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Items: 39

1.

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D.

Brain. 2019 Sep 1;142(9):2558-2571. doi: 10.1093/brain/awz193.

2.

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology.

Möller HE, Bossoni L, Connor JR, Crichton RR, Does MD, Ward RJ, Zecca L, Zucca FA, Ronen I.

Trends Neurosci. 2019 Jun;42(6):384-401. doi: 10.1016/j.tins.2019.03.009. Epub 2019 Apr 29. Review.

PMID:
31047721
3.

Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain.

Cassidy CM, Zucca FA, Girgis RR, Baker SC, Weinstein JJ, Sharp ME, Bellei C, Valmadre A, Vanegas N, Kegeles LS, Brucato G, Jung Kang U, Sulzer D, Zecca L, Abi-Dargham A, Horga G.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5108-5117. doi: 10.1073/pnas.1807983116. Epub 2019 Feb 22.

4.

Dopamine, Oxidative Stress and Protein-Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases.

Monzani E, Nicolis S, Dell'Acqua S, Capucciati A, Bacchella C, Zucca FA, Mosharov EV, Sulzer D, Zecca L, Casella L.

Angew Chem Int Ed Engl. 2019 May 13;58(20):6512-6527. doi: 10.1002/anie.201811122. Epub 2019 Mar 21. Review.

PMID:
30536578
5.

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease.

Zucca FA, Vanna R, Cupaioli FA, Bellei C, De Palma A, Di Silvestre D, Mauri P, Grassi S, Prinetti A, Casella L, Sulzer D, Zecca L.

NPJ Parkinsons Dis. 2018 Jun 5;4:17. doi: 10.1038/s41531-018-0050-8. eCollection 2018.

6.

A lysosome-plasma membrane-sphingolipid axis linking lysosomal storage to cell growth arrest.

Samarani M, Loberto N, Soldà G, Straniero L, Asselta R, Duga S, Lunghi G, Zucca FA, Mauri L, Ciampa MG, Schiumarini D, Bassi R, Giussani P, Chiricozzi E, Prinetti A, Aureli M, Sonnino S.

FASEB J. 2018 Oct;32(10):5685-5702. doi: 10.1096/fj.201701512RR. Epub 2018 May 10.

7.

Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease.

Sulzer D, Cassidy C, Horga G, Kang UJ, Fahn S, Casella L, Pezzoli G, Langley J, Hu XP, Zucca FA, Isaias IU, Zecca L.

NPJ Parkinsons Dis. 2018 Apr 10;4:11. doi: 10.1038/s41531-018-0047-3. eCollection 2018. Review.

8.

Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson's Disease.

Ferrari E, Capucciati A, Prada I, Zucca FA, D'Arrigo G, Pontiroli D, Bridelli MG, Sturini M, Bubacco L, Monzani E, Verderio C, Zecca L, Casella L.

ACS Chem Neurosci. 2017 Mar 15;8(3):501-512. doi: 10.1021/acschemneuro.6b00231. Epub 2016 Nov 28.

PMID:
28292181
9.

Contrast mechanisms associated with neuromelanin-MRI.

Trujillo P, Summers PE, Ferrari E, Zucca FA, Sturini M, Mainardi LT, Cerutti S, Smith AK, Smith SA, Zecca L, Costa A.

Magn Reson Med. 2017 Nov;78(5):1790-1800. doi: 10.1002/mrm.26584. Epub 2016 Dec 26.

PMID:
28019018
10.

Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry.

Biesemeier A, Eibl O, Eswara S, Audinot JN, Wirtz T, Pezzoli G, Zucca FA, Zecca L, Schraermeyer U.

J Neurochem. 2016 Jul;138(2):339-53. doi: 10.1111/jnc.13648. Epub 2016 Jun 2.

11.

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease.

Zucca FA, Segura-Aguilar J, Ferrari E, Muñoz P, Paris I, Sulzer D, Sarna T, Casella L, Zecca L.

Prog Neurobiol. 2017 Aug;155:96-119. doi: 10.1016/j.pneurobio.2015.09.012. Epub 2015 Oct 9. Review.

12.

Melanins and melanogenesis: from pigment cells to human health and technological applications.

d'Ischia M, Wakamatsu K, Cicoira F, Di Mauro E, Garcia-Borron JC, Commo S, Galván I, Ghanem G, Kenzo K, Meredith P, Pezzella A, Santato C, Sarna T, Simon JD, Zecca L, Zucca FA, Napolitano A, Ito S.

