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Items: 23


Time-based pulmonary features from electrical impedance tomography demonstrate ventilation heterogeneity in COPD.

Milne S, Huvanandana J, Nguyen C, Duncan JM, Chapman DG, Tonga KO, Zimmermann SC, Slattery A, King GG, Thamrin C.

J Appl Physiol (1985). 2019 Sep 26. doi: 10.1152/japplphysiol.00304.2019. [Epub ahead of print]


Reduced lung elastic recoil and fixed airflow obstruction in asthma.

Tonga KO, Chapman DG, Farah CS, Oliver BG, Zimmermann SC, Milne S, Sanai F, Jetmalani K, Berend N, Thamrin C, King GG.

Respirology. 2019 Sep 3. doi: 10.1111/resp.13688. [Epub ahead of print]


Dismantling airway disease with the use of new pulmonary function indices.

Zimmermann SC, Tonga KO, Thamrin C.

Eur Respir Rev. 2019 Mar 27;28(151). pii: 180122. doi: 10.1183/16000617.0122-2018. Print 2019 Mar 31. Review.


DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.

Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer M, Slusher BS.

Sci Rep. 2018 Dec 7;8(1):17715. doi: 10.1038/s41598-018-36144-2.


Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase.

Zimmermann SC, Duvall B, Tsukamoto T.

J Med Chem. 2019 Jan 10;62(1):46-59. doi: 10.1021/acs.jmedchem.8b00327. Epub 2018 Jul 3.


N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.

Zimmermann SC, Tichý T, Vávra J, Dash RP, Slusher CE, Gadiano AJ, Wu Y, Jančařík A, Tenora L, Monincová L, Prchalová E, Riggins GJ, Majer P, Slusher BS, Rais R.

J Med Chem. 2018 May 10;61(9):3918-3929. doi: 10.1021/acs.jmedchem.7b01792. Epub 2018 Apr 19.


Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.

Nedelcovych M, Dash RP, Tenora L, Zimmermann SC, Gadiano AJ, Garrett C, Alt J, Hollinger KR, Pommier E, Jančařík A, Rojas C, Thomas AG, Wu Y, Wozniak K, Majer P, Slusher BS, Rais R.

Mol Pharm. 2017 Oct 2;14(10):3248-3257. doi: 10.1021/acs.molpharmaceut.7b00231. Epub 2017 Aug 31.


Discrepancy between in vivo and in vitro comparisons of forced oscillation devices.

Zimmermann SC, Watts JC, Bertolin A, Jetmalani K, King GG, Thamrin C.

J Clin Monit Comput. 2018 Jun;32(3):509-512. doi: 10.1007/s10877-017-0050-y. Epub 2017 Jul 31.


N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.

Nedelcovych MT, Tenora L, Kim BH, Kelschenbach J, Chao W, Hadas E, Jančařík A, Prchalová E, Zimmermann SC, Dash RP, Gadiano AJ, Garrett C, Furtmüller G, Oh B, Brandacher G, Alt J, Majer P, Volsky DJ, Rais R, Slusher BS.

J Med Chem. 2017 Aug 24;60(16):7186-7198. doi: 10.1021/acs.jmedchem.7b00966. Epub 2017 Aug 14.


Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.

Rais R, Vávra J, Tichý T, Dash RP, Gadiano AJ, Tenora L, Monincová L, Bařinka C, Alt J, Zimmermann SC, Slusher CE, Wu Y, Wozniak K, Majer P, Tsukamoto T, Slusher BS.

J Med Chem. 2017 Sep 28;60(18):7799-7809. doi: 10.1021/acs.jmedchem.7b00825. Epub 2017 Sep 18.


Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease.

Date AA, Rais R, Babu T, Ortiz J, Kanvinde P, Thomas AG, Zimmermann SC, Gadiano AJ, Halpert G, Slusher BS, Ensign LM.

J Control Release. 2017 Oct 10;263:132-138. doi: 10.1016/j.jconrel.2017.01.036. Epub 2017 Jan 31.


Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.

Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, Hartung T, Rojas C, Rais R, Tsukamoto T, Semenza GL, Hanes J, Slusher BS, Le A.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5328-36. doi: 10.1073/pnas.1611406113. Epub 2016 Aug 24.


Structural basis for exploring the allosteric inhibition of human kidney type glutaminase.

Ramachandran S, Pan CQ, Zimmermann SC, Duvall B, Tsukamoto T, Low BC, Sivaraman J.

Oncotarget. 2016 Sep 6;7(36):57943-57954. doi: 10.18632/oncotarget.10791.


Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold.

Zimmermann SC, Wolf EF, Luu A, Thomas AG, Stathis M, Poore B, Nguyen C, Le A, Rojas C, Slusher BS, Tsukamoto T.

ACS Med Chem Lett. 2016 Mar 13;7(5):520-4. doi: 10.1021/acsmedchemlett.6b00060. eCollection 2016 May 12.


Design and synthesis of a series of truncated neplanocin fleximers.

Zimmermann SC, O'Neill E, Ebiloma GU, Wallace LJ, De Koning HP, Seley-Radtke KL.

Molecules. 2014 Dec 16;19(12):21200-14. doi: 10.3390/molecules191221200.


Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors.

Zimmermann SC, Rais R, Alt J, Burzynski C, Slusher BS, Tsukamoto T.

ACS Med Chem Lett. 2014 Oct 21;5(11):1251-3. doi: 10.1021/ml500335z. eCollection 2014 Nov 13.


Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.

Hin N, Alt J, Zimmermann SC, Delahanty G, Ferraris DV, Rojas C, Li F, Liu Q, Dong X, Slusher BS, Tsukamoto T.

Bioorg Med Chem. 2014 Nov 1;22(21):5831-7. doi: 10.1016/j.bmc.2014.09.025. Epub 2014 Sep 19.


Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines.

Temburnikar KW, Zimmermann SC, Kim NT, Ross CR, Gelbmann C, Salomon CE, Wilson GM, Balzarini J, Seley-Radtke KL.

Bioorg Med Chem. 2014 Apr 1;22(7):2113-22. doi: 10.1016/j.bmc.2014.02.033. Epub 2014 Mar 3.


"Reverse" carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors.

Zimmermann SC, Sadler JM, O'Daniel PI, Kim NT, Seley-Radtke KL.

Nucleosides Nucleotides Nucleic Acids. 2013;32(3):137-54. doi: 10.1080/15257770.2013.771187.


Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity.

Zimmermann SC, Sadler JM, Andrei G, Snoeck R, Balzarini J, Seley-Radtke KL.

Medchemcomm. 2011 Jul 1;2(7). doi: 10.1039/C1MD00094B.


Hetero-expanded purine nucleosides. Design, synthesis and preliminary biological activity.

Seley-Radtke KL, Zhang Z, Wauchope OR, Zimmermann SC, Ivanov A, Korba B.

Nucleic Acids Symp Ser (Oxf). 2008;(52):635-6. doi: 10.1093/nass/nrn321.


Residents in COTH hospitals by specialty and selected characteristics, 1988.

Kelly JV, Zimmermann SC.

Acad Med. 1990 Dec;65(12):783-4. No abstract available.


[Experimental research on the peculiarity and esthetic effect of the neck-jaw angle].

Rossiwall B, Zimmermann SC.

Fortschr Kieferorthop. 1984 Apr;45(2):101-10. German. No abstract available.


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