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Items: 30

1.

Effects of tanezumab on satellite glial cells in the cervicothoracic ganglion of cynomolgus monkeys: A 26-week toxicity study followed by an 8-week recovery period.

Evans M, Butt M, Belanger P, Cummings T, Gremminger JL, Zorbas M.

Auton Neurosci. 2019 May;218:51-53. doi: 10.1016/j.autneu.2019.02.004. Epub 2019 Feb 23.

2.

Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments.

Gropp KE, Carlson CS, Evans MG, Bagi CM, Reagan WJ, Hurst SI, Shelton DL, Zorbas MA.

Toxicol Pathol. 2018 Jun;46(4):408-420. doi: 10.1177/0192623318772501. Epub 2018 May 16.

PMID:
29768985
3.

From the Cover: Evaluation of the Effects of Tanezumab, a Monoclonal Antibody Against Nerve Growth Factor, on the Sympathetic Nervous System in Adult Cynomolgus Monkeys (Macaca fascicularis): A Stereologic, Histomorphologic, and Cardiofunctional Assessment.

Belanger P, Butler P, Butt M, Bhatt S, Foote S, Shelton D, Evans M, Arends R, Hurst S, Okerberg C, Cummings T, Potter D, Steidl-Nichols J, Zorbas M.

Toxicol Sci. 2017 Aug 1;158(2):319-333. doi: 10.1093/toxsci/kfx089.

4.

Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model.

LaBranche TP, Bendele AM, Omura BC, Gropp KE, Hurst SI, Bagi CM, Cummings TR, Grantham LE 2nd, Shelton DL, Zorbas MA.

Ann Rheum Dis. 2017 Jan;76(1):295-302. doi: 10.1136/annrheumdis-2015-208913. Epub 2016 Jul 5.

5.

Anti-NGF monoclonal antibody muMab 911 does not deplete neurons in the superior cervical ganglia of young or old adult rats.

Marcek J, Okerberg C, Liu CN, Potter D, Butler P, Boucher M, Zorbas M, Mouton P, Nyengaard JR, Somps C.

J Chem Neuroanat. 2016 Oct;76(Pt B):133-141. doi: 10.1016/j.jchemneu.2016.05.007. Epub 2016 May 24.

PMID:
27233661
6.

Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis).

Bowman CJ, Evans M, Cummings T, Oneda S, Butt M, Hurst S, Gremminger JL, Shelton D, Kamperschroer C, Zorbas M.

Reprod Toxicol. 2015 Jun;53:105-18. doi: 10.1016/j.reprotox.2014.10.004. Epub 2014 Oct 14.

PMID:
25461901
7.

Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor.

Butt M, Evans M, Bowman CJ, Cummings T, Oneda S, Shelton D, Zorbas M.

Toxicol Sci. 2014 Dec;142(2):463-76. doi: 10.1093/toxsci/kfu192. Epub 2014 Oct 17.

PMID:
25326242
8.

Sciatic nerve regeneration is not inhibited by anti-NGF antibody treatment in the adult rat.

Lankford KL, Arroyo EJ, Liu CN, Somps CJ, Zorbas MA, Shelton DL, Evans MG, Hurst SI, Kocsis JD.

Neuroscience. 2013 Jun 25;241:157-69. doi: 10.1016/j.neuroscience.2013.03.024. Epub 2013 Mar 24.

PMID:
23531437
9.

A multiple-dose toxicity study of tanezumab in cynomolgus monkeys.

Zorbas M, Hurst S, Shelton D, Evans M, Finco D, Butt M.

Regul Toxicol Pharmacol. 2011 Mar;59(2):334-42. doi: 10.1016/j.yrtph.2010.11.005. Epub 2010 Dec 3.

PMID:
21130822
10.

Lack of respiratory and contact sensitizing potential of the intranasal antiviral drug candidate rupintrivir (AG7088): a weight-of-the-evidence evaluation.

Burns-Naas LA, Lee C, Evering W, Ahern L, Webber S, Zorbas M.

J Immunotoxicol. 2005 Jul 1;2(3):123-39. doi: 10.1080/15476910500203925.

PMID:
18958666
11.

Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2-year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia.

Burns-Naas LA, Zorbas M, Jessen B, Evering W, Stevens G, Ivett JL, Ryan TE, Cook JC, Capen CC, Chen M, Furman G, Theiss JC, Webber S, Wu E, Shetty B, Gasser R, McClain RM.

Hum Exp Toxicol. 2005 Dec;24(12):643-54.

PMID:
16408618
12.

Immunotoxicity evaluation of nelfinavir in rats.

