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Items: 1 to 50 of 168

1.

Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.

Zimmerman JJ, Banks R, Berg RA, Zuppa A, Newth CJ, Wessel D, Pollack MM, Meert KL, Hall MW, Quasney M, Sapru A, Carcillo JA, McQuillen PS, Mourani PM, Wong H, Chima RS, Holubkov R, Coleman W, Sorenson S, Varni JW, McGalliard J, Haaland W, Whitlock K, Dean JM, Reeder RW; Life After Pediatric Sepsis Evaluation (LAPSE) Investigators.

Crit Care Med. 2020 Mar;48(3):329-337. doi: 10.1097/CCM.0000000000004123.

PMID:
32058370
2.

Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.

Zimmerman JJ, Banks R, Berg RA, Zuppa A, Newth CJ, Wessel D, Pollack MM, Meert KL, Hall MW, Quasney M, Sapru A, Carcillo JA, McQuillen PS, Mourani PM, Wong H, Chima RS, Holubkov R, Coleman W, Sorenson S, Varni JW, McGalliard J, Haaland W, Whitlock K, Dean JM, Reeder RW; Life After Pediatric Sepsis Evaluation (LAPSE) Investigators.

Crit Care Med. 2020 Mar;48(3):319-328. doi: 10.1097/CCM.0000000000004122.

PMID:
32058369
3.

Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model.

Pais GM, Liu J, Avedissian SN, Hiner D, Xanthos T, Chalkias A, d'Aloja E, Locci E, Gilchrist A, Prozialeck WC, Rhodes NJ, Lodise TP, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH.

J Antimicrob Chemother. 2020 Feb 3. pii: dkz563. doi: 10.1093/jac/dkz563. [Epub ahead of print]

PMID:
32011685
4.

Structured Chart Review: Assessment of a Structured Chart Review Methodology.

Siems A, Banks R, Holubkov R, Meert KL, Bauerfeld C, Beyda D, Berg RA, Bulut Y, Burd RS, Carcillo J, Dean JM, Gradidge E, Hall MW, McQuillen PS, Mourani PM, Newth CJL, Notterman DA, Priestley MA, Sapru A, Wessel DL, Yates AR, Zuppa AF, Pollack MM.

Hosp Pediatr. 2020 Jan;10(1):61-69. doi: 10.1542/hpeds.2019-0225.

PMID:
31879317
5.

Development and validation of a volumetric absorptive microsampling- liquid chromatography mass spectrometry method for the analysis of cefepime in human whole blood: Application to pediatric pharmacokinetic study.

Moorthy GS, Vedar C, Zane NR, Downes KJ, Prodell JL, DiLiberto MA, Zuppa AF.

J Pharm Biomed Anal. 2020 Feb 5;179:113002. doi: 10.1016/j.jpba.2019.113002. Epub 2019 Nov 20.

PMID:
31785929
6.

Tenofovir urine assay to monitor adherence to HIV pre-exposure prophylaxis (PrEP).

Moorthy GS, Lalley-Chareczko L, Koenig HC, Zuppa AF.

Curr Clin Pharmacol. 2019 Nov 11. doi: 10.2174/1574884714666191111125348. [Epub ahead of print]

PMID:
31713497
7.

A patient-centric liquid chromatography-tandem mass spectrometry microsampling assay for analysis of cannabinoids in human whole blood: Application to pediatric pharmacokinetic study.

Moorthy GS, Vedar C, DiLiberto MA, Zuppa AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Nov 1;1130-1131:121828. doi: 10.1016/j.jchromb.2019.121828. Epub 2019 Oct 21.

PMID:
31670108
8.

Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery.

Zuppa AF, Nicolson SC, Wilder NS, Ibla JC, Gottlieb EA, Burns KM, Stylianou M, Trachtenberg F, Ni H, Skeen TH, Andropoulos DB; Pediatric Heart Network Investigators.

Br J Anaesth. 2019 Dec;123(6):839-852. doi: 10.1016/j.bja.2019.06.026. Epub 2019 Oct 14.

PMID:
31623840
9.

A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure.

