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Items: 1 to 50 of 137

1.

SIV Latency in Macrophages in the CNS.

Gama L, Abreu C, Shirk EN, Queen SE, Beck SE, Metcalf Pate KA, Bullock BT, Zink MC, Mankowski JL, Clements JE.

Curr Top Microbiol Immunol. 2018;417:111-130. doi: 10.1007/82_2018_89. Review.

2.

An SIV/macaque model targeted to study HIV-associated neurocognitive disorders.

Beck SE, Queen SE, Metcalf Pate KA, Mangus LM, Abreu CM, Gama L, Witwer KW, Adams RJ, Zink MC, Clements JE, Mankowski JL.

J Neurovirol. 2018 Apr;24(2):204-212. doi: 10.1007/s13365-017-0582-4. Epub 2017 Oct 3. Review.

3.

Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir.

Avalos CR, Abreu CM, Queen SE, Li M, Price S, Shirk EN, Engle EL, Forsyth E, Bullock BT, Mac Gabhann F, Wietgrefe SW, Haase AT, Zink MC, Mankowski JL, Clements JE, Gama L.

mBio. 2017 Aug 15;8(4). pii: e01186-17. doi: 10.1128/mBio.01186-17.

4.

Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques.

Drewes JL, Croteau JD, Shirk EN, Engle EL, Zink MC, Graham DR.

Front Immunol. 2016 Dec 19;7:605. doi: 10.3389/fimmu.2016.00605. eCollection 2016.

5.

Marked Enteropathy in an Accelerated Macaque Model of AIDS.

Croteau JD, Engle EL, Queen SE, Shirk EN, Zink MC.

Am J Pathol. 2017 Mar;187(3):589-604. doi: 10.1016/j.ajpath.2016.10.019. Epub 2017 Jan 3.

6.

HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.

Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL.

Am J Pathol. 2017 Jan;187(1):91-109. doi: 10.1016/j.ajpath.2016.09.006.

7.

Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection.

Williams DW, Engle EL, Shirk EN, Queen SE, Gama L, Mankowski JL, Zink MC, Clements JE.

Am J Pathol. 2016 Aug;186(8):2068-2087. doi: 10.1016/j.ajpath.2016.03.019. Epub 2016 Jun 18.

8.

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques.

Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE.

J Virol. 2016 May 27;90(12):5643-5656. doi: 10.1128/JVI.00290-16. Print 2016 Jun 15.

9.

Quantitative Comparison of the Walk and Trot of Border Collies and Labrador Retrievers, Breeds with Different Performance Requirements.

Carr BJ, Canapp SO Jr, Zink MC.

PLoS One. 2015 Dec 21;10(12):e0145396. doi: 10.1371/journal.pone.0145396. eCollection 2015.

10.

EXPERIMENTAL CHALLENGE STUDY OF FV3-LIKE RANAVIRUS INFECTION IN PREVIOUSLY FV3-LIKE RANAVIRUS INFECTED EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA) TO ASSESS INFECTION AND SURVIVAL.

Hausmann JC, Wack AN, Allender MC, Cranfield MR, Murphy KJ, Barrett K, Romero JL, Wellehan JF, Blum SA, Zink MC, Bronson E.

J Zoo Wildl Med. 2015 Dec;46(4):732-46. doi: 10.1638/2015-0022.1.

PMID:
26667529
11.

Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior.

Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK.

Transl Psychiatry. 2015 May 19;5:e567. doi: 10.1038/tp.2015.61.

12.

A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads.

Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN.

J Infect Dis. 2015 Nov 1;212(9):1387-96. doi: 10.1093/infdis/jiv230. Epub 2015 Apr 15.

13.

Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.

Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC.

J Neurovirol. 2015 Aug;21(4):449-63. doi: 10.1007/s13365-015-0334-2. Epub 2015 Mar 17.

14.

Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques.

Beck SE, Kelly KM, Queen SE, Adams RJ, Zink MC, Tarwater PM, Mankowski JL.

J Neurovirol. 2015 Apr;21(2):148-58. doi: 10.1007/s13365-015-0313-7. Epub 2015 Feb 12.

PMID:
25672885
15.

Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment.

Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D; ACTG A5235 team.

J Neurovirol. 2014 Dec;20(6):620-6. doi: 10.1007/s13365-014-0292-0. Epub 2014 Nov 7.

16.

Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease.

Meulendyke KA, Queen SE, Engle EL, Shirk EN, Liu J, Steiner JP, Nath A, Tarwater PM, Graham DR, Mankowski JL, Zink MC.

J Neurovirol. 2014 Dec;20(6):591-602. doi: 10.1007/s13365-014-0283-1. Epub 2014 Sep 17.

17.

HIV life cycle, innate immunity and autophagy in the central nervous system.

Meulendyke KA, Croteau JD, Zink MC.

Curr Opin HIV AIDS. 2014 Nov;9(6):565-71. doi: 10.1097/COH.0000000000000106. Review.

18.

Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.

Drewes JL, Szeto GL, Engle EL, Liao Z, Shearer GM, Zink MC, Graham DR.

PLoS One. 2014 Apr 14;9(4):e94375. doi: 10.1371/journal.pone.0094375. eCollection 2014.

19.

TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages.

Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE.

AIDS Res Hum Retroviruses. 2014 Apr;30(4):333-4. doi: 10.1089/aid.2014.0029. No abstract available.

20.

Elevated brain monoamine oxidase activity in SIV- and HIV-associated neurological disease.

Meulendyke KA, Ubaida-Mohien C, Drewes JL, Liao Z, Gama L, Witwer KW, Graham DR, Zink MC.

J Infect Dis. 2014 Sep 15;210(6):904-12. doi: 10.1093/infdis/jiu194. Epub 2014 Mar 31.

21.

Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas.

Zink MC, Farhoody P, Elser SE, Ruffini LD, Gibbons TA, Rieger RH.

J Am Vet Med Assoc. 2014 Feb 1;244(3):309-19. doi: 10.2460/javma.244.3.309.

PMID:
24432963
22.

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system.

Akay C, Cooper M, Odeleye A, Jensen BK, White MG, Vassoler F, Gannon PJ, Mankowski J, Dorsey JL, Buch AM, Cross SA, Cook DR, Peña MM, Andersen ES, Christofidou-Solomidou M, Lindl KA, Zink MC, Clements J, Pierce RC, Kolson DL, Jordan-Sciutto KL.

J Neurovirol. 2014 Feb;20(1):39-53. doi: 10.1007/s13365-013-0227-1. Epub 2014 Jan 14.

23.

Serum albumin and body weight as biomarkers for the antemortem identification of bone and gastrointestinal disease in the common marmoset.

Baxter VK, Shaw GC, Sotuyo NP, Carlson CS, Olson EJ, Zink MC, Mankowski JL, Adams RJ, Hutchinson EK, Metcalf Pate KA.

PLoS One. 2013 Dec 6;8(12):e82747. doi: 10.1371/journal.pone.0082747. eCollection 2013.

24.

Two new tryptophan derivatives from the seed kernels of Entada rheedei: effects on cell viability and HIV infectivity.

Nzowa LK, Teponno RB, Tapondjou LA, Verotta L, Liao Z, Graham D, Zink MC, Barboni L.

Fitoterapia. 2013 Jun;87:37-42. doi: 10.1016/j.fitote.2013.03.017. Epub 2013 Mar 26.

25.

Early emergence and selection of a SIV-LTR C/EBP site variant in SIV-infected macaques that increases virus infectivity.

Ravimohan S, Gama L, Engle EL, Zink MC, Clements JE.

PLoS One. 2012;7(8):e42801. doi: 10.1371/journal.pone.0042801. Epub 2012 Aug 27. Erratum in: PLoS One. 2013;8(3). doi: 10.1371/annotation/050af66e-a935-46e6-96ec-5ac7e0fc4dfc.

27.

Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection.

Gama L, Shirk EN, Russell JN, Carvalho KI, Li M, Queen SE, Kalil J, Zink MC, Clements JE, Kallas EG.

J Leukoc Biol. 2012 May;91(5):803-16. doi: 10.1189/jlb.1111579. Epub 2012 Feb 24.

28.

Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease.

Meulendyke KA, Pletnikov MV, Engle EL, Tarwater PM, Graham DR, Zink MC.

J Neuroimmune Pharmacol. 2012 Jun;7(2):454-64. doi: 10.1007/s11481-011-9332-1. Epub 2011 Dec 27.

29.

Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial.

Sacktor N, Miyahara S, Deng L, Evans S, Schifitto G, Cohen BA, Paul R, Robertson K, Jarocki B, Scarsi K, Coombs RW, Zink MC, Nath A, Smith E, Ellis RJ, Singer E, Weihe J, McCarthy S, Hosey L, Clifford DB; ACTG A5235 team.

Neurology. 2011 Sep 20;77(12):1135-42. doi: 10.1212/WNL.0b013e31822f0412. Epub 2011 Sep 7.

30.

Induction of innate immune responses by SIV in vivo and in vitro: differential expression and function of RIG-I and MDA5.

Co JG, Witwer KW, Gama L, Zink MC, Clements JE.

J Infect Dis. 2011 Oct 1;204(7):1104-14. doi: 10.1093/infdis/jir469.

31.

Placental malaria and mother-to-child transmission of human immunodeficiency virus-1 in rural Rwanda.

Bulterys PL, Chao A, Dalai SC, Zink MC, Dushimimana A, Katzenstein D, Saah AJ, Bulterys M.

Am J Trop Med Hyg. 2011 Aug;85(2):202-6. doi: 10.4269/ajtmh.2011.10-0589.

32.

Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism.

Eugenin EA, Clements JE, Zink MC, Berman JW.

J Neurosci. 2011 Jun 29;31(26):9456-65. doi: 10.1523/JNEUROSCI.1460-11.2011.

33.

Replication-competent simian immunodeficiency virus (SIV) Gag escape mutations archived in latent reservoirs during antiretroviral treatment of SIV-infected macaques.

Queen SE, Mears BM, Kelly KM, Dorsey JL, Liao Z, Dinoso JB, Gama L, Adams RJ, Zink MC, Clements JE, Kent SJ, Mankowski JL.

J Virol. 2011 Sep;85(17):9167-75. doi: 10.1128/JVI.00366-11. Epub 2011 Jun 29.

34.

SIV/macaque model of HIV infection in cocaine users: minimal effects of cocaine on behavior, virus replication, and CNS inflammation.

Weed M, Adams RJ, Hienz RD, Meulendyke KA, Linde ME, Clements JE, Mankowski JL, Zink MC.

J Neuroimmune Pharmacol. 2012 Jun;7(2):401-11. doi: 10.1007/s11481-011-9281-8. Epub 2011 May 28.

35.

Advancing translational research.

Bolon B, Altrock B, Barthold SW, Baumgarth N, Besselsen D, Boivin G, Boyd KL, Brayton C, Cardiff RD, Couto S, Eaton KA, Foreman O, Griffey SM, La Perle K, Lairmore MD, Liu C, Meyerholz DK, Nikitin AY, Schoeb TR, Schwahn D, Sellers RS, Sundberg JP, Tolwani R, Valli VE, Zink MC.

Science. 2011 Mar 25;331(6024):1516-7. doi: 10.1126/science.331.6024.1516-b. No abstract available.

PMID:
21436422
36.

A simian immunodeficiency virus macaque model of highly active antiretroviral treatment: viral latency in the periphery and the central nervous system.

Clements JE, Gama L, Graham DR, Mankowski JL, Zink MC.

Curr Opin HIV AIDS. 2011 Jan;6(1):37-42. doi: 10.1097/COH.0b013e3283412413. Review.

37.

Initiation of HAART during acute simian immunodeficiency virus infection rapidly controls virus replication in the CNS by enhancing immune activity and preserving protective immune responses.

Graham DR, Gama L, Queen SE, Li M, Brice AK, Kelly KM, Mankowski JL, Clements JE, Zink MC.

J Neurovirol. 2011 Feb;17(1):120-30. doi: 10.1007/s13365-010-0005-2. Epub 2010 Dec 7.

38.

