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Pharmacokinetics of Vaginal Progesterone in Pregnancy.

Boelig RC, Zuppa AF, Kraft WK, Caritis S.

Am J Obstet Gynecol. 2019 Jun 15. pii: S0002-9378(19)30783-5. doi: 10.1016/j.ajog.2019.06.019. [Epub ahead of print]


The association of immediate post cardiac arrest diastolic hypertension and survival following pediatric cardiac arrest.

Topjian AA, Sutton RM, Reeder RW, Telford R, Meert KL, Yates AR, Morgan RW, Berger JT, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Notterman DA, Holubkov R, Dean JM, Nadkarni VM, Berg RA, Zuppa AF, Graham K, Twelves C, Diliberto MA, Landis WP, Tomanio E, Kwok J, Bell MJ, Abraham A, Sapru A, Alkhouli MF, Heidemann S, Pawluszka A, Hall MW, Steele L, Shanley TP, Weber M, Dalton HJ, Bell A, Mourani PM, Malone K, Locandro C, Coleman W, Peterson A, Thelen J, Doctor A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) Investigators.

Resuscitation. 2019 Jun 6;141:88-95. doi: 10.1016/j.resuscitation.2019.05.033. [Epub ahead of print]


Brain abscess of odontogenic origin in children: a systematic review of the literature with emphasis on therapeutic aspects and a new case presentation.

Lajolo C, Favia G, Limongelli L, Tempesta A, Zuppa A, Cordaro M, Vanella I, Giuliani M.

Acta Otorhinolaryngol Ital. 2019 Apr;39(2):67-74. doi: 10.14639/0392-100X-2281. Review.


Comparative performance of urinary biomarkers for vancomycin induced kidney injury according to timeline of injury.

Pais GM, Avedissian SN, O'Donnell JN, Rhodes NJ, Lodise TP, Prozialeck WC, Lamar PC, Cluff C, Gulati A, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH.

Antimicrob Agents Chemother. 2019 Apr 15. pii: AAC.00079-19. doi: 10.1128/AAC.00079-19. [Epub ahead of print]


Morphine Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

Zuppa AF, Benitez GR, Zane NR, Curley MAQ, Bradfield J, Hakonarson H, Gastonguay MS, Moorthy G, Prodell J, Gastonguay MR.

Crit Care Med. 2019 Jun;47(6):e485-e494. doi: 10.1097/CCM.0000000000003741.


Vancomycin Prescribing and Therapeutic Drug Monitoring in Children With and Without Acute Kidney Injury After Cardiac Arrest.

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF.

Paediatr Drugs. 2019 Apr;21(2):107-112. doi: 10.1007/s40272-019-00328-8.


Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

Zuppa AF, Conrado DJ, Zane NR, Curley MAQ, Bradfield J, Hakonarson H, Gastonguay MS, Moorthy G, Prodell J, Gastonguay MR.

Crit Care Med. 2019 Apr;47(4):e301-e309. doi: 10.1097/CCM.0000000000003638.


Development of the Pediatric Extracorporeal Membrane Oxygenation Prediction Model for Risk-Adjusting Mortality.

Bailly DK, Reeder RW, Winder M, Barbaro RP, Pollack MM, Moler FW, Meert KL, Berg RA, Carcillo J, Zuppa AF, Newth C, Berger J, Bell MJ, Dean MJ, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Bratton SL, Dalton H; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN).

Pediatr Crit Care Med. 2019 May;20(5):426-434. doi: 10.1097/PCC.0000000000001882.


An improved ultra-high-performance liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in small volume of pediatric plasma.

Moorthy GS, Vedar C, Moorthy AS, Prodell JL, Zuppa AF.

Biomed Chromatogr. 2019 Jun;33(6):e4487. doi: 10.1002/bmc.4487. Epub 2019 Feb 7.


Development and validation of a volumetric absorptive microsampling assay for analysis of voriconazole and voriconazole N-oxide in human whole blood.

Moorthy GS, Vedar C, Zane N, Prodell JL, Zuppa AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 15;1105:67-75. doi: 10.1016/j.jchromb.2018.12.007. Epub 2018 Dec 8.


A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.

Zuppa AF, Zane NR, Moorthy G, Dalton HJ, Abraham A, Reeder RW, Carcillo JA, Yates AR, Meert KL, Berg RA, Sapru A, Mourani P, Notterman DA, Dean JM, Gastonguay MR; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).

Pediatr Crit Care Med. 2019 Jan;20(1):62-70. doi: 10.1097/PCC.0000000000001786.


Use of Intravenous Acetaminophen in Children for Analgesia After Spinal Fusion Surgery: A Randomized Clinical Trial.

Rizkalla N, Zane NR, Prodell JL, Elci OU, Maxwell LG, DiLiberto MA, Zuppa AF.

