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Items: 1 to 50 of 455

1.

Imbalance in zinc homeostasis enhances lung Tissue Loss following cigarette smoke exposure.

Knoell DL, Smith D, Bao S, Sapkota M, Wyatt TA, Zweier JL, Flury J, Borchers MT, Knutson M.

J Trace Elem Med Biol. 2020 Feb 27;60:126483. doi: 10.1016/j.jtemb.2020.126483. [Epub ahead of print]

PMID:
32155573
2.

Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin.

Zweier JL, Ilangovan G.

Antioxid Redox Signal. 2020 Jan 28. doi: 10.1089/ars.2019.7881. [Epub ahead of print]

PMID:
31880165
3.

Discriminative Detection of Biothiols by Electron Paramagnetic Resonance Spectroscopy using a Methanethiosulfonate Trityl Probe.

Tan X, Ji K, Wang X, Yao R, Han G, Villamena FA, Zweier JL, Song Y, Rockenbauer A, Liu Y.

Angew Chem Int Ed Engl. 2020 Jan 7;59(2):928-934. doi: 10.1002/anie.201912832. Epub 2019 Nov 18.

PMID:
31657108
4.

Membrane-specific spin trap, 5-dodecylcarbamoyl-5-N-dodecylacetamide-1-pyroline-N-oxide (diC12PO): theoretical, bioorthogonal fluorescence imaging and EPR studies.

Headley CA, Hoffman CN, Freisen JM, Han Y, Macklin JM, Zweier JL, Rockenbauer A, Kuret J, Villamena FA.

Org Biomol Chem. 2019 Sep 7;17(33):7694-7705. doi: 10.1039/c9ob01334b. Epub 2019 Jul 22.

PMID:
31328213
5.

[D-Ala2, D-Leu5] Enkephalin Improves Liver Preservation During Normothermic Ex Vivo Perfusion.

Beal EW, Kim JL, Reader BF, Akateh C, Maynard K, Washburn WK, Zweier JL, Whitson BA, Black SM.

J Surg Res. 2019 Sep;241:323-335. doi: 10.1016/j.jss.2019.04.010. Epub 2019 May 6.

PMID:
31071481
6.

Development of a fast-scan EPR imaging system for highly accelerated free radical imaging.

Samouilov A, Ahmad R, Boslett J, Liu X, Petryakov S, Zweier JL.

Magn Reson Med. 2019 Aug;82(2):842-853. doi: 10.1002/mrm.27759. Epub 2019 Apr 25.

PMID:
31020713
7.

Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels.

Nimjee SM, Dornbos D 3rd, Pitoc GA, Wheeler DG, Layzer JM, Venetos N, Huttinger A, Talentino SE, Musgrave NJ, Moody H, Rempel RE, Jones C, Carlisle K, Wilson J, Bratton C, Joseph ME, Khan S, Hoffman MR, Sommerville L, Becker RC, Zweier JL, Sullenger BA.

Mol Ther. 2019 Jul 3;27(7):1228-1241. doi: 10.1016/j.ymthe.2019.03.016. Epub 2019 Mar 30.

PMID:
30987839
8.

Intrahepatic Delivery of Pegylated Catalase Is Protective in a Rat Ischemia/Reperfusion Injury Model.

Akateh C, Beal EW, Kim JL, Reader BF, Maynard K, Zweier JL, Whitson BA, Black SM.

J Surg Res. 2019 Jun;238:152-163. doi: 10.1016/j.jss.2019.01.028. Epub 2019 Feb 13.

PMID:
30771685
9.

Inhibition of CD38 with the Thiazoloquin(az)olin(on)e 78c Protects the Heart against Postischemic Injury.

Boslett J, Reddy N, Alzarie YA, Zweier JL.

J Pharmacol Exp Ther. 2019 Apr;369(1):55-64. doi: 10.1124/jpet.118.254557. Epub 2019 Jan 11.

PMID:
30635470
10.

Mitochondrial complex I in the post-ischemic heart: reperfusion-mediated oxidative injury and protein cysteine sulfonation.

Kang PT, Chen CL, Lin P, Zhang L, Zweier JL, Chen YR.

J Mol Cell Cardiol. 2018 Aug;121:190-204. doi: 10.1016/j.yjmcc.2018.07.244. Epub 2018 Jul 20.

11.

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion.

