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Items: 1 to 50 of 72

1.

Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia.

Yonekura Collier AR, Zsengeller Z, Pernicone E, Salahuddin S, Khankin EV, Karumanchi SA.

Hypertens Pregnancy. 2019 Aug;38(3):193-199. doi: 10.1080/10641955.2019.1640725. Epub 2019 Jul 10.

PMID:
31291799
2.

TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance.

Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM.

JCI Insight. 2019 Mar 14;5. pii: 126749. doi: 10.1172/jci.insight.126749.

3.

RNAi modulation of placental sFLT1 for the treatment of preeclampsia.

Turanov AA, Lo A, Hassler MR, Makris A, Ashar-Patel A, Alterman JF, Coles AH, Haraszti RA, Roux L, Godinho BMDC, Echeverria D, Pears S, Iliopoulos J, Shanmugalingam R, Ogle R, Zsengeller ZK, Hennessy A, Karumanchi SA, Moore MJ, Khvorova A.

Nat Biotechnol. 2018 Nov 19. doi: 10.1038/nbt.4297. [Epub ahead of print]

4.

AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts: Relevance for Preeclampsia Pathogenesis.

Covarrubias AE, Lecarpentier E, Lo A, Salahuddin S, Gray KJ, Karumanchi SA, Zsengellér ZK.

Am J Pathol. 2019 Jan;189(1):104-114. doi: 10.1016/j.ajpath.2018.09.007. Epub 2018 Oct 11.

PMID:
30315766
5.

Complement 7 Is Up-Regulated in Human Early Diabetic Kidney Disease.

Sircar M, Rosales IA, Selig MK, Xu D, Zsengeller ZK, Stillman IE, Libermann TA, Karumanchi SA, Thadhani RI.

Am J Pathol. 2018 Oct;188(10):2147-2154. doi: 10.1016/j.ajpath.2018.06.018.

PMID:
30253844
6.

Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice.

Varga ZV, Erdelyi K, Paloczi J, Cinar R, Zsengeller ZK, Jourdan T, Matyas C, Nemeth BT, Guillot A, Xiang X, Mehal A, Haskó G, Stillman IE, Rosen S, Gao B, Kunos G, Pacher P.

Hepatology. 2018 Oct;68(4):1519-1533. doi: 10.1002/hep.29915.

PMID:
29631342
7.

Renal PGC1α May Be Associated with Recovery after Delayed Graft Function.

Drury ER, Zsengeller ZK, Stillman IE, Khankin EV, Pavlakis M, Parikh SM.

Nephron. 2018;138(4):303-309. doi: 10.1159/000485663. Epub 2017 Dec 21.

8.

Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies.

Horvath EM, Zsengellér ZK, Szabo C.

Methods Mol Biol. 2017;1608:19-26. doi: 10.1007/978-1-4939-6993-7_2.

PMID:
28695500
9.

The pathology of eclampsia: An autopsy series.

Hecht JL, Ordi J, Carrilho C, Ismail MR, Zsengeller ZK, Karumanchi SA, Rosen S.

Hypertens Pregnancy. 2017 Aug;36(3):259-268. doi: 10.1080/10641955.2017.1329430. Epub 2017 Jul 5.

PMID:
28678644
10.

Loss of kAE1 expression in collecting ducts of end-stage kidneys from a family with SLC4A1 G609R-associated distal renal tubular acidosis.

Vichot AA, Zsengellér ZK, Shmukler BE, Adams ND, Dahl NK, Alper SL.

Clin Kidney J. 2017 Feb;10(1):135-140. doi: 10.1093/ckj/sfw074. Epub 2016 Aug 31.

11.

Down-regulation of soluble fms-like tyrosine kinase 1 expression in invasive placentation.

Shainker SA, Dannheim K, Gerson KD, Neo D, Zsengeller ZK, Pernicone E, Karumanchi SA, Hacker MR, Hecht JL.

Arch Gynecol Obstet. 2017 Aug;296(2):257-262. doi: 10.1007/s00404-017-4432-7. Epub 2017 Jun 19.

PMID:
28631072
12.

Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.

