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JAMA Psychiatry: Best of 2019.

Zorumski CF.

JAMA Psychiatry. 2020 Jan 2. doi: 10.1001/jamapsychiatry.2019.3272. [Epub ahead of print] No abstract available.


Trial of SAGE-217 in Patients with Major Depressive Disorder. Reply.

Gunduz-Bruce H, Kanes SJ, Zorumski CF.

N Engl J Med. 2019 Nov 28;381(22):2179. doi: 10.1056/NEJMc1913170. No abstract available.


Mild chronic perturbation of inhibition severely alters hippocampal function.

Sun MY, Ziolkowski L, Lambert P, Shu HJ, Keiser M, Rensing N, Warikoo N, Martinek M, Platnick C, Benz A, Bracamontes J, Akk G, Steinbach JH, Zorumski CF, Wong M, Mennerick S.

Sci Rep. 2019 Nov 11;9(1):16431. doi: 10.1038/s41598-019-52851-w.


Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond.

Zorumski CF, Paul SM, Covey DF, Mennerick S.

Neurobiol Stress. 2019 Sep 27;11:100196. doi: 10.1016/j.ynstr.2019.100196. eCollection 2019 Nov.


An Integrative Model of Personality Disorder: Part 3: Mechanism-Based Approach to the Pharmacotherapy of Personality Disorder: An Emerging Concept.

Svrakic D, Mofsen A, Chockalingam R, Divac-Jovanovic M, Zorumski CF.

Psychiatr Danub. 2019 Sep;31(3):290-307. doi: 10.24869/psyd.2019.290.


Trial of SAGE-217 in Patients with Major Depressive Disorder.

Gunduz-Bruce H, Silber C, Kaul I, Rothschild AJ, Riesenberg R, Sankoh AJ, Li H, Lasser R, Zorumski CF, Rubinow DR, Paul SM, Jonas J, Doherty JJ, Kanes SJ.

N Engl J Med. 2019 Sep 5;381(10):903-911. doi: 10.1056/NEJMoa1815981.


Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum.

Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM.

Br J Anaesth. 2019 May;122(5):643-651. doi: 10.1016/j.bja.2019.01.029. Epub 2019 Feb 28.


Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer's disease.

Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y.

Neuropsychiatry (London). 2018;8(1):344-359. doi: 10.4172/Neuropsychiatry.1000356.


Temperoammonic Stimulation Depotentiates Schaffer Collateral LTP via p38 MAPK Downstream of Adenosine A1 Receptors.

Izumi Y, Zorumski CF.

J Neurosci. 2019 Mar 6;39(10):1783-1792. doi: 10.1523/JNEUROSCI.1362-18.2018. Epub 2019 Jan 8.


A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons.

Chen DM, Ziolkowski L, Benz A, Qian M, Zorumski CF, Covey DF, Mennerick S.

Front Neurosci. 2018 Dec 6;12:923. doi: 10.3389/fnins.2018.00923. eCollection 2018.


Dissection method affects electrophysiological properties of hippocampal slices.

Stein LR, Zorumski CF, Izumi Y.

Oruen. 2017 Dec;3(2):94-101.


Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization.

Chisari M, Wilding TJ, Brunwasser S, Krishnan K, Qian M, Benz A, Huettner JE, Zorumski CF, Covey DF, Mennerick S.

Neuropharmacology. 2019 Jan;144:91-103. doi: 10.1016/j.neuropharm.2018.10.015. Epub 2018 Oct 15.


Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model.

Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y.

Sci Rep. 2018 Aug 27;8(1):12851. doi: 10.1038/s41598-018-31239-2.


Chemogenetic Isolation Reveals Synaptic Contribution of δ GABAA Receptors in Mouse Dentate Granule Neurons.

Sun MY, Shu HJ, Benz A, Bracamontes J, Akk G, Zorumski CF, Steinbach JH, Mennerick SJ.

J Neurosci. 2018 Sep 19;38(38):8128-8145. doi: 10.1523/JNEUROSCI.0799-18.2018. Epub 2018 Aug 3.


Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment.

Maloney SE, Creeley CE, Hartman RE, Yuede CM, Zorumski CF, Jevtovic-Todorovic V, Dikranian K, Noguchi KK, Farber NB, Wozniak DF.

