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Items: 1 to 50 of 487

1.

The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors.

Jurynec MJ, Bai X, Bisgrove BW, Jackson H, Nechiporuk A, Palu RAS, Grunwald HA, Su YC, Hoshijima K, Yost HJ, Zon LI, Grunwald DJ.

Development. 2019 Nov 29. pii: dev.180133. doi: 10.1242/dev.180133. [Epub ahead of print]

PMID:
31784460
2.

Use of Zebrafish in Drug Discovery Toxicology.

Cassar S, Adatto I, Freeman JL, Gamse JT, Iturria I, Lawrence C, Muriana A, Peterson RT, Van Cruchten S, Zon LI.

Chem Res Toxicol. 2019 Nov 16. doi: 10.1021/acs.chemrestox.9b00335. [Epub ahead of print]

PMID:
31625720
3.

Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.

Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A.

Nat Immunol. 2019 Nov;20(11):1481-1493. doi: 10.1038/s41590-019-0502-2. Epub 2019 Oct 14.

PMID:
31611699
4.

Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment.

Gómez-Abenza E, Ibáñez-Molero S, García-Moreno D, Fuentes I, Zon LI, Mione MC, Cayuela ML, Gabellini C, Mulero V.

J Exp Clin Cancer Res. 2019 Sep 13;38(1):405. doi: 10.1186/s13046-019-1389-3.

5.

Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis.

Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park TE, Ingber DE, Daisy CC, Moses MA.

ACS Nano. 2019 Sep 10. doi: 10.1021/acsnano.9b04397. [Epub ahead of print]

PMID:
31479239
6.

Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.

Li P, Lahvic JL, Binder V, Pugach EK, Riley EB, Tamplin OJ, Panigrahy D, Bowman TV, Barrett FG, Heffner GC, McKinney-Freeman S, Schlaeger TM, Daley GQ, Zeldin DC, Zon LI.

Nature. 2019 Sep;573(7772):E1. doi: 10.1038/s41586-019-1489-4.

PMID:
31435017
7.

Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.

Tyrkalska SD, Pérez-Oliva AB, Rodríguez-Ruiz L, Martínez-Morcillo FJ, Alcaraz-Pérez F, Martínez-Navarro FJ, Lachaud C, Ahmed N, Schroeder T, Pardo-Sánchez I, Candel S, López-Muñoz A, Choudhuri A, Rossmann MP, Zon LI, Cayuela ML, García-Moreno D, Mulero V.

Immunity. 2019 Jul 16;51(1):50-63.e5. doi: 10.1016/j.immuni.2019.05.005. Epub 2019 Jun 4.

8.

Modeling Cancer with Flies and Fish.

Cagan RL, Zon LI, White RM.

Dev Cell. 2019 May 6;49(3):317-324. doi: 10.1016/j.devcel.2019.04.013. Review.

PMID:
31063751
9.

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate.

Gu Q, Yang X, Lv J, Zhang J, Xia B, Kim JD, Wang R, Xiong F, Meng S, Clements TP, Tandon B, Wagner DS, Diaz MF, Wenzel PL, Miller YI, Traver D, Cooke JP, Li W, Zon LI, Chen K, Bai Y, Fang L.

Science. 2019 Mar 8;363(6431):1085-1088. doi: 10.1126/science.aav1749. Epub 2019 Jan 31.

10.

Improving the visibility of developmental biology: time for induction and specification.

Zon L.

Development. 2019 Jan 16;146(2). pii: dev174631. doi: 10.1242/dev.174631.

11.

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W.

Gastroenterology. 2019 May;156(6):1788-1804.e13. doi: 10.1053/j.gastro.2019.01.010. Epub 2019 Jan 12.

12.

Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish.

Rost MS, Shestopalov I, Liu Y, Vo AH, Richter CE, Emly SM, Barrett FG, Stachura DL, Holinstat M, Zon LI, Shavit JA.

Blood Adv. 2018 Dec 11;2(23):3418-3427. doi: 10.1182/bloodadvances.2018021865.

13.

Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish.

Wattrus SJ, Zon LI.

Blood Adv. 2018 Nov 13;2(21):3063-3069. doi: 10.1182/bloodadvances.2018021725. Review.