Nezu M, Souma T, Yu L, Sekine H, Takahashi N, Wei AZ, Ito S, Fukamizu A, Zsengeller ZK, Nakamura T, Hozawa A, Karumanchi SA, Suzuki N, Yamamoto M.

Sci Signal. 2017 May 16;10(479). pii: eaam5711. doi: 10.1126/scisignal.aam5711.

PMID:
28512147
13.

Placental soluble fms-like tyrosine kinase expression in small for gestational age infants and risk for adverse outcomes.

Spiel M, Salahuddin S, Pernicone E, Zsengeller Z, Wang A, Modest AM, Karumanchi SA, Hecht JL.

Placenta. 2017 Apr;52:10-16. doi: 10.1016/j.placenta.2017.02.011. Epub 2017 Feb 10.

PMID:
28454690
14.

Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats.

Paauw ND, Joles JA, Spradley FT, Bakrania B, Zsengeller ZK, Franx A, Verhaar MC, Granger JP, Lely AT.

Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R664-R670. doi: 10.1152/ajpregu.00510.2016. Epub 2017 Feb 15.

15.

Macrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension.

DuBrock HM, Rodriguez-Lopez JM, LeVarge BL, Curry MP, VanderLaan PA, Zsengeller ZK, Pernicone E, Preston IR, Yu PB, Nikolic I, Xu D, Thadhani RI, Channick RN, Ananth Karumanchi S.

Pulm Circ. 2016 Dec;6(4):498-507. doi: 10.1086/688489.

16.

PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model.

Erpenbeck L, Chowdhury CS, Zsengellér ZK, Gallant M, Burke SD, Cifuni S, Hahn S, Wagner DD, Karumanchi SA.

Biol Reprod. 2016 Dec;95(6):132. doi: 10.1095/biolreprod.116.140293. Epub 2016 Nov 9.

17.

Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1.

Zsengellér ZK, Rajakumar A, Hunter JT, Salahuddin S, Rana S, Stillman IE, Ananth Karumanchi S.

Pregnancy Hypertens. 2016 Oct;6(4):313-319. doi: 10.1016/j.preghy.2016.06.004. Epub 2016 Jun 30.

PMID:
27939475
18.

The Use of Cytochrome C Oxidase Enzyme Activity and Immunohistochemistry in Defining Mitochondrial Injury in Kidney Disease.

Zsengellér ZK, Rosen S.

J Histochem Cytochem. 2016 Sep;64(9):546-55. doi: 10.1369/0022155416660291.

19.

Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia.

Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA.

J Clin Invest. 2016 Jul 1;126(7):2561-74. doi: 10.1172/JCI83918. Epub 2016 Jun 6.

20.

Revisiting decidual vasculopathy.

Hecht JL, Zsengeller ZK, Spiel M, Karumanchi SA, Rosen S.

Placenta. 2016 Jun;42:37-43. doi: 10.1016/j.placenta.2016.04.006. Epub 2016 Apr 8.

PMID:
27238712
21.

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.

Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM.

Nature. 2016 Mar 24;531(7595):528-32. doi: 10.1038/nature17184. Epub 2016 Mar 16.

22.

Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth.

Wang A, Zsengellér ZK, Hecht JL, Buccafusca R, Burke SD, Rajakumar A, Weingart E, Yu PB, Salahuddin S, Karumanchi SA.

J Clin Invest. 2015 Nov 2;125(11):4021-5. doi: 10.1172/JCI80457. Epub 2015 Sep 28.

23.

Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W.

Reimold FR, Balasubramanian S, Doroquez DB, Shmukler BE, Zsengeller ZK, Saslowsky D, Thiagarajah JR, Stillman IE, Lencer WI, Wu BL, Villalpando-Carrion S, Alper SL.

Front Physiol. 2015 Jun 23;6:179. doi: 10.3389/fphys.2015.00179. eCollection 2015.

24.

ADAMTS13 Endopeptidase Protects against Vascular Endothelial Growth Factor Inhibitor-Induced Thrombotic Microangiopathy.

Erpenbeck L, Demers M, Zsengellér ZK, Gallant M, Cifuni SM, Stillman IE, Karumanchi SA, Wagner DD.

