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Assembly Reactions of Hepatitis B Capsid Protein into Capsid Nanoparticles Follow a Narrow Path Through a Complex Reaction Landscape.

Asor R, Selzer L, Schlicksup CJ, Zhao Z, Zlotnick A, Raviv U.

ACS Nano. 2019 Jun 7. doi: 10.1021/acsnano.9b00648. [Epub ahead of print]


Structural differences between the Woodchuck hepatitis virus core protein in dimer and capsid states are consistent with entropic and conformational regulation of assembly.

Zhao Z, Wang JC, Gonzalez-Gutierrez G, Venkatakrishnan B, Asor R, Khaykelson D, Raviv U, Zlotnick A.

J Virol. 2019 May 1. pii: JVI.00141-19. doi: 10.1128/JVI.00141-19. [Epub ahead of print]


Evolution of Intermediates during Capsid Assembly of Hepatitis B Virus with Phenylpropenamide-Based Antivirals.

Kondylis P, Schlicksup CJ, Katen SP, Lee LS, Zlotnick A, Jacobson SC.

ACS Infect Dis. 2019 May 10;5(5):769-777. doi: 10.1021/acsinfecdis.8b00290. Epub 2019 Feb 4.


Competition between Normative and Drug-Induced Virus Self-Assembly Observed with Single-Particle Methods.

Kondylis P, Schlicksup CJ, Brunk NE, Zhou J, Zlotnick A, Jacobson SC.

J Am Chem Soc. 2019 Jan 23;141(3):1251-1260. doi: 10.1021/jacs.8b10131. Epub 2018 Dec 31.


Analytical Techniques to Characterize the Structure, Properties, and Assembly of Virus Capsids.

Kondylis P, Schlicksup CJ, Zlotnick A, Jacobson SC.

Anal Chem. 2019 Jan 2;91(1):622-636. doi: 10.1021/acs.analchem.8b04824. Epub 2018 Dec 3. No abstract available.


Use of a Fluorescent Analogue of a HBV Core Protein-Directed Drug To Interrogate an Antiviral Mechanism.

Nair S, Li L, Francis S, Turner WW, VanNieuwenhze M, Zlotnick A.

J Am Chem Soc. 2018 Nov 14;140(45):15261-15269. doi: 10.1021/jacs.8b07988. Epub 2018 Oct 30.


Effect of dsDNA on the Assembly Pathway and Mechanical Strength of SV40 VP1 Virus-like Particles.

van Rosmalen MGM, Li C, Zlotnick A, Wuite GJL, Roos WH.

Biophys J. 2018 Nov 6;115(9):1656-1665. doi: 10.1016/j.bpj.2018.07.044. Epub 2018 Sep 13.


Virus Assembly Antagonists from Redesigned Antibodies.

Zhao Z, Zlotnick A.

Structure. 2018 Oct 2;26(10):1297-1299. doi: 10.1016/j.str.2018.09.002.


Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals.

Ruan L, Hadden JA, Zlotnick A.

J Virol. 2018 Sep 26;92(20). pii: e01082-18. doi: 10.1128/JVI.01082-18. Print 2018 Oct 15.


An Assembly-Activating Site in the Hepatitis B Virus Capsid Protein Can Also Trigger Disassembly.

Qazi S, Schlicksup CJ, Rittichier J, VanNieuwenhze MS, Zlotnick A.

ACS Chem Biol. 2018 Aug 17;13(8):2114-2120. doi: 10.1021/acschembio.8b00283. Epub 2018 Jul 6.


Molecular jenga: the percolation phase transition (collapse) in virus capsids.

Brunk NE, Lee LS, Glazier JA, Butske W, Zlotnick A.

Phys Biol. 2018 Jun 6;15(5):056005. doi: 10.1088/1478-3975/aac194.


Characterization of Virus Capsids and Their Assembly Intermediates by Multicycle Resistive-Pulse Sensing with Four Pores in Series.

Zhou J, Kondylis P, Haywood DG, Harms ZD, Lee LS, Zlotnick A, Jacobson SC.

