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Items: 1 to 50 of 424

1.

Making HSCs in vitro: don't forget the hemogenic endothelium.

Blaser BW, Zon LI.

Blood. 2018 Aug 8. pii: blood-2018-04-784140. doi: 10.1182/blood-2018-04-784140. [Epub ahead of print]

PMID:
30089629
2.

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

Mansour MR, He S, Li Z, Lobbardi R, Abraham BJ, Hug C, Rahman S, Leon TE, Kuang YY, Zimmerman MW, Blonquist T, Gjini E, Gutierrez A, Tang Q, Garcia-Perez L, Pike-Overzet K, Anders L, Berezovskaya A, Zhou Y, Zon LI, Neuberg D, Fielding AK, Staal FJT, Langenau DM, Sanda T, Young RA, Look AT.

J Exp Med. 2018 Jul 2;215(7):1929-1945. doi: 10.1084/jem.20170484. Epub 2018 Jun 25.

3.

Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche.

Kapp FG, Perlin JR, Hagedorn EJ, Gansner JM, Schwarz DE, O'Connell LA, Johnson NS, Amemiya C, Fisher DE, Wölfle U, Trompouki E, Niemeyer CM, Driever W, Zon LI.

Nature. 2018 Jun;558(7710):445-448. doi: 10.1038/s41586-018-0213-0. Epub 2018 Jun 13.

PMID:
29899448
4.

Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion.

McConnell AM, Mito JK, Ablain J, Dang M, Formichella L, Fisher DE, Zon LI.

Dev Biol. 2018 Jun 5. pii: S0012-1606(17)30855-2. doi: 10.1016/j.ydbio.2018.05.026. [Epub ahead of print]

PMID:
29883661
5.

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Uenishi GI, Jung HS, Kumar A, Park MA, Hadland BK, McLeod E, Raymond M, Moskvin O, Zimmerman CE, Theisen DJ, Swanson S, J Tamplin O, Zon LI, Thomson JA, Bernstein ID, Slukvin II.

Nat Commun. 2018 May 8;9(1):1828. doi: 10.1038/s41467-018-04134-7.

6.

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, Silvis MR, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA, Lee S.

Cancer Cell. 2018 Apr 9;33(4):785. doi: 10.1016/j.ccell.2018.03.009. No abstract available.

PMID:
29634951
7.

RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes.

Bennett AH, O'Donohue MF, Gundry SR, Chan AT, Widrick J, Draper I, Chakraborty A, Zhou Y, Zon LI, Gleizes PE, Beggs AH, Gupta VA.

PLoS Genet. 2018 Mar 8;14(3):e1007226. doi: 10.1371/journal.pgen.1007226. eCollection 2018 Mar.

8.

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, Silvis MR, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA, Lee S.

Cancer Cell. 2018 Feb 12;33(2):322-336.e8. doi: 10.1016/j.ccell.2018.01.002. Erratum in: Cancer Cell. 2018 Apr 9;33(4):785.

9.

The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression.

Yu SH, Zhu KY, Zhang F, Wang J, Yuan H, Chen Y, Jin Y, Dong M, Wang L, Jia XE, Gao L, Dong ZW, Ren CG, Chen LT, Huang QH, Deng M, Zon LI, Zhou Y, Zhu J, Xu PF, Liu TX.

Biochim Biophys Acta. 2018 Feb;1861(2):106-116. doi: 10.1016/j.bbagrm.2017.12.009. Epub 2018 Jan 31.

10.

Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis.

Kulkeaw K, Inoue T, Ishitani T, Nakanishi Y, Zon LI, Sugiyama D.

Br J Haematol. 2018 Feb;180(3):420-431. doi: 10.1111/bjh.15048. Epub 2017 Dec 19.

11.

Cancer immunotherapy: The dark side of PD-1 receptor inhibition.

Ludin A, Zon LI.

Nature. 2017 Dec 7;552(7683):41-42. doi: 10.1038/nature24759. Epub 2017 Nov 15. No abstract available.

PMID:
29143822
12.

Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.

