Eng Biotechnol. 2018;163:39-69. doi: 10.1007/10_2017_30. Review.

PMID:
29071404
15.

A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features.

Sgodda M, Dai Z, Zweigerdt R, Sharma AD, Ott M, Cantz T.

Stem Cells Dev. 2017 Oct 15;26(20):1490-1504. doi: 10.1089/scd.2017.0023. Epub 2017 Aug 24.

PMID:
28699415
16.

Sensitivity of human pluripotent stem cells to insulin precipitation induced by peristaltic pump-based medium circulation: considerations on process development.

Massai D, Bolesani E, Diaz DR, Kropp C, Kempf H, Halloin C, Martin U, Braniste T, Isu G, Harms V, Morbiducci U, Dräger G, Zweigerdt R.

Sci Rep. 2017 Jun 21;7(1):3950. doi: 10.1038/s41598-017-04158-x.

17.

Transplantation of purified iPSC-derived cardiomyocytes in myocardial infarction.

Rojas SV, Kensah G, Rotaermel A, Baraki H, Kutschka I, Zweigerdt R, Martin U, Haverich A, Gruh I, Martens A.

PLoS One. 2017 May 11;12(5):e0173222. doi: 10.1371/journal.pone.0173222. eCollection 2017.

18.

Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms.

Konze SA, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner FF.

J Proteome Res. 2017 Mar 3;16(3):1133-1149. doi: 10.1021/acs.jproteome.6b00534. Epub 2017 Feb 14.

PMID:
28139119
19.

Modulation of cardiomyocyte activity using pulsed laser irradiated gold nanoparticles.

Gentemann L, Kalies S, Coffee M, Meyer H, Ripken T, Heisterkamp A, Zweigerdt R, Heinemann D.

Biomed Opt Express. 2016 Dec 8;8(1):177-192. doi: 10.1364/BOE.8.000177. eCollection 2017 Jan 1.

20.

EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival.

Jara-Avaca M, Kempf H, Rückert M, Robles-Diaz D, Franke A, de la Roche J, Fischer M, Malan D, Sasse P, Solodenko W, Dräger G, Kirschning A, Martin U, Zweigerdt R.

Stem Cell Reports. 2017 Feb 14;8(2):305-317. doi: 10.1016/j.stemcr.2016.12.012. Epub 2017 Jan 12.

21.

Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Göhring G, Dräger G, Pötz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R.

Nat Commun. 2016 Dec 9;7:13602. doi: 10.1038/ncomms13602.

22.

Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes.

Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knörr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T.

Basic Res Cardiol. 2016 Nov;111(6):68. Epub 2016 Oct 14.

PMID:
27743117
23.

Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors.

Kropp C, Kempf H, Halloin C, Robles-Diaz D, Franke A, Scheper T, Kinast K, Knorpp T, Joos TO, Haverich A, Martin U, Zweigerdt R, Olmer R.

Stem Cells Transl Med. 2016 Oct;5(10):1289-1301. Epub 2016 Jul 1.

24.

Multimodal Imaging for In Vivo Evaluation of Induced Pluripotent Stem Cells in a Murine Model of Heart Failure.

Rojas SV, Meier M, Zweigerdt R, Eckardt D, Rathert C, Schecker N, Schmitto JD, Rojas-Hernandez S, Martin U, Kutschka I, Haverich A, Martens A.

Artif Organs. 2017 Feb;41(2):192-199. doi: 10.1111/aor.12728. Epub 2016 Jun 14.

PMID:
27296083
25.

A Microfluidic Bioreactor for Toxicity Testing of Stem Cell Derived 3D Cardiac Bodies.

Christoffersson J, Bergström G, Schwanke K, Kempf H, Zweigerdt R, Mandenius CF.

Methods Mol Biol. 2016;1502:159-68. doi: 10.1007/7651_2016_340.

PMID:
27052611
26.

Long noncoding RNA Chast promotes cardiac remodeling.

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T.

Sci Transl Med. 2016 Feb 17;8(326):326ra22. doi: 10.1126/scitranslmed.aaf1475.

PMID:
26888430
27.
28.

Large-scale production of human pluripotent stem cell derived cardiomyocytes.

Kempf H, Andree B, Zweigerdt R.

