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Items: 1 to 50 of 316

1.

Complement Inhibitors in Clinical Trials for Glomerular Diseases.

Zipfel PF, Wiech T, Rudnick R, Afonso S, Person F, Skerka C.

Front Immunol. 2019 Sep 27;10:2166. doi: 10.3389/fimmu.2019.02166. eCollection 2019. Review.

2.

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.

Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdauskas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C.

Nat Commun. 2019 Jul 4;10(1):2961. doi: 10.1038/s41467-019-10766-0.

3.

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.

Zhao F, Afonso S, Lindner S, Hartmann A, Löschmann I, Nilsson B, Ekdahl KN, Weber LT, Habbig S, Schalk G, Kirschfink M, Zipfel PF, Skerka C.

Front Immunol. 2019 May 31;10:1030. doi: 10.3389/fimmu.2019.01030. eCollection 2019.

4.

Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties.

Röttgerding F, Wagemakers A, Koetsveld J, Fingerle V, Kirschfink M, Hovius JW, Zipfel PF, Wallich R, Kraiczy P.

Sci Rep. 2019 May 2;9(1):7056. doi: 10.1038/s41598-019-42948-7.

5.

Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors.

Top O, Parsons J, Bohlender LL, Michelfelder S, Kopp P, Busch-Steenberg C, Hoernstein SNW, Zipfel PF, Häffner K, Reski R, Decker EL.

Front Plant Sci. 2019 Mar 20;10:260. doi: 10.3389/fpls.2019.00260. eCollection 2019.

6.

Molecular crypsis by pathogenic fungi using human factor H. A numerical model.

Lang SN, Germerodt S, Glock C, Skerka C, Zipfel PF, Schuster S.

PLoS One. 2019 Feb 19;14(2):e0212187. doi: 10.1371/journal.pone.0212187. eCollection 2019.

7.

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR.

Nat Med. 2019 Mar;25(3):529. doi: 10.1038/s41591-019-0378-6.

PMID:
30718908
8.

ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR.

Nat Med. 2019 Mar;25(3):496-506. doi: 10.1038/s41591-018-0336-8. Epub 2019 Jan 28. Erratum in: Nat Med. 2019 Feb 4;:.

9.

C3 glomerulopathy - understanding a rare complement-driven renal disease.

Smith RJH, Appel GB, Blom AM, Cook HT, D'Agati VD, Fakhouri F, Fremeaux-Bacchi V, Józsi M, Kavanagh D, Lambris JD, Noris M, Pickering MC, Remuzzi G, de Córdoba SR, Sethi S, Van der Vlag J, Zipfel PF, Nester CM.

Nat Rev Nephrol. 2019 Mar;15(3):129-143. doi: 10.1038/s41581-018-0107-2. Review.

10.

The Case | A 78-year-old woman with acute kidney injury and hemolytic anemia.

Zecher D, Banas B, Büttner-Herold M, Kirschfink M, Zipfel PF.

Kidney Int. 2019 Feb;95(2):473-474. doi: 10.1016/j.kint.2018.10.013. No abstract available.

PMID:
30665579
11.

Bevacizumab-associated glomerular microangiopathy.

Person F, Rinschen MM, Brix SR, Wulf S, Noriega MLM, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz OM, Reinhard L, Hoxha E, Zipfel PF, Bräsen JH, Wiech T.

Mod Pathol. 2019 May;32(5):684-700. doi: 10.1038/s41379-018-0186-4. Epub 2018 Dec 14.

PMID:
30552416
12.

Cutting Edge: FHR-1 Binding Impairs Factor H-Mediated Complement Evasion by the Malaria Parasite Plasmodium falciparum.

Reiss T, Rosa TFA, Blaesius K, Bobbert RP, Zipfel PF, Skerka C, Pradel G.

J Immunol. 2018 Dec 15;201(12):3497-3502. doi: 10.4049/jimmunol.1800662. Epub 2018 Nov 19.

