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Items: 19

1.

Oligoarginine Peptides, a New Family of nAChR Inhibitors.

Lebedev D, Kryukova E, Ivanov I, Egorova N, Timofeev N, Spirova E, Tufanova E, Siniavin A, Kudryavtsev D, Kasheverov I, Zouridakis M, Katsarava R, Zavradashvili N, Iagorshvili I, Tzartos S, Tsetlin V.

Mol Pharmacol. 2019 Sep 6. pii: mol.119.117713. doi: 10.1124/mol.119.117713. [Epub ahead of print]

2.

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors.

Zouridakis M, Papakyriakou A, Ivanov IA, Kasheverov IE, Tsetlin V, Tzartos S, Giastas P.

Front Pharmacol. 2019 May 1;10:474. doi: 10.3389/fphar.2019.00474. eCollection 2019.

3.

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models.

Kryukova EV, Ivanov IA, Lebedev DS, Spirova EN, Egorova NS, Zouridakis M, Kasheverov IE, Tzartos SJ, Tsetlin VI.

Mar Drugs. 2018 Nov 22;16(12). pii: E460. doi: 10.3390/md16120460.

4.

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors.

Vulfius CA, Kasheverov IE, Kryukova EV, Spirova EN, Shelukhina IV, Starkov VG, Andreeva TV, Faure G, Zouridakis M, Tsetlin VI, Utkin YN.

PLoS One. 2017 Oct 12;12(10):e0186206. doi: 10.1371/journal.pone.0186206. eCollection 2017.

5.

Understanding structure-function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits.

Giastas P, Zouridakis M, Tzartos SJ.

Br J Pharmacol. 2018 Jun;175(11):1880-1891. doi: 10.1111/bph.13838. Epub 2017 Jun 20. Review.

6.

The role of carbohydrate component of recombinant α7 nicotinic acetylcholine receptor extracellular domain in its immunogenicity and functional effects of resulting antibodies.

Lykhmus O, Koval L, Pastuhova D, Zouridakis M, Tzartos S, Komisarenko S, Skok M.

Immunobiology. 2016 Dec;221(12):1355-1361. doi: 10.1016/j.imbio.2016.07.012. Epub 2016 Jul 25.

PMID:
27498631
7.

Inflammation decreases the level of alpha7 nicotinic acetylcholine receptors in the brain mitochondria and makes them more susceptible to apoptosis induction.

Lykhmus O, Gergalova G, Zouridakis M, Tzartos S, Komisarenko S, Skok M.

Int Immunopharmacol. 2015 Nov;29(1):148-51. doi: 10.1016/j.intimp.2015.04.007. Epub 2015 Apr 15.

PMID:
25887272
8.

α7 Nicotinic acetylcholine receptor-specific antibody induces inflammation and amyloid β42 accumulation in the mouse brain to impair memory.

Lykhmus O, Voytenko L, Koval L, Mykhalskiy S, Kholin V, Peschana K, Zouridakis M, Tzartos S, Komisarenko S, Skok M.

PLoS One. 2015 Mar 27;10(3):e0122706. doi: 10.1371/journal.pone.0122706. eCollection 2015.

9.

Molecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptor.

Azam L, Papakyriakou A, Zouridakis M, Giastas P, Tzartos SJ, McIntosh JM.

Mol Pharmacol. 2015 May;87(5):855-64. doi: 10.1124/mol.114.096511. Epub 2015 Mar 4. Erratum in: Mol Pharmacol. 2016 Oct;90(4):415-7.

10.

Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain.

Zouridakis M, Giastas P, Zarkadas E, Chroni-Tzartou D, Bregestovski P, Tzartos SJ.

Nat Struct Mol Biol. 2014 Nov;21(11):976-80. doi: 10.1038/nsmb.2900. Epub 2014 Oct 5.

PMID:
25282151
11.

Expression of a highly antigenic and native-like folded extracellular domain of the human α1 subunit of muscle nicotinic acetylcholine receptor, suitable for use in antigen specific therapies for Myasthenia Gravis.

Niarchos A, Zouridakis M, Douris V, Georgostathi A, Kalamida D, Sotiriadis A, Poulas K, Iatrou K, Tzartos SJ.

PLoS One. 2013 Dec 20;8(12):e84791. doi: 10.1371/journal.pone.0084791. eCollection 2013.

12.

The presence and origin of autoantibodies against α4 and α7 nicotinic acetylcholine receptors in the human blood: possible relevance to Alzheimer's pathology.

Koval L, Lykhmus O, Kalashnyk O, Bachinskaya N, Kravtsova G, Soldatkina M, Zouridakis M, Stergiou C, Tzartos S, Tsetlin V, Komisarenko S, Skok M.

J Alzheimers Dis. 2011;25(4):747-61. doi: 10.3233/JAD-2011-101845.

PMID:
21593571
13.

Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology.

Lykhmus O, Koval L, Skok M, Zouridakis M, Zisimopoulou P, Tzartos S, Tsetlin V, Granon S, Changeux JP, Komisarenko S, Cloëz-Tayarani I.

J Alzheimers Dis. 2011;24(4):693-704. doi: 10.3233/JAD-2011-101842.

PMID:
21321393
14.

Functional effects of antibodies against non-neuronal nicotinic acetylcholine receptors.

Lykhmus O, Koval L, Pavlovych S, Zouridakis M, Zisimopoulou P, Tzartos S, Tsetlin V, Volpina O, Cloëz-Tayarani I, Komisarenko S, Skok M.

Immunol Lett. 2010 Jan 18;128(1):68-73. doi: 10.1016/j.imlet.2009.11.006. Epub 2009 Nov 18.

PMID:
19931311
15.

Recent advances in understanding the structure of nicotinic acetylcholine receptors.

Zouridakis M, Zisimopoulou P, Poulas K, Tzartos SJ.

IUBMB Life. 2009 Apr;61(4):407-23. doi: 10.1002/iub.170. Review.

16.

Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.

Zouridakis M, Zisimopoulou P, Eliopoulos E, Poulas K, Tzartos SJ.

Biochim Biophys Acta. 2009 Feb;1794(2):355-66. doi: 10.1016/j.bbapap.2008.11.002. Epub 2008 Nov 19.

PMID:
19059502
17.

Circular dichroism studies of extracellular domains of human nicotinic acetylcholine receptors provide an insight into their structure.

Zouridakis M, Kostelidou K, Sotiriadis A, Stergiou C, Eliopoulos E, Poulas K, Tzartos SJ.

Int J Biol Macromol. 2007 Oct 1;41(4):423-9. Epub 2007 Jun 8.

PMID:
17659334
18.

Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity.

Kalamida D, Poulas K, Avramopoulou V, Fostieri E, Lagoumintzis G, Lazaridis K, Sideri A, Zouridakis M, Tzartos SJ.

FEBS J. 2007 Aug;274(15):3799-845. Review.

19.

Expression and characterization of soluble forms of the extracellular domains of the beta, gamma and epsilon subunits of the human muscle acetylcholine receptor.

Kostelidou K, Trakas N, Zouridakis M, Bitzopoulou K, Sotiriadis A, Gavra I, Tzartos SJ.

FEBS J. 2006 Aug;273(15):3557-68.

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