14.

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.

Ablain J, Xu M, Rothschild H, Jordan RC, Mito JK, Daniels BH, Bell CF, Joseph NM, Wu H, Bastian BC, Zon LI, Yeh I.

Science. 2018 Nov 30;362(6418):1055-1060. doi: 10.1126/science.aau6509. Epub 2018 Nov 1.

15.

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.

Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH.

J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.

PMID:
30366982
16.

Stu Orkin is a superhero.

Zon LI.

J Clin Invest. 2018 Oct 1;128(10):4213-4217. doi: 10.1172/JCI124493. Epub 2018 Oct 1. No abstract available.

17.

Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies.

Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML.

Dis Model Mech. 2018 Nov 5;11(11). pii: dmm034876. doi: 10.1242/dmm.034876.

18.

Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.

Mandelbaum J, Shestopalov IA, Henderson RE, Chau NG, Knoechel B, Wick MJ, Zon LI.

J Exp Med. 2018 Oct 1;215(10):2673-2685. doi: 10.1084/jem.20180939. Epub 2018 Sep 12.

19.

Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.

Lahvic JL, Ammerman M, Li P, Blair MC, Stillman ER, Fast EM, Robertson AL, Christodoulou C, Perlin JR, Yang S, Chiang N, Norris PC, Daily ML, Redfield SE, Chan IT, Chatrizeh M, Chase ME, Weis O, Zhou Y, Serhan CN, Zon LI.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9252-9257. doi: 10.1073/pnas.1806077115. Epub 2018 Aug 23.

20.

Making HSCs in vitro: don't forget the hemogenic endothelium.

Blaser BW, Zon LI.

Blood. 2018 Sep 27;132(13):1372-1378. doi: 10.1182/blood-2018-04-784140. Epub 2018 Aug 8. Review.

21.

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

Mansour MR, He S, Li Z, Lobbardi R, Abraham BJ, Hug C, Rahman S, Leon TE, Kuang YY, Zimmerman MW, Blonquist T, Gjini E, Gutierrez A, Tang Q, Garcia-Perez L, Pike-Overzet K, Anders L, Berezovskaya A, Zhou Y, Zon LI, Neuberg D, Fielding AK, Staal FJT, Langenau DM, Sanda T, Young RA, Look AT.

J Exp Med. 2018 Jul 2;215(7):1929-1945. doi: 10.1084/jem.20170484. Epub 2018 Jun 25.

22.

Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche.

Kapp FG, Perlin JR, Hagedorn EJ, Gansner JM, Schwarz DE, O'Connell LA, Johnson NS, Amemiya C, Fisher DE, Wölfle U, Trompouki E, Niemeyer CM, Driever W, Zon LI.

Nature. 2018 Jun;558(7710):445-448. doi: 10.1038/s41586-018-0213-0. Epub 2018 Jun 13.

23.

Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion.

McConnell AM, Mito JK, Ablain J, Dang M, Formichella L, Fisher DE, Zon LI.

Dev Biol. 2019 May 15;449(2):107-114. doi: 10.1016/j.ydbio.2018.05.026. Epub 2018 Jun 5.

PMID:
29883661
24.

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Uenishi GI, Jung HS, Kumar A, Park MA, Hadland BK, McLeod E, Raymond M, Moskvin O, Zimmerman CE, Theisen DJ, Swanson S, J Tamplin O, Zon LI, Thomson JA, Bernstein ID, Slukvin II.

Nat Commun. 2018 May 8;9(1):1828. doi: 10.1038/s41467-018-04134-7.

25.

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, Silvis MR, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA, Lee S.

Cancer Cell. 2018 Apr 9;33(4):785. doi: 10.1016/j.ccell.2018.03.009. No abstract available.

26.

RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes.

Bennett AH, O'Donohue MF, Gundry SR, Chan AT, Widrick J, Draper I, Chakraborty A, Zhou Y, Zon LI, Gleizes PE, Beggs AH, Gupta VA.

PLoS Genet. 2018 Mar 8;14(3):e1007226. doi: 10.1371/journal.pgen.1007226. eCollection 2018 Mar.

27.

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, Silvis MR, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA, Lee S.