J Am Soc Nephrol. 2016 Jan;27(1):120-31. doi: 10.1681/ASN.2014121165. Epub 2015 Jun 2.

25.

Placental lesions of vascular insufficiency are associated with anti-angiogenic state in women with preeclampsia.

Baltajian K, Hecht JL, Wenger JB, Salahuddin S, Verlohren S, Perschel FH, Zsengeller ZK, Thadhani R, Karumanchi SA, Rana S.

Hypertens Pregnancy. 2014 Nov;33(4):427-39. doi: 10.3109/10641955.2014.926914. Epub 2014 Jul 25.

PMID:
25062083
26.

Methylmalonic acidemia: a megamitochondrial disorder affecting the kidney.

Zsengellér ZK, Aljinovic N, Teot LA, Korson M, Rodig N, Sloan JL, Venditti CP, Berry GT, Rosen S.

Pediatr Nephrol. 2014 Nov;29(11):2139-46. doi: 10.1007/s00467-014-2847-y. Epub 2014 May 28.

PMID:
24865477
27.

Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor.

Holwerda KM, Burke SD, Faas MM, Zsengeller Z, Stillman IE, Kang PM, van Goor H, McCurley A, Jaffe IZ, Karumanchi SA, Lely AT.

J Am Soc Nephrol. 2014 Apr;25(4):717-25. doi: 10.1681/ASN.2013030291. Epub 2013 Dec 12.

28.

Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle.

Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z.

Cell Rep. 2013 May 30;3(5):1449-56. doi: 10.1016/j.celrep.2013.04.023. Epub 2013 May 23.

29.

Transcriptional patterns in peritoneal tissue of encapsulating peritoneal sclerosis, a complication of chronic peritoneal dialysis.

Reimold FR, Braun N, Zsengellér ZK, Stillman IE, Karumanchi SA, Toka HR, Latus J, Fritz P, Biegger D, Segerer S, Alscher MD, Bhasin MK, Alper SL.

PLoS One. 2013;8(2):e56389. doi: 10.1371/journal.pone.0056389. Epub 2013 Feb 13.

30.

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants.

Mukhopadhyay P, Horváth B, Zsengellėr Z, Bátkai S, Cao Z, Kechrid M, Holovac E, Erdėlyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P.

Free Radic Biol Med. 2012 Sep 1;53(5):1123-38. doi: 10.1016/j.freeradbiomed.2012.05.036. Epub 2012 Jun 6.

31.

Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity.

Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P.

J Histochem Cytochem. 2012 Jul;60(7):521-9. doi: 10.1369/0022155412446227. Epub 2012 Apr 17.

32.

Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia.

Rajakumar A, Cerdeira AS, Rana S, Zsengeller Z, Edmunds L, Jeyabalan A, Hubel CA, Stillman IE, Parikh SM, Karumanchi SA.

Hypertension. 2012 Feb;59(2):256-64. doi: 10.1161/HYPERTENSIONAHA.111.182170. Epub 2012 Jan 3.

33.

Placental origins of angiogenic dysfunction in mirror syndrome.

Bixel K, Silasi M, Zelop CM, Lim KH, Zsengeller Z, Stillman IE, Rana S.

Hypertens Pregnancy. 2012;31(2):211-7. doi: 10.3109/10641955.2011.638959. Epub 2011 Dec 9.

PMID:
22150085
34.

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy.

Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P.

Free Radic Biol Med. 2012 Jan 15;52(2):497-506. doi: 10.1016/j.freeradbiomed.2011.11.001. Epub 2011 Nov 10.

35.

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice.

Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM.

J Clin Invest. 2011 Oct;121(10):4003-14. doi: 10.1172/JCI58662. Epub 2011 Sep 1.

36.

Quantification of PARP activity in human tissues: ex vivo assays in blood cells and immunohistochemistry in human biopsies.

Horvath EM, Zsengellér ZK, Szabo C.

Methods Mol Biol. 2011;780:267-75. doi: 10.1007/978-1-61779-270-0_16.

37.

Placental expression of angiogenic factors in Trisomy 13.

