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Items: 1 to 50 of 107


The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats.

Kreisler AD, Mattock M, Zorrilla EP.

Appetite. 2018 Nov 1;130:59-69. doi: 10.1016/j.appet.2018.07.025. Epub 2018 Jul 29.


Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake.

Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH.

Neuropsychopharmacology. 2018 Aug;43(9):1840-1850. doi: 10.1038/s41386-018-0055-3. Epub 2018 Apr 5.


Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: Sex differences and individual vulnerability.

Spierling SR, Kreisler AD, Williams CA, Fang SY, Pucci SN, Kines KT, Zorrilla EP.

Physiol Behav. 2018 Aug 1;192:3-16. doi: 10.1016/j.physbeh.2018.04.001. Epub 2018 Apr 11.


Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism.

Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP.

Front Psychiatry. 2018 Feb 15;9:28. doi: 10.3389/fpsyt.2018.00028. eCollection 2018.


Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats.

Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF.

Psychopharmacology (Berl). 2018 Apr;235(4):1131-1140. doi: 10.1007/s00213-018-4830-y. Epub 2018 Jan 21.


Corticotropin-Releasing Factor (CRF) and Addictive Behaviors.

Roberto M, Spierling SR, Kirson D, Zorrilla EP.

Int Rev Neurobiol. 2017;136:5-51. doi: 10.1016/bs.irn.2017.06.004. Epub 2017 Aug 7. Review.


CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure.

Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O.

Alcohol Clin Exp Res. 2017 Nov;41(11):1886-1895. doi: 10.1111/acer.13484. Epub 2017 Sep 22.


Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors.

Somkuwar SS, Vendruscolo LF, Fannon MJ, Schmeichel BE, Nguyen TB, Guevara J, Sidhu H, Contet C, Zorrilla EP, Mandyam CD.

Psychoneuroendocrinology. 2017 Oct;84:17-31. doi: 10.1016/j.psyneuen.2017.06.006. Epub 2017 Jun 12.


Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement.

Spierling SR, Mattock M, Zorrilla EP.

Physiol Behav. 2017 Aug 1;177:99-106. doi: 10.1016/j.physbeh.2017.04.016. Epub 2017 Apr 19.


Extended vs. brief intermittent access to palatable food differently promote binge-like intake, rejection of less preferred food, and weight cycling in female rats.

Kreisler AD, Garcia MG, Spierling SR, Hui BE, Zorrilla EP.

Physiol Behav. 2017 Aug 1;177:305-316. doi: 10.1016/j.physbeh.2017.03.039. Epub 2017 Mar 30.


Don't stress about CRF: assessing the translational failures of CRF1antagonists.

Spierling SR, Zorrilla EP.

Psychopharmacology (Berl). 2017 May;234(9-10):1467-1481. doi: 10.1007/s00213-017-4556-2. Epub 2017 Mar 7. Review.


Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers.

Frihauf JB, Fekete ÉM, Nagy TR, Levin BE, Zorrilla EP.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1045-R1059. doi: 10.1152/ajpregu.00023.2016. Epub 2016 Sep 21.


Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal.

Logrip ML, Zorrilla EP.

Front Integr Neurosci. 2014 Apr 8;8:30. doi: 10.3389/fnint.2014.00030. eCollection 2014.


Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats.

Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP.

Neuropsychopharmacology. 2014 Jun;39(7):1722-31. doi: 10.1038/npp.2014.20. Epub 2014 Jan 29.


Corticotropin releasing factor: a key role in the neurobiology of addiction.

Zorrilla EP, Logrip ML, Koob GF.

Front Neuroendocrinol. 2014 Apr;35(2):234-44. doi: 10.1016/j.yfrne.2014.01.001. Epub 2014 Jan 20. Review.


Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice.

Zorrilla EP, Conti B.

Brain Behav Immun. 2014 Mar;37:45-53. doi: 10.1016/j.bbi.2013.12.001. Epub 2013 Dec 6.


Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors.

Zorrilla EP, Roberts AJ, Rivier JE, Koob GF.

PLoS One. 2013 Aug 28;8(8):e63942. doi: 10.1371/journal.pone.0063942. eCollection 2013.


Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala.