Cancer Cell. 2018 Feb 12;33(2):322-336.e8. doi: 10.1016/j.ccell.2018.01.002. Erratum in: Cancer Cell. 2018 Apr 9;33(4):785.

28.

The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression.

Yu SH, Zhu KY, Zhang F, Wang J, Yuan H, Chen Y, Jin Y, Dong M, Wang L, Jia XE, Gao L, Dong ZW, Ren CG, Chen LT, Huang QH, Deng M, Zon LI, Zhou Y, Zhu J, Xu PF, Liu TX.

Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):106-116. doi: 10.1016/j.bbagrm.2017.12.009. Epub 2018 Jan 31.

29.

Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis.

Kulkeaw K, Inoue T, Ishitani T, Nakanishi Y, Zon LI, Sugiyama D.

Br J Haematol. 2018 Feb;180(3):420-431. doi: 10.1111/bjh.15048. Epub 2017 Dec 19.

30.

Cancer immunotherapy: The dark side of PD-1 receptor inhibition.

Ludin A, Zon LI.

Nature. 2017 Dec 7;552(7683):41-42. doi: 10.1038/nature24759. Epub 2017 Nov 15. No abstract available.

31.

PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes.

Ben Nasr M, Tezza S, D'Addio F, Mameli C, Usuelli V, Maestroni A, Corradi D, Belletti S, Albarello L, Becchi G, Fadini GP, Schuetz C, Markmann J, Wasserfall C, Zon L, Zuccotti GV, Fiorina P.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaam7543. doi: 10.1126/scitranslmed.aam7543.

32.

Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.

Norris ML, Pauli A, Gagnon JA, Lord ND, Rogers KW, Mosimann C, Zon LI, Schier AF.

Elife. 2017 Nov 9;6. pii: e22626. doi: 10.7554/eLife.22626.

33.

Loci associated with skin pigmentation identified in African populations.

Crawford NG, Kelly DE, Hansen MEB, Beltrame MH, Fan S, Bowman SL, Jewett E, Ranciaro A, Thompson S, Lo Y, Pfeifer SP, Jensen JD, Campbell MC, Beggs W, Hormozdiari F, Mpoloka SW, Mokone GG, Nyambo T, Meskel DW, Belay G, Haut J; NISC Comparative Sequencing Program, Rothschild H, Zon L, Zhou Y, Kovacs MA, Xu M, Zhang T, Bishop K, Sinclair J, Rivas C, Elliot E, Choi J, Li SA, Hicks B, Burgess S, Abnet C, Watkins-Chow DE, Oceana E, Song YS, Eskin E, Brown KM, Marks MS, Loftus SK, Pavan WJ, Yeager M, Chanock S, Tishkoff SA.

Science. 2017 Nov 17;358(6365). pii: eaan8433. doi: 10.1126/science.aan8433. Epub 2017 Oct 12.

34.

KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.

Neiswender JV, Kortum RL, Bourque C, Kasheta M, Zon LI, Morrison DK, Ceol CJ.

Cancer Res. 2017 Nov 1;77(21):5820-5830. doi: 10.1158/0008-5472.CAN-17-0473. Epub 2017 Sep 25.

35.

Fishing for answers in precision cancer medicine.

Fazio M, Zon LI.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10306-10308. doi: 10.1073/pnas.1713769114. Epub 2017 Sep 15. No abstract available.

36.

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.

Ciarlo C, Kaufman CK, Kinikoglu B, Michael J, Yang S, D Amato C, Blokzijl-Franke S, den Hertog J, Schlaeger TM, Zhou Y, Liao E, Zon LI.

Elife. 2017 Aug 23;6. pii: e29145. doi: 10.7554/eLife.29145.

37.

Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis.

Perlin JR, Robertson AL, Zon LI.

J Exp Med. 2017 Oct 2;214(10):2817-2827. doi: 10.1084/jem.20171069. Epub 2017 Aug 22. Review.

38.

PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo.

McGonigle TA, Dwyer AR, Greenland EL, Scott NM, Keane KN, Newsholme P, Goodridge HS, Zon LI, Pixley FJ, Hart PH.

Exp Hematol. 2017 Dec;56:64-68. doi: 10.1016/j.exphem.2017.08.002. Epub 2017 Aug 16.

