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Items: 1 to 50 of 206

1.

Potential clinical scenarios of tumour budding in colorectal cancer.

Dawson H, Blank A, Zlobec I, Lugli A.

Acta Gastroenterol Belg. 2019 Oct-Dec;82(4):515-518. Review.

PMID:
31950807
2.

A Digital Pathology-Based Shotgun-Proteomics Approach to Biomarker Discovery in Colorectal Cancer.

Zahnd S, Braga-Lagache S, Buchs N, Lugli A, Dawson H, Heller M, Zlobec I.

J Pathol Inform. 2019 Dec 12;10:40. doi: 10.4103/jpi.jpi_65_18. eCollection 2019.

3.

Correction to: Assessment of individual tumor buds using keratin immunohistochemistry: moderate interobserver agreement suggests a role for machine learning.

Bokhorst JM, Blank A, Lugli A, Zlobec I, Dawson H, Vieth M, Rijstenberg LL, Brockmoeller S, Urbanowicz M, Flejou JF, Kirsch R, Ciompi F, van der Laak JAWM, Nagtegaal ID.

Mod Pathol. 2020 Jan 3. doi: 10.1038/s41379-019-0450-2. [Epub ahead of print]

PMID:
31900432
4.

Current opinion, status and future development of digital pathology in Switzerland.

Unternaehrer J, Grobholz R, Janowczyk A, Zlobec I; Swiss Digital Pathology Consortium (SDiPath).

J Clin Pathol. 2019 Dec 19. pii: jclinpath-2019-206155. doi: 10.1136/jclinpath-2019-206155. [Epub ahead of print]

PMID:
31857377
5.

Assessment of individual tumor buds using keratin immunohistochemistry: moderate interobserver agreement suggests a role for machine learning.

Bokhorst JM, Blank A, Lugli A, Zlobec I, Dawson H, Vieth M, Rijstenberg LL, Brockmoeller S, Urbanowicz M, Flejou JF, Kirsch R, Ciompi F, van der Laak JAWM, Nagtegaal ID.

Mod Pathol. 2019 Dec 16. doi: 10.1038/s41379-019-0434-2. [Epub ahead of print] Erratum in: Mod Pathol. 2020 Jan 3;:.

PMID:
31844269
6.

ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics.

Liu H, He Z, Germič N, Ademi H, Frangež Ž, Felser A, Peng S, Riether C, Djonov V, Nuoffer JM, Bovet C, Mlinarič-Raščan I, Zlobec I, Fiedler M, Perren A, Simon HU.

Cell Death Differ. 2019 Dec 16. doi: 10.1038/s41418-019-0476-5. [Epub ahead of print]

PMID:
31844253
7.

Validation of the International Tumor Budding Consensus Conference (ITBCC) 2016 recommendation in squamous cell carcinoma of the lung-a single-center analysis of 354 cases.

Neppl C, Zlobec I, Schmid RA, Berezowska S.

Mod Pathol. 2019 Dec 3. doi: 10.1038/s41379-019-0413-7. [Epub ahead of print]

PMID:
31796876
8.

Evaluation of Tumor Budding in Primary Colorectal Cancer and Corresponding Liver Metastases Based on H&E and Pancytokeratin Staining.

Blank A, Schenker C, Dawson H, Beldi G, Zlobec I, Lugli A.

Front Med (Lausanne). 2019 Oct 31;6:247. doi: 10.3389/fmed.2019.00247. eCollection 2019.

9.

Oncologic long-term outcomes of emergency versus elective resection for colorectal cancer.

Lavanchy JL, Vaisnora L, Haltmeier T, Zlobec I, Brügger LE, Candinas D, Schnüriger B.

Int J Colorectal Dis. 2019 Dec;34(12):2091-2099. doi: 10.1007/s00384-019-03426-8. Epub 2019 Nov 11.

PMID:
31709491
10.

Prospective Validation of Facial Nerve Monitoring to Prevent Nerve Damage During Robotic Drilling.

Ansó J, Dür C, Apelt M, Venail F, Scheidegger O, Seidel K, Rohrbach H, Forterre F, Dettmer MS, Zlobec I, Weber K, Matulic M, Zoka-Assadi M, Huth M, Caversaccio M, Weber S.

