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Items: 1 to 50 of 91

1.

Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure- guided Amelioration of its CYP3A4 Induction Profile.

Werner S, Mesch S, Hillig RC, Ter Laak AM, Klint J, Neagoe I, Laux-Biehlmann A, Dahllöf H, Braeuer N, Puetter V, Nubbemeyer R, Schulz S, Bairlein M, Zollner TM, Steinmeyer A.

J Med Chem. 2019 Nov 20. doi: 10.1021/acs.jmedchem.9b01304. [Epub ahead of print]

PMID:
31746599
2.

Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.

Koppitz M, Bräuer N, Ter Laak A, Irlbacher H, Rotgeri A, Coelho AM, Walter D, Steinmeyer A, Zollner TM, Peters M, Nagel J.

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2700-2705. doi: 10.1016/j.bmcl.2019.07.007. Epub 2019 Jul 24.

PMID:
31362919
3.

Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis.

Bäurle S, Nagel J, Peters O, Bräuer N, Ter Laak A, Preusse C, Rottmann A, Heldmann D, Bothe U, Blume T, Zorn L, Walter D, Zollner TM, Steinmeyer A, Langer G.

J Med Chem. 2019 Mar 14;62(5):2541-2563. doi: 10.1021/acs.jmedchem.8b01862. Epub 2019 Feb 22.

PMID:
30707023
4.

Dynamic weight bearing as a non-reflexive method for the measurement of abdominal pain in mice.

Laux-Biehlmann A, Boyken J, Dahllöf H, Schmidt N, Zollner TM, Nagel J.

Eur J Pain. 2016 May;20(5):742-52. doi: 10.1002/ejp.800. Epub 2015 Dec 18.

PMID:
26684879
5.

Menstruation pulls the trigger for inflammation and pain in endometriosis.

Laux-Biehlmann A, d'Hooghe T, Zollner TM.

Trends Pharmacol Sci. 2015 May;36(5):270-6. doi: 10.1016/j.tips.2015.03.004. Epub 2015 Apr 19. Review.

PMID:
25899467
6.

Use of dynamic weight bearing as a novel end-point for the assessment of abdominal pain in the LPS-induced peritonitis model in the rat.

Gruen M, Laux-Biehlmann A, Zollner TM, Nagel J.

J Neurosci Methods. 2014 Jul 30;232:118-24. doi: 10.1016/j.jneumeth.2014.05.017. Epub 2014 May 24.

PMID:
24861422
7.

The CD24hi smooth muscle subpopulation is the predominant fraction in uterine fibroids.

Drosch M, Schmidt N, Markowski DN, Zollner TM, Koch M, Bullerdiek J.

Mol Hum Reprod. 2014 Jul;20(7):664-76. doi: 10.1093/molehr/gau022. Epub 2014 Mar 21.

PMID:
24657878
8.

A novel mouse model that closely mimics human uterine leiomyomas.

Drosch M, Bullerdiek J, Zollner TM, Prinz F, Koch M, Schmidt N.

Fertil Steril. 2013 Mar 1;99(3):927-935.e6. doi: 10.1016/j.fertnstert.2012.11.032. Epub 2012 Dec 20.

PMID:
23260859
9.

Cancer therapy monitoring in xenografts by quantitative analysis of circulating tumor DNA.

Gorges TM, Schiller J, Schmitz A, Schuetzmann D, Schatz C, Zollner TM, Krahn T, von Ahsen O.

Biomarkers. 2012 Sep;17(6):498-506. doi: 10.3109/1354750X.2012.689133. Epub 2012 May 23.

PMID:
22616911
10.

Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition.

Gorges TM, Tinhofer I, Drosch M, Röse L, Zollner TM, Krahn T, von Ahsen O.

BMC Cancer. 2012 May 16;12:178. doi: 10.1186/1471-2407-12-178.

11.

Induction of overt menstruation in intact mice.

Rudolph M, Döcke WD, Müller A, Menning A, Röse L, Zollner TM, Gashaw I.

