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Items: 1 to 50 of 61

1.

Glucocorticoid Resistance: Is It a Requisite for Increased Cytokine Production in Depression? A Systematic Review and Meta-Analysis.

Perrin AJ, Horowitz MA, Roelofs J, Zunszain PA, Pariante CM.

Front Psychiatry. 2019 Jun 28;10:423. doi: 10.3389/fpsyt.2019.00423. eCollection 2019.

2.

The role of circulatory systemic environment in predicting interferon-alpha-induced depression: The neurogenic process as a potential mechanism.

Borsini A, Pariante CM, Zunszain PA, Hepgul N, Russell A, Zajkowska Z, Mondelli V, Thuret S.

Brain Behav Immun. 2019 Jun 14. pii: S0889-1591(19)30179-5. doi: 10.1016/j.bbi.2019.06.018. [Epub ahead of print]

3.

Persistent fatigue induced by interferon-alpha: a novel, inflammation-based, proxy model of chronic fatigue syndrome.

Russell A, Hepgul N, Nikkheslat N, Borsini A, Zajkowska Z, Moll N, Forton D, Agarwal K, Chalder T, Mondelli V, Hotopf M, Cleare A, Murphy G, Foster G, Wong T, Schütze GA, Schwarz MJ, Harrison N, Zunszain PA, Pariante CM.

Psychoneuroendocrinology. 2019 Feb;100:276-285. doi: 10.1016/j.psyneuen.2018.11.032. Epub 2018 Dec 17.

4.

Intergenerational transmission of depression: clinical observations and molecular mechanisms.

Sawyer KM, Zunszain PA, Dazzan P, Pariante CM.

Mol Psychiatry. 2019 Aug;24(8):1157-1177. doi: 10.1038/s41380-018-0265-4. Epub 2018 Oct 3. Review.

PMID:
30283036
5.

Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: The Psychiatry Research and Motherhood - Depression (PRAM-D) Study.

Osborne S, Biaggi A, Chua TE, Du Preez A, Hazelgrove K, Nikkheslat N, Previti G, Zunszain PA, Conroy S, Pariante CM.

Psychoneuroendocrinology. 2018 Dec;98:211-221. doi: 10.1016/j.psyneuen.2018.06.017. Epub 2018 Jul 19.

6.

Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients.

Nordholm D, Rostrup E, Mondelli V, Randers L, Nielsen MØ, Wulff S, Nørbak-Emig H, Broberg BV, Krakauer K, Dazzan P, Zunszain PA, Nordentoft M, Glenthøj B.

Psychoneuroendocrinology. 2018 Jun;92:72-80. doi: 10.1016/j.psyneuen.2018.03.015. Epub 2018 Mar 27.

PMID:
29635174
7.

The Colombo Twin and Singleton Follow-up Study: a population based twin study of psychiatric disorders and metabolic syndrome in Sri Lanka.

Jayaweera K, Aschan L, Pannala G, Adikari A, Glozier N, Ismail K, Pariante CM, Rijsdijk F, Siribaddana S, Zavos HMS, Zunszain PA, Sumathipala A, Hotopf M.

BMC Public Health. 2018 Jan 17;18(1):145. doi: 10.1186/s12889-017-4992-2.

8.

Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation.

Musaelyan K, Aldridge S, Du Preez A, Egeland M, Zunszain PA, Pariante CM, Thuret S, Fernandes C.

J Psychopharmacol. 2018 Feb;32(2):236-247. doi: 10.1177/0269881117746902. Epub 2018 Jan 17.

PMID:
29338496
9.

Trained innate immunity: a salient factor in the pathogenesis of neuroimmune psychiatric disorders.

Salam AP, Borsini A, Zunszain PA.

Mol Psychiatry. 2018 Feb;23(2):170-176. doi: 10.1038/mp.2017.186. Epub 2017 Dec 12. Review.

PMID:
29230022
10.

Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms.

Borsini A, Cattaneo A, Malpighi C, Thuret S, Harrison NA; MRC ImmunoPsychiatry Consortium, Zunszain PA, Pariante CM.

Int J Neuropsychopharmacol. 2018 Feb 1;21(2):187-200. doi: 10.1093/ijnp/pyx083.

11.

Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.