Anal Chem. 2018 Jun 19;90(12):7267-7274. doi: 10.1021/acs.analchem.8b00452. Epub 2018 May 29.


All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits.

Hadden JA, Perilla JR, Schlicksup CJ, Venkatakrishnan B, Zlotnick A, Schulten K.

Elife. 2018 Apr 27;7. pii: e32478. doi: 10.7554/eLife.32478.


Multiple Pathways in Capsid Assembly.

Lutomski CA, Lyktey NA, Pierson EE, Zhao Z, Zlotnick A, Jarrold MF.

J Am Chem Soc. 2018 May 2;140(17):5784-5790. doi: 10.1021/jacs.8b01804. Epub 2018 Apr 19.


Asymmetric Modification of Hepatitis B Virus (HBV) Genomes by an Endogenous Cytidine Deaminase inside HBV Cores Informs a Model of Reverse Transcription.

Nair S, Zlotnick A.

J Virol. 2018 Apr 27;92(10). pii: e02190-17. doi: 10.1128/JVI.02190-17. Print 2018 May 15.


Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids.

Schlicksup CJ, Wang JC, Francis S, Venkatakrishnan B, Turner WW, VanNieuwenhze M, Zlotnick A.

Elife. 2018 Jan 29;7. pii: e31473. doi: 10.7554/eLife.31473.


Geometric Defects and Icosahedral Viruses.

Wang JC, Mukhopadhyay S, Zlotnick A.

Viruses. 2018 Jan 4;10(1). pii: E25. doi: 10.3390/v10010025. Review.


Hepatitis B Virus Capsid Completion Occurs through Error Correction.

Lutomski CA, Lyktey NA, Zhao Z, Pierson EE, Zlotnick A, Jarrold MF.

J Am Chem Soc. 2017 Nov 22;139(46):16932-16938. doi: 10.1021/jacs.7b09932. Epub 2017 Nov 10.


Length of encapsidated cargo impacts stability and structure of in vitro assembled alphavirus core-like particles.

Rayaprolu V, Moore A, Wang JC, Goh BC, Perilla JR, Zlotnick A, Mukhopadhyay S.

J Phys Condens Matter. 2017 Dec 6;29(48):484003. doi: 10.1088/1361-648X/aa90d0.


A molecular breadboard: Removal and replacement of subunits in a hepatitis B virus capsid.

Lee LS, Brunk N, Haywood DG, Keifer D, Pierson E, Kondylis P, Wang JC, Jacobson SC, Jarrold MF, Zlotnick A.

Protein Sci. 2017 Nov;26(11):2170-2180. doi: 10.1002/pro.3265. Epub 2017 Sep 16.


HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly.

Patel N, White SJ, Thompson RF, Bingham R, Weiß EU, Maskell DP, Zlotnick A, Dykeman E, Tuma R, Twarock R, Ranson NA, Stockley PG.

Nat Microbiol. 2017 Jun 19;2:17098. doi: 10.1038/nmicrobiol.2017.98.


Single Particle Observation of SV40 VP1 Polyanion-Induced Assembly Shows That Substrate Size and Structure Modulate Capsid Geometry.

Li C, Kneller AR, Jacobson SC, Zlotnick A.

ACS Chem Biol. 2017 May 19;12(5):1327-1334. doi: 10.1021/acschembio.6b01066. Epub 2017 Mar 30.


Nanofluidic Devices with 8 Pores in Series for Real-Time, Resistive-Pulse Analysis of Hepatitis B Virus Capsid Assembly.

Kondylis P, Zhou J, Harms ZD, Kneller AR, Lee LS, Zlotnick A, Jacobson SC.

Anal Chem. 2017 May 2;89(9):4855-4862. doi: 10.1021/acs.analchem.6b04491. Epub 2017 Apr 17.


Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors.

Lomonosova E, Zlotnick A, Tavis JE.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02441-16. doi: 10.1128/AAC.02441-16. Print 2017 Mar.


Editorial overview: Virus structure and assembly: Virions - from structure and physics to design principles.

Zlotnick A, Huiskonen JT.

