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Removal of Endotoxin from rAAV Samples Using a Simple Detergent-Based Protocol.

Kondratova L, Kondratov O, Ragheb R, Zolotukhin S.

Mol Ther Methods Clin Dev. 2019 Sep 6;15:112-119. doi: 10.1016/j.omtm.2019.08.013. eCollection 2019 Dec 13.


Taste Receptor Cells in Mice Express Receptors for the Hormone Adiponectin.

Crosson SM, Marques A, Dib P, Dotson CD, Munger SD, Zolotukhin S.

Chem Senses. 2019 Jul 17;44(6):409-422. doi: 10.1093/chemse/bjz030.


Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System.

Joshi PRH, Cervera L, Ahmed I, Kondratov O, Zolotukhin S, Schrag J, Chahal PS, Kamen AA.

Mol Ther Methods Clin Dev. 2019 Feb 16;13:279-289. doi: 10.1016/j.omtm.2019.02.003. eCollection 2019 Jun 14.


Helper-free Production of Laboratory Grade AAV and Purification by Iodixanol Density Gradient Centrifugation.

Crosson SM, Dib P, Smith JK, Zolotukhin S.

Mol Ther Methods Clin Dev. 2018 May 8;10:1-7. doi: 10.1016/j.omtm.2018.05.001. eCollection 2018 Sep 21.


Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells.

Kondratov O, Marsic D, Crosson SM, Mendez-Gomez HR, Moskalenko O, Mietzsch M, Heilbronn R, Allison JR, Green KB, Agbandje-McKenna M, Zolotukhin S.

Mol Ther. 2017 Dec 6;25(12):2661-2675. doi: 10.1016/j.ymthe.2017.08.003. Epub 2017 Aug 10.


An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T Cells.

Palaschak B, Marsic D, Herzog RW, Zolotukhin S, Markusic DM.

Mol Ther Methods Clin Dev. 2017 Apr 19;5:142-152. doi: 10.1016/j.omtm.2017.04.004. eCollection 2017 Jun 16.


Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models.

Markusic DM, Nichols TC, Merricks EP, Palaschak B, Zolotukhin I, Marsic D, Zolotukhin S, Srivastava A, Herzog RW.

J Transl Med. 2017 May 1;15(1):94. doi: 10.1186/s12967-017-1200-1.


[Experience of organ spare sialolitiasis treatment using sialoendoscopy].

Balin VN, Zolotukhin SY.

Stomatologiia (Mosk). 2017;96(1):46-50. doi: 10.17116/stomat201796146-50. Russian.


OneBac 2.0: Sf9 Cell Lines for Production of AAV1, AAV2, and AAV8 Vectors with Minimal Encapsidation of Foreign DNA.

Mietzsch M, Hering H, Hammer EM, Agbandje-McKenna M, Zolotukhin S, Heilbronn R.

Hum Gene Ther Methods. 2017 Feb;28(1):15-22. doi: 10.1089/hgtb.2016.164.


Hypothalamus Specific Re-Introduction of SNORD116 into Otherwise Snord116 Deficient Mice Increased Energy Expenditure.

Qi Y, Purtell L, Fu M, Zhang L, Zolotukhin S, Campbell L, Herzog H.

J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12457.


Ambient temperature modulates the effects of the Prader-Willi syndrome candidate gene Snord116 on energy homeostasis.

Qi Y, Purtell L, Fu M, Sengmany K, Loh K, Zhang L, Zolotukhin S, Sainsbury A, Campbell L, Herzog H.

Neuropeptides. 2017 Feb;61:87-93. doi: 10.1016/j.npep.2016.10.006. Epub 2016 Oct 27.


Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease.

Gully JC, Sergeyev VG, Bhootada Y, Mendez-Gomez H, Meyers CA, Zolotukhin S, Gorbatyuk MS, Gorbatyuk OS.

Neurosci Lett. 2016 Aug 3;627:36-41. doi: 10.1016/j.neulet.2016.05.039. Epub 2016 May 24.


Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa.

Bhootada Y, Kotla P, Zolotukhin S, Gorbatyuk O, Bebok Z, Athar M, Gorbatyuk M.

