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Items: 30

1.

Targeting TNFR2 as a Novel Therapeutic Strategy for Alzheimer's Disease.

Ortí-Casañ N, Wu Y, Naudé PJW, De Deyn PP, Zuhorn IS, Eisel ULM.

Front Neurosci. 2019 Feb 4;13:49. doi: 10.3389/fnins.2019.00049. eCollection 2019.

2.

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy.

De Jong E, Williams DS, Abdelmohsen LKEA, Van Hest JCM, Zuhorn IS.

J Control Release. 2018 Nov 10;289:14-22. doi: 10.1016/j.jconrel.2018.09.015. Epub 2018 Sep 20.

3.

Introduction for the Special Issue on the Blood-Brain Barrier.

Zuhorn IS.

Tissue Barriers. 2016 Apr 4;4(1):e1170456. doi: 10.1080/21688370.2016.1170456. eCollection 2016 Jan-Mar. No abstract available.

4.

Entry of PIP3-containing polyplexes into MDCK epithelial cells by local apical-basal polarity reversal.

Wang C, de Jong E, Sjollema KA, Zuhorn IS.

Sci Rep. 2016 Feb 22;6:21436. doi: 10.1038/srep21436.

5.

A sensor for quantification of macromolecular crowding in living cells.

Boersma AJ, Zuhorn IS, Poolman B.

Nat Methods. 2015 Mar;12(3):227-9, 1 p following 229. doi: 10.1038/nmeth.3257. Epub 2015 Feb 2.

PMID:
25643150
6.

Solid lipid nanoparticles as nucleic acid delivery system: properties and molecular mechanisms.

de Jesus MB, Zuhorn IS.

J Control Release. 2015 Mar 10;201:1-13. doi: 10.1016/j.jconrel.2015.01.010. Epub 2015 Jan 9. Review.

PMID:
25578828
7.

Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood-Brain Barrier.

Georgieva JV, Hoekstra D, Zuhorn IS.

Pharmaceutics. 2014 Nov 17;6(4):557-83. doi: 10.3390/pharmaceutics6040557. Review.

8.

Inclusion of the helper lipid dioleoyl-phosphatidylethanolamine in solid lipid nanoparticles inhibits their transfection efficiency.

de Jesus MB, Radaic A, Hinrichs WL, Ferreira CV, de Paula E, Hoekstra D, Zuhorn IS.

J Biomed Nanotechnol. 2014 Feb;10(2):355-65.

PMID:
24738343
9.

Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis.

ur Rehman Z, Hoekstra D, Zuhorn IS.

ACS Nano. 2013 May 28;7(5):3767-77. doi: 10.1021/nn3049494. Epub 2013 Apr 24.

PMID:
23597090
10.

How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances.

Rehman Zu, Zuhorn IS, Hoekstra D.

J Control Release. 2013 Feb 28;166(1):46-56. doi: 10.1016/j.jconrel.2012.12.014. Epub 2012 Dec 20. Review.

PMID:
23266451
11.

Nonviral gene delivery vectors use syndecan-dependent transport mechanisms in filopodia to reach the cell surface.

ur Rehman Z, Sjollema KA, Kuipers J, Hoekstra D, Zuhorn IS.

ACS Nano. 2012 Aug 28;6(8):7521-32. doi: 10.1021/nn3028562. Epub 2012 Aug 8.

PMID:
22857607
12.

Imaging of cells and nanoparticles: implications for drug delivery to the brain.

Stojanov K, Zuhorn IS, Dierckx RA, de Vries EF.

Pharm Res. 2012 Dec;29(12):3213-34. doi: 10.1007/s11095-012-0826-1. Epub 2012 Jul 18. Review.

PMID:
22806407
13.

Peptide-mediated blood-brain barrier transport of polymersomes.

Georgieva JV, Brinkhuis RP, Stojanov K, Weijers CA, Zuilhof H, Rutjes FP, Hoekstra D, van Hest JC, Zuhorn IS.

Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8339-42. doi: 10.1002/anie.201202001. Epub 2012 Jul 11. No abstract available.

PMID:
22786792
14.

In vivo biodistribution of prion- and GM1-targeted polymersomes following intravenous administration in mice.

Stojanov K, Georgieva JV, Brinkhuis RP, van Hest JC, Rutjes FP, Dierckx RA, de Vries EF, Zuhorn IS.

Mol Pharm. 2012 Jun 4;9(6):1620-7. doi: 10.1021/mp200621v. Epub 2012 May 7.

PMID:
22536790
15.

