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Items: 1 to 50 of 65

1.

Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.

Santa Maria JP Jr, Park Y, Yang L, Murgolo N, Altman MD, Zuck P, Adam G, Chamberlin C, Saradjian P, Dandliker P, Boshoff HIM, Barry CE 3rd, Garlisi C, Olsen DB, Young K, Glick M, Nickbarg E, Kutchukian PS.

ACS Chem Biol. 2017 Sep 15;12(9):2448-2456. doi: 10.1021/acschembio.7b00468. Epub 2017 Aug 29.

2.

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.

Walker SS, Labroli M, Painter RE, Wiltsie J, Sherborne B, Murgolo N, Sher X, Mann P, Zuck P, Garlisi CG, Su J, Kargman S, Xiao L, Scapin G, Salowe S, Devito K, Sheth P, Buist N, Tan CM, Black TA, Roemer T.

PLoS One. 2017 Jul 10;12(7):e0180965. doi: 10.1371/journal.pone.0180965. eCollection 2017.

3.

Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.

Pertusi DA, O'Donnell G, Homsher MF, Solly K, Patel A, Stahler SL, Riley D, Finley MF, Finger EN, Adam GC, Meng J, Bell DJ, Zuck PD, Hudak EM, Weber MJ, Nothstein JE, Locco L, Quinn C, Amoss A, Squadroni B, Hartnett M, Heo MR, White T, May SA, Boots E, Roberts K, Cocchiarella P, Wolicki A, Kreamer A, Kutchukian PS, Wassermann AM, Uebele VN, Glick M, Rusinko A 3rd, Culberson JC.

SLAS Discov. 2017 Sep;22(8):995-1006. doi: 10.1177/2472555217706058. Epub 2017 Apr 20.

PMID:
28426940
4.

High-Throughput Agonist Shift Assay Development for the Analysis of M1-Positive Allosteric Modulators.

Homsher MF, Beshore DC, Cassaday J, Squadroni B, Mohammed E, Hartnett M, Day S, Ma L, Pechter D, Smith MD, Monsma F, Zuck P, Finley MF, Uebele VN, Hermes JD.

SLAS Discov. 2017 Sep;22(8):1060-1066. doi: 10.1177/2472555217705373. Epub 2017 Apr 20.

PMID:
28426939
5.

Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening.

Kutchukian PS, Warren L, Magliaro BC, Amoss A, Cassaday JA, O'Donnell G, Squadroni B, Zuck P, Pascarella D, Culberson JC, Cooke AJ, Hurzy D, Schlegel KS, Thomson F, Johnson EN, Uebele VN, Hermes JD, Parmentier-Batteur S, Finley M.

ACS Chem Biol. 2017 Feb 17;12(2):519-527. doi: 10.1021/acschembio.6b00913. Epub 2017 Jan 6.

PMID:
28032990
6.

Dynamic Compound-Dependent Acoustic Transfer to Investigate Inhibitor Reversibility.

Nothstein J, MacColl E, Zuck P, Cassaday J, Uebele VN, Hermes JD, Homsher MF.

SLAS Technol. 2017 Oct;22(5):485-492. doi: 10.1177/2472630316684807. Epub 2016 Dec 27.

PMID:
28027447
7.

Development of a Platform to Enable Fully Automated Cross-Titration Experiments.

Cassaday J, Finley M, Squadroni B, Jezequel-Sur S, Rauch A, Gajera B, Uebele V, Hermes J, Zuck P.

SLAS Technol. 2017 Apr;22(2):195-205. doi: 10.1177/2211068216679805. Epub 2016 Nov 19.

PMID:
27864339
8.

Assessment and Management of Root Lesion Nematodes in Montana Wheat Production.

May DB, Johnson WA, Zuck PC, Chen CC, Dyer AT.

Plant Dis. 2016 Oct;100(10):2069-2079. doi: 10.1094/PDIS-02-16-0176-RE. Epub 2016 Aug 4.

PMID:
30683011
9.