PLoS One. 2016 May 4;11(5):e0154779. doi: 10.1371/journal.pone.0154779. eCollection 2016.


Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome.

Khor EC, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni RN, Enriquez RF, Purtell L, Lee NJ, Wee NK, Croucher PI, Campbell L, Herzog H, Baldock PA.

PLoS One. 2016 Jan 29;11(1):e0148155. doi: 10.1371/journal.pone.0148155. eCollection 2016.


High-accuracy biodistribution analysis of adeno-associated virus variants by double barcode sequencing.

Marsic D, Méndez-Gómez HR, Zolotukhin S.

Mol Ther Methods Clin Dev. 2015 Oct 28;2:15041. doi: 10.1038/mtm.2015.41. eCollection 2015.


Snord116 is critical in the regulation of food intake and body weight.

Qi Y, Purtell L, Fu M, Lee NJ, Aepler J, Zhang L, Loh K, Enriquez RF, Baldock PA, Zolotukhin S, Campbell LV, Herzog H.

Sci Rep. 2016 Jan 4;6:18614. doi: 10.1038/srep18614.


Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?

Berns KI, Byrne BJ, Flotte TR, Gao G, Hauswirth WW, Herzog RW, Muzyczka N, VandenDriessche T, Xiao X, Zolotukhin S, Srivastava A.

Hum Gene Ther. 2015 Dec;26(12):779-81. doi: 10.1089/hum.2015.29014.kib. No abstract available.


Altering Tropism of rAAV by Directed Evolution.

Marsic D, Zolotukhin S.

Methods Mol Biol. 2016;1382:151-73. doi: 10.1007/978-1-4939-3271-9_11.


E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution.

Grimm D, Zolotukhin S.

Mol Ther. 2015 Dec;23(12):1819-31. doi: 10.1038/mt.2015.173. Epub 2015 Sep 21. Review.


OneBac 2.0: Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA.

Mietzsch M, Casteleyn V, Weger S, Zolotukhin S, Heilbronn R.

Hum Gene Ther. 2015 Oct;26(10):688-97. doi: 10.1089/hum.2015.050. Epub 2015 Aug 6.


The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons.

Salganik M, Sergeyev VG, Shinde V, Meyers CA, Gorbatyuk MS, Lin JH, Zolotukhin S, Gorbatyuk OS.

Neurobiol Aging. 2015 Jun;36(6):2213-23. doi: 10.1016/j.neurobiolaging.2015.02.018. Epub 2015 Mar 5.


An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina.

Rana T, Shinde VM, Starr CR, Kruglov AA, Boitet ER, Kotla P, Zolotukhin S, Gross AK, Gorbatyuk MS.

Cell Death Dis. 2014 Dec 18;5:e1578. doi: 10.1038/cddis.2014.539.


Identification of low-expressing transcripts of the NPY receptors' family in the murine lingual epithelia.

Zolotukhin S.

Methods Mol Biol. 2014;1211:213-28. doi: 10.1007/978-1-4939-1459-3_17.


Vector design Tour de Force: integrating combinatorial and rational approaches to derive novel adeno-associated virus variants.

Marsic D, Govindasamy L, Currlin S, Markusic DM, Tseng YS, Herzog RW, Agbandje-McKenna M, Zolotukhin S.

Mol Ther. 2014 Nov;22(11):1900-9. doi: 10.1038/mt.2014.139. Epub 2014 Jul 22.


Neuropeptide y attenuates stress-induced bone loss through suppression of noradrenaline circuits.

Baldock PA, Lin S, Zhang L, Karl T, Shi Y, Driessler F, Zengin A, Hörmer B, Lee NJ, Wong IP, Lin EJ, Enriquez RF, Stehrer B, During MJ, Yulyaningsih E, Zolotukhin S, Ruohonen ST, Savontaus E, Sainsbury A, Herzog H.

J Bone Miner Res. 2014 Oct;29(10):2238-49. doi: 10.1002/jbmr.2205.


A simplified purification protocol for recombinant adeno-associated virus vectors.

Potter M, Lins B, Mietzsch M, Heilbronn R, Van Vliet K, Chipman P, Agbandje-McKenna M, Cleaver BD, Clément N, Byrne BJ, Zolotukhin S.