Size dependent biodistribution and SPECT imaging of (111)In-labeled polymersomes.

Brinkhuis RP, Stojanov K, Laverman P, Eilander J, Zuhorn IS, Rutjes FP, van Hest JC.

Bioconjug Chem. 2012 May 16;23(5):958-65. doi: 10.1021/bc200578s. Epub 2012 Apr 12.

PMID:
22463082
16.

[18F]FDG labeling of neural stem cells for in vivo cell tracking with positron emission tomography: inhibition of tracer release by phloretin.

Stojanov K, de Vries EF, Hoekstra D, van Waarde A, Dierckx RA, Zuhorn IS.

Mol Imaging. 2012 Feb;11(1):1-12.

PMID:
22418021
17.

Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection.

ur Rehman Z, Hoekstra D, Zuhorn IS.

J Control Release. 2011 Nov 30;156(1):76-84. doi: 10.1016/j.jconrel.2011.07.015. Epub 2011 Jul 20.

PMID:
21787817
18.

Design of solid lipid nanoparticles for gene delivery into prostate cancer.

de Jesus MB, Ferreira CV, de Paula E, Hoekstra D, Zuhorn IS.

J Control Release. 2010 Nov 20;148(1):e89-90. doi: 10.1016/j.jconrel.2010.07.065. No abstract available.

PMID:
21529650
19.

Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood-brain barrier endothelial cells in vitro.

Georgieva JV, Kalicharan D, Couraud PO, Romero IA, Weksler B, Hoekstra D, Zuhorn IS.

Mol Ther. 2011 Feb;19(2):318-25. doi: 10.1038/mt.2010.236. Epub 2010 Nov 2.

20.

Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation.

Meijering BD, Juffermans LJ, van Wamel A, Henning RH, Zuhorn IS, Emmer M, Versteilen AM, Paulus WJ, van Gilst WH, Kooiman K, de Jong N, Musters RJ, Deelman LE, Kamp O.

Circ Res. 2009 Mar 13;104(5):679-87. doi: 10.1161/CIRCRESAHA.108.183806. Epub 2009 Jan 22.

PMID:
19168443
21.

Adhesion receptors mediate efficient non-viral gene delivery.

Zuhorn IS, Kalicharan D, Robillard GT, Hoekstra D.

Mol Ther. 2007 May;15(5):946-53. Epub 2007 Mar 20. Erratum in: Mol Ther. 2007 Jul;15(7):1400.

22.

Gene delivery by cationic lipids: in and out of an endosome.

Hoekstra D, Rejman J, Wasungu L, Shi F, Zuhorn I.

Biochem Soc Trans. 2007 Feb;35(Pt 1):68-71. Review.

PMID:
17233603
23.

Gene delivery by cationic lipid vectors: overcoming cellular barriers.

Zuhorn IS, Engberts JB, Hoekstra D.

Eur Biophys J. 2007 Apr;36(4-5):349-62. Epub 2006 Sep 22. Review.

PMID:
17019592
24.

Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency.

Zuhorn IS, Bakowsky U, Polushkin E, Visser WH, Stuart MC, Engberts JB, Hoekstra D.

Mol Ther. 2005 May;11(5):801-10.

25.

Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis.

Rejman J, Oberle V, Zuhorn IS, Hoekstra D.

Biochem J. 2004 Jan 1;377(Pt 1):159-69.

26.

On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: is that the question?

Zuhorn IS, Hoekstra D.

J Membr Biol. 2002 Oct 1;189(3):167-79. Review.

PMID:
12395282
27.

Phase behavior of cationic amphiphiles and their mixtures with helper lipid influences lipoplex shape, DNA translocation, and transfection efficiency.

Zuhorn IS, Oberle V, Visser WH, Engberts JB, Bakowsky U, Polushkin E, Hoekstra D.

Biophys J. 2002 Oct;83(4):2096-108.

28.

Interference of serum with lipoplex-cell interaction: modulation of intracellular processing.

Zuhorn IS, Visser WH, Bakowsky U, Engberts JB, Hoekstra D.

Biochim Biophys Acta. 2002 Feb 18;1560(1-2):25-36.

29.

Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis.

Zuhorn IS, Kalicharan R, Hoekstra D.

J Biol Chem. 2002 May 17;277(20):18021-8. Epub 2002 Mar 1.

30.

Lipoplex formation under equilibrium conditions reveals a three-step mechanism.

Oberle V, Bakowsky U, Zuhorn IS, Hoekstra D.

Biophys J. 2000 Sep;79(3):1447-54.

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