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Items: 1 to 50 of 53

1.

Genome-wide association study of susceptibility loci for T-cell acute lymphoblastic leukemia in children.

Qian M, Zhao X, Devidas M, Yang W, Gocho Y, Smith C, Gastier-Foster JM, Li Y, Xu H, Zhang S, Jeha S, Zhai X, Sanda T, Winter SS, Dunsmore KP, Raetz EA, Carroll WL, Winick NJ, Rabin KR, Zweidler-Mckay PA, Wood B, Pui CH, Evans WE, Hunger SP, Mullighan CG, Relling MV, Loh ML, Yang JJ.

J Natl Cancer Inst. 2019 Apr 2. pii: djz043. doi: 10.1093/jnci/djz043. [Epub ahead of print]

PMID:
30938820
2.

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia.

Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG.

Nat Genet. 2019 Feb;51(2):296-307. doi: 10.1038/s41588-018-0315-5. Epub 2019 Jan 14.

PMID:
30643249
3.

Replacing cyclophosphamide/cytarabine/mercaptopurine with cyclophosphamide/etoposide during consolidation/delayed intensification does not improve outcome for pediatric B-cell acute lymphoblastic leukemia: a report from the COG.

Burke MJ, Salzer WL, Devidas M, Dai Y, Gore L, Hilden JM, Larsen E, Rabin KR, Zweidler-McKay PA, Borowitz MJ, Wood B, Heerema NA, Carroll AJ, Winick N, Carroll WL, Raetz EA, Loh ML, Hunger SP.

Haematologica. 2019 May;104(5):986-992. doi: 10.3324/haematol.2018.204545. Epub 2018 Dec 13.

4.

CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia.

Angelova E, Audette C, Kovtun Y, Daver N, Wang SA, Pierce S, Konoplev SN, Khogeer H, Jorgensen JL, Konopleva M, Zweidler-McKay PA, Medeiros LJ, Kantarjian HM, Jabbour EJ, Khoury JD.

Haematologica. 2019 Apr;104(4):749-755. doi: 10.3324/haematol.2018.205252. Epub 2018 Oct 25.

5.

Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization.

Winter SS, Dunsmore KP, Devidas M, Wood BL, Esiashvili N, Chen Z, Eisenberg N, Briegel N, Hayashi RJ, Gastier-Foster JM, Carroll AJ, Heerema NA, Asselin BL, Gaynon PS, Borowitz MJ, Loh ML, Rabin KR, Raetz EA, Zweidler-Mckay PA, Winick NJ, Carroll WL, Hunger SP.

J Clin Oncol. 2018 Oct 10;36(29):2926-2934. doi: 10.1200/JCO.2018.77.7250. Epub 2018 Aug 23. Erratum in: J Clin Oncol. 2019 Mar 20;37(9):761.

6.

Characterization of TRKA signaling in acute myeloid leukemia.

Herbrich SM, Kannan S, Nolo RM, Hornbaker M, Chandra J, Zweidler-McKay PA.

Oncotarget. 2018 Jul 10;9(53):30092-30105. doi: 10.18632/oncotarget.25723. eCollection 2018 Jul 10.

7.

HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.

Tharkar-Promod S, Johnson DP, Bennett SE, Dennis EM, Banowsky BG, Jones SS, Shearstone JR, Quayle SN, Min C, Jarpe M, Mosbruger T, Pomicter AD, Miles RR, Chen WY, Bhalla KN, Zweidler-McKay PA, Shrieve DC, Deininger MW, Chandrasekharan MB, Bhaskara S.

Leukemia. 2018 Jan;32(1):49-60. doi: 10.1038/leu.2017.174. Epub 2017 Jun 5.

8.

Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.

Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP.

Blood. 2017 Jun 22;129(25):3352-3361. doi: 10.1182/blood-2016-12-758979. Epub 2017 Apr 13.

9.

CRLF2-Positive B-Cell Acute Lymphoblastic Leukemia in Adult Patients: A Single-Institution Experience.

Konoplev S, Lu X, Konopleva M, Jain N, Ouyang J, Goswami M, Roberts KG, Valentine M, Mullighan CG, Bueso-Ramos C, Zweidler-McKay PA, Jorgensen JL, Wang SA.

