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Items: 32

1.

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.

Cherfils-Vicini J, Iltis C, Cervera L, Pisano S, Croce O, Sadouni N, Győrffy B, Collet R, Renault VM, Rey-Millet M, Leonetti C, Zizza P, Allain F, Ghiringhelli F, Soubeiran N, Shkreli M, Vivier E, Biroccio A, Gilson E.

EMBO J. 2019 Jun 3;38(11). pii: e100012. doi: 10.15252/embj.2018100012. Epub 2019 Apr 18.

PMID:
31000523
2.

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.

Zizza P, Dinami R, Porru M, Cingolani C, Salvati E, Rizzo A, D'Angelo C, Petti E, Amoreo CA, Mottolese M, Sperduti I, Chambery A, Russo R, Ostano P, Chiorino G, Blandino G, Sacconi A, Cherfils-Vicini J, Leonetti C, Gilson E, Biroccio A.

Nucleic Acids Res. 2019 Apr 23;47(7):3365-3382. doi: 10.1093/nar/gkz041.

3.

Tailoring a lead-like compound targeting multiple G-quadruplex structures.

Amato J, Platella C, Iachettini S, Zizza P, Musumeci D, Cosconati S, Pagano A, Novellino E, Biroccio A, Randazzo A, Pagano B, Montesarchio D.

Eur J Med Chem. 2019 Feb 1;163:295-306. doi: 10.1016/j.ejmech.2018.11.058. Epub 2018 Nov 27.

PMID:
30529547
4.

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.

Iachettini S, Trisciuoglio D, Rotili D, Lucidi A, Salvati E, Zizza P, Di Leo L, Del Bufalo D, Ciriolo MR, Leonetti C, Steegborn C, Mai A, Rizzo A, Biroccio A.

Cell Death Dis. 2018 Sep 24;9(10):996. doi: 10.1038/s41419-018-1065-0.

5.

The natural phosphoinositide derivative glycerophosphoinositol inhibits the lipopolysaccharide-induced inflammatory and thrombotic responses.

Vessichelli M, Mariggiò S, Varone A, Zizza P, Di Santo A, Amore C, Dell'Elba G, Cutignano A, Fontana A, Cacciapuoti C, Di Costanzo G, Zannini M, de Cristofaro T, Evangelista V, Corda D.

J Biol Chem. 2017 Aug 4;292(31):12828-12841. doi: 10.1074/jbc.M116.773861. Epub 2017 Jun 9.

6.

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

Salvati E, Botta L, Amato J, Di Leva FS, Zizza P, Gioiello A, Pagano B, Graziani G, Tarsounas M, Randazzo A, Novellino E, Biroccio A, Cosconati S.

J Med Chem. 2017 May 11;60(9):3626-3635. doi: 10.1021/acs.jmedchem.6b01563. Epub 2017 May 1.

PMID:
28445046
7.

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

Musumeci D, Amato J, Zizza P, Platella C, Cosconati S, Cingolani C, Biroccio A, Novellino E, Randazzo A, Giancola C, Pagano B, Montesarchio D.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1341-1352. doi: 10.1016/j.bbagen.2017.01.024. Epub 2017 Jan 24.

PMID:
28130159
8.

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.

Rizzo A, Iachettini S, Salvati E, Zizza P, Maresca C, D'Angelo C, Benarroch-Popivker D, Capolupo A, Del Gaudio F, Cosconati S, Di Maro S, Merlino F, Novellino E, Amoreo CA, Mottolese M, Sperduti I, Gilson E, Biroccio A.

Nucleic Acids Res. 2017 Feb 28;45(4):1820-1834. doi: 10.1093/nar/gkw1202.

9.

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile.

Porru M, Zizza P, Franceschin M, Leonetti C, Biroccio A.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1362-1370. doi: 10.1016/j.bbagen.2016.11.010. Epub 2016 Nov 9. Review.

PMID:
27838395
10.

Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs.

Lauri I, Savorani F, Iaccarino N, Zizza P, Pavone LM, Novellino E, Engelsen SB, Randazzo A.

Metabolites. 2016 Jan 15;6(1). pii: E4. doi: 10.3390/metabo6010004.

11.