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

Lee SH, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, Gill C, Mann P, Sher X, Ha S, Yang SW, Mandal M, Yang C, Liang L, Tan Z, Tawa P, Hou Y, Kuvelkar R, DeVito K, Wen X, Xiao J, Batchlett M, Balibar CJ, Liu J, Xiao J, Murgolo N, Garlisi CG, Sheth PR, Flattery A, Su J, Tan C, Roemer T.

Sci Transl Med. 2016 Mar 9;8(329):329ra32. doi: 10.1126/scitranslmed.aad7364.

PMID:
26962156
10.

Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T.

Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30.

PMID:
26416753
11.

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.

Allen SJ, Parthasarathy G, Darke PL, Diehl RE, Ford RE, Hall DL, Johnson SA, Reid JC, Rickert KW, Shipman JM, Soisson SM, Zuck P, Munshi SK, Lumb KJ.

J Biol Chem. 2015 Aug 14;290(33):20360-73. doi: 10.1074/jbc.M115.648907. Epub 2015 Jul 1.

12.

Screening of HIV-1 Protease Using a Combination of an Ultra-High-Throughput Fluorescent-Based Assay and RapidFire Mass Spectrometry.

Meng J, Lai MT, Munshi V, Grobler J, McCauley J, Zuck P, Johnson EN, Uebele VN, Hermes JD, Adam GC.

J Biomol Screen. 2015 Jun;20(5):606-15. doi: 10.1177/1087057115570838. Epub 2015 Feb 13.

PMID:
25681434
13.

Use of high-throughput mass spectrometry to reduce false positives in protease uHTS screens.

Adam GC, Meng J, Rizzo JM, Amoss A, Lusen JW, Patel A, Riley D, Hunt R, Zuck P, Johnson EN, Uebele VN, Hermes JD.

J Biomol Screen. 2015 Feb;20(2):212-22. doi: 10.1177/1087057114555832. Epub 2014 Oct 21.

PMID:
25336354
14.

Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.

Stachel SJ, Sanders JM, Henze DA, Rudd MT, Su HP, Li Y, Nanda KK, Egbertson MS, Manley PJ, Jones KL, Brnardic EJ, Green A, Grobler JA, Hanney B, Leitl M, Lai MT, Munshi V, Murphy D, Rickert K, Riley D, Krasowska-Zoladek A, Daley C, Zuck P, Kane SA, Bilodeau MT.

J Med Chem. 2014 Jul 10;57(13):5800-16. doi: 10.1021/jm5006429. Epub 2014 Jun 19.

PMID:
24914455
15.

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.

Wang H, Gill CJ, Lee SH, Mann P, Zuck P, Meredith TC, Murgolo N, She X, Kales S, Liang L, Liu J, Wu J, Santa Maria J, Su J, Pan J, Hailey J, Mcguinness D, Tan CM, Flattery A, Walker S, Black T, Roemer T.

Chem Biol. 2013 Feb 21;20(2):272-84. doi: 10.1016/j.chembiol.2012.11.013.

16.

Discovery of pyrrolidine-based β-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.

Stachel SJ, Steele TG, Petrocchi A, Haugabook SJ, McGaughey G, Katharine Holloway M, Allison T, Munshi S, Zuck P, Colussi D, Tugasheva K, Wolfe A, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):240-4. doi: 10.1016/j.bmcl.2011.11.024. Epub 2011 Nov 12.

PMID:
22130130
17.

[Acute dry coughs have underestimated impacts on patients' everyday lives].

Zuck P, Allaert FA.

Rev Pneumol Clin. 2011 Oct;67(5):304-8. doi: 10.1016/j.pneumo.2010.12.009. Epub 2011 Mar 17. French.

PMID:
22017950
18.

High-throughput scintillation proximity assay for stearoyl-CoA desaturase-1.

Tawa P, Falgueyret JP, Guiral S, Isabel E, Powell DA, Zuck P, Skorey K.