Neurobiol Learn Mem. 2019 Nov;165:106834. doi: 10.1016/j.nlm.2018.03.014. Epub 2018 Mar 14.


Positive Allosteric Modulation as a Potential Therapeutic Strategy in Anti-NMDA Receptor Encephalitis.

Warikoo N, Brunwasser SJ, Benz A, Shu HJ, Paul SM, Lewis M, Doherty J, Quirk M, Piccio L, Zorumski CF, Day GS, Mennerick S.

J Neurosci. 2018 Mar 28;38(13):3218-3229. doi: 10.1523/JNEUROSCI.3377-17.2018. Epub 2018 Feb 23.


Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts.

Nagele P, Zorumski CF, Conway C.

J Clin Psychopharmacol. 2018 Apr;38(2):144-148. doi: 10.1097/JCP.0000000000000837. Review.


Neuregulin and Dopamine D4 Receptors Contribute Independently to Depotentiation of Schaffer Collateral LTP by Temperoammonic Path Stimulation.

Izumi Y, Zorumski CF.

eNeuro. 2017 Aug 21;4(4). pii: ENEURO.0176-17.2017. doi: 10.1523/ENEURO.0176-17.2017. eCollection 2017 Jul-Aug.


The role of T-type calcium channels in the subiculum: to burst or not to burst?

Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM.

J Physiol. 2017 Oct 1;595(19):6327-6348. doi: 10.1113/JP274565. Epub 2017 Aug 18.


Contributions of space-clamp errors to apparent time-dependent loss of Mg2+ block induced by NMDA.

Sun MY, Chisari M, Eisenman LN, Zorumski CF, Mennerick SJ.

J Neurophysiol. 2017 Jul 1;118(1):532-543. doi: 10.1152/jn.00106.2017. Epub 2017 Mar 29.


24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation.

Sun MY, Taylor A, Zorumski CF, Mennerick S.

PLoS One. 2017 Mar 27;12(3):e0174416. doi: 10.1371/journal.pone.0174416. eCollection 2017.


Use of Ketamine in Clinical Practice: A Time for Optimism and Caution.

Zorumski CF, Conway CR.

JAMA Psychiatry. 2017 Apr 1;74(4):405-406. doi: 10.1001/jamapsychiatry.2017.0078. No abstract available.


High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy: A Prospective, Observational Cohort Study.

Duma A, Pal S, Johnston J, Helwani MA, Bhat A, Gill B, Rosenkvist J, Cartmill C, Brown F, Miller JP, Scott MG, Sanchez-Conde F, Jarvis M, Farber NB, Zorumski CF, Conway C, Nagele P.

Anesthesiology. 2017 Apr;126(4):643-652. doi: 10.1097/ALN.0000000000001531.


A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons.

Emnett C, Li H, Jiang X, Benz A, Boggiano J, Conyers S, Wozniak DF, Zorumski CF, Reichert DE, Mennerick S.

Sci Rep. 2016 Dec 16;6:38808. doi: 10.1038/srep38808.


Ketamine: NMDA Receptors and Beyond.

Zorumski CF, Izumi Y, Mennerick S.

J Neurosci. 2016 Nov 2;36(44):11158-11164.


24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.

Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y.

Sci Rep. 2016 Sep 22;6:33886. doi: 10.1038/srep33886.


TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model.

Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y.

Neuropharmacology. 2016 Dec;111:142-159. doi: 10.1016/j.neuropharm.2016.09.001. Epub 2016 Sep 3.


Effect of electrical parameters on ECT convulsive threshold and duration.

Isenberg KE, Dinwiddie S, Heath AC, Osborne V, Tepper M, Jarvis M, Spitznagel EL, Zorumski CF, North CS.

Ann Clin Psychiatry. 2016 May;28(2):105-16.


Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats.

Stein LR, O'Dell KA, Funatsu M, Zorumski CF, Izumi Y.

Neuroscience. 2016 Aug 4;329:294-305. doi: 10.1016/j.neuroscience.2016.05.020. Epub 2016 May 18.


A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition.

Jiang X, Shu HJ, Krishnan K, Qian M, Taylor AA, Covey DF, Zorumski CF, Mennerick S.

Neuropharmacology. 2016 Sep;108:193-206. doi: 10.1016/j.neuropharm.2016.04.031. Epub 2016 Apr 22.