Carcillo JA, Berg RA, Wessel D, Pollack M, Meert K, Hall M, Newth C, Lin JC, Doctor A, Shanley T, Cornell T, Harrison RE, Zuppa AF, Reeder RW, Banks R, Kellum JA, Holubkov R, Notterman DA, Dean JM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network.

Pediatr Crit Care Med. 2019 Dec;20(12):1137-1146. doi: 10.1097/PCC.0000000000002105.

PMID:
31568246
10.

Platelet Transfusion Practice and Related Outcomes in Pediatric Extracorporeal Membrane Oxygenation.

Cashen K, Dalton H, Reeder RW, Saini A, Zuppa AF, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Dean JM, Meert KL; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).

Pediatr Crit Care Med. 2020 Feb;21(2):178-185. doi: 10.1097/PCC.0000000000002102.

PMID:
31568245
11.

Mechanisms of antimicrobial-induced nephrotoxicity in children.

Downes KJ, Hayes M, Fitzgerald JC, Pais GM, Liu J, Zane NR, Goldstein SL, Scheetz MH, Zuppa AF.

J Antimicrob Chemother. 2020 Jan 1;75(1):1-13. doi: 10.1093/jac/dkz325.

PMID:
31369087
12.

Pharmacokinetics of vaginal progesterone in pregnancy.

Boelig RC, Zuppa AF, Kraft WK, Caritis S.

Am J Obstet Gynecol. 2019 Sep;221(3):263.e1-263.e7. doi: 10.1016/j.ajog.2019.06.019. Epub 2019 Jun 15.

PMID:
31211965
13.

The association of immediate post cardiac arrest diastolic hypertension and survival following pediatric cardiac arrest.

Topjian AA, Sutton RM, Reeder RW, Telford R, Meert KL, Yates AR, Morgan RW, Berger JT, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Notterman DA, Holubkov R, Dean JM, Nadkarni VM, Berg RA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) Investigators, Zuppa AF, Graham K, Twelves C, Diliberto MA, Landis WP, Tomanio E, Kwok J, Bell MJ, Abraham A, Sapru A, Alkhouli MF, Heidemann S, Pawluszka A, Hall MW, Steele L, Shanley TP, Weber M, Dalton HJ, Bell A, Mourani PM, Malone K, Locandro C, Coleman W, Peterson A, Thelen J, Doctor A.

Resuscitation. 2019 Aug;141:88-95. doi: 10.1016/j.resuscitation.2019.05.033. Epub 2019 Jun 6.

PMID:
31176666
14.

Brain abscess of odontogenic origin in children: a systematic review of the literature with emphasis on therapeutic aspects and a new case presentation.

Lajolo C, Favia G, Limongelli L, Tempesta A, Zuppa A, Cordaro M, Vanella I, Giuliani M.

Acta Otorhinolaryngol Ital. 2019 Apr;39(2):67-74. doi: 10.14639/0392-100X-2281. Review.

15.

Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury.

Pais GM, Avedissian SN, O'Donnell JN, Rhodes NJ, Lodise TP, Prozialeck WC, Lamar PC, Cluff C, Gulati A, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00079-19. doi: 10.1128/AAC.00079-19. Print 2019 Jul.

16.

Morphine Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

Zuppa AF, Benitez GR, Zane NR, Curley MAQ, Bradfield J, Hakonarson H, Gastonguay MS, Moorthy G, Prodell J, Gastonguay MR.

Crit Care Med. 2019 Jun;47(6):e485-e494. doi: 10.1097/CCM.0000000000003741.

PMID:
30920410
17.

Vancomycin Prescribing and Therapeutic Drug Monitoring in Children With and Without Acute Kidney Injury After Cardiac Arrest.

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF.

Paediatr Drugs. 2019 Apr;21(2):107-112. doi: 10.1007/s40272-019-00328-8.

PMID:
30864056
18.

Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

Zuppa AF, Conrado DJ, Zane NR, Curley MAQ, Bradfield J, Hakonarson H, Gastonguay MS, Moorthy G, Prodell J, Gastonguay MR.

Crit Care Med. 2019 Apr;47(4):e301-e309. doi: 10.1097/CCM.0000000000003638.

PMID:
30672747
19.

Development of the Pediatric Extracorporeal Membrane Oxygenation Prediction Model for Risk-Adjusting Mortality.