Am J Clin Pathol. 2017 Apr 1;147(4):357-363. doi: 10.1093/ajcp/aqx005.

PMID:
28340183
10.

Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD.

Yuan T, Yang Y, Chen J, Li W, Li W, Zhang Q, Mi Y, Goswami RS, You JQ, Lin D, Qian MD, Calin S, Liang Y, Miranda RN, Calin GA, Zhou X, Ma L, Zweidler-McKay PA, Liu B, Weng AP, Medeiros LJ, Zhang Y, You MJ.

Leukemia. 2017 Nov;31(11):2355-2364. doi: 10.1038/leu.2017.80. Epub 2017 Mar 10.

11.

BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells.

Valls E, Lobry C, Geng H, Wang L, Cardenas M, Rivas M, Cerchietti L, Oh P, Yang SN, Oswald E, Graham CW, Jiang Y, Hatzi K, Agirre X, Perkey E, Li Z, Tam W, Bhatt K, Leonard JP, Zweidler-McKay PA, Maillard I, Elemento O, Ci W, Aifantis I, Melnick A.

Cancer Discov. 2017 May;7(5):506-521. doi: 10.1158/2159-8290.CD-16-1189. Epub 2017 Feb 23.

12.

Non-fucosylated CB CD34+ cells represent a good target for enforced fucosylation to improve engraftment following cord blood transplantation.

Robinson SN, Thomas MW, Simmons PJ, Lu J, Yang H, Javni JA, Shpall EJ, Zweidler-Mckay PA.

Cytotherapy. 2017 Feb;19(2):285-292. doi: 10.1016/j.jcyt.2016.11.001. Epub 2016 Dec 2.

PMID:
27919572
13.

Inducible epithelial resistance protects mice against leukemia-associated pneumonia.

Leiva-Juárez MM, Ware HH, Kulkarni VV, Zweidler-McKay PA, Tuvim MJ, Evans SE.

Blood. 2016 Aug 18;128(7):982-92. doi: 10.1182/blood-2016-03-708511. Epub 2016 Jun 17.

14.

Navigating your career path in pediatric hematology/oncology: On and off the beaten track.

Zweidler-McKay PA, Hogan MJ, Jubran R, Black V, Casillas J, Harper J, Malempati S, Margolin J, Felgenhauer J, Sakamoto KM, Franklin J, Shah M, Seibel N, Buchanan G, Vaiselbuh SR, Hastings C, Hilden J, Stork LC.

Pediatr Blood Cancer. 2016 Oct;63(10):1723-30. doi: 10.1002/pbc.26094. Epub 2016 Jun 13. No abstract available.

PMID:
27295503
15.

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

Benito JM, Godfrey L, Kojima K, Hogdal L, Wunderlich M, Geng H, Marzo I, Harutyunyan KG, Golfman L, North P, Kerry J, Ballabio E, Chonghaile TN, Gonzalo O, Qiu Y, Jeremias I, Debose L, O'Brien E, Ma H, Zhou P, Jacamo R, Park E, Coombes KR, Zhang N, Thomas DA, O'Brien S, Kantarjian HM, Leverson JD, Kornblau SM, Andreeff M, Müschen M, Zweidler-McKay PA, Mulloy JC, Letai A, Milne TA, Konopleva M.

Cell Rep. 2015 Dec 29;13(12):2715-27. doi: 10.1016/j.celrep.2015.12.003. Epub 2015 Dec 17.

16.

The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling.

Trinh BQ, Barengo N, Kim SB, Lee JS, Zweidler-McKay PA, Naora H.

J Cell Sci. 2015 Aug 15;128(16):3055-67. doi: 10.1242/jcs.168187. Epub 2015 Jul 24.

17.

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation.