J Pediatr Pharmacol Ther. 2018 Sep-Oct;23(5):395-404. doi: 10.5863/1551-6776-23.5.395.


Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans.

Torgersen J, Bellamy SL, Ratshaa B, Han X, Mosepele M, Zuppa AF, Vujkovic M, Steenhoff AP, Bisson GP, Gross R.

Eur J Drug Metab Pharmacokinet. 2019 Apr;44(2):179-187. doi: 10.1007/s13318-018-0507-5.


Mother-to-child transmission of hepatitis C virus.

Compagnone A, Catenazzi P, Riccardi R, Zuppa AA.

Minerva Pediatr. 2019 Apr;71(2):174-180. doi: 10.23736/S0026-4946.18.04898-3. Epub 2018 Jul 2. Review.


Delivery of TDF/FTC for Pre-exposure Prophylaxis to Prevent HIV-1 Acquisition in Young Adult Men Who Have Sex With Men and Transgender Women of Color Using a Urine Adherence Assay.

Lalley-Chareczko L, Clark D, Conyngham C, Zuppa A, Moorthy G, Mounzer K, Koenig H.

J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):173-178. doi: 10.1097/QAI.0000000000001772.


Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana.

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay MR, Moorthy GS, Ratshaa B, Han X, Steenhoff AP, Mosepele M, Strom BL, Bisson GP, Aplenc R, Gross R.

Pharmacogenomics J. 2018 Sep;18(5):678-688. doi: 10.1038/s41397-018-0028-2. Epub 2018 Jun 1.


Face and content validity of variables associated with the difficult-to-sedate child in the paediatric intensive care unit: A survey of paediatric critical care clinicians.

Lebet RM, Asaro LA, Zuppa AF, Curley MAQ.

Aust Crit Care. 2018 May;31(3):167-173. doi: 10.1016/j.aucc.2017.12.091. Epub 2018 Mar 19.


Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling.

Elia J, Ungal G, Kao C, Ambrosini A, De Jesus-Rosario N, Larsen L, Chiavacci R, Wang T, Kurian C, Titchen K, Sykes B, Hwang S, Kumar B, Potts J, Davis J, Malatack J, Slattery E, Moorthy G, Zuppa A, Weller A, Byrne E, Li YR, Kraft WK, Hakonarson H.

Nat Commun. 2018 Jan 16;9(1):4. doi: 10.1038/s41467-017-02244-2.


Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice.

Chikara S, Mamidi S, Sreedasyam A, Chittem K, Pietrofesa R, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM.

Cancer Prev Res (Phila). 2018 Jan;11(1):27-37. doi: 10.1158/1940-6207.CAPR-17-0119. Epub 2017 Oct 26.


Development and validation of a sensitive assay for analysis of midazolam, free and conjugated 1-hydroxymidazolam and 4-hydroxymidazolam in pediatric plasma: Application to Pediatric Pharmacokinetic Study.

Moorthy GS, Jogiraju H, Vedar C, Zuppa AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 1;1067:1-9. doi: 10.1016/j.jchromb.2017.09.030. Epub 2017 Sep 28.


Ketamine and norketamine stability in whole blood at ambient and 4°C conditions.

Tran BD, Moorthy GS, Zuppa AF.

Biomed Chromatogr. 2018 Mar;32(3). doi: 10.1002/bmc.4104. Epub 2017 Nov 9.


Sedation Analgesia and Neuromuscular Blockade in Pediatric Critical Care: Overview and Current Landscape.

Zuppa AF, Curley MAQ.

Pediatr Clin North Am. 2017 Oct;64(5):1103-1116. doi: 10.1016/j.pcl.2017.06.013. Epub 2017 Aug 18. Review.


CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.

Gross R, Bellamy SL, Ratshaa B, Han X, Vujkovic M, Aplenc R, Steenhoff AP, Mosepele M, Moorthy G, Zuppa AF, Strom BL, Bisson GP.

AIDS. 2017 Sep 24;31(15):2107-2113. doi: 10.1097/QAD.0000000000001593.


A Population Pharmacokinetic Analysis to Study the Effect of Therapeutic Hypothermia on Vancomycin Disposition in Children Resuscitated From Cardiac Arrest.

Zane NR, Reedy MD, Gastonguay MR, Himebauch AS, Ramsey EZ, Topjian AA, Zuppa AF.

Pediatr Crit Care Med. 2017 Jul;18(7):e290-e297. doi: 10.1097/PCC.0000000000001198.


Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana.

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay M, Moorthy GS, Ratshaa BR, Han X, Steenhoff AP, Mosepele M, Strom BL, Aplenc R, Bisson GP, Gross R.