J Biomol Screen. 2011 Jun;16(5):506-17. doi: 10.1177/1087057111399436. Epub 2011 Mar 15.

PMID:
21406617
19.

Small molecule mimetics of an HIV-1 gp41 fusion intermediate as vaccine leads.

Caulfield MJ, Dudkin VY, Ottinger EA, Getty KL, Zuck PD, Kaufhold RM, Hepler RW, McGaughey GB, Citron M, Hrin RC, Wang YJ, Miller MD, Joyce JG.

J Biol Chem. 2010 Dec 24;285(52):40604-11. doi: 10.1074/jbc.M110.172197. Epub 2010 Oct 13.

20.

[Relevance of fluoroquinolone use in Lorraine: results of the first survey].

Doco-Lecompte T, Demoré B, Burty C, Rondelot G, Scheid P, Zuck P, Simon L, Letranchant L, Robert C, Frentiu E, Petitfrère M, Simplot B, Bevilacqua S, Voltz C, Rabaud C, May T; le réseau Antibiolor.

Med Mal Infect. 2010 Feb;40(2):106-11. doi: 10.1016/j.medmal.2009.08.022. Epub 2009 Oct 8. French.

PMID:
19818570
21.

Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.

Stachel SJ, Coburn CA, Rush D, Jones KL, Zhu H, Rajapakse H, Graham SL, Simon A, Katharine Holloway M, Allison TJ, Munshi SK, Espeseth AS, Zuck P, Colussi D, Wolfe A, Pietrak BL, Lai MT, Vacca JP.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2977-80. doi: 10.1016/j.bmcl.2009.04.033. Epub 2009 Apr 18.

PMID:
19409780
22.

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.

Converso A, Hartingh T, Garbaccio RM, Tasber E, Rickert K, Fraley ME, Yan Y, Kreatsoulas C, Stirdivant S, Drakas B, Walsh ES, Hamilton K, Buser CA, Mao X, Abrams MT, Beck SC, Tao W, Lobell R, Sepp-Lorenzino L, Zugay-Murphy J, Sardana V, Munshi SK, Jezequel-Sur SM, Zuck PD, Hartman GD.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1240-4. doi: 10.1016/j.bmcl.2008.12.076. Epub 2008 Dec 24.

PMID:
19155174
23.

Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.

Steele TG, Hills ID, Nomland AA, de León P, Allison T, McGaughey G, Colussi D, Tugusheva K, Haugabook SJ, Espeseth AS, Zuck P, Graham SL, Stachel SJ.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):17-20. doi: 10.1016/j.bmcl.2008.11.027. Epub 2008 Nov 13.

PMID:
19036583
24.

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.

Barrow JC, Stauffer SR, Rittle KE, Ngo PL, Yang Z, Selnick HG, Graham SL, Munshi S, McGaughey GB, Holloway MK, Simon AJ, Price EA, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Espeseth AS, Xu M, Huang Q, Wolfe A, Pietrak B, Zuck P, Levorse DA, Hazuda D, Vacca JP.

J Med Chem. 2008 Oct 23;51(20):6259-62. doi: 10.1021/jm800914n. Epub 2008 Sep 24.

PMID:
18811140
25.

[Routine use of extended-release clarithromycin tablets for short-course treatment of acute exacerbations of non-severe COPD].

Léophonte P, Zuck P, Perronne C, Baconnet B.

Med Mal Infect. 2008 Sep;38(9):471-6. doi: 10.1016/j.medmal.2008.06.029. Epub 2008 Aug 21. French.

PMID:
18722065
26.

[Profile and management of patients consulting for a non severe exacerbation of chronic obstructive pulmonary disease (Pragma survey)].

Léophonte P, Zuck P, Perronne C.

Med Mal Infect. 2008 Apr;38(4):200-7. doi: 10.1016/j.medmal.2008.01.006. Epub 2008 Mar 12. French.

PMID:
18339501
27.

Miniaturization and automation of an ubiquitin ligase cascade enzyme-linked immunosorbent assay in 1,536-well format.