Agís-Balboa RC, Pinheiro PS, Rebola N, Kerimoglu C, Benito E, Gertig M, Bahari-Javan S, Jain G, Burkhardt S, Delalle I, Jatzko A, Dettenhofer M, Zunszain PA, Schmitt A, Falkai P, Pape JC, Binder EB, Mulle C, Fischer A, Sananbenesi F.

EMBO J. 2017 Oct 2;36(19):2815-2828. doi: 10.15252/embj.201796821. Epub 2017 Aug 2.

12.

The relationship between salivary C-reactive protein and cognitive function in children aged 11-14years: Does psychopathology have a moderating effect?

Cullen AE, Tappin BM, Zunszain PA, Dickson H, Roberts RE, Nikkheslat N, Khondoker M, Pariante CM, Fisher HL, Laurens KR.

Brain Behav Immun. 2017 Nov;66:221-229. doi: 10.1016/j.bbi.2017.07.002. Epub 2017 Jul 8.

13.

Advances in Stem Cells Biology: New Approaches to Understand Depression.

Borsini A, Zunszain PA.

In: Pfaff D, Christen Y, editors. Stem Cells in Neuroendocrinology [Internet]. Cham (CH): Springer; 2016.
2016 Jul 27.

14.

Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants.

Borsini A, Alboni S, Horowitz MA, Tojo LM, Cannazza G, Su KP, Pariante CM, Zunszain PA.

Brain Behav Immun. 2017 Oct;65:230-238. doi: 10.1016/j.bbi.2017.05.006. Epub 2017 May 18.

15.

Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression.

Egeland M, Guinaudie C, Du Preez A, Musaelyan K, Zunszain PA, Fernandes C, Pariante CM, Thuret S.

Transl Psychiatry. 2017 Apr 25;7(4):e1101. doi: 10.1038/tp.2017.68.

16.

Animal models to improve our understanding and treatment of suicidal behavior.

Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson ZR, Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry CA, Renshaw PF, Rujescu D, Smith EG, Turecki G, Zanos P, Zarate CA Jr, Zunszain PA, Postolache TT.

Transl Psychiatry. 2017 Apr 11;7(4):e1092. doi: 10.1038/tp.2017.50. Review.

17.

Perinatal hypothalamic-pituitary-adrenal axis regulation among women with eating disorders and their infants.

Easter A, Taborelli E, Bye A, Zunszain PA, Pariante CM, Treasure J, Schmidt U, Micali N.

Psychoneuroendocrinology. 2017 Feb;76:127-134. doi: 10.1016/j.psyneuen.2016.11.004. Epub 2016 Nov 11.

PMID:
27914245
18.

Prenatal maternal depression is associated with offspring inflammation at 25 years: a prospective longitudinal cohort study.

Plant DT, Pawlby S, Sharp D, Zunszain PA, Pariante CM.

Transl Psychiatry. 2016 Nov 1;6(11):e936. doi: 10.1038/tp.2015.155.

19.

Inflammatory insults and mental health consequences: does timing matter when it comes to depression?

Du Preez A, Leveson J, Zunszain PA, Pariante CM.

Psychol Med. 2016 Jul;46(10):2041-57. doi: 10.1017/S0033291716000672. Epub 2016 May 16.

20.

Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?

Boorman E, Zajkowska Z, Ahmed R, Pariante CM, Zunszain PA.

Psychopharmacology (Berl). 2016 May;233(9):1591-604. doi: 10.1007/s00213-015-4105-9. Epub 2015 Oct 20. Review.

21.

Improving the treatment for depressive symptoms and major depression with anti-inflammatory drugs.

Zunszain PA.

Evid Based Ment Health. 2015 Nov;18(4):116. doi: 10.1136/eb-2015-102063. Epub 2015 Sep 7. No abstract available.

PMID:
26345323
22.

Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin.

Horowitz MA, Zunszain PA.

Ann N Y Acad Sci. 2015 Sep;1351:68-79. doi: 10.1111/nyas.12781. Epub 2015 May 5.

PMID:
25943397
23.

Cortisol and Inflammatory Biomarkers Predict Poor Treatment Response in First Episode Psychosis.

Mondelli V, Ciufolini S, Belvederi Murri M, Bonaccorso S, Di Forti M, Giordano A, Marques TR, Zunszain PA, Morgan C, Murray RM, Pariante CM, Dazzan P.