Burns-Naas LA, White KL Jr, McCay JA, Ivett J, Webber S, Zorbas M.

Hum Exp Toxicol. 2005 Feb;24(2):67-78.

PMID:
15850281
13.

Absence of reproductive and developmental toxicity in rats following oral dosing with nelfinavir.

Burns-Naas LA, Stump DG, Webber S, Holson JF, Masarjian L, Furman G, Zorbas M.

Regul Toxicol Pharmacol. 2003 Dec;38(3):304-16.

PMID:
14623481
14.

Absence of embryo-fetal toxicity in rats or rabbits following oral dosing with nelfinavir.

Burns-Naas LA, Webber S, Stump DG, Holson JF, Masarjian L, Zorbas M.

Regul Toxicol Pharmacol. 2003 Dec;38(3):291-303.

PMID:
14623480
15.

Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities.

Zhang KE, Wu E, Patick AK, Kerr B, Zorbas M, Lankford A, Kobayashi T, Maeda Y, Shetty B, Webber S.

Antimicrob Agents Chemother. 2001 Apr;45(4):1086-93. Erratum in: Antimicrob Agents Chemother 2001 Aug;45(8):2405.

16.

Pharmacokinetic and pharmacodynamic evaluation of the glycinamide ribonucleotide formyltransferase inhibitor AG2034.

McLeod HL, Cassidy J, Powrie RH, Priest DG, Zorbas MA, Synold TW, Shibata S, Spicer D, Bissett D, Pithavala YK, Collier MA, Paradiso LJ, Roberts JD.

Clin Cancer Res. 2000 Jul;6(7):2677-84.

17.

c-Myb is critical for murine colon development.

Zorbas M, Sicurella C, Bertoncello I, Venter D, Ellis S, Mucenski ML, Ramsay RG.

Oncogene. 1999 Oct 14;18(42):5821-30.

18.

c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression.

Thompson MA, Rosenthal MA, Ellis SL, Friend AJ, Zorbas MI, Whitehead RH, Ramsay RG.

Cancer Res. 1998 Nov 15;58(22):5168-75.

19.
20.

The gamma delta T lymphocytes of the perinatal murine thymus.

Zorbas MI, Scollay R.

Dev Immunol. 1995;4(2):93-100.

21.

Down-modulation of epidermal growth factor receptor accompanies TNF-induced differentiation of the DiFi human adenocarcinoma cell line toward a goblet-like phenotype.

Novotny-Smith CL, Zorbas MA, Mcisaac AM, Irimura T, Boman BM, Yeoman LC, Gallick GE.

J Cell Physiol. 1993 Nov;157(2):253-62.

PMID:
8227158
22.

Development of gamma delta T cells in the adult murine thymus.

Zorbas M, Scollay R.

Eur J Immunol. 1993 Jul;23(7):1655-60.

PMID:
8100777
23.
24.

Transforming growth factor-alpha production and autoinduction in a colorectal carcinoma cell line (DiFi) with an amplified epidermal growth factor receptor gene.

Untawale S, Zorbas MA, Hodgson CP, Coffey RJ, Gallick GE, North SM, Wildrick DM, Olive M, Blick M, Yeoman LC, et al.

Cancer Res. 1993 Apr 1;53(7):1630-6.

25.
26.

Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patient.

Gross ME, Zorbas MA, Danels YJ, Garcia R, Gallick GE, Olive M, Brattain MG, Boman BM, Yeoman LC.

Cancer Res. 1991 Mar 1;51(5):1452-9.

27.

Importance of reactive metabolites to the in vivo hepatic clearance of phencyclidine (PCP).

Zorbas MA, Owens SM.

NIDA Res Monogr. 1990;105:429-30. No abstract available.

PMID:
1876062
28.

The pharmacokinetics of [3H]1-[1-(2-thienyl)cyclohexyl]piperidine (TCP) in Sprague-Dawley rats.

Zorbas M, Owens SM, Plunkett LM, Bui H.

Drug Metab Dispos. 1989 Nov-Dec;17(6):641-5.

PMID:
2575500
29.

Antibodies against arylcyclohexylamines and their similarities in binding specificity with the phencyclidine receptor.

Owens SM, Zorbas M, Lattin DL, Gunnell M, Polk M.

J Pharmacol Exp Ther. 1988 Aug;246(2):472-8.

PMID:
2457075
30.

Myocardial responsiveness to isoproterenol and calcium: a comparison of SD and F344 rats.

Zorbas M, Kennedy RH, Seifen E.

Comp Biochem Physiol C. 1988;89(2):333-6.

PMID:
2899008

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