Norris ML, Pauli A, Gagnon JA, Lord ND, Rogers KW, Mosimann C, Zon LI, Schier AF.

Elife. 2017 Nov 9;6. pii: e22626. doi: 10.7554/eLife.22626.

13.

KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.

Neiswender JV, Kortum RL, Bourque C, Kasheta M, Zon LI, Morrison DK, Ceol CJ.

Cancer Res. 2017 Nov 1;77(21):5820-5830. doi: 10.1158/0008-5472.CAN-17-0473. Epub 2017 Sep 25.

PMID:
28947418
14.

Fishing for answers in precision cancer medicine.

Fazio M, Zon LI.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10306-10308. doi: 10.1073/pnas.1713769114. Epub 2017 Sep 15. No abstract available.

15.

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.

Ciarlo C, Kaufman CK, Kinikoglu B, Michael J, Yang S, D Amato C, Blokzijl-Franke S, den Hertog J, Schlaeger TM, Zhou Y, Liao E, Zon LI.

Elife. 2017 Aug 23;6. pii: e29145. doi: 10.7554/eLife.29145.

16.

Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis.

Perlin JR, Robertson AL, Zon LI.

J Exp Med. 2017 Oct 2;214(10):2817-2827. doi: 10.1084/jem.20171069. Epub 2017 Aug 22. Review.

17.

PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo.

McGonigle TA, Dwyer AR, Greenland EL, Scott NM, Keane KN, Newsholme P, Goodridge HS, Zon LI, Pixley FJ, Hart PH.

Exp Hematol. 2017 Dec;56:64-68. doi: 10.1016/j.exphem.2017.08.002. Epub 2017 Aug 16.

18.

Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment.

Perlin JR, Sporrij A, Zon LI.

J Mol Med (Berl). 2017 Aug;95(8):809-819. doi: 10.1007/s00109-017-1559-8. Epub 2017 Jul 13. Review.

19.

Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration.

Choudhuri A, Fast EM, Zon LI.

Stem Cell Reports. 2017 Jun 6;8(6):1465-1471. doi: 10.1016/j.stemcr.2017.05.018. Review.

20.

Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors.

Fazio M, Avagyan S, van Rooijen E, Mannherz W, Kaufman CK, Lobbardi R, Langenau DM, Zon LI.

Zebrafish. 2017 Aug;14(4):379-382. doi: 10.1089/zeb.2017.1434. Epub 2017 May 30.

21.

Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization.

Theodore LN, Hagedorn EJ, Cortes M, Natsuhara K, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI, North TE.

Stem Cell Reports. 2017 May 9;8(5):1226-1241. doi: 10.1016/j.stemcr.2017.03.016. Epub 2017 Apr 13.

22.

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CV.

Elife. 2017 Apr 7;6. pii: e21231. doi: 10.7554/eLife.21231.

23.

From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics.

van Rooijen E, Fazio M, Zon LI.

Pigment Cell Melanoma Res. 2017 Jul;30(4):402-412. doi: 10.1111/pcmr.12592. Epub 2017 Jun 8. Review.

24.

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment.

Blaser BW, Moore JL, Hagedorn EJ, Li B, Riquelme R, Lichtig A, Yang S, Zhou Y, Tamplin OJ, Binder V, Zon LI.

J Exp Med. 2017 Apr 3;214(4):1011-1027. doi: 10.1084/jem.20161616. Epub 2017 Mar 28.

25.

Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors.

Doulatov S, Vo LT, Macari ER, Wahlster L, Kinney MA, Taylor AM, Barragan J, Gupta M, McGrath K, Lee HY, Humphries JM, DeVine A, Narla A, Alter BP, Beggs AH, Agarwal S, Ebert BL, Gazda HT, Lodish HF, Sieff CA, Schlaeger TM, Zon LI, Daley GQ.

Sci Transl Med. 2017 Feb 8;9(376). pii: eaah5645. doi: 10.1126/scitranslmed.aah5645.

26.

Chemical screening in zebrafish for novel biological and therapeutic discovery.

Wiley DS, Redfield SE, Zon LI.

