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Items: 43


An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability.

Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM.

Nucleic Acids Res. 2019 Aug 22;47(14):7716-7717. doi: 10.1093/nar/gkz587. No abstract available.


Golgi Oncoprotein GOLPH3 Gene Expression Is Regulated by Functional E2F and CREB/ATF Promoter Elements.

Peñalver-González B, Vallejo-Rodríguez J, Mentxaka G, Fullaondo A, Iglesias-Ara A, Field SJ, Zubiaga AM.

Genes (Basel). 2019 Mar 25;10(3). pii: E247. doi: 10.3390/genes10030247.


Does arterial hypertension influence the onset of Huntington's disease?

Valcárcel-Ocete L, Fullaondo A, Alkorta-Aranburu G, García-Barcina M, Roos RAC, Hjermind LE, Saft C, Frontali M, Reilmann R, Rickards H; REGISTRY investigators of the European Huntington’s Disease Network (EHDN), Zubiaga AM, Aguirre A.

PLoS One. 2018 May 23;13(5):e0197975. doi: 10.1371/journal.pone.0197975. eCollection 2018.


An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability.

Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM.

Nucleic Acids Res. 2018 May 18;46(9):4546-4559. doi: 10.1093/nar/gky218. Erratum in: Nucleic Acids Res. 2019 Aug 22;47(14):7716-7717.


Detection of E2F-Induced Transcriptional Activity Using a Dual Luciferase Reporter Assay.

Iglesias-Ara A, Osinalde N, Zubiaga AM.

Methods Mol Biol. 2018;1726:153-166. doi: 10.1007/978-1-4939-7565-5_14.


The stress of coping with E2F loss.

Iglesias-Ara A, Zubiaga AM.

Mol Cell Oncol. 2015 May 26;3(1):e1038423. doi: 10.1080/23723556.2015.1038423. eCollection 2016 Jan.


Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes.

Osinalde N, Mitxelena J, Sánchez-Quiles V, Akimov V, Aloria K, Arizmendi JM, Zubiaga AM, Blagoev B, Kratchmarova I.

Mol Cell Proteomics. 2016 Jun;15(6):2076-92. doi: 10.1074/mcp.M115.057158. Epub 2016 Apr 11.


E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation.

Mitxelena J, Apraiz A, Vallejo-Rodríguez J, Malumbres M, Zubiaga AM.

Nucleic Acids Res. 2016 Mar 9. pii: gkw146. [Epub ahead of print]


LDLR and PCSK9 Are Associated with the Presence of Antiphospholipid Antibodies and the Development of Thrombosis in aPLA Carriers.

Ochoa E, Iriondo M, Manzano C, Fullaondo A, Villar I, Ruiz-Irastorza G, Zubiaga AM, Estonba A.

PLoS One. 2016 Jan 28;11(1):e0146990. doi: 10.1371/journal.pone.0146990. eCollection 2016.


Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene.

Valcárcel-Ocete L, Alkorta-Aranburu G, Iriondo M, Fullaondo A, García-Barcina M, Fernández-García JM, Lezcano-García E, Losada-Domingo JM, Ruiz-Ojeda J, Álvarez de Arcaya A, Pérez-Ramos JM, Roos RA, Nielsen JE, Saft C; REGISTRY investigators of the European Huntington's Disease Network, Zubiaga AM, Aguirre A.

PLoS One. 2015 Jul 6;10(7):e0131573. doi: 10.1371/journal.pone.0131573. eCollection 2015.


E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.

Iglesias-Ara A, Zenarruzabeitia O, Buelta L, Merino J, Zubiaga AM.

Cell Death Differ. 2015 Oct;22(10):1577-89. doi: 10.1038/cdd.2015.4. Epub 2015 Feb 6.


E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes.

Laresgoiti U, Apraiz A, Olea M, Mitxelena J, Osinalde N, Rodriguez JA, Fullaondo A, Zubiaga AM.

Nucleic Acids Res. 2013 Dec;41(22):10185-98. doi: 10.1093/nar/gkt821. Epub 2013 Sep 12.


Thrombotic antiphospholipid syndrome shows strong haplotypic association with SH2B3-ATXN2 locus.

Ochoa E, Iriondo M, Bielsa A, Ruiz-Irastorza G, Estonba A, Zubiaga AM.

PLoS One. 2013 Jul 3;8(7):e67897. doi: 10.1371/journal.pone.0067897. Print 2013.


The nuclear protein ALY binds to and modulates the activity of transcription factor E2F2.

Osinalde N, Olea M, Mitxelena J, Aloria K, Rodriguez JA, Fullaondo A, Arizmendi JM, Zubiaga AM.

Mol Cell Proteomics. 2013 May;12(5):1087-98. doi: 10.1074/mcp.M112.024158. Epub 2013 Jan 7.


Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation.

Arrizabalaga O, Lacerda HM, Zubiaga AM, Zugaza JL.

J Biol Chem. 2012 Apr 6;287(15):11878-90. doi: 10.1074/jbc.M111.297804. Epub 2012 Feb 15.


Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics.

Osinalde N, Moss H, Arrizabalaga O, Omaetxebarria MJ, Blagoev B, Zubiaga AM, Fullaondo A, Arizmendi JM, Kratchmarova I.

J Proteomics. 2011 Dec 10;75(1):177-91. doi: 10.1016/j.jprot.2011.06.007. Epub 2011 Jun 23.


A role for transcription factor E2F2 in hepatocyte proliferation and timely liver regeneration.