Schizophr Bull. 2015 Sep;41(5):1162-70. doi: 10.1093/schbul/sbv028. Epub 2015 Mar 31.

24.

Molecular mechanisms in the regulation of adult neurogenesis during stress.

Egeland M, Zunszain PA, Pariante CM.

Nat Rev Neurosci. 2015 Apr;16(4):189-200. doi: 10.1038/nrn3855. Review.

PMID:
25790864
25.

Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression.

Nikkheslat N, Zunszain PA, Horowitz MA, Barbosa IG, Parker JA, Myint AM, Schwarz MJ, Tylee AT, Carvalho LA, Pariante CM.

Brain Behav Immun. 2015 Aug;48:8-18. doi: 10.1016/j.bbi.2015.02.002. Epub 2015 Feb 12.

26.

Immune mechanisms linked to depression via oxidative stress and neuroprogression.

Bakunina N, Pariante CM, Zunszain PA.

Immunology. 2015 Mar;144(3):365-373. doi: 10.1111/imm.12443. Epub 2015 Jan 10.

27.

The role of inflammatory cytokines as key modulators of neurogenesis.

Borsini A, Zunszain PA, Thuret S, Pariante CM.

Trends Neurosci. 2015 Mar;38(3):145-57. doi: 10.1016/j.tins.2014.12.006. Epub 2015 Jan 8. Review.

PMID:
25579391
28.

Antidepressant compounds can be both pro- and anti-inflammatory in human hippocampal cells.

Horowitz MA, Wertz J, Zhu D, Cattaneo A, Musaelyan K, Nikkheslat N, Thuret S, Pariante CM, Zunszain PA.

Int J Neuropsychopharmacol. 2014 Oct 31;18(3). pii: pyu076. doi: 10.1093/ijnp/pyu076.

29.

Circadian and homeostatic modulation of functional connectivity and regional cerebral blood flow in humans under normal entrained conditions.

Hodkinson DJ, O'Daly O, Zunszain PA, Pariante CM, Lazurenko V, Zelaya FO, Howard MA, Williams SC.

J Cereb Blood Flow Metab. 2014 Sep;34(9):1493-9. doi: 10.1038/jcbfm.2014.109. Epub 2014 Jun 18.

30.

Modulation of adult hippocampal neurogenesis by early-life environmental challenges triggering immune activation.

Musaelyan K, Egeland M, Fernandes C, Pariante CM, Zunszain PA, Thuret S.

Neural Plast. 2014;2014:194396. doi: 10.1155/2014/194396. Epub 2014 May 7. Review.

31.

Cortisol awakening response and diurnal cortisol among children at elevated risk for schizophrenia: relationship to psychosocial stress and cognition.

Cullen AE, Zunszain PA, Dickson H, Roberts RE, Fisher HL, Pariante CM, Laurens KR.

Psychoneuroendocrinology. 2014 Aug;46:1-13. doi: 10.1016/j.psyneuen.2014.03.010. Epub 2014 Mar 29.

32.

Towards a personalized treatment in depression: endocannabinoids, inflammation and stress response.

Zajkowska ZE, Englund A, Zunszain PA.

Pharmacogenomics. 2014 Apr;15(5):687-98. doi: 10.2217/pgs.14.40. Review.

33.

Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease.

Roqué Rosell NR, Mokhlesi L, Milton NE, Sweeney TR, Zunszain PA, Curry S, Leatherbarrow RJ.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):490-4. doi: 10.1016/j.bmcl.2013.12.045. Epub 2013 Dec 17.

34.

Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties.

Zunszain PA, Horowitz MA, Cattaneo A, Lupi MM, Pariante CM.

Mol Psychiatry. 2013 Dec;18(12):1236-41. doi: 10.1038/mp.2013.87. Epub 2013 Jul 23. Review.

35.

Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis.

Anacker C, Cattaneo A, Musaelyan K, Zunszain PA, Horowitz M, Molteni R, Luoni A, Calabrese F, Tansey K, Gennarelli M, Thuret S, Price J, Uher R, Riva MA, Pariante CM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8708-13. doi: 10.1073/pnas.1300886110. Epub 2013 May 6.

36.

Depression pathogenesis and treatment: what can we learn from blood mRNA expression?

Hepgul N, Cattaneo A, Zunszain PA, Pariante CM.

BMC Med. 2013 Feb 5;11:28. doi: 10.1186/1741-7015-11-28. Review.