Beal EW, Dumond C, Kim JL, Akateh C, Eren E, Maynard K, Sen CK, Zweier JL, Washburn K, Whitson BA, Black SM.

J Vis Exp. 2018 Jun 27;(136). doi: 10.3791/57541.

12.

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.

Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN.

Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.

13.

Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase.

Abdelghany TM, Ismail RS, Mansoor FA, Zweier JR, Lowe F, Zweier JL.

Nitric Oxide. 2018 Jun 1;76:113-121. doi: 10.1016/j.niox.2018.02.009. Epub 2018 Mar 7.

PMID:
29524646
14.

Synthesis and Characterization of the Perthiatriarylmethyl Radical and Its Dendritic Derivatives with High Sensitivity and Selectivity to Superoxide Radical.

Tan X, Tao S, Liu W, Rockenbauer A, Villamena FA, Zweier JL, Song Y, Liu Y.

Chemistry. 2018 May 11;24(27):6958-6967. doi: 10.1002/chem.201800134. Epub 2018 Mar 30.

PMID:
29505165
15.

Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides.

Boslett J, Helal M, Chini E, Zweier JL.

J Mol Cell Cardiol. 2018 May;118:81-94. doi: 10.1016/j.yjmcc.2018.02.015. Epub 2018 Feb 21.

16.

Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion.

Boslett J, Hemann C, Christofi FL, Zweier JL.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C297-C309. doi: 10.1152/ajpcell.00139.2017. Epub 2017 Nov 29.

17.

Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease.

Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL.

Front Cardiovasc Med. 2017 Nov 1;4:64. doi: 10.3389/fcvm.2017.00064. eCollection 2017. Review.

18.

Angiotensin Receptor Expression and Vascular Endothelial Dysfunction in Obstructive Sleep Apnea.

Khayat RN, Varadharaj S, Porter K, Sow A, Jarjoura D, Gavrilin MA, Zweier JL.

Am J Hypertens. 2018 Feb 9;31(3):355-361. doi: 10.1093/ajh/hpx174.

19.

Thiol-Dependent Reduction of the Triester and Triamide Derivatives of Finland Trityl Radical Triggers O2-Dependent Superoxide Production.

Tan X, Chen L, Song Y, Rockenbauer A, Villamena FA, Zweier JL, Liu Y.

Chem Res Toxicol. 2017 Sep 18;30(9):1664-1672. doi: 10.1021/acs.chemrestox.7b00086. Epub 2017 Aug 14.

PMID:
28759716
20.

Oxygen binding and nitric oxide dioxygenase activity of cytoglobin are altered to different extents by cysteine modification.

Zhou D, Hemann C, Boslett J, Luo A, Zweier JL, Liu X.

FEBS Open Bio. 2017 May 18;7(6):845-853. doi: 10.1002/2211-5463.12230. eCollection 2017 Jun.

21.

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.

Liu X, El-Mahdy MA, Boslett J, Varadharaj S, Hemann C, Abdelghany TM, Ismail RS, Little SC, Zhou D, Thuy LT, Kawada N, Zweier JL.

Nat Commun. 2017 Apr 10;8:14807. doi: 10.1038/ncomms14807.

22.

Kcnj11 Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy.

Zhang B, Novitskaya T, Wheeler DG, Xu Z, Chepurko E, Huttinger R, He H, Varadharaj S, Zweier JL, Song Y, Xu M, Harrell FE Jr, Su YR, Absi T, Kohr MJ, Ziolo MT, Roden DM, Shaffer CM, Galindo CL, Wells QS, Gumina RJ.

Circ Heart Fail. 2017 Feb;10(2). pii: e003523. doi: 10.1161/CIRCHEARTFAILURE.116.003523.

23.

Mitochondrial Electron Transport Chain-Derived Superoxide Exits Macrophages: Implications for Mononuclear Cell-Mediated Pathophysiological Processes.

Li Y, Zhu H, Kuppusamy P, Zweier JL, Trush MA.

React Oxyg Species (Apex). 2016;1(1):81-98. doi: 10.20455/ros.2016.815.

24.

Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H).

Boslett J, Hemann C, Zhao YJ, Lee HC, Zweier JL.

J Pharmacol Exp Ther. 2017 Apr;361(1):99-108. doi: 10.1124/jpet.116.239459. Epub 2017 Jan 20.

25.

Synthesis and Characterization of PEGylated Trityl Radicals: Effect of PEGylation on Physicochemical Properties.