Delgado I, Fresnedo O, Iglesias A, Rueda Y, Syn WK, Zubiaga AM, Ochoa B.

Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G20-31. doi: 10.1152/ajpgi.00481.2010. Epub 2011 Apr 28.


Accelerated DNA replication in E2F1- and E2F2-deficient macrophages leads to induction of the DNA damage response and p21(CIP1)-dependent senescence.

Iglesias-Ara A, Zenarruzabeitia O, Fernandez-Rueda J, Sánchez-Tilló E, Field SJ, Celada A, Zubiaga AM.

Oncogene. 2010 Oct 14;29(41):5579-90. doi: 10.1038/onc.2010.296. Epub 2010 Aug 2.


Differential proteomics analysis reveals a role for E2F2 in the regulation of the Ahr pathway in T lymphocytes.

Azkargorta M, Fullaondo A, Laresgoiti U, Aloria K, Infante A, Arizmendi JM, Zubiaga AM.

Mol Cell Proteomics. 2010 Oct;9(10):2184-94. doi: 10.1074/mcp.M110.001263. Epub 2010 Jun 23.


Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice.

Ochoa B, Syn WK, Delgado I, Karaca GF, Jung Y, Wang J, Zubiaga AM, Fresnedo O, Omenetti A, Zdanowicz M, Choi SS, Diehl AM.

Hepatology. 2010 May;51(5):1712-23. doi: 10.1002/hep.23525.


Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.

Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández-Piqueras J, Zubiaga AM, Malumbres M.

Mol Cell Biol. 2010 Jun;30(12):2983-95. doi: 10.1128/MCB.01372-09. Epub 2010 Apr 19.


Microarray analysis of autoimmune diseases by machine learning procedures.

Armañanzas R, Calvo B, Inza I, López-Hoyos M, Martínez-Taboada V, Ucar E, Bernales I, Fullaondo A, Larrañaga P, Zubiaga AM.

IEEE Trans Inf Technol Biomed. 2009 May;13(3):341-50. doi: 10.1109/TITB.2008.2011984.


E2F2 represses cell cycle regulators to maintain quiescence.

Infante A, Laresgoiti U, Fernández-Rueda J, Fullaondo A, Galán J, Díaz-Uriarte R, Malumbres M, Field SJ, Zubiaga AM.

Cell Cycle. 2008 Dec 15;7(24):3915-27. Epub 2008 Dec 10.


Developmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissues.

Zhang J, Bahi N, Zubiaga AM, Comella JX, Llovera M, Sanchis D.

FEBS Lett. 2007 Dec 22;581(30):5781-6. Epub 2007 Nov 26.


Innate immune response gene expression profiles characterize primary antiphospholipid syndrome.

Bernales I, Fullaondo A, Marín-Vidalled MJ, Ucar E, Martínez-Taboada V, López-Hoyos M, Zubiaga AM.

Genes Immun. 2008 Jan;9(1):38-46. Epub 2007 Oct 25.


Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells.

Real PJ, Sanz C, Gutierrez O, Pipaon C, Zubiaga AM, Fernandez-Luna JL.

FEBS Lett. 2006 Oct 30;580(25):5905-9. Epub 2006 Oct 2.


SDS-CGE of proteins in microchannels made of SU-8 films.

Agirregabiria M, Blanco FJ, Berganzo J, Fullaondo A, Zubiaga AM, Mayora K, Ruano-López JM.

Electrophoresis. 2006 Sep;27(18):3627-34.


Differential proteome profiles in E2F2-deficient T lymphocytes.

Azkargorta M, Arizmendi JM, Elortza F, Alkorta N, Zubiaga AM, Fullaondo A.

Proteomics. 2006 Apr;6 Suppl 1:S42-50.


Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice.

Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, Moreno B, Lloreta J, Field SJ, Real FX, Zubiaga AM.

J Clin Invest. 2004 May;113(10):1398-407.


Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity.

Murga M, Fernández-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, Balomenos D, Vicario A, Carrera AC, Orkin SH, Greenberg ME, Zubiaga AM.

Immunity. 2001 Dec;15(6):959-70.


A role for E2F1 in the induction of apoptosis during thymic negative selection.

García I, Murga M, Vicario A, Field SJ, Zubiaga AM.

Cell Growth Differ. 2000 Feb;11(2):91-8.


E2F-1 functions in mice to promote apoptosis and suppress proliferation.

Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG Jr, Livingston DM, Orkin SH, Greenberg ME.

Cell. 1996 May 17;85(4):549-61.


The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation.

Zubiaga AM, Belasco JG, Greenberg ME.

Mol Cell Biol. 1995 Apr;15(4):2219-30.


IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis.

Zubiaga AM, Munoz E, Huber BT.

J Immunol. 1992 Jul 1;149(1):107-12.


Superinduction of IL-2 gene transcription in the presence of cycloheximide.

Zubiaga AM, Muñoz E, Huber BT.

J Immunol. 1991 Jun 1;146(11):3857-63.


Production of IL-1 alpha by activated Th type 2 cells. Its role as an autocrine growth factor.

Zubiaga AM, Muñoz E, Huber BT.

J Immunol. 1991 Jun 1;146(11):3849-56.


IL-1 signal transduction pathways. I. Two functional IL-1 receptors are expressed in T cells.

Muñoz E, Zubiaga AM, Sims JE, Huber BT.

J Immunol. 1991 Jan 1;146(1):136-43.


Regulation of interleukin 6 production in T helper cells.

Zubiaga AM, Munoz E, Merrow M, Huber BT.

Int Immunol. 1990;2(11):1047-54.


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