39.

Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment.

Perlin JR, Sporrij A, Zon LI.

J Mol Med (Berl). 2017 Aug;95(8):809-819. doi: 10.1007/s00109-017-1559-8. Epub 2017 Jul 13. Review.

40.

Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice.

Khajavi M, Zhou Y, Birsner AE, Bazinet L, Rosa Di Sant A, Schiffer AJ, Rogers MS, Krishnaji ST, Hu B, Nguyen V, Zon L, D'Amato RJ.

PLoS Genet. 2017 Jun 15;13(6):e1006848. doi: 10.1371/journal.pgen.1006848. eCollection 2017 Jun.

41.

Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration.

Choudhuri A, Fast EM, Zon LI.

Stem Cell Reports. 2017 Jun 6;8(6):1465-1471. doi: 10.1016/j.stemcr.2017.05.018. Review.

42.

Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors.

Fazio M, Avagyan S, van Rooijen E, Mannherz W, Kaufman CK, Lobbardi R, Langenau DM, Zon LI.

Zebrafish. 2017 Aug;14(4):379-382. doi: 10.1089/zeb.2017.1434. Epub 2017 May 30.

43.

Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization.

Theodore LN, Hagedorn EJ, Cortes M, Natsuhara K, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI, North TE.

Stem Cell Reports. 2017 May 9;8(5):1226-1241. doi: 10.1016/j.stemcr.2017.03.016. Epub 2017 Apr 13.

44.

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CV.

Elife. 2017 Apr 7;6. pii: e21231. doi: 10.7554/eLife.21231.

45.

From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics.

van Rooijen E, Fazio M, Zon LI.

Pigment Cell Melanoma Res. 2017 Jul;30(4):402-412. doi: 10.1111/pcmr.12592. Epub 2017 Jun 8. Review.

46.

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment.

Blaser BW, Moore JL, Hagedorn EJ, Li B, Riquelme R, Lichtig A, Yang S, Zhou Y, Tamplin OJ, Binder V, Zon LI.

J Exp Med. 2017 Apr 3;214(4):1011-1027. doi: 10.1084/jem.20161616. Epub 2017 Mar 28.

47.

Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors.

Doulatov S, Vo LT, Macari ER, Wahlster L, Kinney MA, Taylor AM, Barragan J, Gupta M, McGrath K, Lee HY, Humphries JM, DeVine A, Narla A, Alter BP, Beggs AH, Agarwal S, Ebert BL, Gazda HT, Lodish HF, Sieff CA, Schlaeger TM, Zon LI, Daley GQ.

Sci Transl Med. 2017 Feb 8;9(376). pii: eaah5645. doi: 10.1126/scitranslmed.aah5645.

48.

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay.

Volpi S, Yamazaki Y, Brauer PM, van Rooijen E, Hayashida A, Slavotinek A, Sun Kuehn H, Di Rocco M, Rivolta C, Bortolomai I, Du L, Felgentreff K, Ott de Bruin L, Hayashida K, Freedman G, Marcovecchio GE, Capuder K, Rath P, Luche N, Hagedorn EJ, Buoncompagni A, Royer-Bertrand B, Giliani S, Poliani PL, Imberti L, Dobbs K, Poulain FE, Martini A, Manis J, Linhardt RJ, Bosticardo M, Rosenzweig SD, Lee H, Puck JM, Zúñiga-Pflücker JC, Zon L, Park PW, Superti-Furga A, Notarangelo LD.

J Exp Med. 2017 Mar 6;214(3):623-637. doi: 10.1084/jem.20161525. Epub 2017 Feb 1.

49.

Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.

Henninger J, Santoso B, Hans S, Durand E, Moore J, Mosimann C, Brand M, Traver D, Zon L.

Nat Cell Biol. 2017 Jan 31;19(2):142. doi: 10.1038/ncb3462. No abstract available.

50.

Chemical screening in zebrafish for novel biological and therapeutic discovery.

Wiley DS, Redfield SE, Zon LI.

Methods Cell Biol. 2017;138:651-679. doi: 10.1016/bs.mcb.2016.10.004. Epub 2016 Dec 29. Review.

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