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance.

Zizza P, Cingolani C, Artuso S, Salvati E, Rizzo A, D'Angelo C, Porru M, Pagano B, Amato J, Randazzo A, Novellino E, Stoppacciaro A, Gilson E, Stassi G, Leonetti C, Biroccio A.

Nucleic Acids Res. 2016 Feb 29;44(4):1579-90. doi: 10.1093/nar/gkv1122. Epub 2015 Oct 27.

12.

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

Rizzo A, Iachettini S, Zizza P, Cingolani C, Porru M, Artuso S, Stevens M, Hummersone M, Biroccio A, Salvati E, Leonetti C.

J Exp Clin Cancer Res. 2015 Feb 5;34:9. doi: 10.1186/s13046-014-0101-x. No abstract available.

13.

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules.

Pagano B, Amato J, Iaccarino N, Cingolani C, Zizza P, Biroccio A, Novellino E, Randazzo A.

ChemMedChem. 2015 Apr;10(4):640-9. doi: 10.1002/cmdc.201402552. Epub 2015 Feb 18.

PMID:
25694275
14.

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.

Salvati E, Rizzo A, Iachettini S, Zizza P, Cingolani C, D'Angelo C, Porru M, Mondello C, Aiello A, Farsetti A, Gilson E, Leonetti C, Biroccio A.

Nucleic Acids Res. 2015 Feb 18;43(3):1759-69. doi: 10.1093/nar/gkv006. Epub 2015 Jan 23.

15.

Identification of novel interactors of human telomeric G-quadruplex DNA.

Pagano B, Margarucci L, Zizza P, Amato J, Iaccarino N, Cassiano C, Salvati E, Novellino E, Biroccio A, Casapullo A, Randazzo A.

Chem Commun (Camb). 2015 Feb 18;51(14):2964-7. doi: 10.1039/c4cc07231f.

PMID:
25594748
16.

Shading the TRF2 recruiting function: a new horizon in drug development.

Di Maro S, Zizza P, Salvati E, De Luca V, Capasso C, Fotticchia I, Pagano B, Marinelli L, Gilson E, Novellino E, Cosconati S, Biroccio A.

J Am Chem Soc. 2014 Dec 3;136(48):16708-11. doi: 10.1021/ja5080773. Epub 2014 Nov 19.

PMID:
25393214
17.

Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage.

Franceschin M, Nocioni D, Biroccio A, Micheli E, Cacchione S, Cingolani C, Venditti A, Zizza P, Bianco A, Altieri A.

Org Biomol Chem. 2014 Dec 21;12(47):9572-82. doi: 10.1039/c4ob01658k. Epub 2014 Nov 3.

PMID:
25363232
18.

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

Rizzo A, Iachettini S, Zizza P, Cingolani C, Porru M, Artuso S, Stevens M, Hummersone M, Biroccio A, Salvati E, Leonetti C.

J Exp Clin Cancer Res. 2014 Oct 6;33:81. doi: 10.1186/s13046-014-0081-x. Erratum in: J Exp Clin Cancer Res. 2015;34:9.

19.

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex.

Amato J, Iaccarino N, Pagano B, Morigi R, Locatelli A, Leoni A, Rambaldi M, Zizza P, Biroccio A, Novellino E, Randazzo A.

Front Chem. 2014 Jul 24;2:54. doi: 10.3389/fchem.2014.00054. eCollection 2014.

20.

A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy.

Cherfils-Vicini J, Zizza P, Gilson E, Biroccio A.

Oncoimmunology. 2014 Jan 1;3(1):e27358.

21.

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.

Salvati E, Zizza P, Rizzo A, Iachettini S, Cingolani C, D'Angelo C, Porru M, Randazzo A, Pagano B, Novellino E, Pisanu ME, Stoppacciaro A, Spinella F, Bagnato A, Gilson E, Leonetti C, Biroccio A.

Nucleic Acids Res. 2014 Mar;42(5):2945-57. doi: 10.1093/nar/gkt1289. Epub 2013 Dec 11. Erratum in: Nucleic Acids Res. 2014 Dec 16;42(22):14083.

22.

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.

Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, Porru M, D'Incalci M, Leonetti C, Biroccio A, Salvati E.