Curr Opin Virol. 2016 Jun;18:vii-viii. doi: 10.1016/j.coviro.2016.07.001. No abstract available.


Importin β Can Bind Hepatitis B Virus Core Protein and Empty Core-Like Particles and Induce Structural Changes.

Chen C, Wang JC, Pierson EE, Keifer DZ, Delaleau M, Gallucci L, Cazenave C, Kann M, Jarrold MF, Zlotnick A.

PLoS Pathog. 2016 Aug 12;12(8):e1005802. doi: 10.1371/journal.ppat.1005802. eCollection 2016 Aug.


The Structural Biology of Hepatitis B Virus: Form and Function.

Venkatakrishnan B, Zlotnick A.

Annu Rev Virol. 2016 Sep 29;3(1):429-451. Epub 2016 Aug 1. Review.


Phosphorylation of the Brome Mosaic Virus Capsid Regulates the Timing of Viral Infection.

Hoover HS, Wang JC, Middleton S, Ni P, Zlotnick A, Vaughan RC, Kao CC.

J Virol. 2016 Aug 12;90(17):7748-60. doi: 10.1128/JVI.00833-16. Print 2016 Sep 1.


Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket.

Venkatakrishnan B, Katen SP, Francis S, Chirapu S, Finn MG, Zlotnick A.

J Virol. 2016 Mar 28;90(8):3994-4004. doi: 10.1128/JVI.03058-15. Print 2016 Apr.


Assembly and Release of Hepatitis B Virus.

Selzer L, Zlotnick A.

Cold Spring Harb Perspect Med. 2015 Nov 9;5(12). pii: a021394. doi: 10.1101/cshperspect.a021394. Review.


Hepatitis B Virus Core Protein Phosphorylation Sites Affect Capsid Stability and Transient Exposure of the C-terminal Domain.

Selzer L, Kant R, Wang JC, Bothner B, Zlotnick A.

J Biol Chem. 2015 Nov 20;290(47):28584-93. doi: 10.1074/jbc.M115.678441. Epub 2015 Sep 24.


Diffuse Atherosclerosis of the Left Internal Mammary Artery.

Elami A, Zlotnick AY.

J Card Surg. 2015 Nov;30(11):819. doi: 10.1111/jocs.12613. Epub 2015 Aug 19. No abstract available.


Self-Assembly of an Alphavirus Core-like Particle Is Distinguished by Strong Intersubunit Association Energy and Structural Defects.

Wang JC, Chen C, Rayaprolu V, Mukhopadhyay S, Zlotnick A.

ACS Nano. 2015 Sep 22;9(9):8898-906. doi: 10.1021/acsnano.5b02632. Epub 2015 Aug 21.


Monitoring Assembly of Virus Capsids with Nanofluidic Devices.

Harms ZD, Selzer L, Zlotnick A, Jacobson SC.

ACS Nano. 2015 Sep 22;9(9):9087-96. doi: 10.1021/acsnano.5b03231. Epub 2015 Aug 26.


Charge Detection Mass Spectrometry Identifies Preferred Non-Icosahedral Polymorphs in the Self-Assembly of Woodchuck Hepatitis Virus Capsids.

Pierson EE, Keifer DZ, Kukreja AA, Wang JC, Zlotnick A, Jarrold MF.

J Mol Biol. 2016 Jan 29;428(2 Pt A):292-300. doi: 10.1016/j.jmb.2015.06.019. Epub 2015 Jul 4.


Leaking Aortic Pseudoaneurysm Originating from the Left Main Coronary Artery Anastomosis: CT-Angio image and reality.

Zlotnick AY, Gaspar T, Rubinshtein R, Halon D, Elami A.

Isr Med Assoc J. 2015 May;17(5):329-30. No abstract available.


Core protein: A pleiotropic keystone in the HBV lifecycle.

Zlotnick A, Venkatakrishnan B, Tan Z, Lewellyn E, Turner W, Francis S.

Antiviral Res. 2015 Sep;121:82-93. doi: 10.1016/j.antiviral.2015.06.020. Epub 2015 Jun 27. Review.