PLoS One. 2012;7(3):e32922. doi: 10.1371/journal.pone.0032922. Epub 2012 Mar 7.

12.

Mast cells in endometriosis: guilty or innocent bystanders?

Kirchhoff D, Kaulfuss S, Fuhrmann U, Maurer M, Zollner TM.

Expert Opin Ther Targets. 2012 Mar;16(3):237-41. doi: 10.1517/14728222.2012.661415. Epub 2012 Feb 14.

PMID:
22332753
13.

Extended DNFB-induced contact hypersensitivity models display characteristics of chronic inflammatory dermatoses.

Röse L, Schneider C, Stock C, Zollner TM, Döcke WD.

Exp Dermatol. 2012 Jan;21(1):25-31. doi: 10.1111/j.1600-0625.2011.01395.x.

PMID:
22151387
14.

Shortened treatment duration of glucocorticoid-induced skin atrophy in rats.

Schoepe S, Vonk R, Schäcke H, Zollner TM, Asadullah K, Röse L.

Exp Dermatol. 2011 Oct;20(10):853-5. doi: 10.1111/j.1600-0625.2011.01341.x. Epub 2011 Aug 8.

PMID:
21824195
15.

High-resolution ultrasound imaging: a novel technique for the noninvasive in vivo analysis of endometriotic lesion and cyst formation in small animal models.

Laschke MW, Körbel C, Rudzitis-Auth J, Gashaw I, Reinhardt M, Hauff P, Zollner TM, Menger MD.

Am J Pathol. 2010 Feb;176(2):585-93. doi: 10.2353/ajpath.2010.090617. Epub 2009 Dec 30.

16.

The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammation.

Schottelius AJ, Zügel U, Döcke WD, Zollner TM, Röse L, Mengel A, Buchmann B, Becker A, Grütz G, Naundorf S, Friedrich A, Gaestel M, Asadullah K.

J Invest Dermatol. 2010 Feb;130(2):481-91. doi: 10.1038/jid.2009.218. Epub 2009 Aug 6.

17.

Acute neuroinflammation in Lewis rats - a model for acute multiple sclerosis relapses.

Schneider C, Schuetz G, Zollner TM.

J Neuroimmunol. 2009 Aug 18;213(1-2):84-90. doi: 10.1016/j.jneuroim.2009.05.015. Epub 2009 Jun 26.

PMID:
19560215
18.

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases.

Schäcke H, Zollner TM, Döcke WD, Rehwinkel H, Jaroch S, Skuballa W, Neuhaus R, May E, Zügel U, Asadullah K.

Br J Pharmacol. 2009 Oct;158(4):1088-103. doi: 10.1111/j.1476-5381.2009.00238.x. Epub 2009 May 6.

19.

Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors.

Lucas JL, Mirshahpanah P, Haas-Stapleton E, Asadullah K, Zollner TM, Numerof RP.

Cell Immunol. 2009;257(1-2):97-104. doi: 10.1016/j.cellimm.2009.03.004. Epub 2009 Apr 8.

PMID:
19358983
20.

Mast cells in health and disease: from basic science to clinical application 4-5 July 2008, Stuttgart, Germany.

Kirchhoff D, Bischoff SC, Maurer M, Zollner TM.

Expert Opin Ther Targets. 2008 Dec;12(12):1591-4. doi: 10.1517/14728220802546512 .

PMID:
19007326
21.

Chronic mouse model of TMA-induced contact hypersensitivity.

Schneider C, Döcke WD, Zollner TM, Röse L.

J Invest Dermatol. 2009 Apr;129(4):899-907. doi: 10.1038/jid.2008.307. Epub 2008 Oct 2.

22.

Targeting leukocyte recruitment in the treatment of psoriasis.

Li YY, Zollner TM, Schön MP.

Clin Dermatol. 2008 Sep-Oct;26(5):527-38. doi: 10.1016/j.clindermatol.2007.11.002. Review.

PMID:
18755372
23.

The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassay.

Li YY, Bao M, Meurer J, Skuballa W, Bauman JG, Doecke WD, Zollner TM.

