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Items: 26


Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages.

Dandela R, Mashiach R, Adepu R, Gregor R, Athamna M, Zecharia E, Ernst O, Zor T, Meijler MM.

Chem Commun (Camb). 2017 Mar 30;53(27):3842-3845. doi: 10.1039/c6cc09849e.


Exogenous ceramide-1-phosphate (C1P) and phospho-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors.

Katz S, Ernst O, Avni D, Athamna M, Philosoph A, Arana L, Ouro A, Hoeferlin LA, Meijler MM, Chalfant CE, Gómez-Muñoz A, Zor T.

Immunol Lett. 2016 Jan;169:73-81. doi: 10.1016/j.imlet.2015.12.001. Epub 2015 Dec 3.


Integrated microfluidic approach for quantitative high-throughput measurements of transcription factor binding affinities.

Glick Y, Orenstein Y, Chen D, Avrahami D, Zor T, Shamir R, Gerber D.

Nucleic Acids Res. 2016 Apr 7;44(6):e51. doi: 10.1093/nar/gkv1327. Epub 2015 Dec 3.


The bacterial quorum-sensing signal molecule N-3-oxo-dodecanoyl-L-homoserine lactone reciprocally modulates pro- and anti-inflammatory cytokines in activated macrophages.

Glucksam-Galnoy Y, Sananes R, Silberstein N, Krief P, Kravchenko VV, Meijler MM, Zor T.

J Immunol. 2013 Jul 1;191(1):337-44. doi: 10.4049/jimmunol.1300368. Epub 2013 May 29.


Species selective diazirine positioning in tag-free photoactive quorum sensing probes.

Dubinsky L, Delago A, Amara N, Krief P, Rayo J, Zor T, Kravchenko VV, Meijler MM.

Chem Commun (Camb). 2013 Jul 4;49(52):5826-8. doi: 10.1039/c3cc43092h. Epub 2013 May 24.


Identification of elements that dictate the specificity of mitochondrial Hsp60 for its co-chaperonin.

Parnas A, Nisemblat S, Weiss C, Levy-Rimler G, Pri-Or A, Zor T, Lund PA, Bross P, Azem A.

PLoS One. 2012;7(12):e50318. doi: 10.1371/journal.pone.0050318. Epub 2012 Dec 4.


Hyaluronan-modified and regular multilamellar liposomes provide sub-cellular targeting to macrophages, without eliciting a pro-inflammatory response.

Glucksam-Galnoy Y, Zor T, Margalit R.

J Control Release. 2012 Jun 10;160(2):388-93. doi: 10.1016/j.jconrel.2011.10.008. Epub 2011 Oct 12.


The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism.

Avni D, Glucksam Y, Zor T.

Biochem Pharmacol. 2012 Jan 1;83(1):106-14. doi: 10.1016/j.bcp.2011.09.025. Epub 2011 Oct 12.


A ceramide analog inhibits cPLA(2) activity and consequent PGE(2) formation in LPS-stimulated macrophages.

Goldsmith M, Daka A, Lamour NF, Mashiach R, Glucksam Y, Meijler MM, Chalfant CE, Zor T.

Immunol Lett. 2011 Mar 30;135(1-2):136-43. doi: 10.1016/j.imlet.2010.10.014. Epub 2010 Oct 30.


Linearization of the bradford protein assay.

Ernst O, Zor T.

J Vis Exp. 2010 Apr 12;(38). pii: 1918. doi: 10.3791/1918.


Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264.7 macrophages.

Avni D, Ernst O, Philosoph A, Zor T.

Mol Immunol. 2010 Apr;47(7-8):1396-403. doi: 10.1016/j.molimm.2010.02.015. Epub 2010 Mar 19.


The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.

Avni D, Philosoph A, Meijler MM, Zor T.

Immunology. 2010 Mar;129(3):375-85. doi: 10.1111/j.1365-2567.2009.03188.x. Epub 2009 Nov 16.


Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1).

Levi M, Meijler MM, Gómez-Muñoz A, Zor T.

Mol Cell Endocrinol. 2010 Jan 27;314(2):248-55. doi: 10.1016/j.mce.2009.05.007. Epub 2009 May 23. Review.


Synergistic IL-10 induction by LPS and the ceramide-1-phosphate analog PCERA-1 is mediated by the cAMP and p38 MAP kinase pathways.

Goldsmith M, Avni D, Ernst O, Glucksam Y, Levy-Rimler G, Meijler MM, Zor T.

Mol Immunol. 2009 Jun;46(10):1979-87. doi: 10.1016/j.molimm.2009.03.009. Epub 2009 Apr 10.


Modulation of TNFalpha, IL-10 and IL-12p40 levels by a ceramide-1-phosphate analog, PCERA-1, in vivo and ex vivo in primary macrophages.

Avni D, Goldsmith M, Ernst O, Mashiach R, Tuntland T, Meijler MM, Gray NS, Rosen H, Zor T.

Immunol Lett. 2009 Mar 24;123(1):1-8. doi: 10.1016/j.imlet.2008.12.011. Epub 2009 Jan 29.


A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages.

Goldsmith M, Avni D, Levy-Rimler G, Mashiach R, Ernst O, Levi M, Webb B, Meijler MM, Gray NS, Rosen H, Zor T.

Immunology. 2009 May;127(1):103-15. doi: 10.1111/j.1365-2567.2008.02928.x.


Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.

Best JL, Amezcua CA, Mayr B, Flechner L, Murawsky CM, Emerson B, Zor T, Gardner KH, Montminy M.

Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17622-7. Epub 2004 Dec 7.


Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb.

Zor T, De Guzman RN, Dyson HJ, Wright PE.

J Mol Biol. 2004 Mar 26;337(3):521-34.


Role of secondary structure in discrimination between constitutive and inducible activators.

Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK.

Mol Cell Biol. 1999 Aug;19(8):5601-7.


Guanosine triphosphatase stimulation of oncogenic Ras mutants.

Ahmadian MR, Zor T, Vogt D, Kabsch W, Selinger Z, Wittinghofer A, Scheffzek K.

Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7065-70.


GTP analogue hydrolysis by the Gs protein: implication for the role of catalytic glutamine in the GTPase reaction.

Zor T, Andorn R, Sofer I, Chorev M, Selinger Z.

FEBS Lett. 1998 Aug 21;433(3):326-30.


Rescue of a mutant G-protein by substrate-assisted catalysis.

Zor T, Bar-Yaacov M, Elgavish S, Shaanan B, Selinger Z.

Eur J Biochem. 1997 Oct 1;249(1):330-6.


m-Acetylanilido-GTP, a novel photoaffinity label for GTP-binding proteins: synthesis and application.

Zor T, Halifa I, Kleinhaus S, Chorev M, Selinger Z.

Biochem J. 1995 Feb 15;306 ( Pt 1):253-8.

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