Blasio A, Iemolo A, Sabino V, Petrosino S, Steardo L, Rice KC, Orlando P, Iannotti FA, Di Marzo V, Zorrilla EP, Cottone P.

Neuropsychopharmacology. 2013 Nov;38(12):2498-507. doi: 10.1038/npp.2013.153. Epub 2013 Jun 24.


Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats.

Cottone P, Sabino V, Nagy TR, Coscina DV, Levin BE, Zorrilla EP.

Int J Obes (Lond). 2013 Dec;37(12):1515-23. doi: 10.1038/ijo.2013.22. Epub 2013 Mar 12.


Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism.

Zorrilla EP, Heilig M, de Wit H, Shaham Y.

Drug Alcohol Depend. 2013 Mar 1;128(3):175-86. doi: 10.1016/j.drugalcdep.2012.12.017. Epub 2013 Jan 5. Review.


Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1.

Ha Y, Saul A, Tawfik A, Zorrilla EP, Ganapathy V, Smith SB.

Mol Vis. 2012;18:2860-70. Epub 2012 Nov 30.


Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley.

Zorrilla EP, Koob GF.

Neurosci Biobehav Rev. 2013 Nov;37(9 Pt A):1932-45. doi: 10.1016/j.neubiorev.2012.11.019. Epub 2012 Dec 7. Review.


Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses.

Parylak SL, Cottone P, Sabino V, Rice KC, Zorrilla EP.

Physiol Behav. 2012 Sep 10;107(2):231-42. doi: 10.1016/j.physbeh.2012.06.017. Epub 2012 Jul 6.


Stress history increases alcohol intake in relapse: relation to phosphodiesterase 10A.

Logrip ML, Zorrilla EP.

Addict Biol. 2012 Sep;17(5):920-33. doi: 10.1111/j.1369-1600.2012.00460.x. Epub 2012 Jun 28.


Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats.

Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW Jr, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF.

J Neurosci. 2012 May 30;32(22):7563-71. doi: 10.1523/JNEUROSCI.0069-12.2012.


Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view.

Koob GF, Zorrilla EP.

Neuropsychopharmacology. 2012 Jan;37(1):308-9. doi: 10.1038/npp.2011.213. No abstract available.


Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice.

Zakhari JS, Zorrilla EP, Zhou B, Mayorov AV, Janda KD.

Mol Pharm. 2012 Feb 6;9(2):281-9. doi: 10.1021/mp200376c. Epub 2011 Dec 23.


Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder.

Logrip ML, Zorrilla EP, Koob GF.

Neuropharmacology. 2012 Feb;62(2):552-64. doi: 10.1016/j.neuropharm.2011.07.007. Epub 2011 Jul 19. Review.


Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats.

Zorrilla EP, Wee S, Zhao Y, Specio S, Boutrel B, Koob GF, Weiss F.

Addict Biol. 2012 Mar;17(2):300-8. doi: 10.1111/j.1369-1600.2011.00329.x. Epub 2011 Jul 18.


Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress.

Fekete EM, Zhao Y, Szücs A, Sabino V, Cottone P, Rivier J, Vale WW, Koob GF, Zorrilla EP.

Br J Pharmacol. 2011 Dec;164(8):1959-75. doi: 10.1111/j.1476-5381.2011.01512.x.


The dark side of food addiction.

Parylak SL, Koob GF, Zorrilla EP.

Physiol Behav. 2011 Jul 25;104(1):149-56. doi: 10.1016/j.physbeh.2011.04.063. Epub 2011 May 8. Review.


Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention.

Logrip ML, Koob GF, Zorrilla EP.

CNS Drugs. 2011 Apr;25(4):271-87. doi: 10.2165/11587790-000000000-00000. Review.


Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats.

Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP.

Neuropsychopharmacology. 2011 May;36(6):1207-18. doi: 10.1038/npp.2011.5. Epub 2011 Feb 23.


Pattern of maternal circulating CRH in laboratory-housed squirrel and owl monkeys.

Power ML, Williams LE, Gibson SV, Schulkin J, Helfers J, Zorrilla EP.

Am J Primatol. 2010 Nov;72(11):1004-12. doi: 10.1002/ajp.20850.


Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.

Walker BM, Zorrilla EP, Koob GF.