Cassaday J, Shah T, Murray J, O'Donnell GT, Kornienko O, Strulovici B, Ferrer M, Zuck P.

Assay Drug Dev Technol. 2007 Aug;5(4):493-500.

PMID:
17767417
28.

A high-precision fluorogenic cholesteryl ester transfer protein assay compatible with animal serum and 3456-well assay technology.

Eveland SS, Milot DP, Guo Q, Chen Y, Hyland SA, Peterson LB, Jezequel-Sur S, O'Donnell GT, Zuck PD, Ferrer M, Strulovici B, Wagner JA, Tanaka WK, Hilliard DA, Laterza O, Wright SD, Sparrow CP, Anderson MS.

Anal Biochem. 2007 Sep 15;368(2):239-49. Epub 2007 Jun 8.

PMID:
17601482
29.

Mixing two differently labeled substrates in one immobilized metal assay for phosphochemicals assay to improve data quality.

Jezequel-Sur S, Murray J, Lucumi E, Ferrer M, Zuck P.

Anal Biochem. 2007 Jan 15;360(2):312-4. Epub 2006 Nov 10. No abstract available.

PMID:
17129572
30.

Fluorogenic substrates for high-throughput measurements of endothelial lipase activity.

Mitnaul LJ, Tian J, Burton C, Lam MH, Zhu Y, Olson SH, Schneeweis JE, Zuck P, Pandit S, Anderson M, Maletic MM, Waddell ST, Wright SD, Sparrow CP, Lund EG.

J Lipid Res. 2007 Feb;48(2):472-82. Epub 2006 Nov 7.

31.

[Efficacy and safety of telithromycin in the treatment of acute exacerbation of chronic obstructive pulmonary disease].

Benhamou D, Zuck P, Piperno D, Tremolieres F; Groupe Investigateur.

Med Mal Infect. 2005 Sep;35(9):455-62. Epub 2005 Nov 4. French.

PMID:
16271840
32.

[Efficacy and safety of extended-release clarithromycin (5-day short-course) vs telithromycin, in acute bacterial exacerbation of chronic bronchitis].

Perronne C, Drugeon H, Zuck P, Filipecki J, Vincent-Lacaze N, Goldfarb G, Léophonte P.

Med Mal Infect. 2005 Oct;35(10):507-15. Epub 2005 Oct 18. French.

PMID:
16239090
33.

Miniaturization of absorbance assays using the fluorescent properties of white microplates.

Zuck P, O'Donnell GT, Cassaday J, Chase P, Hodder P, Strulovici B, Ferrer M.

Anal Biochem. 2005 Jul 15;342(2):254-9.

PMID:
15949786
34.

Moxifloxacin monotherapy compared to amoxicillin-clavulanate plus roxithromycin for nonsevere community-acquired pneumonia in adults with risk factors.

Portier H, Brambilla C, Garre M, Paganin F, Poubeau P, Zuck P.

Eur J Clin Microbiol Infect Dis. 2005 Jun;24(6):367-76.

PMID:
15944847
35.

[Hemothorax in a 78-year-old woman].

Martin P, Termignon JL, Nicolas S, Zuck P.

Rev Pneumol Clin. 2005 Feb;61(1 Pt 1):44-6. French.

PMID:
15772580
36.

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

Espeseth AS, Xu M, Huang Q, Coburn CA, Jones KL, Ferrer M, Zuck PD, Strulovici B, Price EA, Wu G, Wolfe AL, Lineberger JE, Sardana M, Tugusheva K, Pietrak BL, Crouthamel MC, Lai MT, Dodson EC, Bazzo R, Shi XP, Simon AJ, Li Y, Hazuda DJ.

J Biol Chem. 2005 May 6;280(18):17792-7. Epub 2005 Feb 25.

37.

[Efficacy of levofloxacin in the treatment of acute exacerbation of chronic bronchitis in patients with risk factors].

Zuck P, Veyssier P, Brumpt I.

Rev Pneumol Clin. 2004 Nov;60(5 Pt 1):269-77. French.