Methods Cell Biol. 2017;138:651-679. doi: 10.1016/bs.mcb.2016.10.004. Epub 2016 Dec 29. Review.

27.

Transplantation in zebrafish.

Gansner JM, Dang M, Ammerman M, Zon LI.

Methods Cell Biol. 2017;138:629-647. doi: 10.1016/bs.mcb.2016.08.006. Epub 2016 Sep 24. Review.

PMID:
28129861
28.

Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity.

Gansner JM, Leung AD, Superdock M, Blair MC, Ammerman MB, Durand EM, Barut B, Handin RI, Stachura DL, Lu C, Springer TA, Zon LI.

Blood. 2017 Mar 9;129(10):1394-1397. doi: 10.1182/blood-2016-12-759993. Epub 2017 Jan 26. No abstract available.

29.

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

van Rooij FJA, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, Hofman A, van Duijn CM, Desch KC, Saba Y, Ozel AB, Snively BM, Wu JY, Schmidt R, Fornage M, Klein RJ, Fox CS, Matsuda K, Kamatani N, Wild PS, Stott DJ, Ford I, Slagboom PE, Yang J, Chu AY, Lambert AJ, Uitterlinden AG, Franco OH, Hofer E, Ginsburg D, Hu B, Keating B, Schick UM, Brody JA, Li JZ, Chen Z, Zeller T, Guralnik JM, Chasman DI, Peters LL, Kubo M, Becker DM, Li J, Eiriksdottir G, Rotter JI, Levy D, Grossmann V, Patel KV, Chen CH; BioBank Japan Project, Ridker PM, Tang H, Launer LJ, Rice KM, Li-Gao R, Ferrucci L, Evans MK, Choudhuri A, Trompouki E, Abraham BJ, Yang S, Takahashi A, Kamatani Y, Kooperberg C, Harris TB, Jee SH, Coresh J, Tsai FJ, Longo DL, Chen YT, Felix JF, Yang Q, Psaty BM, Boerwinkle E, Becker LC, Mook-Kanamori DO, Wilson JG, Gudnason V, O'Donnell CJ, Dehghan A, Cupples LA, Nalls MA, Morris AP, Okada Y, Reiner AP, Zon LI, Ganesh SK.

Am J Hum Genet. 2017 Jan 5;100(1):51-63. doi: 10.1016/j.ajhg.2016.11.016. Epub 2016 Dec 22.

30.

Aging Hematopoietic Stem Cells Make Their History.

Fast EM, Zon LI.

Dev Cell. 2016 Nov 21;39(4):390-391. doi: 10.1016/j.devcel.2016.11.005.

31.

Development: For cloche the Bell Tolls.

Rossmann MP, Zhou Y, Zon LI.

Curr Biol. 2016 Oct 10;26(19):R890-R892. doi: 10.1016/j.cub.2016.08.009. Epub 2016 Oct 10.

32.

Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish.

Robertson AL, Avagyan S, Gansner JM, Zon LI.

FEBS Lett. 2016 Nov;590(22):4016-4033. doi: 10.1002/1873-3468.12415. Epub 2016 Sep 25. Review.

33.

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.

Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I.

Cell Stem Cell. 2016 Dec 1;19(6):784-799. doi: 10.1016/j.stem.2016.08.004. Epub 2016 Aug 25.

34.

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes.

Nasrallah R, Fast EM, Solaimani P, Knezevic K, Eliades A, Patel R, Thambyrajah R, Unnikrishnan A, Thoms J, Beck D, Vink CS, Smith A, Wong J, Shepherd M, Kent D, Roychoudhuri R, Paul F, Klippert J, Hammes A, Willnow T, Göttgens B, Dzierzak E, Zon LI, Lacaud G, Kouskoff V, Pimanda JE.

Blood. 2016 Oct 13;128(15):1928-1939. Epub 2016 Aug 23. Erratum in: Blood. 2017 Nov 16;130(20):2234.

35.

Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies.

Dang M, Henderson RE, Garraway LA, Zon LI.