Addict Biol. 2011 Jan;16(1):116-9. doi: 10.1111/j.1369-1600.2010.00226.x.


Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake.

Repunte-Canonigo V, van der Stap LD, Chen J, Sabino V, Wagner U, Zorrilla EP, Schumann G, Roberts AJ, Sanna PP.

Brain Res. 2010 Jun 21;1339:1-10. doi: 10.1016/j.brainres.2010.03.063. Epub 2010 Apr 10.


Progress in corticotropin-releasing factor-1 antagonist development.

Zorrilla EP, Koob GF.

Drug Discov Today. 2010 May;15(9-10):371-83. doi: 10.1016/j.drudis.2010.02.011. Epub 2010 Mar 3. Review.


Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence.

Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH.

Biol Psychiatry. 2010 May 1;67(9):831-9. doi: 10.1016/j.biopsych.2009.11.007. Epub 2010 Jan 8.


Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor.

Koob GF, Zorrilla EP.

Curr Opin Investig Drugs. 2010 Jan;11(1):63-71. Review.


Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin.

Martin-Fardon R, Zorrilla EP, Ciccocioppo R, Weiss F.

Brain Res. 2010 Feb 16;1314:145-61. doi: 10.1016/j.brainres.2009.12.027. Epub 2009 Dec 21. Review.


CRF system recruitment mediates dark side of compulsive eating.

Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB, Fekete EM, Steardo L, Rice KC, Grigoriadis DE, Conti B, Koob GF, Zorrilla EP.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20016-20. doi: 10.1073/pnas.0908789106. Epub 2009 Nov 9.


Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats.

Fonareva I, Spangler E, Cannella N, Sabino V, Cottone P, Ciccocioppo R, Zorrilla EP, Ryabinin AE.

Alcohol Clin Exp Res. 2009 Nov;33(11):1956-65. doi: 10.1111/j.1530-0277.2009.01033.x. Epub 2009 Aug 10.


Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist.

Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP.

Psychopharmacology (Berl). 2009 Aug;205(2):327-35. doi: 10.1007/s00213-009-1548-x. Epub 2009 May 14.


Urocortin 2 protects against retinal degeneration following bilateral common carotid artery occlusion in the rat.

Szabadfi K, Atlasz T, Reglodi D, Kiss P, Dányádi B, Fekete EM, Zorrilla EP, Tamás A, Szabó K, Gábriel R.

Neurosci Lett. 2009 May 8;455(1):42-5. doi: 10.1016/j.neulet.2009.03.013. Epub 2009 Mar 11.


Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.

Francesconi W, Berton F, Repunte-Canonigo V, Hagihara K, Thurbon D, Lekic D, Specio SE, Greenwell TN, Chen SA, Rice KC, Richardson HN, O'Dell LE, Zorrilla EP, Morales M, Koob GF, Sanna PP.

J Neurosci. 2009 Apr 29;29(17):5389-401. doi: 10.1523/JNEUROSCI.5129-08.2009.


Social defeat stress activates medial amygdala cells that express type 2 corticotropin-releasing factor receptor mRNA.

Fekete EM, Zhao Y, Li C, Sabino V, Vale WW, Zorrilla EP.

Neuroscience. 2009 Aug 4;162(1):5-13. doi: 10.1016/j.neuroscience.2009.03.078. Epub 2009 Apr 7.


Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats.

Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF.

Addict Biol. 2009 Apr;14(2):130-43. doi: 10.1111/j.1369-1600.2008.00142.x.


Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala.

Nie Z, Zorrilla EP, Madamba SG, Rice KC, Roberto M, Siggins GR.

ScientificWorldJournal. 2009 Jan 18;9:68-85. doi: 10.1100/tsw.2009.1.


Sigma-1 receptor knockout mice display a depressive-like phenotype.

Sabino V, Cottone P, Parylak SL, Steardo L, Zorrilla EP.

Behav Brain Res. 2009 Mar 17;198(2):472-6. doi: 10.1016/j.bbr.2008.11.036. Epub 2008 Nov 30.


Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice.

Mayorov AV, Amara N, Chang JY, Moss JA, Hixon MS, Ruiz DI, Meijler MM, Zorrilla EP, Janda KD.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17487-92. doi: 10.1073/pnas.0711808105. Epub 2008 Nov 3.

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