Liu W, Nie J, Tan X, Liu H, Yu N, Han G, Zhu Y, Villamena FA, Song Y, Zweier JL, Liu Y.

J Org Chem. 2017 Jan 6;82(1):588-596. doi: 10.1021/acs.joc.6b02590. Epub 2016 Dec 28.

PMID:
28005365
26.

Trityl radicals in perfluorocarbon emulsions as stable, sensitive, and biocompatible oximetry probes.

Dhimitruka I, Alzarie YA, Hemann C, Samouilov A, Zweier JL.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5685-5688. doi: 10.1016/j.bmcl.2016.10.066. Epub 2016 Oct 24.

27.

Accelerated dynamic EPR imaging using fast acquisition and compressive recovery.

Ahmad R, Samouilov A, Zweier JL.

J Magn Reson. 2016 Dec;273:105-112. doi: 10.1016/j.jmr.2016.10.001. Epub 2016 Oct 8.

28.

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.

Griendling KK, Touyz RM, Zweier JL, Dikalov S, Chilian W, Chen YR, Harrison DG, Bhatnagar A; American Heart Association Council on Basic Cardiovascular Sciences.

Circ Res. 2016 Aug 19;119(5):e39-75. doi: 10.1161/RES.0000000000000110. Epub 2016 Jul 14. Review.

29.

Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe.

Driesschaert B, Bobko AA, Khramtsov VV, Zweier JL.

Cell Biochem Biophys. 2017 Jun;75(2):241-246. doi: 10.1007/s12013-016-0732-y. Epub 2016 May 20.

30.

Poly-arginine conjugated triarylmethyl radical as intracellular spin label.

Driesschaert B, Bobko AA, Eubank TD, Samouilov A, Khramtsov VV, Zweier JL.

Bioorg Med Chem Lett. 2016 Apr 1;26(7):1742-4. doi: 10.1016/j.bmcl.2016.02.048. Epub 2016 Feb 19.

31.

Sulfite Oxidase Activity of Cytochrome c: Role of Hydrogen Peroxide.

Velayutham M, Hemann CF, Cardounel AJ, Zweier JL.

Biochem Biophys Rep. 2016 Mar 1;5:96-104.

32.

Supramolecular host-guest interaction of trityl-nitroxide biradicals with cyclodextrins: modulation of spin-spin interaction and redox sensitivity.

Tan X, Song Y, Liu H, Zhong Q, Rockenbauer A, Villamena FA, Zweier JL, Liu Y.

Org Biomol Chem. 2016 Feb 7;14(5):1694-701. doi: 10.1039/c5ob02450a.

33.

Insulin-like growth factor 1 prevents diastolic and systolic dysfunction associated with cardiomyopathy and preserves adrenergic sensitivity.

Roof SR, Boslett J, Russell D, del Rio C, Alecusan J, Zweier JL, Ziolo MT, Hamlin R, Mohler PJ, Curran J.

Acta Physiol (Oxf). 2016 Apr;216(4):421-34. doi: 10.1111/apha.12607. Epub 2015 Oct 8.

34.

Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart.

Reyes LA, Boslett J, Varadharaj S, De Pascali F, Hemann C, Druhan LJ, Ambrosio G, El-Mahdy M, Zweier JL.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11648-53. doi: 10.1073/pnas.1505556112. Epub 2015 Aug 21.

35.

Efficient Dynamic Nuclear Polarization at 800 MHz/527 GHz with Trityl-Nitroxide Biradicals.

Mathies G, Caporini MA, Michaelis VK, Liu Y, Hu KN, Mance D, Zweier JL, Rosay M, Baldus M, Griffin RG.

Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11770-4. doi: 10.1002/anie.201504292. Epub 2015 Aug 12.

36.

Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury.

Conklin DJ, Guo Y, Jagatheesan G, Kilfoil PJ, Haberzettl P, Hill BG, Baba SP, Guo L, Wetzelberger K, Obal D, Rokosh DG, Prough RA, Prabhu SD, Velayutham M, Zweier JL, Hoetker JD, Riggs DW, Srivastava S, Bolli R, Bhatnagar A.

Circ Res. 2015 Aug 14;117(5):437-49. doi: 10.1161/CIRCRESAHA.114.305518. Epub 2015 Jul 13.

37.

Liposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection.

Xie L, Talukder MA, Sun J, Varadharaj S, Zweier JL.