Silasi M, Rana S, Powe C, Cohen B, Lim KH, Zsengellér ZK, Karumanchi SA, Stillman IE.

Am J Obstet Gynecol. 2011 Jun;204(6):546.e1-4. doi: 10.1016/j.ajog.2011.02.027. Epub 2011 Apr 20.

PMID:
21507376
38.

A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury.

Dib M, Zsengeller Z, Mitsialis A, Lu B, Craig S, Gerard C, Gerard NP.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L687-97. doi: 10.1152/ajplung.90509.2008. Epub 2009 Jul 24.

39.

Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.

Mukhopadhyay P, Bátkai S, Rajesh M, Czifra N, Harvey-White J, Haskó G, Zsengeller Z, Gerard NP, Liaudet L, Kunos G, Pacher P.

J Am Coll Cardiol. 2007 Aug 7;50(6):528-36. Epub 2007 Jul 23.

40.

Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes.

Tóth-Zsámboki E, Horváth E, Vargova K, Pankotai E, Murthy K, Zsengellér Z, Bárány T, Pék T, Fekete K, Kiss RG, Préda I, Lacza Z, Gerö D, Szabó C.

Mol Med. 2006 Sep-Oct;12(9-10):221-8.

41.

Indices of apoptosis activation after blood cardioplegia and cardiopulmonary bypass.

Ramlawi B, Feng J, Mieno S, Szabo C, Zsengeller Z, Clements R, Sodha N, Boodhwani M, Bianchi C, Sellke FW.

Circulation. 2006 Jul 4;114(1 Suppl):I257-63.

PMID:
16820582
42.

Potential role of poly(adenosine 5'-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock.

Soriano FG, Nogueira AC, Caldini EG, Lins MH, Teixeira AC, Cappi SB, Lotufo PA, Bernik MM, Zsengellér Z, Chen M, Szabó C.

Crit Care Med. 2006 Apr;34(4):1073-9.

PMID:
16484919
43.

Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury.

Kendirci M, Zsengellér Z, Bivalacqua TJ, Gur S, Usta MF, Chen M, Szabó C, Hellstrom WJ.

J Urol. 2005 Nov;174(5):2054-9.

PMID:
16217393
44.

Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation.

Mabley JG, Horváth EM, Murthy KG, Zsengellér Z, Vaslin A, Benko R, Kollai M, Szabó C.

J Pharmacol Exp Ther. 2005 Nov;315(2):812-20. Epub 2005 Aug 3.

PMID:
16079296
45.

Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat.

Besson VC, Zsengellér Z, Plotkine M, Szabó C, Marchand-Verrecchia C.

Brain Res. 2005 Apr 18;1041(2):149-56.

PMID:
15829224
46.

Poly(ADP-ribose) polymerase inhibition attenuates biventricular reperfusion injury after orthotopic heart transplantation.

Szabó G, Soós P, Heger U, Flechtenmacher C, Bährle S, Zsengellér Z, Szabó C, Hagl S.

Eur J Cardiothorac Surg. 2005 Feb;27(2):226-34.

PMID:
15691675
47.

Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.

Obrosova IG, Pacher P, Szabó C, Zsengeller Z, Hirooka H, Stevens MJ, Yorek MA.

Diabetes. 2005 Jan;54(1):234-42.

48.

Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst.

Obrosova IG, Mabley JG, Zsengellér Z, Charniauskaya T, Abatan OI, Groves JT, Szabó C.

FASEB J. 2005 Mar;19(3):401-3. Epub 2004 Dec 20.

PMID:
15611153
49.

Mesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase.

Szabó G, Soós P, Mandera S, Heger U, Flechtenmacher C, Seres L, Zsengellér Z, Sack FU, Szabó C, Hagl S.

Crit Care Med. 2004 Dec;32(12):2392-7.

PMID:
15599141
50.

Poly-ADP-ribose polymerase inhibition reduces mesenteric injury after cardiopulmonary bypass.

Szabó G, Seres L, Soós P, Flechtenmacher C, Zsengellér Z, Sack FU, Szabó C, Hagl S.

Thorac Cardiovasc Surg. 2004 Dec;52(6):338-43.

PMID:
15573274

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