Popat U, Mehta RS, Rezvani K, Fox P, Kondo K, Marin D, McNiece I, Oran B, Hosing C, Olson A, Parmar S, Shah N, Andreeff M, Kebriaei P, Kaur I, Yvon E, de Lima M, Cooper LJ, Tewari P, Champlin RE, Nieto Y, Andersson BS, Alousi A, Jones RB, Qazilbash MH, Bashir Q, Ciurea S, Ahmed S, Anderlini P, Bosque D, Bollard C, Molldrem JJ, Chen J, Rondon G, Thomas M, Miller L, Wolpe S, Simmons P, Robinson S, Zweidler-McKay PA, Shpall EJ.

Blood. 2015 May 7;125(19):2885-92. doi: 10.1182/blood-2015-01-607366. Epub 2015 Mar 16.

18.

Integration of cytogenomic data for furthering the characterization of pediatric B-cell acute lymphoblastic leukemia: a multi-institution, multi-platform microarray study.

Baughn LB, Biegel JA, South ST, Smolarek TA, Volkert S, Carroll AJ, Heerema NA, Rabin KR, Zweidler-McKay PA, Loh M, Hirsch B.

Cancer Genet. 2015 Jan-Feb;208(1-2):1-18. doi: 10.1016/j.cancergen.2014.11.003. Epub 2014 Nov 21.

19.

Expression of a surface antigen (MA6) by peripheral blood CD34+ cells is correlated with improved platelet engraftment and may explain delayed platelet engraftment following cord blood transplantation.

Simmons PJ, Robinson SN, Munsell MF, Thomas MW, Javni JA, Brouard N, Zweidler-McKay PA, Shpall EJ.

Stem Cells Dev. 2015 May 1;24(9):1066-72. doi: 10.1089/scd.2014.0439. Epub 2015 Mar 18.

20.

Phenotypic and functional comparison of mobilized peripheral blood versus umbilical cord blood megakaryocyte populations.

Kellner J, Li S, Zweidler-McKay PA, Shpall EJ, McNiece I.

Cytotherapy. 2015 Apr;17(4):418-27. doi: 10.1016/j.jcyt.2014.11.004. Epub 2014 Dec 19.

21.

The challenge of targeting notch in hematologic malignancies.

Hernandez Tejada FN, Galvez Silva JR, Zweidler-McKay PA.

Front Pediatr. 2014 Jun 10;2:54. doi: 10.3389/fped.2014.00054. eCollection 2014. Review.

22.

Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment.

Robinson SN, Thomas MW, Simmons PJ, Lu J, Yang H, Parmar S, Liu X, Shah N, Martín-Antonio B, Bollard C, Dotti G, Savoldo B, Cooper LJ, Najjar A, Rezvani K, Kaur I, McNiece IK, Champlin RE, Miller LP, Zweidler-McKay PA, Shpall EJ.

Cytotherapy. 2014 Jan;16(1):84-9. doi: 10.1016/j.jcyt.2013.07.003. Epub 2013 Oct 1.

23.

Reply to "Peripheral blood lymphocyte recovery and overall survival in pediatric acute lymphoblastic leukemia".

Rabin KR, Gramatges MM, Margolin JF, Zweidler-McKay PA.

Pediatr Blood Cancer. 2014 Jan;61(1):180. doi: 10.1002/pbc.24733. Epub 2013 Aug 17. No abstract available.

PMID:
23956240
24.

Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia.

Kuang SQ, Fang Z, Zweidler-McKay PA, Yang H, Wei Y, Gonzalez-Cervantes EA, Boumber Y, Garcia-Manero G.

PLoS One. 2013 Apr 26;8(4):e61807. doi: 10.1371/journal.pone.0061807. Print 2013.

25.

Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers.

Pickering CR, Zhang J, Yoo SY, Bengtsson L, Moorthy S, Neskey DM, Zhao M, Ortega Alves MV, Chang K, Drummond J, Cortez E, Xie TX, Zhang D, Chung W, Issa JP, Zweidler-McKay PA, Wu X, El-Naggar AK, Weinstein JN, Wang J, Muzny DM, Gibbs RA, Wheeler DA, Myers JN, Frederick MJ.

Cancer Discov. 2013 Jul;3(7):770-81. doi: 10.1158/2159-8290.CD-12-0537. Epub 2013 Apr 25.

26.

Notch activation inhibits AML growth and survival: a potential therapeutic approach.