PMID:
30455399
13.

Complement 5a Receptor Polymorphisms Are Associated With Panton-Valentine Leukocidin-positive Staphylococcus aureus Colonization in African Pygmies.

Schaumburg F, Witten A, Flamen A, Stoll M, Alabi AS, Kremsner PG, Löffler B, Zipfel PF, Velavan TP, Peters G.

Clin Infect Dis. 2019 Feb 15;68(5):854-856. doi: 10.1093/cid/ciy666.

PMID:
30192927
15.

Aspf2 From Aspergillus fumigatus Recruits Human Immune Regulators for Immune Evasion and Cell Damage.

Dasari P, Shopova IA, Stroe M, Wartenberg D, Martin-Dahse H, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF.

Front Immunol. 2018 Aug 3;9:1635. doi: 10.3389/fimmu.2018.01635. eCollection 2018.

16.

Membranoproliferative glomerulonephritis and C3 glomerulopathy in children: change in treatment modality? A report of a case series.

Spartà G, Gaspert A, Neuhaus TJ, Weitz M, Mohebbi N, Odermatt U, Zipfel PF, Bergmann C, Laube GF.

Clin Kidney J. 2018 Aug;11(4):479-490. doi: 10.1093/ckj/sfy006. Epub 2018 Feb 28.

17.

Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration.

Pujol-Lereis LM, Liebisch G, Schick T, Lin Y, Grassmann F, Uchida K, Zipfel PF, Fauser S, Skerka C, Weber BHF.

PLoS One. 2018 Aug 2;13(8):e0200739. doi: 10.1371/journal.pone.0200739. eCollection 2018.

18.

Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease.

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM.

Front Immunol. 2018 Jun 25;9:1459. doi: 10.3389/fimmu.2018.01459. eCollection 2018.

19.

Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism.

Hummert S, Glock C, Lang SN, Hummert C, Skerka C, Zipfel PF, Germerodt S, Schuster S.

J R Soc Interface. 2018 May;15(142). pii: 20170963. doi: 10.1098/rsif.2017.0963.

20.

FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF.

J Immunol. 2018 Apr 1;200(7):2280-2290. doi: 10.4049/jimmunol.1701641. Epub 2018 Feb 26.

21.

The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential.

Michelfelder S, Fischer F, Wäldin A, Hörle KV, Pohl M, Parsons J, Reski R, Decker EL, Zipfel PF, Skerka C, Häffner K.

J Am Soc Nephrol. 2018 Apr;29(4):1141-1153. doi: 10.1681/ASN.2017070738. Epub 2018 Jan 15.

22.

Kallikrein Cleaves C3 and Activates Complement.

Irmscher S, Döring N, Halder LD, Jo EAH, Kopka I, Dunker C, Jacobsen ID, Luo S, Slevogt H, Lorkowski S, Beyersdorf N, Zipfel PF, Skerka C.

J Innate Immun. 2018;10(2):94-105. doi: 10.1159/000484257. Epub 2017 Dec 14.

23.

Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells.

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Coldewey SM, Cseresnyés Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF.

J Infect Dis. 2018 Jan 17;217(3):358-370. doi: 10.1093/infdis/jix305.

PMID:
28968817
24.

The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments.

Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF.

Mol Immunol. 2018 Jan;93:266-277. doi: 10.1016/j.molimm.2017.07.010. Epub 2017 Aug 30.

PMID:
28860090
25.

Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium.

Busch C, Annamalai B, Abdusalamova K, Reichhart N, Huber C, Lin Y, Jo EAH, Zipfel PF, Skerka C, Wildner G, Diedrichs-Möhring M, Rohrer B, Strauß O.

Front Immunol. 2017 Jun 15;8:703. doi: 10.3389/fimmu.2017.00703. eCollection 2017.

26.

Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4+ T Cells.