Immunol Lett. 2008 Apr 15;117(1):114-8. doi: 10.1016/j.imlet.2007.08.013. Epub 2007 Oct 2.

PMID:
18241931
24.

CCR4 and CCR10 ligands play additive roles in mouse contact hypersensitivity.

Mirshahpanah P, Li YY, Burkhardt N, Asadullah K, Zollner TM.

Exp Dermatol. 2008 Jan;17(1):30-4.

PMID:
18095942
25.

Superior nuclear receptor selectivity and therapeutic index of methylprednisolone aceponate versus mometasone furoate.

Mirshahpanah P, Döcke WD, Merbold U, Asadullah K, Röse L, Schäcke H, Zollner TM.

Exp Dermatol. 2007 Sep;16(9):753-61.

PMID:
17697148
26.

Psoriasis: a possible risk factor for development of coronary artery calcification.

Ludwig RJ, Herzog C, Rostock A, Ochsendorf FR, Zollner TM, Thaci D, Kaufmann R, Vogl TJ, Boehncke WH.

Br J Dermatol. 2007 Feb;156(2):271-6.

PMID:
17223866
27.

Targeting leukocyte trafficking to inflamed skin: still an attractive therapeutic approach?

Zollner TM, Asadullah K, Schön MP.

Exp Dermatol. 2007 Jan;16(1):1-12. Review.

PMID:
17181631
28.

Efomycine M: an inhibitor of selectins?

von Bonin A, Buchmann B, Bader B, Rausch A, Venstrom K, Schäfer M, Gründemann S, Günther J, Zorn L, Nubbemeyer R, Asadullah K, Zollner TM.

Nat Med. 2006 Aug;12(8):873; author reply 873-4. No abstract available.

PMID:
16892024
29.

Fatalities in natalizumab treatment--a 'no go' for leukocyte recirculation approaches?

Li YY, Perez HD, Zollner TM.

Expert Opin Ther Targets. 2006 Aug;10(4):489-99.

PMID:
16848686
30.

Humanised mouse models in drug discovery for skin inflammation.

Igney FH, Asadullah K, Zollner TM.

Expert Opin Drug Discov. 2006 Jun;1(1):53-68. doi: 10.1517/17460441.1.1.53.

PMID:
23506032
31.

Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation.

Ludwig RJ, Zollner TM, Santoso S, Hardt K, Gille J, Baatz H, Johann PS, Pfeffer J, Radeke HH, Schön MP, Kaufmann R, Boehncke WH, Podda M.

J Invest Dermatol. 2005 Nov;125(5):969-76.

32.

Eosinophilic cellulitis (Wells' syndrome) associated with colon carcinoma.

Hirsch K, Ludwig RJ, Wolter M, Zollner TM, Hardt K, Kaufmann R, Boehncke WH.

J Dtsch Dermatol Ges. 2005 Jul;3(7):530-1.

PMID:
15967014
33.

Acute and chronic models of allergic contact dermatitis: advantages and limitations.

Zollner TM, Igney FH, Asadullah K.

Ernst Schering Res Found Workshop. 2005;(50):255-75. Review. No abstract available.

PMID:
15526948
34.

Techniques: species' finest blend--humanized mouse models in inflammatory skin disease research.

Igney FH, Asadullah K, Zollner TM.

Trends Pharmacol Sci. 2004 Oct;25(10):543-9. Review.

PMID:
15380939
35.

Animal models of T-cell-mediated skin diseases.

Zollner TM, Renz H, Igney FH, Asadullah K.

Bioessays. 2004 Jun;26(6):693-6. No abstract available.

PMID:
15170867
36.

Narrowband UVB and cream psoralen-UVA combination therapy for plaque-type psoriasis.

Grundmann-Kollmann M, Ludwig R, Zollner TM, Ochsendorf F, Thaci D, Boehncke WH, Krutmann J, Kaufmann R, Podda M.

J Am Acad Dermatol. 2004 May;50(5):734-9.

PMID:
15097957
37.

Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis.