Mol Ther Methods Clin Dev. 2014 Aug 13;1:14034. doi: 10.1038/mtm.2014.34. eCollection 2014.


OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy.

Mietzsch M, Grasse S, Zurawski C, Weger S, Bennett A, Agbandje-McKenna M, Muzyczka N, Zolotukhin S, Heilbronn R.

Hum Gene Ther. 2014 Mar;25(3):212-22. doi: 10.1089/hum.2013.184. Epub 2014 Jan 23.


Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversion.

Hurtado MD, Sergeyev VG, Acosta A, Spegele M, La Sala M, Waler NJ, Chiriboga-Hurtado J, Currlin SW, Herzog H, Dotson CD, Gorbatyuk OS, Zolotukhin S.

J Neurosci. 2013 Nov 20;33(47):18368-80. doi: 10.1523/JNEUROSCI.1064-13.2013.


Modulation of taste responsiveness by the satiation hormone peptide YY.

La Sala MS, Hurtado MD, Brown AR, Bohórquez DV, Liddle RA, Herzog H, Zolotukhin S, Dotson CD.

FASEB J. 2013 Dec;27(12):5022-33. doi: 10.1096/fj.13-228064. Epub 2013 Sep 16.


Structural insights into adeno-associated virus serotype 5.

Govindasamy L, DiMattia MA, Gurda BL, Halder S, McKenna R, Chiorini JA, Muzyczka N, Zolotukhin S, Agbandje-McKenna M.

J Virol. 2013 Oct;87(20):11187-99. doi: 10.1128/JVI.00867-13. Epub 2013 Aug 7.


[Immediate results of complex treatment of resectable rectal neoplasms of distal localization].

Bondar' GV, Basheev VKh, Zolotukhin SÉ, Sovpel' IV, Sovpel' OV.

Klin Khir. 2013 Feb;(2):5-8. Russian.


[The two-staged intervention for complicated colonic cancer].

Bondar' GV, Basheev VKh, Ponce Prado AO, Bondarenko AI, Zolotukhin SÉ.

Klin Khir. 2013 Jan;(1):52-5. Russian.


[Neoadjuvant chemotherapy and radiation therapy of resectable cancer recti of distal localization].

Bondar' GV, Basheev VKh, Zolotukhin SÉ, Sovpel' IV, Sovpel' OV.

Klin Khir. 2013 Jan;(1):44-7. Russian.


Development of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia.

Zhong L, Jayandharan GR, Aslanidi GV, Zolotukhin S, Herzog RW, Srivastava A.

J Genet Syndr Gene Ther. 2012 Jan 10;S1. pii: 008.


Distribution of Y-receptors in murine lingual epithelia.

Hurtado MD, Acosta A, Riveros PP, Baum BJ, Ukhanov K, Brown AR, Dotson CD, Herzog H, Zolotukhin S.

PLoS One. 2012;7(9):e46358. doi: 10.1371/journal.pone.0046358. Epub 2012 Sep 26.


Metabolic hormones in saliva: origins and functions.

Zolotukhin S.

Oral Dis. 2013 Apr;19(3):219-29. doi: 10.1111/odi.12015. Epub 2012 Sep 21. Review.


Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice.

Nguyen AD, Mitchell NF, Lin S, Macia L, Yulyaningsih E, Baldock PA, Enriquez RF, Zhang L, Shi YC, Zolotukhin S, Herzog H, Sainsbury A.

PLoS One. 2012;7(6):e40191. doi: 10.1371/journal.pone.0040191. Epub 2012 Jun 29.


High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors.

Aslanidi GV, Rivers AE, Ortiz L, Govindasamy L, Ling C, Jayandharan GR, Zolotukhin S, Agbandje-McKenna M, Srivastava A.

Vaccine. 2012 Jun 6;30(26):3908-17. doi: 10.1016/j.vaccine.2012.03.079. Epub 2012 Apr 10.


Structural insight into the unique properties of adeno-associated virus serotype 9.