Macromolecular Crystallography for Synthetic Abiological Molecules: Combining xMDFF and PHENIX for Structure Determination of Cyanostar Macrocycles.

Singharoy A, Venkatakrishnan B, Liu Y, Mayne CG, Lee S, Chen CH, Zlotnick A, Schulten K, Flood AH.

J Am Chem Soc. 2015 Jul 15;137(27):8810-8. doi: 10.1021/jacs.5b04407. Epub 2015 Jun 29.


The reply.

Lavie G, Henig O, Weber G, Zlotnick AY, Cohen S.

Am J Med. 2015 May;128(5):e19. doi: 10.1016/j.amjmed.2014.12.031. No abstract available.


The interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription.

Tan Z, Pionek K, Unchwaniwala N, Maguire ML, Loeb DD, Zlotnick A.

J Virol. 2015 Mar;89(6):3275-84. doi: 10.1128/JVI.03545-14. Epub 2015 Jan 7.


Single-particle electrophoresis in nanochannels.

Harms ZD, Haywood DG, Kneller AR, Selzer L, Zlotnick A, Jacobson SC.

Anal Chem. 2015 Jan 6;87(1):699-705. doi: 10.1021/ac503527d. Epub 2014 Dec 9.


Afebrile endocarditis presenting as purpura and acute renal failure.

Lavie G, Henig O, Weber G, Zlotnick AY, Cohen S.

Am J Med. 2015 Mar;128(3):e5-6. doi: 10.1016/j.amjmed.2014.10.028. Epub 2014 Nov 8. No abstract available.


Structurally similar woodchuck and human hepadnavirus core proteins have distinctly different temperature dependences of assembly.

Kukreja AA, Wang JC, Pierson E, Keifer DZ, Selzer L, Tan Z, Dragnea B, Jarrold MF, Zlotnick A.

J Virol. 2014 Dec;88(24):14105-15. doi: 10.1128/JVI.01840-14. Epub 2014 Sep 24.


A controlled intervention to increase participation in cardiac rehabilitation.

Dankner R, Drory Y, Geulayov G, Ziv A, Novikov I, Zlotnick AY, Moshkovitz Y, Elami A, Schwammenthal E, Goldbourt U.

Eur J Prev Cardiol. 2015 Sep;22(9):1121-8. doi: 10.1177/2047487314548815. Epub 2014 Sep 2.


The hepatitis B virus core protein intradimer interface modulates capsid assembly and stability.

Selzer L, Katen SP, Zlotnick A.

Biochemistry. 2014 Sep 2;53(34):5496-504. doi: 10.1021/bi500732b. Epub 2014 Aug 18.


Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase.

Wang JC, Zlotnick A, Mecinović J.

Chem Commun (Camb). 2014 Sep 14;50(71):10281-3. doi: 10.1039/c4cc04650a.


Encapsidated hepatitis B virus reverse transcriptase is poised on an ordered RNA lattice.

Wang JC, Nickens DG, Lentz TB, Loeb DD, Zlotnick A.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11329-34. doi: 10.1073/pnas.1321424111. Epub 2014 Jul 17.


Detection of late intermediates in virus capsid assembly by charge detection mass spectrometry.

Pierson EE, Keifer DZ, Selzer L, Lee LS, Contino NC, Wang JC, Zlotnick A, Jarrold MF.

J Am Chem Soc. 2014 Mar 5;136(9):3536-41. doi: 10.1021/ja411460w. Epub 2014 Feb 19.


Scaffold properties are a key determinant of the size and shape of self-assembled virus-derived particles.

Kler S, Wang JC, Dhason M, Oppenheim A, Zlotnick A.

ACS Chem Biol. 2013 Dec 20;8(12):2753-61. doi: 10.1021/cb4005518. Epub 2013 Oct 23.


Hepatitis virus capsid polymorph stability depends on encapsulated cargo size.

He L, Porterfield Z, van der Schoot P, Zlotnick A, Dragnea B.

ACS Nano. 2013 Oct 22;7(10):8447-54. doi: 10.1021/nn4017839. Epub 2013 Sep 30.

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