Adv Drug Deliv Rev. 2016 Jan 15;96:18-30. doi: 10.1016/j.addr.2015.11.016. Epub 2015 Dec 3. Review.

PMID:
26658242
29.

Cardiac differentiation of human pluripotent stem cells in scalable suspension culture.

Kempf H, Kropp C, Olmer R, Martin U, Zweigerdt R.

Nat Protoc. 2015 Sep;10(9):1345-61. doi: 10.1038/nprot.2015.089. Epub 2015 Aug 13.

PMID:
26270394
30.

Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging.

Bergström G, Christoffersson J, Schwanke K, Zweigerdt R, Mandenius CF.

Lab Chip. 2015 Aug 7;15(15):3242-9. doi: 10.1039/c5lc00449g.

PMID:
26135270
31.

Transplantation Effectiveness of Induced Pluripotent Stem Cells Is Improved by a Fibrinogen Biomatrix in an Experimental Model of Ischemic Heart Failure.

Rojas SV, Martens A, Zweigerdt R, Baraki H, Rathert C, Schecker N, Rojas-Hernandez S, Schwanke K, Martin U, Haverich A, Kutschka I.

Tissue Eng Part A. 2015 Jul;21(13-14):1991-2000. doi: 10.1089/ten.TEA.2014.0537.

32.

Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture.

Kempf H, Olmer R, Kropp C, Rückert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R.

Stem Cell Reports. 2014 Dec 9;3(6):1132-46. doi: 10.1016/j.stemcr.2014.09.017. Epub 2014 Oct 30.

33.

Successful re-endothelialization of a perfusable biological vascularized matrix (BioVaM) for the generation of 3D artificial cardiac tissue.

Andrée B, Bela K, Horvath T, Lux M, Ramm R, Venturini L, Ciubotaru A, Zweigerdt R, Haverich A, Hilfiker A.

Basic Res Cardiol. 2014;109(6):441. doi: 10.1007/s00395-014-0441-x. Epub 2014 Sep 18.

PMID:
25231595
34.

Macroscopic fluorescence imaging: a novel technique to monitor retention and distribution of injected microspheres in an experimental model of ischemic heart failure.

Martens A, Rojas SV, Baraki H, Rathert C, Schecker N, Hernandez SR, Schwanke K, Zweigerdt R, Martin U, Saito S, Haverich A, Kutschka I.

PLoS One. 2014 Aug 4;9(8):e101775. doi: 10.1371/journal.pone.0101775. eCollection 2014.

35.

Your heart on a chip: iPSC-based modeling of Barth-syndrome-associated cardiomyopathy.

Zweigerdt R, Gruh I, Martin U.

Cell Stem Cell. 2014 Jul 3;15(1):9-11. doi: 10.1016/j.stem.2014.06.015.

36.

Substantial early loss of induced pluripotent stem cells following transplantation in myocardial infarction.

Martens A, Rojas SV, Baraki H, Rathert C, Schecker N, Zweigerdt R, Schwanke K, Rojas-Hernandez S, Martin U, Saito S, Schmitto JD, Haverich A, Kutschka I.

Artif Organs. 2014 Nov;38(11):978-84. doi: 10.1111/aor.12268. Epub 2014 Feb 21.

PMID:
24571740
37.

Fast and efficient multitransgenic modification of human pluripotent stem cells.

Schwanke K, Merkert S, Kempf H, Hartung S, Jara-Avaca M, Templin C, Göhring G, Haverich A, Martin U, Zweigerdt R.

Hum Gene Ther Methods. 2014 Apr;25(2):136-53. doi: 10.1089/hgtb.2012.248. Epub 2014 Mar 21.

38.

Cleavage of E-cadherin and β-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells.

Konze SA, van Diepen L, Schröder A, Olmer R, Möller H, Pich A, Weißmann R, Kuss AW, Zweigerdt R, Buettner FF.

Mol Cell Proteomics. 2014 Apr;13(4):990-1007. doi: 10.1074/mcp.M113.033423. Epub 2014 Jan 30.

39.

Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Göhring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T.

Biomaterials. 2014 Feb;35(5):1531-42. doi: 10.1016/j.biomaterials.2013.11.024. Epub 2013 Nov 26.

PMID:
24290698
40.