J Mol Cell Cardiol. 2015 Sep;86:14-22. doi: 10.1016/j.yjmcc.2015.06.015. Epub 2015 Jun 25.

38.

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY.

EMBO Mol Med. 2015 Jun;7(6):695-713. doi: 10.15252/emmm.201404511.

39.

Silver-zinc redox-coupled electroceutical wound dressing disrupts bacterial biofilm.

Banerjee J, Das Ghatak P, Roy S, Khanna S, Hemann C, Deng B, Das A, Zweier JL, Wozniak D, Sen CK.

PLoS One. 2015 Mar 24;10(3):e0119531. doi: 10.1371/journal.pone.0119531. eCollection 2015.

40.

Arterial levels of oxygen stimulate intimal hyperplasia in human saphenous veins via a ROS-dependent mechanism.

Joddar B, Firstenberg MS, Reen RK, Varadharaj S, Khan M, Childers RC, Zweier JL, Gooch KJ.

PLoS One. 2015 Mar 23;10(3):e0120301. doi: 10.1371/journal.pone.0120301. eCollection 2015.

41.

Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling.

Long VP 3rd, Bonilla IM, Vargas-Pinto P, Nishijima Y, Sridhar A, Li C, Mowrey K, Wright P, Velayutham M, Kumar S, Lee NY, Zweier JL, Mohler PJ, Györke S, Carnes CA.

Life Sci. 2015 Feb 15;123:61-71. doi: 10.1016/j.lfs.2014.12.024. Epub 2015 Jan 14.

42.

Endothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction.

Varadharaj S, Porter K, Pleister A, Wannemacher J, Sow A, Jarjoura D, Zweier JL, Khayat RN.

Respir Physiol Neurobiol. 2015 Feb 1;207:40-7. doi: 10.1016/j.resp.2014.12.012. Epub 2014 Dec 19.

43.

Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective.

Scheitlin CG, Nair DM, Crestanello JA, Zweier JL, Alevriadou BR.

Cell Mol Bioeng. 2014 Dec;7(4):483-496.

44.

Proton-Electron Double-Resonance Imaging of pH using phosphonated trityl probe.

Takahashi W, Bobko AA, Dhimitruka I, Hirata H, Zweier JL, Samouilov A, Khramtsov VV.

Appl Magn Reson. 2014 Sep 1;45(9):817-826.

45.

Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.

Lee MC, Velayutham M, Komatsu T, Hille R, Zweier JL.

Biochemistry. 2014 Oct 21;53(41):6615-23. doi: 10.1021/bi500582r. Epub 2014 Oct 6.

46.

Mitochondrial uncoupling does not decrease reactive oxygen species production after ischemia-reperfusion.

Quarrie R, Lee DS, Reyes L, Erdahl W, Pfeiffer DR, Zweier JL, Crestanello JA.

Am J Physiol Heart Circ Physiol. 2014 Oct 1;307(7):H996-H1004. doi: 10.1152/ajpheart.00189.2014. Epub 2014 Aug 1.

47.

Effect of temperature, pH and heme ligands on the reduction of Cygb(Fe(3+)) by ascorbate.

Tong J, Zweier JR, Huskey RL, Ismail RS, Hemann C, Zweier JL, Liu X.

Arch Biochem Biophys. 2014 Jul 15;554:1-5. doi: 10.1016/j.abb.2014.04.011. Epub 2014 Apr 26.

48.

Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation.

De Pascali F, Hemann C, Samons K, Chen CA, Zweier JL.

Biochemistry. 2014 Jun 10;53(22):3679-88. doi: 10.1021/bi500076r. Epub 2014 May 29.

49.

Iron and noncontrast magnetic resonance T2* as a marker of intraplaque iron in human atherosclerosis.

Winner MW 3rd, Sharkey-Toppen T, Zhang X, Pennell ML, Simonetti OP, Zweier JL, Vaccaro PS, Raman SV.

J Vasc Surg. 2015 Jun;61(6):1556-64. doi: 10.1016/j.jvs.2014.02.006. Epub 2014 Mar 24.

50.

Fourier transform EPR spectroscopy of trityl radicals for multifunctional assessment of chemical microenvironment.

Bobko AA, Dhimitruka I, Zweier JL, Khramtsov VV.

Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2735-8. doi: 10.1002/anie.201310841. Epub 2014 Feb 2.

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