Front Surg. 2019 Oct 1;6:58. doi: 10.3389/fsurg.2019.00058. eCollection 2019.

11.

Tumour Budding/T-cell infiltrates in Colorectal Cancer: Proposal of a Novel Combined Score.

Dawson H, Christe L, Eichmann M, Reinhard S, Zlobec I, Blank A, Lugli A.

Histopathology. 2019 Sep 27. doi: 10.1111/his.14006. [Epub ahead of print]

PMID:
31560788
12.

Comparison of the 7th and 8th Edition of the UICC/AJCC TNM Staging System in Primary Resected Squamous Cell Carcinomas of the Lung-A Single Center Analysis of 354 Cases.

Neppl C, Keller MD, Scherz A, Dorn P, Schmid RA, Zlobec I, Berezowska S.

Front Med (Lausanne). 2019 Sep 4;6:196. doi: 10.3389/fmed.2019.00196. eCollection 2019.

13.

Synaptic proximity enables NMDAR signalling to promote brain metastasis.

Zeng Q, Michael IP, Zhang P, Saghafinia S, Knott G, Jiao W, McCabe BD, Galván JA, Robinson HPC, Zlobec I, Ciriello G, Hanahan D.

Nature. 2019 Sep;573(7775):526-531. doi: 10.1038/s41586-019-1576-6. Epub 2019 Sep 18.

PMID:
31534217
14.

TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells.

Kappel S, Stokłosa P, Hauert B, Ross-Kaschitza D, Borgström A, Baur R, Galván JA, Zlobec I, Peinelt C.

Mol Oncol. 2019 Nov;13(11):2393-2405. doi: 10.1002/1878-0261.12566. Epub 2019 Sep 12.

15.

Cell Line Derived Xenograft Mouse Models Are a Suitable in vivo Model for Studying Tumor Budding in Colorectal Cancer.

Georges LMC, De Wever O, Galván JA, Dawson H, Lugli A, Demetter P, Zlobec I.

Front Med (Lausanne). 2019 Jun 27;6:139. doi: 10.3389/fmed.2019.00139. eCollection 2019.

16.

The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer.

Pastille E, Wasmer MH, Adamczyk A, Vu VP, Mager LF, Phuong NNT, Palmieri V, Simillion C, Hansen W, Kasper S, Schuler M, Muggli B, McCoy KD, Buer J, Zlobec I, Westendorf AM, Krebs P.

Mucosal Immunol. 2019 Jul;12(4):990-1003. doi: 10.1038/s41385-019-0176-y. Epub 2019 Jun 5.

17.

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.

Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schürch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galván JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T.

Cell. 2019 Apr 18;177(3):572-586.e22. doi: 10.1016/j.cell.2019.03.010. Epub 2019 Apr 4.

PMID:
30955884
18.

Co-expression of cytokeratin and vimentin in colorectal cancer highlights a subset of tumor buds and an atypical cancer-associated stroma.

Meyer SN, Galván JA, Zahnd S, Sokol L, Dawson H, Lugli A, Zlobec I.

Hum Pathol. 2019 May;87:18-27. doi: 10.1016/j.humpath.2019.02.002. Epub 2019 Feb 20.

PMID:
30794893
19.

Impact of the Microenvironment on Tumour Budding in Colorectal Cancer.

Georges LM, Verset L, Zlobec I, Demetter P, De Wever O.

Adv Exp Med Biol. 2018;1110:101-111. doi: 10.1007/978-3-030-02771-1_7. Review.

PMID:
30623368
20.

Validation of the International Tumor Budding Consensus Conference 2016 recommendations on tumor budding in stage I-IV colorectal cancer.

Dawson H, Galuppini F, Träger P, Berger MD, Studer P, Brügger L, Zlobec I, Inderbitzin D, Lugli A.

Hum Pathol. 2019 Mar;85:145-151. doi: 10.1016/j.humpath.2018.10.023. Epub 2018 Nov 11.

21.

Stromal PD-1/PD-L1 Expression Predicts Outcome in Colon Cancer Patients.