Kannan S, Sutphin RM, Hall MG, Golfman LS, Fang W, Nolo RM, Akers LJ, Hammitt RA, McMurray JS, Kornblau SM, Melnick AM, Figueroa ME, Zweidler-McKay PA.

J Exp Med. 2013 Feb 11;210(2):321-37. doi: 10.1084/jem.20121527. Epub 2013 Jan 28.

27.

Clone wars: IgH subclones in preB-ALL.

Zweidler-McKay PA.

Blood. 2012 Nov 22;120(22):4280-1. doi: 10.1182/blood-2012-09-455402. No abstract available.

28.

CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors.

Blonska M, Joo D, Zweidler-McKay PA, Zhao Q, Lin X.

J Immunol. 2012 Apr 1;188(7):3160-8. doi: 10.4049/jimmunol.1102943. Epub 2012 Feb 27.

29.

Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγ(null) mice.

Robinson SN, Simmons PJ, Thomas MW, Brouard N, Javni JA, Trilok S, Shim JS, Yang H, Steiner D, Decker WK, Xing D, Shultz LD, Savoldo B, Dotti G, Bollard CM, Miller L, Champlin RE, Shpall EJ, Zweidler-McKay PA.

Exp Hematol. 2012 Jun;40(6):445-56. doi: 10.1016/j.exphem.2012.01.015. Epub 2012 Feb 2.

30.

Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells.

Almeida MI, Nicoloso MS, Zeng L, Ivan C, Spizzo R, Gafà R, Xiao L, Zhang X, Vannini I, Fanini F, Fabbri M, Lanza G, Reis RM, Zweidler-McKay PA, Calin GA.

Gastroenterology. 2012 Apr;142(4):886-896.e9. doi: 10.1053/j.gastro.2011.12.047. Epub 2012 Jan 10.

31.

Absolute lymphocyte counts refine minimal residual disease-based risk stratification in childhood acute lymphoblastic leukemia.

Rabin KR, Gramatges MM, Borowitz MJ, Palla SL, Shi X, Margolin JF, Zweidler-McKay PA.

Pediatr Blood Cancer. 2012 Sep;59(3):468-74. doi: 10.1002/pbc.23395. Epub 2011 Nov 18.

32.

Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.

Benito J, Shi Y, Szymanska B, Carol H, Boehm I, Lu H, Konoplev S, Fang W, Zweidler-McKay PA, Campana D, Borthakur G, Bueso-Ramos C, Shpall E, Thomas DA, Jordan CT, Kantarjian H, Wilson WR, Lock R, Andreeff M, Konopleva M.

PLoS One. 2011;6(8):e23108. doi: 10.1371/journal.pone.0023108. Epub 2011 Aug 11.

33.

Notch pathway activation induces neuroblastoma tumor cell growth arrest.

Zage PE, Nolo R, Fang W, Stewart J, Garcia-Manero G, Zweidler-McKay PA.

Pediatr Blood Cancer. 2012 May;58(5):682-9. doi: 10.1002/pbc.23202. Epub 2011 Jul 8.

34.

Targeting glycolysis in leukemia: a novel inhibitor 3-BrOP in combination with rapamycin.

Akers LJ, Fang W, Levy AG, Franklin AR, Huang P, Zweidler-McKay PA.

Leuk Res. 2011 Jun;35(6):814-20. doi: 10.1016/j.leukres.2010.12.028. Epub 2011 Feb 12.

35.

Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.

Kannan S, Fang W, Song G, Mullighan CG, Hammitt R, McMurray J, Zweidler-McKay PA.

Blood. 2011 Mar 10;117(10):2891-900. doi: 10.1182/blood-2009-12-253419. Epub 2011 Jan 11.

36.

The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan.

Zage PE, Graham TC, Zeng L, Fang W, Pien C, Thress K, Omer C, Brown JL, Zweidler-McKay PA.

Cancer. 2011 Mar 15;117(6):1321-91. doi: 10.1002/cncr.25674. Epub 2010 Oct 19.

37.

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma.