37.

Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis.

Anacker C, Cattaneo A, Luoni A, Musaelyan K, Zunszain PA, Milanesi E, Rybka J, Berry A, Cirulli F, Thuret S, Price J, Riva MA, Gennarelli M, Pariante CM.

Neuropsychopharmacology. 2013 Apr;38(5):872-83. doi: 10.1038/npp.2012.253. Epub 2012 Dec 6.

38.

Glucocorticoids and inflammation: a double-headed sword in depression? How do neuroendocrine and inflammatory pathways interact during stress to contribute to the pathogenesis of depression?

Horowitz MA, Zunszain PA, Anacker C, Musaelyan K, Pariante CM.

Mod Trends Pharmacopsychiatry. 2013;28:127-43. doi: 10.1159/000343980. Epub 2013 Feb 27. Review.

PMID:
25224896
39.

Chemokines in bipolar disorder: trait or state?

Barbosa IG, Rocha NP, Bauer ME, de Miranda AS, Huguet RB, Reis HJ, Zunszain PA, Horowitz MA, Pariante CM, Teixeira AL.

Eur Arch Psychiatry Clin Neurosci. 2013 Mar;263(2):159-65. doi: 10.1007/s00406-012-0327-6. Epub 2012 May 15.

PMID:
22584806
40.

Inflammation and depression.

Zunszain PA, Hepgul N, Pariante CM.

Curr Top Behav Neurosci. 2013;14:135-51. doi: 10.1007/7854_2012_211. Review.

PMID:
22553073
41.

Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis.

Zunszain PA, Anacker C, Cattaneo A, Choudhury S, Musaelyan K, Myint AM, Thuret S, Price J, Pariante CM.

Neuropsychopharmacology. 2012 Mar;37(4):939-49. doi: 10.1038/npp.2011.277. Epub 2011 Nov 9.

42.

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor.

Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J, Pariante CM.

Mol Psychiatry. 2011 Jul;16(7):738-50. doi: 10.1038/mp.2011.26. Epub 2011 Apr 12.

43.

Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.

Ryan AJ, Ghuman J, Zunszain PA, Chung CW, Curry S.

J Struct Biol. 2011 Apr;174(1):84-91. doi: 10.1016/j.jsb.2010.10.004. Epub 2010 Oct 19.

44.

Glucocorticoids, cytokines and brain abnormalities in depression.

Zunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM.

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):722-9. doi: 10.1016/j.pnpbp.2010.04.011. Epub 2010 Apr 18. Review.

45.

The glucocorticoid receptor: pivot of depression and of antidepressant treatment?

Anacker C, Zunszain PA, Carvalho LA, Pariante CM.

Psychoneuroendocrinology. 2011 Apr;36(3):415-25. doi: 10.1016/j.psyneuen.2010.03.007. Review.

46.

Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate.

Zunszain PA, Knox SR, Sweeney TR, Yang J, Roqué-Rosell N, Belsham GJ, Leatherbarrow RJ, Curry S.

J Mol Biol. 2010 Jan 15;395(2):375-89. doi: 10.1016/j.jmb.2009.10.048. Epub 2009 Oct 31.

47.

Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha.

Zunszain PA, Ghuman J, McDonagh AF, Curry S.

J Mol Biol. 2008 Aug 29;381(2):394-406. doi: 10.1016/j.jmb.2008.06.016. Epub 2008 Jun 12.

48.

Genetic engineering of the heme pocket in human serum albumin: modulation of O2 binding of iron protoporphyrin IX by variation of distal amino acids.

Komatsu T, Nakagawa A, Zunszain PA, Curry S, Tsuchida E.

J Am Chem Soc. 2007 Sep 12;129(36):11286-95. Epub 2007 Aug 18.

PMID:
17705494
49.

Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?

Curry S, Roqué-Rosell N, Sweeney TR, Zunszain PA, Leatherbarrow RJ.

Biochem Soc Trans. 2007 Jun;35(Pt 3):594-8. Review.

PMID:
17511659
50.

Photosensitized reduction of water to hydrogen using human serum albumin complexed with zinc-protoporphyrin IX.

Komatsu T, Wang RM, Zunszain PA, Curry S, Tsuchida E.

J Am Chem Soc. 2006 Dec 20;128(50):16297-301.

PMID:
17165784

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