Wyss J, Dislich B, Koelzer VH, Galván JA, Dawson H, Hädrich M, Inderbitzin D, Lugli A, Zlobec I, Berger MD.

Clin Colorectal Cancer. 2019 Mar;18(1):e20-e38. doi: 10.1016/j.clcc.2018.09.007. Epub 2018 Sep 21.

PMID:
30389315
22.

Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data.

Trinh A, Lädrach C, Dawson HE, Ten Hoorn S, Kuppen PJK, Reimers MS, Koopman M, Punt CJA, Lugli A, Vermeulen L, Zlobec I.

Br J Cancer. 2018 Nov;119(10):1244-1251. doi: 10.1038/s41416-018-0230-7. Epub 2018 Nov 2.

23.

CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway.

Graule J, Uth K, Fischer E, Centeno I, Galván JA, Eichmann M, Rau TT, Langer R, Dawson H, Nitsche U, Traeger P, Berger MD, Schnüriger B, Hädrich M, Studer P, Inderbitzin D, Lugli A, Tschan MP, Zlobec I.

Clin Epigenetics. 2018 Sep 26;10(1):120. doi: 10.1186/s13148-018-0548-2.

24.

Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree?

Blank A, Roberts DE 2nd, Dawson H, Zlobec I, Lugli A.

Front Med (Lausanne). 2018 Aug 31;5:234. doi: 10.3389/fmed.2018.00234. eCollection 2018. Review.

25.

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.

Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J.

Lancet. 2018 May 26;391(10135):2128-2139. doi: 10.1016/S0140-6736(18)30789-X. Epub 2018 May 10.

PMID:
29754777
26.

Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance.

Wartenberg M, Cibin S, Zlobec I, Vassella E, Eppenberger-Castori S, Terracciano L, Eichmann MD, Worni M, Gloor B, Perren A, Karamitopoulou E.

Clin Cancer Res. 2018 Sep 15;24(18):4444-4454. doi: 10.1158/1078-0432.CCR-17-3401. Epub 2018 Apr 16.

27.

GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.

Li L, Zeng Q, Bhutkar A, Galván JA, Karamitopoulou E, Noordermeer D, Peng MW, Piersigilli A, Perren A, Zlobec I, Robinson H, Iruela-Arispe ML, Hanahan D.

Cancer Cell. 2018 Apr 9;33(4):736-751.e5. doi: 10.1016/j.ccell.2018.02.011. Epub 2018 Mar 29.

28.

Application of the 8th edition of the AJCC yTNM staging system shows improved prognostication in a single center cohort of esophageal carcinomas.

Kröll D, Noser L, Erdem S, Storni F, Arnold D, Dislich B, Zlobec I, Candinas D, Seiler CA, Langer R.

Surg Oncol. 2018 Mar;27(1):100-105. doi: 10.1016/j.suronc.2017.12.005. Epub 2018 Jan 31.

PMID:
29549896
29.

Tumour budding in pancreatic cancer revisited: validation of the ITBCC scoring system.

Karamitopoulou E, Wartenberg M, Zlobec I, Cibin S, Worni M, Gloor B, Lugli A.

Histopathology. 2018 Jul;73(1):137-146. doi: 10.1111/his.13508. Epub 2018 Apr 17.

PMID:
29495092
30.

Tumour budding in colorectal cancer: molecular rationale for clinical translation.

Zlobec I, Lugli A.

Nat Rev Cancer. 2018 Apr;18(4):203-204. doi: 10.1038/nrc.2018.1. Epub 2018 Jan 29. No abstract available.

PMID:
29376521
31.

Immunophenotypic profile of tumor buds in breast cancer.

Laedrach C, Salhia B, Cihoric N, Zlobec I, Tapia C.

Pathol Res Pract. 2018 Jan;214(1):25-29. doi: 10.1016/j.prp.2017.11.023. Epub 2017 Dec 5.

32.

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer.

Faget J, Groeneveld S, Boivin G, Sankar M, Zangger N, Garcia M, Guex N, Zlobec I, Steiner L, Piersigilli A, Xenarios I, Meylan E.

Cell Rep. 2017 Dec 12;21(11):3190-3204. doi: 10.1016/j.celrep.2017.11.052.

33.