J Acquir Immune Defic Syndr. 2017 Aug 1;75(4):488-491. doi: 10.1097/QAI.0000000000001442.


Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis.

Koenig HC, Mounzer K, Daughtridge GW, Sloan CE, Lalley-Chareczko L, Moorthy GS, Conyngham SC, Zuppa AF, Montaner LJ, Tebas P.

HIV Med. 2017 Jul;18(6):412-418. doi: 10.1111/hiv.12518. Epub 2017 Apr 26.


Neonatal neurological examination during the first 6h after birth.

Romeo DM, Bompard S, Cocca C, Serrao F, De Carolis MP, Zuppa AA, Ricci D, Gallini F, Maddaloni C, Romagnoli C, Mercuri E.

Early Hum Dev. 2017 May;108:41-44. doi: 10.1016/j.earlhumdev.2017.03.013. Epub 2017 Apr 5.


Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation.

Dalton HJ, Reeder R, Garcia-Filion P, Holubkov R, Berg RA, Zuppa A, Moler FW, Shanley T, Pollack MM, Newth C, Berger J, Wessel D, Carcillo J, Bell M, Heidemann S, Meert KL, Harrison R, Doctor A, Tamburro RF, Dean JM, Jenkins T, Nicholson C; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):762-771. doi: 10.1164/rccm.201609-1945OC.


A case study of chewed Truvada® for PrEP maintaining protective drug levels as measured by a novel urine tenofovir assay.

Lalley-Chareczko L, Clark D, Zuppa AF, Moorthy G, Conyngham C, Mounzer K, Koenig H.

Antivir Ther. 2017;22(7):639-641. doi: 10.3851/IMP3151. Epub 2017 Mar 6.


Neonatal lupus: Follow-up in infants with anti-SSA/Ro antibodies and review of the literature.

Zuppa AA, Riccardi R, Frezza S, Gallini F, Luciano RM, Alighieri G, Romagnoli C, De Carolis S.

Autoimmun Rev. 2017 Apr;16(4):427-432. doi: 10.1016/j.autrev.2017.02.010. Epub 2017 Feb 14. Review.


Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.

Darwich AS, Ogungbenro K, Vinks AA, Powell JR, Reny JL, Marsousi N, Daali Y, Fairman D, Cook J, Lesko LJ, McCune JS, Knibbe C, de Wildt SN, Leeder JS, Neely M, Zuppa AF, Vicini P, Aarons L, Johnson TN, Boiani J, Rostami-Hodjegan A.

Clin Pharmacol Ther. 2017 May;101(5):646-656. doi: 10.1002/cpt.659. Epub 2017 Apr 4. Review.


Perfusion Index and Pulse Oximetry Screening for Congenital Heart Defects.

Schena F, Picciolli I, Agosti M, Zuppa AA, Zuccotti G, Parola L, Pomero G, Stival G, Markart M, Graziani S, Gagliardi L, Bellan C, La Placa S, Limoli G, Calzetti G, Guala A, Bonello E, Mosca F; Neonatal Cardiology Study Group of the Italian Society of Neonatology.

J Pediatr. 2017 Apr;183:74-79.e1. doi: 10.1016/j.jpeds.2016.12.076. Epub 2017 Jan 30.


Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn.

Giaccone A, Zuppa AF, Sood B, Cohen MS, O'Byrne ML, Moorthy G, Mathur A, Kirpalani H.

Am J Perinatol. 2017 Jul;34(8):749-758. doi: 10.1055/s-0036-1597996. Epub 2017 Jan 18.


Dexmedetomidine does not interfere with meta-iodobenzylguanidine (MIBG) uptake at clinically relevant concentrations.

Batra V, Makvandi M, Zuppa AF, Patel N, Elias J, Pryma DA, Maris JM.

Pediatr Blood Cancer. 2017 Apr;64(4). doi: 10.1002/pbc.26268. Epub 2016 Sep 22.


Pharmacotherapy during pediatric extracorporeal membrane oxygenation: a review.

Himebauch AS, Kilbaugh TJ, Zuppa AF.

Expert Opin Drug Metab Toxicol. 2016 Oct;12(10):1133-42. doi: 10.1080/17425255.2016.1201066. Epub 2016 Jul 1. Review.


Skeletal muscle and plasma concentrations of cefazolin during complex paediatric spinal surgery.

Himebauch AS, Sankar WN, Flynn JM, Sisko MT, Moorthy GS, Gerber JS, Zuppa AF, Fox E, Dormans JP, Kilbaugh TJ.

Br J Anaesth. 2016 Jul;117(1):87-94. doi: 10.1093/bja/aew032.


Efficacy of a galactogogue containing silymarin-phosphatidylserine and galega in mothers of preterm infants: a randomized controlled trial.

