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Items: 1 to 50 of 196

1.

Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics.

Melková K, Zapletal V, Jansen S, Nomilner E, Zachrdla M, Hritz J, Nováček J, Zweckstetter M, Jensen MR, Blackledge M, Zidek L.

J Biol Chem. 2018 Jun 20. pii: jbc.RA118.001769. doi: 10.1074/jbc.RA118.001769. [Epub ahead of print]

2.

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.

Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30.

PMID:
29728653
3.

The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease.

Aliakbari F, Mohammad-Beigi H, Rezaei-Ghaleh N, Becker S, Dehghani Esmatabad F, Eslampanah Seyedi HA, Bardania H, Tayaranian Marvian A, Collingwood JF, Christiansen G, Zweckstetter M, Otzen DE, Morshedi D.

Nanoscale. 2018 May 17;10(19):9174-9185. doi: 10.1039/c8nr00632f.

PMID:
29725687
4.

Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity.

Tolö J, Taschenberger G, Leite K, Stahlberg MA, Spehlbrink G, Kues J, Munari F, Capaldi S, Becker S, Zweckstetter M, Dean C, Bähr M, Kügler S.

Front Mol Neurosci. 2018 Mar 7;11:49. doi: 10.3389/fnmol.2018.00049. eCollection 2018.

5.

Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view.

Jaipuria G, Ukmar-Godec T, Zweckstetter M.

Cell Mol Life Sci. 2018 Jun;75(12):2137-2151. doi: 10.1007/s00018-018-2789-9. Epub 2018 Mar 8. Review.

PMID:
29520423
6.

The Binding Mode of a Tau Peptide with Tubulin.

Kadavath H, Cabrales Fontela Y, Jaremko M, Jaremko Ł, Overkamp K, Biernat J, Mandelkow E, Zweckstetter M.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3246-3250. doi: 10.1002/anie.201712089. Epub 2018 Feb 22.

PMID:
29314492
7.

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.

Cabrales Fontela Y, Kadavath H, Biernat J, Riedel D, Mandelkow E, Zweckstetter M.

Nat Commun. 2017 Dec 7;8(1):1981. doi: 10.1038/s41467-017-02230-8.

8.

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.

Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A.

EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825.

9.

Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4.

Bharat V, Siebrecht M, Burk K, Ahmed S, Reissner C, Kohansal-Nodehi M, Steubler V, Zweckstetter M, Ting JT, Dean C.

Cell Rep. 2017 Nov 21;21(8):2118-2133. doi: 10.1016/j.celrep.2017.10.084.

10.

Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.

Miotto MC, Pavese MD, Quintanar L, Zweckstetter M, Griesinger C, Fernández CO.

Inorg Chem. 2017 Sep 5;56(17):10387-10395. doi: 10.1021/acs.inorgchem.7b01292. Epub 2017 Aug 18.

PMID:
28820253
11.

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.

Ambadipudi S, Biernat J, Riedel D, Mandelkow E, Zweckstetter M.

Nat Commun. 2017 Aug 17;8(1):275. doi: 10.1038/s41467-017-00480-0.

12.

Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.

Fonseca-Ornelas L, Schmidt C, Camacho-Zarco AR, Fernandez CO, Becker S, Zweckstetter M.

Chemistry. 2017 Sep 21;23(53):13010-13014. doi: 10.1002/chem.201703001. Epub 2017 Aug 23.

PMID:
28763125
13.

Human cyclophilin 40 unravels neurotoxic amyloids.

Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, Zweckstetter M, Dickey CA, Koren J 3rd, Blair LJ.

PLoS Biol. 2017 Jun 27;15(6):e2001336. doi: 10.1371/journal.pbio.2001336. eCollection 2017 Jun.

14.

Elucidating the structure of an infectious protein.

Zweckstetter M, Requena JR, Wille H.

PLoS Pathog. 2017 Apr 13;13(4):e1006229. doi: 10.1371/journal.ppat.1006229. eCollection 2017 Apr. Review. No abstract available.

15.

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.

Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.

Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.

PMID:
28398476
16.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Apr 5;15(4):e1002601. doi: 10.1371/journal.pbio.1002601. eCollection 2017 Apr.

17.

Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure.

Jaipuria G, Leonov A, Giller K, Vasa SK, Jaremko Ł, Jaremko M, Linser R, Becker S, Zweckstetter M.

Nat Commun. 2017 Mar 30;8:14893. doi: 10.1038/ncomms14893.

18.

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 Apr 5;15(4):e1002601.

19.

Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90.

Oroz J, Kim JH, Chang BJ, Zweckstetter M.