Bailly DK, Reeder RW, Winder M, Barbaro RP, Pollack MM, Moler FW, Meert KL, Berg RA, Carcillo J, Zuppa AF, Newth C, Berger J, Bell MJ, Dean MJ, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Bratton SL, Dalton H; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN).

Pediatr Crit Care Med. 2019 May;20(5):426-434. doi: 10.1097/PCC.0000000000001882.

PMID:
30664590
20.

An improved ultra-high-performance liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in small volume of pediatric plasma.

Moorthy GS, Vedar C, Moorthy AS, Prodell JL, Zuppa AF.

Biomed Chromatogr. 2019 Jun;33(6):e4487. doi: 10.1002/bmc.4487. Epub 2019 Feb 7.

PMID:
30664276
21.

Development and validation of a volumetric absorptive microsampling assay for analysis of voriconazole and voriconazole N-oxide in human whole blood.

Moorthy GS, Vedar C, Zane N, Prodell JL, Zuppa AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 15;1105:67-75. doi: 10.1016/j.jchromb.2018.12.007. Epub 2018 Dec 8.

PMID:
30572203
22.

A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.

Zuppa AF, Zane NR, Moorthy G, Dalton HJ, Abraham A, Reeder RW, Carcillo JA, Yates AR, Meert KL, Berg RA, Sapru A, Mourani P, Notterman DA, Dean JM, Gastonguay MR; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).

Pediatr Crit Care Med. 2019 Jan;20(1):62-70. doi: 10.1097/PCC.0000000000001786.

23.

Use of Intravenous Acetaminophen in Children for Analgesia After Spinal Fusion Surgery: A Randomized Clinical Trial.

Rizkalla N, Zane NR, Prodell JL, Elci OU, Maxwell LG, DiLiberto MA, Zuppa AF.

J Pediatr Pharmacol Ther. 2018 Sep-Oct;23(5):395-404. doi: 10.5863/1551-6776-23.5.395.

24.

Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans.

Torgersen J, Bellamy SL, Ratshaa B, Han X, Mosepele M, Zuppa AF, Vujkovic M, Steenhoff AP, Bisson GP, Gross R.

Eur J Drug Metab Pharmacokinet. 2019 Apr;44(2):179-187. doi: 10.1007/s13318-018-0507-5.

PMID:
30168000
25.

Mother-to-child transmission of hepatitis C virus.

Compagnone A, Catenazzi P, Riccardi R, Zuppa AA.

Minerva Pediatr. 2019 Apr;71(2):174-180. doi: 10.23736/S0026-4946.18.04898-3. Epub 2018 Jul 2. Review.

PMID:
29968442
26.

Delivery of TDF/FTC for Pre-exposure Prophylaxis to Prevent HIV-1 Acquisition in Young Adult Men Who Have Sex With Men and Transgender Women of Color Using a Urine Adherence Assay.

Lalley-Chareczko L, Clark D, Conyngham C, Zuppa A, Moorthy G, Mounzer K, Koenig H.

J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):173-178. doi: 10.1097/QAI.0000000000001772.

PMID:
29905593
27.

Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana.

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay MR, Moorthy GS, Ratshaa B, Han X, Steenhoff AP, Mosepele M, Strom BL, Bisson GP, Aplenc R, Gross R.

Pharmacogenomics J. 2018 Sep;18(5):678-688. doi: 10.1038/s41397-018-0028-2. Epub 2018 Jun 1.

28.

Face and content validity of variables associated with the difficult-to-sedate child in the paediatric intensive care unit: A survey of paediatric critical care clinicians.

Lebet RM, Asaro LA, Zuppa AF, Curley MAQ.

Aust Crit Care. 2018 May;31(3):167-173. doi: 10.1016/j.aucc.2017.12.091. Epub 2018 Mar 19.

29.

Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling.

Elia J, Ungal G, Kao C, Ambrosini A, De Jesus-Rosario N, Larsen L, Chiavacci R, Wang T, Kurian C, Titchen K, Sykes B, Hwang S, Kumar B, Potts J, Davis J, Malatack J, Slattery E, Moorthy G, Zuppa A, Weller A, Byrne E, Li YR, Kraft WK, Hakonarson H.