PMID:
15687910
38.

[Prevention of COPD exacerbations: conducting a clinical trial evaluating the benefits of inhaled steroids].

Chabot F, Devillier P, Drugeon H, Dusser D, Fournier M, Gaillard J, Grouin JM, Housset B, Huchon G, Léophonte P, Muir JF, Raffy O, Tonnel AB, Tremolieres F, Zück P, Attali V, Boucot I, Chemali-Hudry J, Daniloski M; Groupe REFLEX BPCO.

Rev Mal Respir. 2004 Sep;21(4 Pt 1):685-8. French. No abstract available.

PMID:
15536368
39.

A cell-based beta-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication.

Zuck P, Murray EM, Stec E, Grobler JA, Simon AJ, Strulovici B, Inglese J, Flores OA, Ferrer M.

Anal Biochem. 2004 Nov 15;334(2):344-55.

PMID:
15494142
40.

A fully automated [35S]GTPgammaS scintillation proximity assay for the high-throughput screening of Gi-linked G protein-coupled receptors.

Ferrer M, Kolodin GD, Zuck P, Peltier R, Berry K, Mandala SM, Rosen H, Ota H, Ozaki S, Inglese J, Strulovici B.

Assay Drug Dev Technol. 2003 Apr;1(2):261-73.

PMID:
15090191
41.

Miniaturizable homogenous time-resolved fluorescence assay for carboxypeptidase B activity.

Ferrer M, Zuck P, Kolodin G, Mao SS, Peltier RR, Bailey C, Gardell SJ, Strulovici B, Inglese J.

Anal Biochem. 2003 Jun 1;317(1):94-8.

PMID:
12729605
42.

Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening.

Kunapuli P, Ransom R, Murphy KL, Pettibone D, Kerby J, Grimwood S, Zuck P, Hodder P, Lacson R, Hoffman I, Inglese J, Strulovici B.

Anal Biochem. 2003 Mar 1;314(1):16-29.

PMID:
12633598
43.
44.

Randomized controlled trial of sequential intravenous (i.v.) and oral moxifloxacin compared with sequential i.v. and oral co-amoxiclav with or without clarithromycin in patients with community-acquired pneumonia requiring initial parenteral treatment.

Finch R, Schürmann D, Collins O, Kubin R, McGivern J, Bobbaers H, Izquierdo JL, Nikolaides P, Ogundare F, Raz R, Zuck P, Hoeffken G.

Antimicrob Agents Chemother. 2002 Jun;46(6):1746-54.

45.

Dry powder ipratropium bromide is as safe and effective as metered-dose inhaler formulation: a cumulative dose-response study in chronic obstructive pulmonary disease patients.

Cuvelier A, Muir JF, Benhamou D, Weitzenblum E, Zuck P, Delacenserie R, Taytard A, Iacono P.

Respir Care. 2002 Feb;47(2):159-66.

PMID:
11812272
46.

[Treatment of community-acquired pneumonia with levofloxacin: 500 mg once a day or 500 mg twice a day?].

Zuck P, Bru JP.

Presse Med. 2000 May 27-Jun 3;29(19):1062-5. French.

PMID:
10874918
47.
48.

Randomized, double-blind study of short-course (5 day) grepafloxacin versus 10 day clarithromycin in patients with acute bacterial exacerbations of chronic bronchitis.

Langan CE, Zuck P, Vogel F, McIvor A, Peirzchala W, Smakal M, Staley H, Marr C.

J Antimicrob Chemother. 1999 Oct;44(4):515-23.

PMID:
10588313
49.

Ligand-receptor binding measured by laser-scanning imaging.

Zuck P, Lao Z, Skwish S, Glickman JF, Yang K, Burbaum J, Inglese J.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11122-7.

50.

[The role of ciprofloxacin in the treatment of chronic bronchitis].

Zuck P.

Presse Med. 1998 Mar 28;27(12):594-6. French. No abstract available.

PMID:
9767959

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