Pigment Cell Melanoma Res. 2015 Sep;28(5):520-44. doi: 10.1111/pcmr.12393. Review.

PMID:
26176788
13.

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus.

Wakamatsu K, Tabuchi K, Ojika M, Zucca FA, Zecca L, Ito S.

J Neurochem. 2015 Nov;135(4):768-76. doi: 10.1111/jnc.13237. Epub 2015 Sep 4.

14.

The role of iron in brain ageing and neurodegenerative disorders.

Ward RJ, Zucca FA, Duyn JH, Crichton RR, Zecca L.

Lancet Neurol. 2014 Oct;13(10):1045-60. doi: 10.1016/S1474-4422(14)70117-6. Review.

15.

Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin.

Wakamatsu K, Tanaka H, Tabuchi K, Ojika M, Zucca FA, Zecca L, Ito S.

Molecules. 2014 Jun 16;19(6):8039-50. doi: 10.3390/molecules19068039.

16.

Engineered nanoparticles. How brain friendly is this new guest?

Cupaioli FA, Zucca FA, Boraschi D, Zecca L.

Prog Neurobiol. 2014 Aug-Sep;119-120:20-38. doi: 10.1016/j.pneurobio.2014.05.002. Epub 2014 May 10. Review.

PMID:
24820405
17.

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.

Cebrián C, Zucca FA, Mauri P, Steinbeck JA, Studer L, Scherzer CR, Kanter E, Budhu S, Mandelbaum J, Vonsattel JP, Zecca L, Loike JD, Sulzer D.

Nat Commun. 2014 Apr 16;5:3633. doi: 10.1038/ncomms4633.

18.

Protective and toxic roles of dopamine in Parkinson's disease.

Segura-Aguilar J, Paris I, Muñoz P, Ferrari E, Zecca L, Zucca FA.

J Neurochem. 2014 Jun;129(6):898-915. doi: 10.1111/jnc.12686. Epub 2014 Mar 18. Review.

19.

Neuromelanin of the human substantia nigra: an update.

Zucca FA, Basso E, Cupaioli FA, Ferrari E, Sulzer D, Casella L, Zecca L.

Neurotox Res. 2014 Jan;25(1):13-23. doi: 10.1007/s12640-013-9435-y. Epub 2013 Oct 24. Review.

PMID:
24155156
20.

Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure.

Engelen M, Vanna R, Bellei C, Zucca FA, Wakamatsu K, Monzani E, Ito S, Casella L, Zecca L.

PLoS One. 2012;7(11):e48490. doi: 10.1371/journal.pone.0048490. Epub 2012 Nov 5.

21.

Biosynthetic pathway to neuromelanin and its aging process.

Wakamatsu K, Murase T, Zucca FA, Zecca L, Ito S.

Pigment Cell Melanoma Res. 2012 Nov;25(6):792-803. doi: 10.1111/pcmr.12014. Epub 2012 Oct 1.

PMID:
22938712
22.

Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease.

Zhang W, Phillips K, Wielgus AR, Liu J, Albertini A, Zucca FA, Faust R, Qian SY, Miller DS, Chignell CF, Wilson B, Jackson-Lewis V, Przedborski S, Joset D, Loike J, Hong JS, Sulzer D, Zecca L.

Neurotox Res. 2011 Jan;19(1):63-72. doi: 10.1007/s12640-009-9140-z. Epub 2009 Dec 3.

23.

Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids.

Ward WC, Zucca FA, Bellei C, Zecca L, Simon JD.

Arch Biochem Biophys. 2009 Apr 1;484(1):94-9. doi: 10.1016/j.abb.2009.01.013. Epub 2009 Jan 20.

PMID:
19467634
24.

Neuromelanins isolated from different regions of the human brain exhibit a common surface photoionization threshold.

Bush WD, Garguilo J, Zucca FA, Bellei C, Nemanich RJ, Edwards GS, Zecca L, Simon JD.

Photochem Photobiol. 2009 Jan-Feb;85(1):387-90. doi: 10.1111/j.1751-1097.2008.00476.x. Epub 2008 Nov 19.

PMID:
19067944
25.

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals.