Nat Commun. 2018 Jan 16;9(1):4. doi: 10.1038/s41467-017-02244-2.

30.

Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice.

Chikara S, Mamidi S, Sreedasyam A, Chittem K, Pietrofesa R, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM.

Cancer Prev Res (Phila). 2018 Jan;11(1):27-37. doi: 10.1158/1940-6207.CAPR-17-0119. Epub 2017 Oct 26.

31.

Development and validation of a sensitive assay for analysis of midazolam, free and conjugated 1-hydroxymidazolam and 4-hydroxymidazolam in pediatric plasma: Application to Pediatric Pharmacokinetic Study.

Moorthy GS, Jogiraju H, Vedar C, Zuppa AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 1;1067:1-9. doi: 10.1016/j.jchromb.2017.09.030. Epub 2017 Sep 28.

32.

Ketamine and norketamine stability in whole blood at ambient and 4°C conditions.

Tran BD, Moorthy GS, Zuppa AF.

Biomed Chromatogr. 2018 Mar;32(3). doi: 10.1002/bmc.4104. Epub 2017 Nov 9.

33.

Sedation Analgesia and Neuromuscular Blockade in Pediatric Critical Care: Overview and Current Landscape.

Zuppa AF, Curley MAQ.

Pediatr Clin North Am. 2017 Oct;64(5):1103-1116. doi: 10.1016/j.pcl.2017.06.013. Epub 2017 Aug 18. Review.

PMID:
28941538
34.

CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.

Gross R, Bellamy SL, Ratshaa B, Han X, Vujkovic M, Aplenc R, Steenhoff AP, Mosepele M, Moorthy G, Zuppa AF, Strom BL, Bisson GP.

AIDS. 2017 Sep 24;31(15):2107-2113. doi: 10.1097/QAD.0000000000001593.

35.

A Population Pharmacokinetic Analysis to Study the Effect of Therapeutic Hypothermia on Vancomycin Disposition in Children Resuscitated From Cardiac Arrest.

Zane NR, Reedy MD, Gastonguay MR, Himebauch AS, Ramsey EZ, Topjian AA, Zuppa AF.

Pediatr Crit Care Med. 2017 Jul;18(7):e290-e297. doi: 10.1097/PCC.0000000000001198.

36.

Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana.

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay M, Moorthy GS, Ratshaa BR, Han X, Steenhoff AP, Mosepele M, Strom BL, Aplenc R, Bisson GP, Gross R.

J Acquir Immune Defic Syndr. 2017 Aug 1;75(4):488-491. doi: 10.1097/QAI.0000000000001442.

37.

Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis.

Koenig HC, Mounzer K, Daughtridge GW, Sloan CE, Lalley-Chareczko L, Moorthy GS, Conyngham SC, Zuppa AF, Montaner LJ, Tebas P.

HIV Med. 2017 Jul;18(6):412-418. doi: 10.1111/hiv.12518. Epub 2017 Apr 26.

38.

Neonatal neurological examination during the first 6h after birth.

Romeo DM, Bompard S, Cocca C, Serrao F, De Carolis MP, Zuppa AA, Ricci D, Gallini F, Maddaloni C, Romagnoli C, Mercuri E.

Early Hum Dev. 2017 May;108:41-44. doi: 10.1016/j.earlhumdev.2017.03.013. Epub 2017 Apr 5.

PMID:
28390243
39.

Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation.

Dalton HJ, Reeder R, Garcia-Filion P, Holubkov R, Berg RA, Zuppa A, Moler FW, Shanley T, Pollack MM, Newth C, Berger J, Wessel D, Carcillo J, Bell M, Heidemann S, Meert KL, Harrison R, Doctor A, Tamburro RF, Dean JM, Jenkins T, Nicholson C; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):762-771. doi: 10.1164/rccm.201609-1945OC.

40.

A case study of chewed Truvada® for PrEP maintaining protective drug levels as measured by a novel urine tenofovir assay.

Lalley-Chareczko L, Clark D, Zuppa AF, Moorthy G, Conyngham C, Mounzer K, Koenig H.

Antivir Ther. 2017;22(7):639-641. doi: 10.3851/IMP3151. Epub 2017 Mar 6.

PMID:
28260694
41.

