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Items: 42

1.

Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy.

Rumping L, Büttner B, Maier O, Rehmann H, Lequin M, Schlump JU, Schmitt B, Schiebergen-Bronkhorst B, Prinsen HCMT, Losa M, Fingerhut R, Lemke JR, Zwartkruis FJT, Houwen RHJ, Jans JJM, Verhoeven-Duif NM, van Hasselt PM, Jamra R.

JAMA Neurol. 2018 Dec 21. doi: 10.1001/jamaneurol.2018.2941. [Epub ahead of print]

PMID:
30575854
2.

A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization.

Bruurs LJM, van der Net MC, Zwakenberg S, Zwartkruis FJT, Bos JL.

PLoS One. 2018 Nov 8;13(11):e0207159. doi: 10.1371/journal.pone.0207159. eCollection 2018.

3.

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.

Rumping L, Tessadori F, Pouwels PJW, Vringer E, Wijnen JP, Bhogal AA, Savelberg SMC, Duran KJ, Bakkers MJG, Ramos RJJ, Schellekens PAW, Kroes HY, Klomp DWJ, Black GCM, Taylor RL, Bakkers JPW, Prinsen HCMT, van der Knaap MS, Dansen TB, Rehmann H, Zwartkruis FJT, Houwen RHJ, van Haaften G, Verhoeven-Duif NM, Jans JJM, van Hasselt PM.

Hum Mol Genet. 2019 Jan 1;28(1):96-104. doi: 10.1093/hmg/ddy330.

PMID:
30239721
4.

The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size.

Bruurs LJM, van der Net MC, Zwakenberg S, Rosendahl Huber AKM, Post A, Zwartkruis FJ, Bos JL.

Mol Cell Biol. 2018 May 29;38(12). pii: e00102-18. doi: 10.1128/MCB.00102-18. Print 2018 Jun 15.

5.

A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization.

Bruurs LJM, Zwakenberg S, van der Net MC, Zwartkruis FJ, Bos JL.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00547-16. doi: 10.1128/MCB.00547-16. Print 2017 Apr 1.

6.

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.

Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL.

J Cell Biol. 2015 Sep 28;210(7):1055-63. doi: 10.1083/jcb.201505118.

7.

Rheb and mammalian target of rapamycin in mitochondrial homoeostasis.

Groenewoud MJ, Zwartkruis FJ.

Open Biol. 2013 Dec 18;3(12):130185. doi: 10.1098/rsob.130185. Review.

8.

Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.

Groenewoud MJ, Goorden SM, Kassies J, Pellis-van Berkel W, Lamb RF, Elgersma Y, Zwartkruis FJ.

PLoS One. 2013 Nov 26;8(11):e81649. doi: 10.1371/journal.pone.0081649. eCollection 2013.

9.

Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.

Magliozzi R, Low TY, Weijts BG, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJ, Bos JL, de Bruin A, Heck AJ, Guardavaccaro D.

Dev Cell. 2013 Dec 9;27(5):574-85. doi: 10.1016/j.devcel.2013.10.023. Epub 2013 Nov 27.

10.

CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.

De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D, Achsel T, Posthuma D, Smit AB, Bagni C.

Neuron. 2013 Sep 18;79(6):1169-82. doi: 10.1016/j.neuron.2013.06.039.

11.

Rheb and Rags come together at the lysosome to activate mTORC1.

Groenewoud MJ, Zwartkruis FJ.

Biochem Soc Trans. 2013 Aug;41(4):951-5. doi: 10.1042/BST20130037. Review.

PMID:
23863162
12.

Ras and macropinocytosis: trick and treat.

Zwartkruis FJ, Burgering BM.

Cell Res. 2013 Aug;23(8):982-3. doi: 10.1038/cr.2013.79. Epub 2013 Jun 18.

13.

Rap2A links intestinal cell polarity to brush border formation.

Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL.

Nat Cell Biol. 2012 Aug;14(8):793-801. doi: 10.1038/ncb2537. Epub 2012 Jul 15.

PMID:
22797597
14.

Evolution of the TOR pathway.

van Dam TJ, Zwartkruis FJ, Bos JL, Snel B.

J Mol Evol. 2011 Oct;73(3-4):209-20. doi: 10.1007/s00239-011-9469-9. Epub 2011 Nov 5.

15.

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.

Pannekoek WJ, van Dijk JJ, Chan OY, Huveneers S, Linnemann JR, Spanjaard E, Brouwer PM, van der Meer AJ, Zwartkruis FJ, Rehmann H, de Rooij J, Bos JL.

Cell Signal. 2011 Dec;23(12):2056-64. doi: 10.1016/j.cellsig.2011.07.022. Epub 2011 Aug 4.

PMID:
21840392
16.

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.

Eijkelkamp N, Wang H, Garza-Carbajal A, Willemen HL, Zwartkruis FJ, Wood JN, Dantzer R, Kelley KW, Heijnen CJ, Kavelaars A.

J Neurosci. 2010 Sep 22;30(38):12806-15. doi: 10.1523/JNEUROSCI.3142-10.2010.

17.

Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.

Gloerich M, Ponsioen B, Vliem MJ, Zhang Z, Zhao J, Kooistra MR, Price LS, Ritsma L, Zwartkruis FJ, Rehmann H, Jalink K, Bos JL.

Mol Cell Biol. 2010 Nov;30(22):5421-31. doi: 10.1128/MCB.00463-10. Epub 2010 Sep 20.

18.

Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity.

