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Items: 11

1.

Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease.

Vilariño-Güell C, Zimprich A, Martinelli-Boneschi F, Herculano B, Wang Z, Matesanz F, Urcelay E, Vandenbroeck K, Leyva L, Gris D, Massaad C, Quandt JA, Traboulsee AL, Encarnacion M, Bernales CQ, Follett J, Yee IM, Criscuoli MG, Deutschländer A, Reinthaler EM, Zrzavy T, Mascia E, Zauli A, Esposito F, Alcina A, Izquierdo G, Espino-Paisán L, Mena J, Antigüedad A, Urbaneja-Romero P, Ortega-Pinazo J, Song W, Sadovnick AD.

PLoS Genet. 2019 Jun 6;15(6):e1008180. doi: 10.1371/journal.pgen.1008180. eCollection 2019 Jun.

2.

Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis.

Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, Tröscher AR, Kitic M, Ueda S, Bradl M, Lassmann H.

Acta Neuropathol Commun. 2019 Jan 31;7(1):14. doi: 10.1186/s40478-019-0667-9.

3.

TPP2 mutation associated with sterile brain inflammation mimicking MS.

Reinthaler EM, Graf E, Zrzavy T, Wieland T, Hotzy C, Kopecky C, Pferschy S, Schmied C, Leutmezer F, Keilani M, Lill CM, Hoffjan S, Epplen JT, Zettl UK, Hecker M, Deutschländer A, Meuth SG, Ahram M, Mustafa B, El-Khateeb M, Vilariño-Güell C, Sadovnick AD, Zimprich F, Tomkinson B, Strom T, Kristoferitsch W, Lassmann H, Zimprich A.

Neurol Genet. 2018 Nov 13;4(6):e285. doi: 10.1212/NXG.0000000000000285. eCollection 2018 Dec.

4.

A rare P2RX7 variant in a Hungarian family with multiple sclerosis.

Zrzavy T, Kovacs-Nagy R, Reinthaler E, Deutschländer A, Schmied C, Kornek B, Leutmezer F, Zimprich A.

Mult Scler Relat Disord. 2019 Jan;27:340-341. doi: 10.1016/j.msard.2018.10.110. Epub 2018 Oct 27. No abstract available.

PMID:
30472412
5.

Neuroinflammatory responses in experimental and human stroke lesions.

Wimmer I, Zrzavy T, Lassmann H.

J Neuroimmunol. 2018 Oct 15;323:10-18. doi: 10.1016/j.jneuroim.2018.07.003. Epub 2018 Jul 6. Review.

6.

Pro-inflammatory activation of microglia in the brain of patients with sepsis.

Zrzavy T, Höftberger R, Berger T, Rauschka H, Butovsky O, Weiner H, Lassmann H.

Neuropathol Appl Neurobiol. 2019 Apr;45(3):278-290. doi: 10.1111/nan.12502. Epub 2018 Jun 19.

7.

Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts.

Zrzavy T, Machado-Santos J, Christine S, Baumgartner C, Weiner HL, Butovsky O, Lassmann H.

Brain Pathol. 2018 Nov;28(6):791-805. doi: 10.1111/bpa.12583. Epub 2017 Dec 28.

8.

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O.

Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008.

9.

Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis.

Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H.

Brain. 2017 Jul 1;140(7):1900-1913. doi: 10.1093/brain/awx113.

10.

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain.

Haider L, Zrzavy T, Hametner S, Höftberger R, Bagnato F, Grabner G, Trattnig S, Pfeifenbring S, Brück W, Lassmann H.

Brain. 2016 Mar;139(Pt 3):807-15. doi: 10.1093/brain/awv398. Epub 2016 Feb 8.

11.

Disease-specific molecular events in cortical multiple sclerosis lesions.

Fischer MT, Wimmer I, Höftberger R, Gerlach S, Haider L, Zrzavy T, Hametner S, Mahad D, Binder CJ, Krumbholz M, Bauer J, Bradl M, Lassmann H.

Brain. 2013 Jun;136(Pt 6):1799-815. doi: 10.1093/brain/awt110. Epub 2013 May 17.

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