Levy AG, Zage PE, Akers LJ, Ghisoli ML, Chen Z, Fang W, Kannan S, Graham T, Zeng L, Franklin AR, Huang P, Zweidler-McKay PA.

Invest New Drugs. 2012 Feb;30(1):191-9. doi: 10.1007/s10637-010-9551-y. Epub 2010 Oct 5.

38.

Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion.

Xing D, Ramsay AG, Gribben JG, Decker WK, Burks JK, Munsell M, Li S, Robinson SN, Yang H, Steiner D, Shah N, McMannis JD, Champlin RE, Hosing C, Zweidler-McKay PA, Shpall EJ, Bollard CM.

J Immunother. 2010 Sep;33(7):684-96. doi: 10.1097/CJI.0b013e3181e475e9.

39.

Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo.

Richards KN, Zweidler-McKay PA, Van Roy N, Speleman F, Trevino J, Zage PE, Hughes DP.

Cancer. 2010 Jul 1;116(13):3233-43. doi: 10.1002/cncr.25073.

40.
41.

Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness.

Zhang P, Yang Y, Nolo R, Zweidler-McKay PA, Hughes DP.

Oncogene. 2010 May 20;29(20):2916-26. doi: 10.1038/onc.2010.62. Epub 2010 Mar 8. Erratum in: Oncogene. 2012 Nov 1;31(44):4732.

42.

Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.

Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV.

Oncogene. 2010 May 20;29(20):2938-49. doi: 10.1038/onc.2010.60. Epub 2010 Mar 8.

PMID:
20208561
43.

Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma.

Schadler KL, Zweidler-McKay PA, Guan H, Kleinerman ES.

Clin Cancer Res. 2010 Feb 1;16(3):848-56. doi: 10.1158/1078-0432.CCR-09-1299. Epub 2010 Jan 26.

44.

Noninvasive bioluminescent imaging demonstrates long-term multilineage engraftment of ex vivo-expanded CD34-selected umbilical cord blood cells.

Steiner D, Gelovani J, Savoldo B, Robinson SN, Decker WK, Brouard N, Najjar A, Xing D, Yang H, Li S, Marini F, Zweidler-McKay PA, Bollard CM, Shpall EJ, Dotti G, Simmons PJ.

Stem Cells. 2009 Aug;27(8):1932-40. doi: 10.1002/stem.111.

45.

Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway.

Thress K, Macintyre T, Wang H, Whitston D, Liu ZY, Hoffmann E, Wang T, Brown JL, Webster K, Omer C, Zage PE, Zeng L, Zweidler-McKay PA.

Mol Cancer Ther. 2009 Jul;8(7):1818-27. doi: 10.1158/1535-7163.MCT-09-0036. Epub 2009 Jun 9.

46.

Notch signaling in pediatric malignancies.

Zweidler-McKay PA.

Curr Oncol Rep. 2008 Nov;10(6):459-68. Review.

PMID:
18928660
47.

Critical role of notch signaling in osteosarcoma invasion and metastasis.

Zhang P, Yang Y, Zweidler-McKay PA, Hughes DP.

Clin Cancer Res. 2008 May 15;14(10):2962-9. doi: 10.1158/1078-0432.CCR-07-1992. Retraction in: Zhang P, Yang Y, Zweidler-McKay P, Hughes DP. Clin Cancer Res. 2013 Sep 15;19(18):5256-7.

48.

The ABCs of infant leukemia.

Zweidler-McKay PA, Hilden JM.

Curr Probl Pediatr Adolesc Health Care. 2008 Mar;38(3):78-94. doi: 10.1016/j.cppeds.2007.12.001. Review. No abstract available.

PMID:
18279790
49.

Absolute lymphocyte count is a novel prognostic indicator in ALL and AML: implications for risk stratification and future studies.

De Angulo G, Yuen C, Palla SL, Anderson PM, Zweidler-McKay PA.

Cancer. 2008 Jan 15;112(2):407-15.

50.

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.

Zweidler-McKay PA, He Y, Xu L, Rodriguez CG, Karnell FG, Carpenter AC, Aster JC, Allman D, Pear WS.

Blood. 2005 Dec 1;106(12):3898-906. Epub 2005 Aug 23.

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