Nat Struct Mol Biol. 2017 Apr;24(4):407-413. doi: 10.1038/nsmb.3380. Epub 2017 Feb 20.

PMID:
28218749
20.

Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation.

Kim JH, Oroz J, Zweckstetter M.

Angew Chem Int Ed Engl. 2016 Dec 23;55(52):16168-16171. doi: 10.1002/anie.201608516. Epub 2016 Nov 25.

PMID:
27885756
21.

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515. Epub 2016 Oct 5.

22.

Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1.

Briones R, Weichbrodt C, Paltrinieri L, Mey I, Villinger S, Giller K, Lange A, Zweckstetter M, Griesinger C, Becker S, Steinem C, de Groot BL.

Biophys J. 2016 Sep 20;111(6):1223-1234. doi: 10.1016/j.bpj.2016.08.007.

23.

High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins.

Jaremko M, Jaremko Ł, Villinger S, Schmidt CD, Griesinger C, Becker S, Zweckstetter M.

Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10518-21. doi: 10.1002/anie.201602639. Epub 2016 Jul 27.

24.

Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus.

Rezaei-Ghaleh N, Kumar S, Walter J, Zweckstetter M.

J Biol Chem. 2016 Jul 29;291(31):16059-67. doi: 10.1074/jbc.M116.728956. Epub 2016 Jun 1.

25.

The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein.

Fonseca-Ornelas L, Zweckstetter M.

Protein Sci. 2016 Aug;25(8):1563-7. doi: 10.1002/pro.2947. Epub 2016 Jun 1.

26.

Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ-3-x -Peptides.

Beyer I, Rezaei-Ghaleh N, Klafki HW, Jahn O, Haußmann U, Wiltfang J, Zweckstetter M, Knölker HJ.

Chemistry. 2016 Jun 13;22(25):8685-93. doi: 10.1002/chem.201600892. Epub 2016 May 11.

27.

Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.

Tatenhorst L, Eckermann K, Dambeck V, Fonseca-Ornelas L, Walle H, Lopes da Fonseca T, Koch JC, Becker S, Tönges L, Bähr M, Outeiro TF, Zweckstetter M, Lingor P.

Acta Neuropathol Commun. 2016 Apr 22;4:39. doi: 10.1186/s40478-016-0310-y.

28.

Phosphorylation modifies the molecular stability of β-amyloid deposits.

Rezaei-Ghaleh N, Amininasab M, Kumar S, Walter J, Zweckstetter M.

Nat Commun. 2016 Apr 13;7:11359. doi: 10.1038/ncomms11359.

29.

Molecular Plasticity of the Human Voltage-Dependent Anion Channel Embedded Into a Membrane.

Ge L, Villinger S, Mari SA, Giller K, Griesinger C, Becker S, Müller DJ, Zweckstetter M.

Structure. 2016 Apr 5;24(4):585-594. doi: 10.1016/j.str.2016.02.012. Epub 2016 Mar 24.

30.

Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.

Akoury E, Mukrasch MD, Biernat J, Tepper K, Ozenne V, Mandelkow E, Blackledge M, Zweckstetter M.

Protein Sci. 2016 May;25(5):1010-20. doi: 10.1002/pro.2911. Epub 2016 Mar 24.

31.

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

Kumar S, Wirths O, Stüber K, Wunderlich P, Koch P, Theil S, Rezaei-Ghaleh N, Zweckstetter M, Bayer TA, Brüstle O, Thal DR, Walter J.

Acta Neuropathol. 2016 Apr;131(4):525-37. doi: 10.1007/s00401-016-1546-0. Epub 2016 Feb 22.

32.

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.

Tenreiro S, Rosado-Ramos R, Gerhardt E, Favretto F, Magalhães F, Popova B, Becker S, Zweckstetter M, Braus GH, Outeiro TF.

Hum Mol Genet. 2016 Jan 15;25(2):275-90. doi: 10.1093/hmg/ddv470. Epub 2015 Nov 18.

PMID:
26586132
33.

Structural Ensembles of Intrinsically Disordered Proteins Depend Strongly on Force Field: A Comparison to Experiment.

Rauscher S, Gapsys V, Gajda MJ, Zweckstetter M, de Groot BL, Grubmüller H.

J Chem Theory Comput. 2015 Nov 10;11(11):5513-24. doi: 10.1021/acs.jctc.5b00736. Epub 2015 Oct 22.

PMID:
26574339
34.

Structure of the mammalian TSPO/PBR protein.

Jaremko M, Jaremko Ł, Jaipuria G, Becker S, Zweckstetter M.