Expression Patterns of TNFα, MAdCAM1, and STAT3 in Intestinal and Skin Manifestations of Inflammatory Bowel Disease.

Vavricka SR, Galván JA, Dawson H, Soltermann A, Biedermann L, Scharl M, Schoepfer AM, Rogler G, Prinz Vavricka MB, Terracciano L, Navarini A, Zlobec I, Lugli A, Greuter T.

J Crohns Colitis. 2018 Feb 28;12(3):347-354. doi: 10.1093/ecco-jcc/jjx158.

34.

TREM-1 promotes intestinal tumorigenesis.

Saurer L, Zysset D, Rihs S, Mager L, Gusberti M, Simillion C, Lugli A, Zlobec I, Krebs P, Mueller C.

Sci Rep. 2017 Nov 1;7(1):14870. doi: 10.1038/s41598-017-14516-4.

35.

The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer.

Mele V, Sokol L, Kölzer VH, Pfaff D, Muraro MG, Keller I, Stefan Z, Centeno I, Terracciano LM, Dawson H, Zlobec I, Iezzi G, Lugli A.

Oncotarget. 2017 Aug 3;8(41):70617-70629. doi: 10.18632/oncotarget.19904. eCollection 2017 Sep 19.

36.

The ESRP1-GPR137 axis contributes to intestinal pathogenesis.

Mager LF, Koelzer VH, Stuber R, Thoo L, Keller I, Koeck I, Langenegger M, Simillion C, Pfister SP, Faderl M, Genitsch V, Tcymbarevich I, Juillerat P, Li X, Xia Y, Karamitopoulou E, Lyck R, Zlobec I, Hapfelmeier S, Bruggmann R, McCoy KD, Macpherson AJ, Müller C, Beutler B, Krebs P.

Elife. 2017 Oct 4;6. pii: e28366. doi: 10.7554/eLife.28366.

37.

Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer.

Niklaus M, Adams O, Berezowska S, Zlobec I, Graber F, Slotta-Huspenina J, Nitsche U, Rosenberg R, Tschan MP, Langer R.

Oncotarget. 2017 May 2;8(33):54604-54615. doi: 10.18632/oncotarget.17554. eCollection 2017 Aug 15.

38.

Neuroendocrine Differentiation in Metastatic Conventional Prostate Cancer Is Significantly Increased in Lymph Node Metastases Compared to the Primary Tumors.

Genitsch V, Zlobec I, Seiler R, Thalmann GN, Fleischmann A.

Int J Mol Sci. 2017 Jul 28;18(8). pii: E1640. doi: 10.3390/ijms18081640.

39.

Cytokeratin-based assessment of tumour budding in colorectal cancer: analysis in stage II patients and prospective diagnostic experience.

Koelzer VH, Assarzadegan N, Dawson H, Mitrovic B, Grin A, Messenger DE, Kirsch R, Riddell RH, Lugli A, Zlobec I.

J Pathol Clin Res. 2017 Jul 26;3(3):171-178. doi: 10.1002/cjp2.73. eCollection 2017 Jul.

40.

Low co-expression of epidermal growth factor receptor and its chaperone heat shock protein 90 is associated with worse prognosis in primary glioblastoma, IDH-wild-type.

Sartori E, Langer R, Vassella E, Hewer E, Schucht P, Zlobec I, Berezowska S.

Oncol Rep. 2017 Oct;38(4):2394-2400. doi: 10.3892/or.2017.5863. Epub 2017 Aug 1.

PMID:
28765916
41.

Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.

Lugli A, Kirsch R, Ajioka Y, Bosman F, Cathomas G, Dawson H, El Zimaity H, Fléjou JF, Hansen TP, Hartmann A, Kakar S, Langner C, Nagtegaal I, Puppa G, Riddell R, Ristimäki A, Sheahan K, Smyrk T, Sugihara K, Terris B, Ueno H, Vieth M, Zlobec I, Quirke P.

Mod Pathol. 2017 Sep;30(9):1299-1311. doi: 10.1038/modpathol.2017.46. Epub 2017 May 26. Review.

42.

Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer.

Koelzer VH, Sokol L, Zahnd S, Christe L, Dawson H, Berger MD, Inderbitzin D, Zlobec I, Lugli A.