Bergfeld A, Dasari P, Werner S, Hughes TR, Song WC, Hortschansky P, Brakhage AA, Hünig T, Zipfel PF, Beyersdorf N.

Front Microbiol. 2017 May 11;8:844. doi: 10.3389/fmicb.2017.00844. eCollection 2017.

27.

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties.

Röttgerding F, Wagemakers A, Koetsveld J, Fingerle V, Kirschfink M, Hovius JW, Zipfel PF, Wallich R, Kraiczy P.

Sci Rep. 2017 Mar 22;7(1):303. doi: 10.1038/s41598-017-00412-4. Erratum in: Sci Rep. 2019 May 2;9(1):7056.

28.

Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells.

Klaile E, Müller MM, Schäfer MR, Clauder AK, Feer S, Heyl KA, Stock M, Klassert TE, Zipfel PF, Singer BB, Slevogt H.

MBio. 2017 Mar 14;8(2). pii: e02142-16. doi: 10.1128/mBio.02142-16.

29.

Successful discontinuation of eculizumab under immunosuppressive therapy in DEAP-HUS.

Hackl A, Ehren R, Kirschfink M, Zipfel PF, Beck BB, Weber LT, Habbig S.

Pediatr Nephrol. 2017 Jun;32(6):1081-1087. doi: 10.1007/s00467-017-3612-9. Epub 2017 Feb 20. Review.

PMID:
28220235
30.

Factor H Binds to Extracellular DNA Traps Released from Human Blood Monocytes in Response to Candida albicans.

Halder LD, Abdelfatah MA, Jo EA, Jacobsen ID, Westermann M, Beyersdorf N, Lorkowski S, Zipfel PF, Skerka C.

Front Immunol. 2017 Jan 13;7:671. doi: 10.3389/fimmu.2016.00671. eCollection 2016.

31.

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator.

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C.

J Neuroinflammation. 2017 Jan 5;14(1):4. doi: 10.1186/s12974-016-0776-3.

32.

Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases.

Schäfer N, Grosche A, Reinders J, Hauck SM, Pouw RB, Kuijpers TW, Wouters D, Ehrenstein B, Enzmann V, Zipfel PF, Skerka C, Pauly D.

Front Immunol. 2016 Nov 28;7:542. eCollection 2016.

33.

Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders.

Michelfelder S, Parsons J, Bohlender LL, Hoernstein SNW, Niederkrüger H, Busch A, Krieghoff N, Koch J, Fode B, Schaaf A, Frischmuth T, Pohl M, Zipfel PF, Reski R, Decker EL, Häffner K.

J Am Soc Nephrol. 2017 May;28(5):1462-1474. doi: 10.1681/ASN.2015070745. Epub 2016 Dec 8.

34.

Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction.

Mühlenkamp MC, Hallström T, Autenrieth IB, Bohn E, Linke D, Rinker J, Riesbeck K, Singh B, Leo JC, Hammerschmidt S, Zipfel PF, Schütz MS.

J Innate Immun. 2017;9(1):33-51. doi: 10.1159/000449200. Epub 2016 Nov 1.

35.

Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.

Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M.

EBioMedicine. 2016 Oct;12:227-238. doi: 10.1016/j.ebiom.2016.08.037. Epub 2016 Sep 15.

36.

Deciphering the Counterplay of Aspergillus fumigatus Infection and Host Inflammation by Evolutionary Games on Graphs.

Pollmächer J, Timme S, Schuster S, Brakhage AA, Zipfel PF, Figge MT.

Sci Rep. 2016 Jun 13;6:27807. doi: 10.1038/srep27807.

37.

FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.

Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C.

J Immunol. 2016 Jul 15;197(2):620-9. doi: 10.4049/jimmunol.1600053. Epub 2016 Jun 8.

38.

The Complement Inhibitor Factor H Generates an Anti-Inflammatory and Tolerogenic State in Monocyte-Derived Dendritic Cells.