Zemojtel T, Duchniewicz M, Zhang Z, Paluch T, Luz H, Penzkofer T, Scheele JS, Zwartkruis FJ.

BMC Evol Biol. 2010 Feb 19;10:55. doi: 10.1186/1471-2148-10-55.

19.

Rap1, a mercenary among the Ras-like GTPases.

Frische EW, Zwartkruis FJ.

Dev Biol. 2010 Apr 1;340(1):1-9. doi: 10.1016/j.ydbio.2009.12.043. Epub 2010 Jan 7. Review.

20.

Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells.

Geest CR, Zwartkruis FJ, Vellenga E, Coffer PJ, Buitenhuis M.

Haematologica. 2009 Jul;94(7):901-10. doi: 10.3324/haematol.13766. Epub 2009 Jun 16.

21.

Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.

Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL.

Biochim Biophys Acta. 2009 Apr;1788(4):790-6. doi: 10.1016/j.bbamem.2008.12.010. Epub 2008 Dec 29. Review.

22.

Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb.

Rehmann H, Brüning M, Berghaus C, Schwarten M, Köhler K, Stocker H, Stoll R, Zwartkruis FJ, Wittinghofer A.

FEBS Lett. 2008 Sep 3;582(20):3005-10. doi: 10.1016/j.febslet.2008.07.057. Epub 2008 Aug 8.

23.

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8286-91. doi: 10.1073/pnas.0712268105. Epub 2008 Jun 11.

24.

RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.

Frische EW, Pellis-van Berkel W, van Haaften G, Cuppen E, Plasterk RH, Tijsterman M, Bos JL, Zwartkruis FJ.

EMBO J. 2007 Dec 12;26(24):5083-92. Epub 2007 Nov 8.

25.

Biochemistry of the Rap-specific guanine nucleotide exchange factors PDZ-GEF1 and -2.

Kuiperij HB, Rehmann H, Zwartkruis FJ.

Methods Enzymol. 2006;407:174-86.

PMID:
16757323
26.

Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion.

Duchniewicz M, Zemojtel T, Kolanczyk M, Grossmann S, Scheele JS, Zwartkruis FJ.

Mol Cell Biol. 2006 Jan;26(2):643-53.

27.

HRap1B-retro: a novel human processed rap1B gene blurs the picture?

Zemojtel T, Penzkofer T, Duchniewicz M, Zwartkruis FJ.

Leukemia. 2006 Jan;20(1):145-6; author reply 146-7. No abstract available.

PMID:
16307016
28.

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14238-43. Epub 2005 Sep 21.

29.

Regulation of the small GTPase Rheb by amino acids.

Roccio M, Bos JL, Zwartkruis FJ.

Oncogene. 2006 Feb 2;25(5):657-64.

PMID:
16170341
30.

Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP.

Kuiperij HB, van der Horst A, Raaijmakers J, Weijzen S, Medema RH, Bos JL, Burgering BM, Zwartkruis FJ.

Oncogene. 2005 Mar 17;24(12):2087-95.

PMID:
15688004
31.

Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.

Pellis-van Berkel W, Verheijen MH, Cuppen E, Asahina M, de Rooij J, Jansen G, Plasterk RH, Bos JL, Zwartkruis FJ.

Mol Biol Cell. 2005 Jan;16(1):106-16. Epub 2004 Nov 3.

32.

Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes.

Remans PH, Gringhuis SI, van Laar JM, Sanders ME, Papendrecht-van der Voort EA, Zwartkruis FJ, Levarht EW, Rosas M, Coffer PJ, Breedveld FC, Bos JL, Tak PP, Verweij CL, Reedquist KA.

J Immunol. 2004 Jul 15;173(2):920-31.

33.

Rap1 regulates E-cadherin-mediated cell-cell adhesion.

Price LS, Hajdo-Milasinovic A, Zhao J, Zwartkruis FJ, Collard JG, Bos JL.

J Biol Chem. 2004 Aug 20;279(34):35127-32. Epub 2004 May 27.

34.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G.

Mol Cell. 2003 Jun;11(6):1457-66.

35.

The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.

de Bruyn KM, Zwartkruis FJ, de Rooij J, Akkerman JW, Bos JL.

J Biol Chem. 2003 Jun 20;278(25):22412-7. Epub 2003 Apr 10.

36.

Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.

Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ.

Biochim Biophys Acta. 2003 Feb 17;1593(2-3):141-9.

37.

The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

Reedquist KA, Ross E, Koop EA, Wolthuis RM, Zwartkruis FJ, van Kooyk Y, Salmon M, Buckley CD, Bos JL.

J Cell Biol. 2000 Mar 20;148(6):1151-8.

38.

Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways.

Dremier S, Vandeput F, Zwartkruis FJ, Bos JL, Dumont JE, Maenhaut C.

Biochem Biophys Res Commun. 2000 Jan 7;267(1):7-11.

PMID:
10623565
39.

Ras and Rap1: two highly related small GTPases with distinct function.

Zwartkruis FJ, Bos JL.

Exp Cell Res. 1999 Nov 25;253(1):157-65. Review.

PMID:
10579920
40.

Signal transduction. Rhapsody in G proteins.

Bos JL, Zwartkruis FJ.

Nature. 1999 Aug 26;400(6747):820-1. No abstract available.

PMID:
10476955
41.

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL.

Nature. 1998 Dec 3;396(6710):474-7.

PMID:
9853756
42.

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling.

Zwartkruis FJ, Wolthuis RM, Nabben NM, Franke B, Bos JL.

EMBO J. 1998 Oct 15;17(20):5905-12.

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