DiMattia MA, Nam HJ, Van Vliet K, Mitchell M, Bennett A, Gurda BL, McKenna R, Olson NH, Sinkovits RS, Potter M, Byrne BJ, Aslanidi G, Zolotukhin S, Muzyczka N, Baker TS, Agbandje-McKenna M.

J Virol. 2012 Jun;86(12):6947-58. doi: 10.1128/JVI.07232-11. Epub 2012 Apr 11.


Design and construction of functional AAV vectors.

Gray JT, Zolotukhin S.

Methods Mol Biol. 2011;807:25-46. doi: 10.1007/978-1-61779-370-7_2.


Salivary PYY: a putative bypass to satiety.

Acosta A, Hurtado MD, Gorbatyuk O, La Sala M, Duncan D, Aslanidi G, Campbell-Thompson M, Zhang L, Herzog H, Voutetakis A, Baum BJ, Zolotukhin S.

PLoS One. 2011;6(10):e26137. doi: 10.1371/journal.pone.0026137. Epub 2011 Oct 10.


Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models.

Rapti K, Louis-Jeune V, Kohlbrenner E, Ishikawa K, Ladage D, Zolotukhin S, Hajjar RJ, Weber T.

Mol Ther. 2012 Jan;20(1):73-83. doi: 10.1038/mt.2011.177. Epub 2011 Sep 13.


High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.

Markusic DM, Herzog RW, Aslanidi GV, Hoffman BE, Li B, Li M, Jayandharan GR, Ling C, Zolotukhin I, Ma W, Zolotukhin S, Srivastava A, Zhong L.

Mol Ther. 2010 Dec;18(12):2048-56. doi: 10.1038/mt.2010.172. Epub 2010 Aug 24.


An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.

Ojano-Dirain C, Glushakova LG, Zhong L, Zolotukhin S, Muzyczka N, Srivastava A, Stacpoole PW.

Mol Genet Metab. 2010 Oct-Nov;101(2-3):183-91. doi: 10.1016/j.ymgme.2010.07.008. Epub 2010 Jul 15.


Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.

Mitchell M, Nam HJ, Carter A, McCall A, Rence C, Bennett A, Gurda B, McKenna R, Porter M, Sakai Y, Byrne BJ, Muzyczka N, Aslanidi G, Zolotukhin S, Agbandje-McKenna M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt 7):715-8. doi: 10.1107/S1744309109021460. Epub 2009 Jun 27.


An inducible system for highly efficient production of recombinant adeno-associated virus (rAAV) vectors in insect Sf9 cells.

Aslanidi G, Lamb K, Zolotukhin S.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5059-64. doi: 10.1073/pnas.0810614106. Epub 2009 Mar 11.


High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors.

Petrs-Silva H, Dinculescu A, Li Q, Min SH, Chiodo V, Pang JJ, Zhong L, Zolotukhin S, Srivastava A, Lewin AS, Hauswirth WW.

Mol Ther. 2009 Mar;17(3):463-71. doi: 10.1038/mt.2008.269. Epub 2008 Dec 16.


Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression.

Zhong L, Li B, Jayandharan G, Mah CS, Govindasamy L, Agbandje-McKenna M, Herzog RW, Weigel-Van Aken KA, Hobbs JA, Zolotukhin S, Muzyczka N, Srivastava A.

Virology. 2008 Nov 25;381(2):194-202. doi: 10.1016/j.virol.2008.08.027. Epub 2008 Oct 2.


[Insufficience of the large intestine anastomosis sutures. Statistics, causes of occurrence, diagnosis, treatment and prophylaxis].

Bondar' GV, Basheev VKh, Psaras GG, Bondarenko NV, Borota AV, Zolotukhin SE, Zaika AN.

Klin Khir. 2008 Mar;(3):60-4. Russian. No abstract available.


Conditional, genetic disruption of ciliary neurotrophic factor receptors reveals a role in adult motor neuron survival.

Lee N, Robitz R, Zurbrugg RJ, Karpman AM, Mahler AM, Cronier SA, Vesey R, Spearry RP, Zolotukhin S, Maclennan AJ.

Eur J Neurosci. 2008 Jun;27(11):2830-7. doi: 10.1111/j.1460-9568.2008.06298.x. Erratum in: Eur J Neurosci. 2008 Jul;28(1):238.

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