Biochem Soc Trans. 2015 Aug;43(4):566-71. doi: 10.1042/BST20150029. Epub 2015 Aug 3. Review.

PMID:
26551694
35.

Targeting intrinsically disordered proteins in rational drug discovery.

Ambadipudi S, Zweckstetter M.

Expert Opin Drug Discov. 2016;11(1):65-77. doi: 10.1517/17460441.2016.1107041. Epub 2015 Nov 7. Review.

PMID:
26549326
36.

Retention and splicing complex (RES) - the importance of cooperativity.

Wysoczanski P, Zweckstetter M.

RNA Biol. 2016;13(2):128-33. doi: 10.1080/15476286.2015.1096484. Epub 2015 Oct 19.

37.

Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings.

Gapsys V, Narayanan RL, Xiang S, de Groot BL, Zweckstetter M.

J Biomol NMR. 2015 Nov;63(3):299-307. doi: 10.1007/s10858-015-9990-z. Epub 2015 Oct 3.

PMID:
26433382
38.

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells.

Moree B, Yin G, Lázaro DF, Munari F, Strohäker T, Giller K, Becker S, Outeiro TF, Zweckstetter M, Salafsky J.

J Biol Chem. 2015 Nov 13;290(46):27582-93. doi: 10.1074/jbc.M114.636027. Epub 2015 Sep 22.

39.

Conformational Flexibility in the Transmembrane Protein TSPO.

Jaremko Ł, Jaremko M, Giller K, Becker S, Zweckstetter M.

Chemistry. 2015 Nov 9;21(46):16555-63. doi: 10.1002/chem.201502314. Epub 2015 Sep 23.

40.

Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand.

Jaremko M, Jaremko Ł, Giller K, Becker S, Zweckstetter M.

Biomol NMR Assign. 2016 Apr;10(1):79-83. doi: 10.1007/s12104-015-9642-y. Epub 2015 Sep 12.

PMID:
26364056
41.

Structures of intermediates during RES complex assembly.

Wysoczanski P, Becker S, Zweckstetter M.

Sci Rep. 2015 Jul 27;5:12545. doi: 10.1038/srep12545.

42.

Structural Impact of Tau Phosphorylation at Threonine 231.

Schwalbe M, Kadavath H, Biernat J, Ozenne V, Blackledge M, Mandelkow E, Zweckstetter M.

Structure. 2015 Aug 4;23(8):1448-1458. doi: 10.1016/j.str.2015.06.002. Epub 2015 Jul 9.

43.

Folding of the Tau Protein on Microtubules.

Kadavath H, Jaremko M, Jaremko Ł, Biernat J, Mandelkow E, Zweckstetter M.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10347-51. doi: 10.1002/anie.201501714. Epub 2015 Jun 19.

PMID:
26094605
44.

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.

Kadavath H, Hofele RV, Biernat J, Kumar S, Tepper K, Urlaub H, Mandelkow E, Zweckstetter M.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7501-6. doi: 10.1073/pnas.1504081112. Epub 2015 Jun 1.

45.

Lost in translocation: the functions of the 18-kD translocator protein.

Gut P, Zweckstetter M, Banati RB.

Trends Endocrinol Metab. 2015 Jul;26(7):349-56. doi: 10.1016/j.tem.2015.04.001. Epub 2015 May 28. Review.

46.

Structural Integrity of the A147T Polymorph of Mammalian TSPO.

Jaremko M, Jaremko Ł, Giller K, Becker S, Zweckstetter M.

Chembiochem. 2015 Jul 6;16(10):1483-9. doi: 10.1002/cbic.201500217. Epub 2015 Jun 10.

47.

Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding.

Miotto MC, Valiente-Gabioud AA, Rossetti G, Zweckstetter M, Carloni P, Selenko P, Griesinger C, Binolfi A, Fernández CO.

J Am Chem Soc. 2015 May 27;137(20):6444-7. doi: 10.1021/jacs.5b01911. Epub 2015 May 15.

PMID:
25939020
48.

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA.

Hum Mol Genet. 2015 Jul 15;24(14):3971-81. doi: 10.1093/hmg/ddv135. Epub 2015 Apr 16.

49.

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.

Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A.

Acta Neuropathol. 2015 May;129(5):695-713. doi: 10.1007/s00401-015-1408-1. Epub 2015 Mar 17.

50.

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.

Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA.

J Biol Chem. 2015 Apr 10;290(15):9412-27. doi: 10.1074/jbc.M114.610774. Epub 2015 Feb 5.

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