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Items: 1 to 50 of 55

1.

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Goncharov T, Hedayati S, Mulvihill MM, Izrael-Tomasevic A, Zobel K, Jeet S, Fedorova AV, Eidenschenk C, deVoss J, Yu K, Shaw AS, Kirkpatrick DS, Fairbrother WJ, Deshayes K, Vucic D.

Mol Cell. 2018 Feb 15;69(4):551-565.e7. doi: 10.1016/j.molcel.2018.01.016.

2.

N-Cadherin modified lipid bilayers promote neural network formation and circuitry.

Zobel K, Choi SE, Minakova R, Gocyla M, Offenhäusser A.

Soft Matter. 2017 Nov 15;13(44):8096-8107. doi: 10.1039/c7sm01214d.

PMID:
29085948
3.

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.

Lueck SC, Russ AC, Botzenhardt U, Schlenk RF, Zobel K, Deshayes K, Vucic D, Döhner H, Döhner K, Fulda S, Bullinger L.

Oncotarget. 2016 Aug 2;7(31):49539-49551. doi: 10.18632/oncotarget.10390.

4.

Blood-brain barrier properties in vitro depend on composition and assembly of endogenous extracellular matrices.

Zobel K, Hansen U, Galla HJ.

Cell Tissue Res. 2016 Aug;365(2):233-45. doi: 10.1007/s00441-016-2397-7. Epub 2016 Apr 6.

PMID:
27053246
5.

Plasticity in plant functional traits is shaped by variability in neighbourhood species composition.

Abakumova M, Zobel K, Lepik A, Semchenko M.

New Phytol. 2016 Jul;211(2):455-63. doi: 10.1111/nph.13935. Epub 2016 Mar 21.

6.

Is the positive relationship between species richness and shoot morphological plasticity mediated by ramet density or is there a direct link?

Lepik M, Zobel K.

Oecologia. 2015 Jul;178(3):867-73. doi: 10.1007/s00442-015-3288-4. Epub 2015 Mar 12.

PMID:
25761447
7.

Internal motions prime cIAP1 for rapid activation.

Phillips AH, Schoeffler AJ, Matsui T, Weiss TM, Blankenship JW, Zobel K, Giannetti AM, Dueber EC, Fairbrother WJ.

Nat Struct Mol Biol. 2014 Dec;21(12):1068-74. doi: 10.1038/nsmb.2916. Epub 2014 Nov 10.

PMID:
25383668
8.

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Tao ZF, Hasvold L, Wang L, Wang X, Petros AM, Park CH, Boghaert ER, Catron ND, Chen J, Colman PM, Czabotar PE, Deshayes K, Fairbrother WJ, Flygare JA, Hymowitz SG, Jin S, Judge RA, Koehler MF, Kovar PJ, Lessene G, Mitten MJ, Ndubaku CO, Nimmer P, Purkey HE, Oleksijew A, Phillips DC, Sleebs BE, Smith BJ, Smith ML, Tahir SK, Watson KG, Xiao Y, Xue J, Zhang H, Zobel K, Rosenberg SH, Tse C, Leverson JD, Elmore SW, Souers AJ.

ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93. doi: 10.1021/ml5001867. eCollection 2014 Oct 9.

9.

Climate warming may facilitate invasion of the exotic shrub Lantana camara.

Zhang Q, Zhang Y, Peng S, Zobel K.

PLoS One. 2014 Sep 3;9(9):e105500. doi: 10.1371/journal.pone.0105500. eCollection 2014.

10.

Further insights into the effects of pre-organizing the BimBH3 helix.

Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE.

ACS Chem Biol. 2014 Mar 21;9(3):838-9. doi: 10.1021/cb400638p. Epub 2014 Feb 18. No abstract available.

PMID:
24547872
11.

Structure-guided design of a selective BCL-X(L) inhibitor.

Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DC, Watson KG.

Nat Chem Biol. 2013 Jun;9(6):390-7. doi: 10.1038/nchembio.1246. Epub 2013 Apr 21.

PMID:
23603658
12.

Functional species pool framework to test for biotic effects on community assembly.

de Bello F, Price JN, Münkemüller T, Liira J, Zobel M, Thuiller W, Gerhold P, Götzenberger L, Lavergne S, Leps J, Zobel K, Pärtel M.

Ecology. 2012 Oct;93(10):2263-73.

PMID:
23185887
13.

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE.

ACS Chem Biol. 2013 Feb 15;8(2):297-302. doi: 10.1021/cb3005403. Epub 2012 Dec 10.

PMID:
23151250
14.

Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.

Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, Vucic D, Debatin KM, Fulda S.

Oncogene. 2013 Feb 21;32(8):988-97. doi: 10.1038/onc.2012.108. Epub 2012 Apr 2.

PMID:
22469979
15.

Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Varfolomeev E, Goncharov T, Maecker H, Zobel K, Kömüves LG, Deshayes K, Vucic D.