PrPC, the cellular isoform of the human prion protein, is a novel biomarker of HIV-associated neurocognitive impairment and mediates neuroinflammation.

Roberts TK, Eugenin EA, Morgello S, Clements JE, Zink MC, Berman JW.

Am J Pathol. 2010 Oct;177(4):1848-60. doi: 10.2353/ajpath.2010.091006. Epub 2010 Aug 19.

39.

Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA.

Zink MC, Brice AK, Kelly KM, Queen SE, Gama L, Li M, Adams RJ, Bartizal C, Varrone J, Rabi SA, Graham DR, Tarwater PM, Mankowski JL, Clements JE.

J Infect Dis. 2010 Jul 1;202(1):161-70. doi: 10.1086/653213.

40.

Coordinated regulation of SIV replication and immune responses in the CNS.

Witwer KW, Gama L, Li M, Bartizal CM, Queen SE, Varrone JJ, Brice AK, Graham DR, Tarwater PM, Mankowski JL, Zink MC, Clements JE.

PLoS One. 2009 Dec 17;4(12):e8129. doi: 10.1371/journal.pone.0008129.

41.

A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy.

Dinoso JB, Rabi SA, Blankson JN, Gama L, Mankowski JL, Siliciano RF, Zink MC, Clements JE.

J Virol. 2009 Sep;83(18):9247-57. doi: 10.1128/JVI.00840-09. Epub 2009 Jul 1.

42.

Altered cutaneous nerve regeneration in a simian immunodeficiency virus / macaque intracutaneous axotomy model.

Ebenezer GJ, Laast VA, Dearman B, Hauer P, Tarwater PM, Adams RJ, Zink MC, McArthur JC, Mankowski JL.

J Comp Neurol. 2009 May 20;514(3):272-83. doi: 10.1002/cne.22019.

43.

Mechanisms of minocycline-induced suppression of simian immunodeficiency virus encephalitis: inhibition of apoptosis signal-regulating kinase 1.

Follstaedt SC, Barber SA, Zink MC.

J Neurovirol. 2008 Oct;14(5):376-88. doi: 10.1080/13550280802199898. Epub 2008 Nov 12.

44.

The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: from mechanism to treatment.

Clements JE, Mankowski JL, Gama L, Zink MC.

J Neurovirol. 2008 Aug;14(4):309-17. doi: 10.1080/13550280802132832. Review.

PMID:
18780232
45.

Dose-dependent protection against or exacerbation of disease by a polylactide glycolide microparticle-adsorbed, alphavirus-based measles virus DNA vaccine in rhesus macaques.

Pan CH, Nair N, Adams RJ, Zink MC, Lee EY, Polack FP, Singh M, O'Hagan DT, Griffin DE.

Clin Vaccine Immunol. 2008 Apr;15(4):697-706. doi: 10.1128/CVI.00045-08. Epub 2008 Feb 20.

46.

Translational research models and novel adjunctive therapies for neuroAIDS.

Zink MC.

J Neuroimmune Pharmacol. 2007 Mar;2(1):14-9. Epub 2007 Jan 9. Review.

PMID:
18040821
47.

Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host.

Easterbrook JD, Zink MC, Klein SL.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15502-7. Epub 2007 Sep 18.

48.

Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection.

Chase AJ, Sedaghat AR, German JR, Gama L, Zink MC, Clements JE, Siliciano RF.

J Virol. 2007 Dec;81(23):12748-57. Epub 2007 Sep 12.

49.

Characterization of human immunodeficiency virus (HIV)-infected cells in infiltrates associated with CNS opportunistic infections in patients with HIV clade C infection.

Mahadevan A, Shankar SK, Satishchandra P, Ranga U, Chickabasaviah YT, Santosh V, Vasanthapuram R, Pardo CA, Nath A, Zink MC.

J Neuropathol Exp Neurol. 2007 Sep;66(9):799-808.

PMID:
17805010
50.

Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal ganglia.

Laast VA, Pardo CA, Tarwater PM, Queen SE, Reinhart TA, Ghosh M, Adams RJ, Zink MC, Mankowski JL.

J Neuropathol Exp Neurol. 2007 Jan;66(1):26-34.

PMID:
17204934

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