Zecca L, Bellei C, Costi P, Albertini A, Monzani E, Casella L, Gallorini M, Bergamaschi L, Moscatelli A, Turro NJ, Eisner M, Crippa PR, Ito S, Wakamatsu K, Bush WD, Ward WC, Simon JD, Zucca FA.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17567-72. doi: 10.1073/pnas.0808768105. Epub 2008 Nov 6.

26.

Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease.

Zecca L, Casella L, Albertini A, Bellei C, Zucca FA, Engelen M, Zadlo A, Szewczyk G, Zareba M, Sarna T.

J Neurochem. 2008 Aug;106(4):1866-75. doi: 10.1111/j.1471-4159.2008.05541.x. Epub 2008 Jul 4.

27.

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease.

Sulzer D, Mosharov E, Talloczy Z, Zucca FA, Simon JD, Zecca L.

J Neurochem. 2008 Jul;106(1):24-36. doi: 10.1111/j.1471-4159.2008.05385.x. Epub 2008 Apr 1. Review.

28.

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease.

Zecca L, Wilms H, Geick S, Claasen JH, Brandenburg LO, Holzknecht C, Panizza ML, Zucca FA, Deuschl G, Sievers J, Lucius R.

Acta Neuropathol. 2008 Jul;116(1):47-55. doi: 10.1007/s00401-008-0361-7. Epub 2008 Mar 15.

PMID:
18343932
29.

Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain.

Ward WC, Guan Z, Zucca FA, Fariello RG, Kordestani R, Zecca L, Raetz CR, Simon JD.

J Lipid Res. 2007 Jul;48(7):1457-62. Epub 2007 Apr 19.

30.

A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.

Zecca L, Zucca FA, Albertini A, Rizzio E, Fariello RG.

Neurology. 2006 Oct 10;67(7 Suppl 2):S8-11. Review.

PMID:
17030740
31.

The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.

Bush WD, Garguilo J, Zucca FA, Albertini A, Zecca L, Edwards GS, Nemanich RJ, Simon JD.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14785-9. Epub 2006 Sep 25.

32.

Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability.

Zucca FA, Bellei C, Giannelli S, Terreni MR, Gallorini M, Rizzio E, Pezzoli G, Albertini A, Zecca L.

J Neural Transm (Vienna). 2006 Jun;113(6):757-67. Epub 2006 Apr 28.

PMID:
16755380
33.

Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference.

Rao KS, Hegde ML, Anitha S, Musicco M, Zucca FA, Turro NJ, Zecca L.

Prog Neurobiol. 2006 Apr;78(6):364-73. Epub 2006 May 8. Review.

PMID:
16682109
34.

The neuromelanin of human substantia nigra: physiological and pathogenic aspects.

Zucca FA, Giaveri G, Gallorini M, Albertini A, Toscani M, Pezzoli G, Lucius R, Wilms H, Sulzer D, Ito S, Wakamatsu K, Zecca L.

Pigment Cell Res. 2004 Dec;17(6):610-7. Review.

PMID:
15541018
35.

Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells.

Shamoto-Nagai M, Maruyama W, Akao Y, Osawa T, Tribl F, Gerlach M, Zucca FA, Zecca L, Riederer P, Naoi M.

J Neural Transm (Vienna). 2004 Oct;111(10-11):1253-65.

PMID:
15480837
36.

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging.

Zecca L, Stroppolo A, Gatti A, Tampellini D, Toscani M, Gallorini M, Giaveri G, Arosio P, Santambrogio P, Fariello RG, Karatekin E, Kleinman MH, Turro N, Hornykiewicz O, Zucca FA.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9843-8. Epub 2004 Jun 21.

37.

Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics.

Zecca L, Zucca FA, Wilms H, Sulzer D.

Trends Neurosci. 2003 Nov;26(11):578-80. Review.

PMID:
14585596
38.

The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour.

Zecca L, Zucca FA, Costi P, Tampellini D, Gatti A, Gerlach M, Riederer P, Fariello RG, Ito S, Gallorini M, Sulzer D.

J Neural Transm Suppl. 2003;(65):145-55. Review.

PMID:
12946053
39.

The structure of neuromelanin as studied by chemical degradative methods.

Wakamatsu K, Fujikawa K, Zucca FA, Zecca L, Ito S.

J Neurochem. 2003 Aug;86(4):1015-23.

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