The use of agarose microwells for scalable embryoid body formation and cardiac differentiation of human and murine pluripotent stem cells.

Dahlmann J, Kensah G, Kempf H, Skvorc D, Gawol A, Elliott DA, Dräger G, Zweigerdt R, Martin U, Gruh I.

Biomaterials. 2013 Mar;34(10):2463-71. doi: 10.1016/j.biomaterials.2012.12.024. Epub 2013 Jan 16.

PMID:
23332176
41.

Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors.

Hartung S, Schwanke K, Haase A, David R, Franz WM, Martin U, Zweigerdt R.

Stem Cells Dev. 2013 Apr 1;22(7):1112-25. doi: 10.1089/scd.2012.0351. Epub 2013 Jan 18.

42.

Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro.

Kensah G, Roa Lara A, Dahlmann J, Zweigerdt R, Schwanke K, Hegermann J, Skvorc D, Gawol A, Azizian A, Wagner S, Maier LS, Krause A, Dräger G, Ochs M, Haverich A, Gruh I, Martin U.

Eur Heart J. 2013 Apr;34(15):1134-46. doi: 10.1093/eurheartj/ehs349. Epub 2012 Oct 26.

PMID:
23103664
43.

Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodium iodide symporter transgene expression.

Templin C, Zweigerdt R, Schwanke K, Olmer R, Ghadri JR, Emmert MY, Müller E, Küest SM, Cohrs S, Schibli R, Kronen P, Hilbe M, Reinisch A, Strunk D, Haverich A, Hoerstrup S, Lüscher TF, Kaufmann PA, Landmesser U, Martin U.

Circulation. 2012 Jul 24;126(4):430-9. doi: 10.1161/CIRCULATIONAHA.111.087684. Epub 2012 Jul 5.

PMID:
22767659
44.

Suspension culture of human pluripotent stem cells in controlled, stirred bioreactors.

Olmer R, Lange A, Selzer S, Kasper C, Haverich A, Martin U, Zweigerdt R.

Tissue Eng Part C Methods. 2012 Oct;18(10):772-84. Epub 2012 Jun 4.

45.

Distinct regulation of mitogen-activated protein kinase activities is coupled with enhanced cardiac differentiation of human embryonic stem cells.

Kempf H, Lecina M, Ting S, Zweigerdt R, Oh S.

Stem Cell Res. 2011 Nov;7(3):198-209. doi: 10.1016/j.scr.2011.06.001. Epub 2011 Jul 23.

46.

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells.

Paleček J, Zweigerdt R, Olmer R, Martin U, Kirschning A, Dräger G.

Org Biomol Chem. 2011 Aug 7;9(15):5503-10. doi: 10.1039/c1ob05332a. Epub 2011 Jun 16.

PMID:
21677986
47.

Induced pluripotent stem cell (iPSC)-derived Flk-1 progenitor cells engraft, differentiate, and improve heart function in a mouse model of acute myocardial infarction.

Mauritz C, Martens A, Rojas SV, Schnick T, Rathert C, Schecker N, Menke S, Glage S, Zweigerdt R, Haverich A, Martin U, Kutschka I.

Eur Heart J. 2011 Nov;32(21):2634-41. doi: 10.1093/eurheartj/ehr166. Epub 2011 May 19.

PMID:
21596799
48.

Scalable expansion of human pluripotent stem cells in suspension culture.

Zweigerdt R, Olmer R, Singh H, Haverich A, Martin U.

Nat Protoc. 2011 May;6(5):689-700. doi: 10.1038/nprot.2011.318. Epub 2011 Apr 28.

PMID:
21527925
49.

Lentiviral labeling reveals three germ layer differentiation potential of a single unrestricted somatic stem cell from human cord blood.

Wernet P, Trapp T, Zweigerdt R, Mann J, Trompeter HI.

Exp Hematol. 2010 Nov;38(11):1099-104. doi: 10.1016/j.exphem.2010.09.006. Epub 2010 Sep 29.

PMID:
20869422
50.

Up-scaling single cell-inoculated suspension culture of human embryonic stem cells.

Singh H, Mok P, Balakrishnan T, Rahmat SN, Zweigerdt R.

Stem Cell Res. 2010 May;4(3):165-79. doi: 10.1016/j.scr.2010.03.001. Epub 2010 Mar 12.

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