Dis Model Mech. 2016 Jul 1;9(7):811-20. doi: 10.1242/dmm.024166. Epub 2016 May 11.

36.

c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish.

Liu W, Wu M, Huang Z, Lian J, Chen J, Wang T, Leung AY, Liao Y, Zhang Z, Liu Q, Yen K, Lin S, Zon LI, Wen Z, Zhang Y, Zhang W.

Leukemia. 2017 Jan;31(1):222-233. doi: 10.1038/leu.2016.170. Epub 2016 Jun 14.

37.

Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes.

Yang S, Ott CJ, Rossmann MP, Superdock M, Zon LI, Zhou Y.

Methods Cell Biol. 2016;135:387-412. doi: 10.1016/bs.mcb.2016.04.019. Epub 2016 Jun 20.

38.

Tissue-specific gene targeting using CRISPR/Cas9.

Ablain J, Zon LI.

Methods Cell Biol. 2016;135:189-202. doi: 10.1016/bs.mcb.2016.03.004. Epub 2016 Apr 23.

39.

Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae.

Hagedorn EJ, Cillis JL, Curley CR, Patch TC, Li B, Blaser BW, Riquelme R, Zon LI, Shah DI.

J Vis Exp. 2016 Jun 11;(112). doi: 10.3791/54168.

40.

Embryonic cell culture in zebrafish.

Ciarlo CA, Zon LI.

Methods Cell Biol. 2016;133:1-10. doi: 10.1016/bs.mcb.2016.02.010. Epub 2016 Mar 31.

41.

Engineering Hematopoietic Stem Cells: Lessons from Development.

Rowe RG, Mandelbaum J, Zon LI, Daley GQ.

Cell Stem Cell. 2016 Jun 2;18(6):707-20. doi: 10.1016/j.stem.2016.05.016. Review.

42.

Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish.

Dang M, Fogley R, Zon LI.

Adv Exp Med Biol. 2016;916:103-24. doi: 10.1007/978-3-319-30654-4_5. Review.

43.

Ex vivo tools for the clonal analysis of zebrafish hematopoiesis.

Svoboda O, Stachura DL, Machonova O, Zon LI, Traver D, Bartunek P.

Nat Protoc. 2016 May;11(5):1007-20. doi: 10.1038/nprot.2016.053. Epub 2016 Apr 28.

44.

A Tribute to George Stamatoyannopoulos.

Srivastava A, Kay MA, Athanasopoulos T, Angastiniotis M, Anagnostopoulos A, Karponi G, Yannaki E, Zon LI, Lederer CW, Phylactides MS, Kleanthous M.

Hum Gene Ther. 2016 Apr;27(4):280-6. doi: 10.1089/hum.2016.29025.gst. No abstract available.

PMID:
27074151
45.

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI.

Mol Cell. 2016 Apr 7;62(1):34-46. doi: 10.1016/j.molcel.2016.03.013.

46.

Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders.

Wakabayashi A, Ulirsch JC, Ludwig LS, Fiorini C, Yasuda M, Choudhuri A, McDonel P, Zon LI, Sankaran VG.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4434-9. doi: 10.1073/pnas.1521754113. Epub 2016 Apr 4.

47.

Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis.

Avagyan S, Zon LI.

Hum Gene Ther. 2016 Apr;27(4):287-94. doi: 10.1089/hum.2016.024. Review.

48.

The Red Light District and Its Effects on Zebrafish Reproduction.

Adatto I, Krug L, Zon LI.

Zebrafish. 2016 Jun;13(3):226-9. doi: 10.1089/zeb.2015.1228. Epub 2016 Mar 15.

PMID:
26978703
49.

GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis.

Gao X, Wu T, Johnson KD, Lahvic JL, Ranheim EA, Zon LI, Bresnick EH.

Stem Cell Reports. 2016 Mar 8;6(3):368-82. doi: 10.1016/j.stemcr.2016.01.008. Epub 2016 Feb 18.

50.

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.

Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI.

Science. 2016 Jan 29;351(6272):aad2197. doi: 10.1126/science.aad2197. Epub 2016 Jan 28.

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