Sci Signal. 2012 Mar 20;5(216):ra22. doi: 10.1126/scisignal.2001878.

16.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG, Elliott LO, Feng B, Franklin MC, Reisner SF, Gazzard L, Halladay J, Hymowitz SG, La H, LoRusso P, Maurer B, Murray L, Plise E, Quan C, Stephan JP, Young SG, Tom J, Tsui V, Um J, Varfolomeev E, Vucic D, Wagner AJ, Wallweber HJ, Wang L, Ware J, Wen Z, Wong H, Wong JM, Wong M, Wong S, Yu R, Zobel K, Fairbrother WJ.

J Med Chem. 2012 May 10;55(9):4101-13. doi: 10.1021/jm300060k. Epub 2012 Mar 28.

17.

Interleukin 6, lipopolysaccharide-binding protein and interleukin 10 in the prediction of risk and etiologic patterns in patients with community-acquired pneumonia: results from the German competence network CAPNETZ.

Zobel K, Martus P, Pletz MW, Ewig S, Prediger M, Welte T, Bühling F; CAPNETZ study group.

BMC Pulm Med. 2012 Feb 20;12:6. doi: 10.1186/1471-2466-12-6.

18.

Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.

Stadel D, Cristofanon S, Abhari BA, Deshayes K, Zobel K, Vucic D, Debatin KM, Fulda S.

Neoplasia. 2011 Dec;13(12):1162-70.

19.

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

Laukens B, Jennewein C, Schenk B, Vanlangenakker N, Schier A, Cristofanon S, Zobel K, Deshayes K, Vucic D, Jeremias I, Bertrand MJ, Vandenabeele P, Fulda S.

Neoplasia. 2011 Oct;13(10):971-9.

20.

Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.

Dueber EC, Schoeffler AJ, Lingel A, Elliott JM, Fedorova AV, Giannetti AM, Zobel K, Maurer B, Varfolomeev E, Wu P, Wallweber HJ, Hymowitz SG, Deshayes K, Vucic D, Fairbrother WJ.

Science. 2011 Oct 21;334(6054):376-80. doi: 10.1126/science.1207862.

21.

The development of peptide-based tools for the analysis of angiogenesis.

Fedorova A, Zobel K, Gill HS, Ogasawara A, Flores JE, Tinianow JN, Vanderbilt AN, Wu P, Meng YG, Williams SP, Wiesmann C, Murray J, Marik J, Deshayes K.

Chem Biol. 2011 Jul 29;18(7):839-45. doi: 10.1016/j.chembiol.2011.05.011.

22.

Ecological assembly rules in plant communities--approaches, patterns and prospects.

Götzenberger L, de Bello F, Bråthen KA, Davison J, Dubuis A, Guisan A, Lepš J, Lindborg R, Moora M, Pärtel M, Pellissier L, Pottier J, Vittoz P, Zobel K, Zobel M.

Biol Rev Camb Philos Soc. 2012 Feb;87(1):111-27. doi: 10.1111/j.1469-185X.2011.00187.x. Epub 2011 Jun 21. Review.

PMID:
21692965
23.

Limited phenotypic plasticity in range-edge populations: a comparison of co-occurring populations of two Agrimonia species with different geographical distributions.

Mägi M, Semchenko M, Kalamees R, Zobel K.

Plant Biol (Stuttg). 2011 Jan;13(1):177-84. doi: 10.1111/j.1438-8677.2010.00342.x.

PMID:
21143739
24.

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production.

Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, Vucic D, Fulda S, Vandenabeele P, Bertrand MJ.

Cell Death Differ. 2011 Apr;18(4):656-65. doi: 10.1038/cdd.2010.138. Epub 2010 Nov 5.

25.

The productivity-diversity relationship: varying aims and approaches.

Pärtel M, Zobel K, Laanisto L, Szava-Kovats R, Zobel M.

Ecology. 2010 Sep;91(9):2565-7. No abstract available.

PMID:
20957950
26.

X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists.

Varfolomeev E, Alicke B, Elliott JM, Zobel K, West K, Wong H, Scheer JM, Ashkenazi A, Gould SE, Fairbrother WJ, Vucic D.

J Biol Chem. 2009 Dec 11;284(50):34553-60. doi: 10.1074/jbc.M109.040139. Epub 2009 Oct 23.

27.

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

Lee EF, Fedorova A, Zobel K, Boyle MJ, Yang H, Perugini MA, Colman PM, Huang DC, Deshayes K, Fairlie WD.

J Biol Chem. 2009 Nov 6;284(45):31315-26. doi: 10.1074/jbc.M109.048009. Epub 2009 Sep 10.

28.

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, Maurer B, Fedorova AV, Dynek JN, Koehler M, Hymowitz SG, Tsui V, Deshayes K, Fairbrother WJ, Flygare JA, Vucic D.