Ludwig RJ, Boehme B, Podda M, Henschler R, Jager E, Tandi C, Boehncke WH, Zollner TM, Kaufmann R, Gille J.

Cancer Res. 2004 Apr 15;64(8):2743-50.

38.

Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules.

Ludwig RJ, Schultz JE, Boehncke WH, Podda M, Tandi C, Krombach F, Baatz H, Kaufmann R, von Andrian UH, Zollner TM.

J Invest Dermatol. 2004 Mar;122(3):830-6.

39.
40.

Selectin and selectin ligand binding: a bittersweet attraction.

Zollner TM, Asadullah K.

J Clin Invest. 2003 Oct;112(7):980-3.

41.

Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome).

Ludwig RJ, Grundmann-Kollmann M, Holtmeier W, Wolter M, Glas J, Podda M, Kaufmann R, Zollner TM.

J Am Acad Dermatol. 2003 May;48(5 Suppl):S60-1.

PMID:
12734477
42.

Proteasome inhibition: a new anti-inflammatory strategy.

Elliott PJ, Zollner TM, Boehncke WH.

J Mol Med (Berl). 2003 Apr;81(4):235-45. Epub 2003 Mar 26. Review.

PMID:
12700891
43.

CD4+ CD56+ neoplasia: clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis X.

Kim SZ, Zollner TM, Schui DK, Chow KU, Sterry W, Kriener S, Hoelzer D, Mitrou PS, Weidmann E.

Leuk Lymphoma. 2003 Feb;44(2):281-9. Review.

PMID:
12688346
44.

The selective cyclooxygenase-2 inhibitor rofecoxib may improve the treatment of chronic idiopathic urticaria.

Boehncke WH, Ludwig RJ, Zollner TM, Ochsendorf F, Kaufmann R, Gibbs BF.

Br J Dermatol. 2003 Mar;148(3):604-6. No abstract available.

PMID:
12653769
45.

Distinct TCR delta repertoires are present in the cutaneous lesions and inflamed duodenum of patients with dermatitis herpetiformis.

Holtmeier W, Pfänder M, Zollner TM, Kaufmann R, Caspary WF.

Exp Dermatol. 2002 Dec;11(6):527-31.

PMID:
12473060
46.

Decorative cosmetics improve the quality of life in patients with disfiguring skin diseases.

Boehncke WH, Ochsendorf F, Paeslack I, Kaufmann R, Zollner TM.

Eur J Dermatol. 2002 Nov-Dec;12(6):577-80.

PMID:
12459532
47.

The responsiveness of human V delta 1 gamma delta T cells to Borrelia burgdorferi is largely restricted to synovial-fluid cells from patients with Lyme arthritis.

Glatzel A, Entschladen F, Zollner TM, Kraiczy P, Brade V, Kaufmann R, Janssen O, Lengl-Janssen B, Wesch D, Kabelitz D.

J Infect Dis. 2002 Oct 1;186(7):1043-6. Epub 2002 Sep 13.

PMID:
12232849
48.

Caffeine hypersensitivity.

Hinrichs R, Hunzelmann N, Ritzkowsky A, Zollner TM, Krieg T, Scharffetter-Kochanek K.

Allergy. 2002 Sep;57(9):859-60. No abstract available.

PMID:
12169187
49.

Increased incidence of skin infections in atopy: evidence for an antigen-specific homing defect?

Zollner TM, Podda M, Kaufmann R, Platts-Mills TA, Woodfolk JA.

Clin Exp Allergy. 2002 Feb;32(2):180-5. Review. No abstract available.

PMID:
11929479
50.

Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation.

Schön MP, Krahn T, Schön M, Rodriguez ML, Antonicek H, Schultz JE, Ludwig RJ, Zollner TM, Bischoff E, Bremm KD, Schramm M, Henninger K, Kaufmann R, Gollnick HP, Parker CM, Boehncke WH.

Nat Med. 2002 Apr;8(4):366-72. Erratum in: Nat Med 2002 Jun;8(6):639.

PMID:
11927942

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