GABA and Endocannabinoids Mediate Depotentiation of Schaffer Collateral Synapses Induced by Stimulation of Temperoammonic Inputs.

Izumi Y, Zorumski CF.

PLoS One. 2016 Feb 10;11(2):e0149034. doi: 10.1371/journal.pone.0149034. eCollection 2016.


Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices.

Sun MY, Izumi Y, Benz A, Zorumski CF, Mennerick S.

J Neurophysiol. 2016 Mar;115(3):1263-72. doi: 10.1152/jn.00890.2015. Epub 2015 Dec 23.


Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy.

Zorumski CF, Nagele P, Mennerick S, Conway CR.

Front Psychiatry. 2015 Dec 9;6:172. doi: 10.3389/fpsyt.2015.00172. eCollection 2015. Review.


Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors.

Stein LR, Zorumski CF, Imai S, Izumi Y.

Brain Res Bull. 2015 Oct;119(Pt A):41-51. doi: 10.1016/j.brainresbull.2015.10.005. Epub 2015 Oct 19.


Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis.

Izumi Y, O'Dell KA, Zorumski CF.

Front Cell Neurosci. 2015 Jul 3;9:254. doi: 10.3389/fncel.2015.00254. eCollection 2015.


Experimentally Induced Mammalian Models of Glaucoma.

Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y.

Biomed Res Int. 2015;2015:281214. doi: 10.1155/2015/281214. Epub 2015 May 3. Review.


Quantification of bursting and synchrony in cultured hippocampal neurons.

Eisenman LN, Emnett CM, Mohan J, Zorumski CF, Mennerick S.

J Neurophysiol. 2015 Aug;114(2):1059-71. doi: 10.1152/jn.00079.2015. Epub 2015 Jun 3.


24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival.

Sun MY, Linsenbardt AJ, Emnett CM, Eisenman LN, Izumi Y, Zorumski CF, Mennerick S.

Neuroscientist. 2016 Apr;22(2):132-44. doi: 10.1177/1073858414568122. Epub 2015 Jan 27. Review.


Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.

Nagele P, Duma A, Kopec M, Gebara MA, Parsoei A, Walker M, Janski A, Panagopoulos VN, Cristancho P, Miller JP, Zorumski CF, Conway CR.

Biol Psychiatry. 2015 Jul 1;78(1):10-18. doi: 10.1016/j.biopsych.2014.11.016. Epub 2014 Dec 9.


Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.

Izumi Y, Zorumski CF.

J Pharmacol Exp Ther. 2015 Feb;352(2):267-73. doi: 10.1124/jpet.114.220582. Epub 2014 Nov 20.


Neurosteroids are endogenous neuroprotectants in an ex vivo glaucoma model.

Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y.

Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12):8531-41. doi: 10.1167/iovs.14-15624.


Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.

Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF, Mennerick S.

Br J Pharmacol. 2015 Mar;172(5):1333-47. doi: 10.1111/bph.13007. Epub 2015 Jan 13.


Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function.

Izumi Y, Zorumski CF.

Neuropharmacology. 2014 Nov;86:273-81. doi: 10.1016/j.neuropharm.2014.08.002. Epub 2014 Aug 13.


Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.

Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S.

Neuropharmacology. 2014 Oct;85:232-42. doi: 10.1016/j.neuropharm.2014.05.027. Epub 2014 May 27.


Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function.

Stein LR, Wozniak DF, Dearborn JT, Kubota S, Apte RS, Izumi Y, Zorumski CF, Imai S.

J Neurosci. 2014 Apr 23;34(17):5800-15. doi: 10.1523/JNEUROSCI.4730-13.2014.


11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS.

Psychopharmacology (Berl). 2014 Sep;231(17):3479-91. doi: 10.1007/s00213-014-3568-4. Epub 2014 Apr 23.


Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus.

Purgert CA, Izumi Y, Jong YJ, Kumar V, Zorumski CF, O'Malley KL.

J Neurosci. 2014 Mar 26;34(13):4589-98. doi: 10.1523/JNEUROSCI.3451-13.2014.


Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.

Mennerick S, Taylor AA, Zorumski CF.

Psychopharmacology (Berl). 2014 Sep;231(17):3493-501. doi: 10.1007/s00213-014-3486-5. Epub 2014 Feb 20.


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