ACS Chem Biol. 2009 Jul 17;4(7):557-66. doi: 10.1021/cb900083m.

PMID:
19492850
29.

Understory plant diversity is related to higher variability of vegetative mobility of coexisting species.

Moora M, Opik M, Zobel K, Zobel M.

Oecologia. 2009 Mar;159(2):355-61. doi: 10.1007/s00442-008-1209-5. Epub 2008 Nov 4.

PMID:
18982354
30.

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D.

Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885.

PMID:
18939944
31.

Foraging for space and avoidance of physical obstructions by plant roots: a comparative study of grasses from contrasting habitats.

Semchenko M, Zobel K, Heinemeyer A, Hutchings MJ.

New Phytol. 2008;179(4):1162-70. doi: 10.1111/j.1469-8137.2008.02543.x.

32.

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D.

J Biol Chem. 2008 Sep 5;283(36):24295-9. doi: 10.1074/jbc.C800128200. Epub 2008 Jul 11.

33.

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D.

Cell. 2007 Nov 16;131(4):669-81.

34.

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.

Lee EF, Czabotar PE, Smith BJ, Deshayes K, Zobel K, Colman PM, Fairlie WD.

Cell Death Differ. 2007 Sep;14(9):1711-3. Epub 2007 Jun 15. No abstract available.

35.
36.

Monitoring of biological diversity: a common-ground approach.

Teder T, Moora M, Roosaluste E, Zobel K, Pärtel M, Kõljalg U, Zobel M.

Conserv Biol. 2007 Apr;21(2):313-7.

PMID:
17391181
37.

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K.

ACS Chem Biol. 2006 Sep 19;1(8):525-33. Erratum in: ACS Chem Biol. 2006 Oct 20;1(9):601.

PMID:
17168540
38.

High shoot plasticity favours plant coexistence in herbaceous vegetation.

Lepik M, Liira J, Zobel K.

Oecologia. 2005 Sep;145(3):465-74. Epub 2005 Sep 29.

PMID:
15983752
39.

Phosphate ester serum albumin affinity tags greatly improve peptide half-life in vivo.

Zobel K, Koehler MF, Beresini MH, Caris LD, Combs D.

Bioorg Med Chem Lett. 2003 May 5;13(9):1513-5.

PMID:
12699744
40.

Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain.

Skelton NJ, Koehler MF, Zobel K, Wong WL, Yeh S, Pisabarro MT, Yin JP, Lasky LA, Sidhu SS.

J Biol Chem. 2003 Feb 28;278(9):7645-54. Epub 2002 Nov 20.

41.

Albumin affinity tags increase peptide half-life in vivo.

Koehler MF, Zobel K, Beresini MH, Caris LD, Combs D, Paasch BD, Lazarus RA.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2883-6.

PMID:
12270169
42.

Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.

Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K, Deshayes K, Baca M, Pisabarro MT, Lowman HB.

Biochemistry. 2001 Jul 24;40(29):8487-98.

PMID:
11456486
43.

Barium ions reduce contraction kinetics in rat tracheal smooth muscle.

Peiper U, Zobel K.

Pflugers Arch. 1987 Apr;408(4):373-8.

PMID:
3588254
44.

[Diagnosis and conservative therapy of metatarsal injuries].

Zobel K.

Z Orthop Ihre Grenzgeb. 1975 Aug;113(4):706-9. German. No abstract available.

PMID:
1210611
45.

[Comment on M. Stöhrer, D. Franke: Nail osteosynthesis in distal extra-articular lower-leg fractures, this journal 75, 312, 1972].

Zobel K.

Monatsschr Unfallheilkd Versicher Versorg Verkehrsmed. 1973 Apr;76(4):184-6. German. No abstract available.

PMID:
4267092
46.

[Comment on the paper: "Sport injuries and sport lesions on the shoulder and elbow joints"].

Zobel K.

Z Orthop Ihre Grenzgeb. 1973 Feb;111(1):112-3. German. No abstract available.

PMID:
4267778
47.

[Notes on the paper: "the articular meniscus as a cause of juvenile knee joint problems". 2. Orthopädic 1970, 108, 2H, P217].

Zobel K.

Z Orthop Ihre Grenzgeb. 1971 Mar;109(1):181-2. German. No abstract available.

PMID:
4259453
48.
49.

A method of lengthening the tibialis posterior tendon to facilitate its transplantation in the fore part of the foot.

Zobel K.

J Bone Joint Surg Am. 1967 Sep;49(6):1199. No abstract available.

PMID:
6038867
50.

[SUDECK'S SYNDROME FOLLOWING WRONG TREATMENT].

ZOBEL K, FISCHER-WASELS J, SCHWETLICK W.

Monatsschr Unfallheilkd Versicher Versorg Verkehrsmed. 1964 Feb;67:89-94. German. No abstract available.

PMID:
14153611

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