J Exp Clin Cancer Res. 2013 Sep 19;32:68. doi: 10.1186/1756-9966-32-68.

23.

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence.

Di Leva FS, Zizza P, Cingolani C, D'Angelo C, Pagano B, Amato J, Salvati E, Sissi C, Pinato O, Marinelli L, Cavalli A, Cosconati S, Novellino E, Randazzo A, Biroccio A.

J Med Chem. 2013 Dec 12;56(23):9646-54. doi: 10.1021/jm401185b. Epub 2013 Nov 27.

PMID:
24256368
24.

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.

Biroccio A, Cherfils-Vicini J, Augereau A, Pinte S, Bauwens S, Ye J, Simonet T, Horard B, Jamet K, Cervera L, Mendez-Bermudez A, Poncet D, Grataroli R, de Rodenbeeke CT, Salvati E, Rizzo A, Zizza P, Ricoul M, Cognet C, Kuilman T, Duret H, Lépinasse F, Marvel J, Verhoeyen E, Cosset FL, Peeper D, Smyth MJ, Londoño-Vallejo A, Sabatier L, Picco V, Pages G, Scoazec JY, Stoppacciaro A, Leonetti C, Vivier E, Gilson E.

Nat Cell Biol. 2013 Jul;15(7):818-28. doi: 10.1038/ncb2774. Epub 2013 Jun 23.

PMID:
23792691
25.

Phospholipase A2IVα regulates phagocytosis independent of its enzymatic activity.

Zizza P, Iurisci C, Bonazzi M, Cossart P, Leslie CC, Corda D, Mariggiò S.

J Biol Chem. 2012 May 11;287(20):16849-59. doi: 10.1074/jbc.M111.309419. Epub 2012 Mar 5.

26.

The glycerophosphoinositols and their cellular functions.

Corda D, Zizza P, Varone A, Bruzik KS, Mariggiò S.

Biochem Soc Trans. 2012 Feb;40(1):101-7. doi: 10.1042/BST20110679.

PMID:
22260673
27.

Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport.

San Pietro E, Capestrano M, Polishchuk EV, DiPentima A, Trucco A, Zizza P, Mariggiò S, Pulvirenti T, Sallese M, Tete S, Mironov AA, Leslie CC, Corda D, Luini A, Polishchuk RS.

PLoS Biol. 2009 Sep;7(9):e1000194. doi: 10.1371/journal.pbio.1000194. Epub 2009 Sep 15.

28.

The glycerophosphoinositols: cellular metabolism and biological functions.

Corda D, Zizza P, Varone A, Filippi BM, Mariggiò S.

Cell Mol Life Sci. 2009 Nov;66(21):3449-67. doi: 10.1007/s00018-009-0113-4. Epub 2009 Aug 9. Review.

PMID:
19669618
29.

The developmentally regulated osteoblast phosphodiesterase GDE3 is glycerophosphoinositol-specific and modulates cell growth.

Corda D, Kudo T, Zizza P, Iurisci C, Kawai E, Kato N, Yanaka N, Mariggiò S.

J Biol Chem. 2009 Sep 11;284(37):24848-56. doi: 10.1074/jbc.M109.035444. Epub 2009 Jul 13.

30.

Glycerophosphoinositol-4-phosphate enhances SDF-1alpha-stimulated T-cell chemotaxis through PTK-dependent activation of Vav.

Patrussi L, Mariggio' S, Paccani SR, Capitani N, Zizza P, Corda D, Baldari CT.

Cell Signal. 2007 Nov;19(11):2351-60. Epub 2007 Jul 28.

PMID:
17716865
31.

Galpha13 mediates activation of the cytosolic phospholipase A2alpha through fine regulation of ERK phosphorylation.

Mariggiò S, Bavec A, Natale E, Zizza P, Salmona M, Corda D, Di Girolamo M.

Cell Signal. 2006 Dec;18(12):2200-8. Epub 2006 May 20.

PMID:
16806823
32.

An American Board of Orthodontics case report.

Zizza P.

Am J Orthod Dentofacial Orthop. 1986 Oct;90(4):342-9. No abstract available.

PMID:
3464196

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