Zecca E, Zuppa AA, D'Antuono A, Tiberi E, Giordano L, Pianini T, Romagnoli C.

Eur J Clin Nutr. 2016 Oct;70(10):1151-1154. doi: 10.1038/ejcn.2016.86. Epub 2016 Jun 1.


Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7.

Ruocco N, Varrella S, Romano G, Ianora A, Bentley MG, Somma D, Leonardi A, Mellone S, Zuppa A, Costantini M.

Aquat Toxicol. 2016 Jul;176:128-40. doi: 10.1016/j.aquatox.2016.04.012. Epub 2016 Apr 22.


Epidemiology of Polypharmacy and Potential Drug-Drug Interactions Among Pediatric Patients in ICUs of U.S. Children's Hospitals.

Dai D, Feinstein JA, Morrison W, Zuppa AF, Feudtner C.

Pediatr Crit Care Med. 2016 May;17(5):e218-28. doi: 10.1097/PCC.0000000000000684.


Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs.

Berg RA, Nadkarni VM, Clark AE, Moler F, Meert K, Harrison RE, Newth CJ, Sutton RM, Wessel DL, Berger JT, Carcillo J, Dalton H, Heidemann S, Shanley TP, Zuppa AF, Doctor A, Tamburro RF, Jenkins TL, Dean JM, Holubkov R, Pollack MM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network.

Crit Care Med. 2016 Apr;44(4):798-808. doi: 10.1097/CCM.0000000000001484.


Special population considerations and regulatory affairs for clinical research.

Grimsrud KN, Sherwin CM, Constance JE, Tak C, Zuppa AF, Spigarelli MG, Mihalopoulos NL.

Clin Res Regul Aff. 2015;32(2):47-56.


A pilot and feasibility study of the plasma and tissue pharmacokinetics of cefazolin in an immature porcine model of pediatric cardiac surgery.

Kilbaugh TJ, Himebauch AS, Zaoutis T, Jobes D, Greeley WJ, Nicolson SC, Zuppa AF.

Paediatr Anaesth. 2015 Nov;25(11):1111-9. doi: 10.1111/pan.12756. Epub 2015 Sep 15.


Dexmedetomidine Pharmacology in Neonates and Infants After Open Heart Surgery.

Su F, Gastonguay MR, Nicolson SC, DiLiberto M, Ocampo-Pelland A, Zuppa AF.

Anesth Analg. 2016 May;122(5):1556-66. doi: 10.1213/ANE.0000000000000869.


Diagnostic accuracy of heart murmur in newborns with suspected congenital heart disease.

Brunetti ND, Rosania S, D'Antuono C, D'Antuono A, De Gennaro L, Zuppa AA, Di Biase M.

J Cardiovasc Med (Hagerstown). 2015 Aug;16(8):556-61. doi: 10.2459/JCM.0b013e3283649953.


Intraoperative dexmedetomidine reduces postoperative mechanical ventilation in infants after open heart surgery.

Achuff BJ, Nicolson SC, Elci OU, Zuppa AF.

Pediatr Crit Care Med. 2015 Jun;16(5):440-7. doi: 10.1097/PCC.0000000000000382.


Population pharmacokinetics of ϵ-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery.

Stricker PA, Gastonguay MR, Singh D, Fiadjoe JE, Sussman EM, Pruitt EY, Goebel TK, Zuppa AF.

Br J Anaesth. 2015 Apr;114(4):689-99. doi: 10.1093/bja/aeu459. Epub 2015 Jan 13.


Epidural analgesia, neonatal care and breastfeeding.

Zuppa AA, Alighieri G, Riccardi R, Cavani M, Iafisco A, Cota F, Romagnoli C.

Ital J Pediatr. 2014 Nov 29;40:82. doi: 10.1186/s13052-014-0082-6.


Skeletal muscle and plasma concentrations of cefazolin during cardiac surgery in infants.

Himebauch AS, Nicolson SC, Sisko M, Moorthy G, Fuller S, Gaynor JW, Zuppa AF, Fox E, Kilbaugh TJ.

J Thorac Cardiovasc Surg. 2014 Dec;148(6):2634-41. doi: 10.1016/j.jtcvs.2014.06.064. Epub 2014 Jul 22.


Individualized follow up programme and early discharge in term neonates.

De Carolis MP, Cocca C, Valente E, Lacerenza S, Rubortone SA, Zuppa AA, Romagnoli C.

Ital J Pediatr. 2014 Jul 15;40:70. doi: 10.1186/1824-7288-40-70.


Comparative sequence analysis of bacterial symbionts from the marine sponges Geodia cydonium and Ircinia muscarum.

Zuppa A, Costantini S, Costantini M.

Bioinformation. 2014 Apr 23;10(4):196-200. doi: 10.6026/97320630010196. eCollection 2014.

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