Olivar R, Luque A, Cárdenas-Brito S, Naranjo-Gómez M, Blom AM, Borràs FE, Rodriguez de Córdoba S, Zipfel PF, Aran JM.

J Immunol. 2016 May 15;196(10):4274-90. doi: 10.4049/jimmunol.1500455. Epub 2016 Apr 13.

39.

The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension.

Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UO.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1356-65. doi: 10.1152/ajprenal.00040.2016. Epub 2016 Apr 6.

40.

Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif.

Hallström T, Singh B, Kraiczy P, Hammerschmidt S, Skerka C, Zipfel PF, Riesbeck K.

PLoS One. 2016 Jan 25;11(1):e0147709. doi: 10.1371/journal.pone.0147709. eCollection 2016.

41.

CipA of Acinetobacter baumannii Is a Novel Plasminogen Binding and Complement Inhibitory Protein.

Koenigs A, Stahl J, Averhoff B, Göttig S, Wichelhaus TA, Wallich R, Zipfel PF, Kraiczy P.

J Infect Dis. 2016 May 1;213(9):1388-99. doi: 10.1093/infdis/jiv601. Epub 2015 Dec 17.

PMID:
26681776
42.

The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement.

Rosa TF, Flammersfeld A, Ngwa CJ, Kiesow M, Fischer R, Zipfel PF, Skerka C, Pradel G.

Cell Microbiol. 2016 Apr;18(4):573-90. doi: 10.1111/cmi.12535. Epub 2015 Nov 12.

43.

BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex.

Hammerschmidt C, Klevenhaus Y, Koenigs A, Hallström T, Fingerle V, Skerka C, Pos KM, Zipfel PF, Wallich R, Kraiczy P.

Mol Microbiol. 2016 Jan;99(2):407-24. doi: 10.1111/mmi.13239. Epub 2015 Oct 27.

44.

Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces.

Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF.

J Am Soc Nephrol. 2016 May;27(5):1413-25. doi: 10.1681/ASN.2015020212. Epub 2015 Oct 2.

45.

Plant Protochlorophyllide Oxidoreductases A and B: CATALYTIC EFFICIENCY AND INITIAL REACTION STEPS.

Garrone A, Archipowa N, Zipfel PF, Hermann G, Dietzek B.

J Biol Chem. 2015 Nov 20;290(47):28530-9. doi: 10.1074/jbc.M115.663161. Epub 2015 Sep 25.

46.

Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack.

Hallström T, Uhde M, Singh B, Skerka C, Riesbeck K, Zipfel PF.

PLoS One. 2015 Sep 14;10(9):e0137630. doi: 10.1371/journal.pone.0137630. eCollection 2015.

47.

Correction: Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein.

Koenigs A, Zipfel PF, Kraiczy P.

PLoS One. 2015 Sep 14;10(9):e0138398. doi: 10.1371/journal.pone.0138398. eCollection 2015. No abstract available.

48.

Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein.

Koenigs A, Zipfel PF, Kraiczy P.

PLoS One. 2015 Jul 31;10(7):e0134418. doi: 10.1371/journal.pone.0134418. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138398.

49.

Host-pathogen interactions between the human innate immune system and Candida albicans-understanding and modeling defense and evasion strategies.

Dühring S, Germerodt S, Skerka C, Zipfel PF, Dandekar T, Schuster S.

Front Microbiol. 2015 Jun 30;6:625. doi: 10.3389/fmicb.2015.00625. eCollection 2015. Review.

50.

The role of complement in C3 glomerulopathy.

Zipfel PF, Skerka C, Chen Q, Wiech T, Goodship T, Johnson S, Fremeaux-Bacchi V, Nester C, de Córdoba SR, Noris M, Pickering M, Smith R.

Mol Immunol. 2015 Sep;67(1):21-30. doi: 10.1016/j.molimm.2015.03.012. Epub 2015 Apr 28. Review.

PMID:
25929733

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