Oncoimmunology. 2017 Feb 6;6(4):e1288330. doi: 10.1080/2162402X.2017.1288330. eCollection 2017.

43.

Correction: DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells.

Ivanovska J, Zlobec I, Forster S, Karamitopoulou E, Dawson H, Koelzer VH, Agaimy A, Garreis F, Söder S, Laqua W, Lugli A, Hartmann A, Rau TT, Schneider-Stock R.

Oncotarget. 2017 Mar 14;8(11):18615-18616. doi: 10.18632/oncotarget.16154. No abstract available.

44.

Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study.

Domingo E, Freeman-Mills L, Rayner E, Glaire M, Briggs S, Vermeulen L, Fessler E, Medema JP, Boot A, Morreau H, van Wezel T, Liefers GJ, Lothe RA, Danielsen SA, Sveen A, Nesbakken A, Zlobec I, Lugli A, Koelzer VH, Berger MD, Castellví-Bel S, Muñoz J; Epicolon consortium, de Bruyn M, Nijman HW, Novelli M, Lawson K, Oukrif D, Frangou E, Dutton P, Tejpar S, Delorenzi M, Kerr R, Kerr D, Tomlinson I, Church DN.

Lancet Gastroenterol Hepatol. 2016 Nov;1(3):207-216. doi: 10.1016/S2468-1253(16)30014-0. Epub 2016 Jul 20.

PMID:
28404093
45.

Expression patterns of programmed death-ligand 1 in esophageal adenocarcinomas: comparison between primary tumors and metastases.

Dislich B, Stein A, Seiler CA, Kröll D, Berezowska S, Zlobec I, Galvan J, Slotta-Huspenina J, Walch A, Langer R.

Cancer Immunol Immunother. 2017 Jun;66(6):777-786. doi: 10.1007/s00262-017-1982-2. Epub 2017 Mar 13.

PMID:
28289861
46.

Construction and analysis of tissue microarrays in the era of digital pathology: a pilot study targeting CDX1 and CDX2 in a colon cancer cohort of 612 patients.

Nolte S, Zlobec I, Lugli A, Hohenberger W, Croner R, Merkel S, Hartmann A, Geppert CI, Rau TT.

J Pathol Clin Res. 2017 Jan 13;3(1):58-70. doi: 10.1002/cjp2.62. eCollection 2017 Jan.

47.

DNA profiling of tumor buds in colorectal cancer indicates that they have the same mutation profile as the tumor from which they derive.

Centeno I, Paasinen Sohns A, Flury M, Galván JA, Zahnd S, Koelzer VH, Sokol L, Dawson HE, Lugli A, Cathomas G, Zlobec I.

Virchows Arch. 2017 Mar;470(3):341-346. doi: 10.1007/s00428-017-2071-9. Epub 2017 Jan 27. No abstract available.

PMID:
28130698
48.

Comprehensive assessment of tumour budding by cytokeratin staining in colorectal cancer.

Rieger G, Koelzer VH, Dawson HE, Berger MD, Hädrich M, Inderbitzin D, Lugli A, Zlobec I.

Histopathology. 2017 Jun;70(7):1044-1051. doi: 10.1111/his.13164. Epub 2017 Mar 2.

49.

CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia.

Riether C, Schürch CM, Bührer ED, Hinterbrandner M, Huguenin AL, Hoepner S, Zlobec I, Pabst T, Radpour R, Ochsenbein AF.

J Exp Med. 2017 Feb;214(2):359-380. doi: 10.1084/jem.20152008. Epub 2016 Dec 28.

50.

Macroscopy predicts tumor progression in gastric cancer: A retrospective patho-historical analysis based on Napoleon Bonaparte's autopsy report.

Dawson H, Novotny A, Becker K, Reim D, Langer R, Gullo I, Svrcek M, Niess JH, Tutuian R, Truninger K, Diamantis I, Blank A, Zlobec I, Riddell RH, Carneiro F, Fléjou JF, Genta RM, Lugli A.

Dig Liver Dis. 2016 Nov;48(11):1378-1385. doi: 10.1016/j.dld.2016.07.013. Epub 2016 Jul 21.

PMID:
27522550

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