Neonatal lupus: Follow-up in infants with anti-SSA/Ro antibodies and review of the literature.

Zuppa AA, Riccardi R, Frezza S, Gallini F, Luciano RM, Alighieri G, Romagnoli C, De Carolis S.

Autoimmun Rev. 2017 Apr;16(4):427-432. doi: 10.1016/j.autrev.2017.02.010. Epub 2017 Feb 14. Review.

PMID:
28212920
42.

Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.

Darwich AS, Ogungbenro K, Vinks AA, Powell JR, Reny JL, Marsousi N, Daali Y, Fairman D, Cook J, Lesko LJ, McCune JS, Knibbe C, de Wildt SN, Leeder JS, Neely M, Zuppa AF, Vicini P, Aarons L, Johnson TN, Boiani J, Rostami-Hodjegan A.

Clin Pharmacol Ther. 2017 May;101(5):646-656. doi: 10.1002/cpt.659. Epub 2017 Apr 4. Review.

PMID:
28182269
43.

Perfusion Index and Pulse Oximetry Screening for Congenital Heart Defects.

Schena F, Picciolli I, Agosti M, Zuppa AA, Zuccotti G, Parola L, Pomero G, Stival G, Markart M, Graziani S, Gagliardi L, Bellan C, La Placa S, Limoli G, Calzetti G, Guala A, Bonello E, Mosca F; Neonatal Cardiology Study Group of the Italian Society of Neonatology.

J Pediatr. 2017 Apr;183:74-79.e1. doi: 10.1016/j.jpeds.2016.12.076. Epub 2017 Jan 30.

PMID:
28153478
44.

Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn.

Giaccone A, Zuppa AF, Sood B, Cohen MS, O'Byrne ML, Moorthy G, Mathur A, Kirpalani H.

Am J Perinatol. 2017 Jul;34(8):749-758. doi: 10.1055/s-0036-1597996. Epub 2017 Jan 18.

45.

Dexmedetomidine does not interfere with meta-iodobenzylguanidine (MIBG) uptake at clinically relevant concentrations.

Batra V, Makvandi M, Zuppa AF, Patel N, Elias J, Pryma DA, Maris JM.

Pediatr Blood Cancer. 2017 Apr;64(4). doi: 10.1002/pbc.26268. Epub 2016 Sep 22.

PMID:
27654664
46.

Pharmacotherapy during pediatric extracorporeal membrane oxygenation: a review.

Himebauch AS, Kilbaugh TJ, Zuppa AF.

Expert Opin Drug Metab Toxicol. 2016 Oct;12(10):1133-42. doi: 10.1080/17425255.2016.1201066. Epub 2016 Jul 1. Review.

PMID:
27322360
47.

Skeletal muscle and plasma concentrations of cefazolin during complex paediatric spinal surgery.

Himebauch AS, Sankar WN, Flynn JM, Sisko MT, Moorthy GS, Gerber JS, Zuppa AF, Fox E, Dormans JP, Kilbaugh TJ.

Br J Anaesth. 2016 Jul;117(1):87-94. doi: 10.1093/bja/aew032.

48.

Efficacy of a galactogogue containing silymarin-phosphatidylserine and galega in mothers of preterm infants: a randomized controlled trial.

Zecca E, Zuppa AA, D'Antuono A, Tiberi E, Giordano L, Pianini T, Romagnoli C.

Eur J Clin Nutr. 2016 Oct;70(10):1151-1154. doi: 10.1038/ejcn.2016.86. Epub 2016 Jun 1.

PMID:
27245206
49.

Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7.

Ruocco N, Varrella S, Romano G, Ianora A, Bentley MG, Somma D, Leonardi A, Mellone S, Zuppa A, Costantini M.

Aquat Toxicol. 2016 Jul;176:128-40. doi: 10.1016/j.aquatox.2016.04.012. Epub 2016 Apr 22.

PMID:
27130972
50.

Epidemiology of Polypharmacy and Potential Drug-Drug Interactions Among Pediatric Patients in ICUs of U.S. Children's Hospitals.

Dai D, Feinstein JA, Morrison W, Zuppa AF, Feudtner C.

Pediatr Crit Care Med. 2016 May;17(5):e218-28. doi: 10.1097/PCC.0000000000000684.

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