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Items: 1 to 50 of 100

1.

Polymeric "Clickase" Accelerates the Copper Click Reaction of Small Molecules, Proteins, and Cells.

Chen J, Wang J, Li K, Wang Y, Gruebele M, Ferguson AL, Zimmerman SC.

J Am Chem Soc. 2019 Jun 4. doi: 10.1021/jacs.9b04181. [Epub ahead of print]

PMID:
31124359
2.

Development of novel macrocyclic small molecules that target CTG trinucleotide repeats.

Serrano JF, Lee J, Daniel Curet L, Hagler LD, Bonson SE, Schuster EJ, Zimmerman SC.

Bioorg Med Chem. 2019 Jul 1;27(13):2978-2984. doi: 10.1016/j.bmc.2019.05.022. Epub 2019 May 14.

PMID:
31113691
3.

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1.

Lee J, Bai Y, Chembazhi UV, Peng S, Yum K, Luu LM, Hagler LD, Serrano JF, Chan HYE, Kalsotra A, Zimmerman SC.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8709-8714. doi: 10.1073/pnas.1820827116. Epub 2019 Apr 11.

PMID:
30975744
4.

Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers.

Miller KA, Morado EG, Samanta SR, Walker BA, Nelson AZ, Sen S, Tran DT, Whitaker DJ, Ewoldt RH, Braun PV, Zimmerman SC.

J Am Chem Soc. 2019 Feb 20;141(7):2838-2842. doi: 10.1021/jacs.8b07705. Epub 2019 Feb 6.

PMID:
30698426
5.

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models.

Hong H, Koon AC, Chen ZS, Wei Y, An Y, Li W, Lau MHY, Lau KF, Ngo JCK, Wong CH, Au-Yeung HY, Zimmerman SC, Chan HYE.

J Biol Chem. 2019 Feb 22;294(8):2757-2770. doi: 10.1074/jbc.RA118.006307. Epub 2018 Dec 28.

PMID:
30593503
6.

Enzyme-like Click Catalysis by a Copper-Containing Single-Chain Nanoparticle.

Chen J, Wang J, Bai Y, Li K, Garcia ES, Ferguson AL, Zimmerman SC.

J Am Chem Soc. 2018 Oct 24;140(42):13695-13702. doi: 10.1021/jacs.8b06875. Epub 2018 Sep 20.

PMID:
30192530
7.

Designed transition metal catalysts for intracellular organic synthesis.

Bai Y, Chen J, Zimmerman SC.

Chem Soc Rev. 2018 Mar 5;47(5):1811-1821. doi: 10.1039/c7cs00447h. Review.

PMID:
29367988
8.

Engineering the Surface of Therapeutic "Living" Cells.

Park J, Andrade B, Seo Y, Kim MJ, Zimmerman SC, Kong H.

Chem Rev. 2018 Feb 28;118(4):1664-1690. doi: 10.1021/acs.chemrev.7b00157. Epub 2018 Jan 16. Review.

PMID:
29336552
9.

Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand.

Xing H, Bai Y, Bai Y, Tan LH, Tao J, Pedretti B, Vincil GA, Lu Y, Zimmerman SC.

J Am Chem Soc. 2017 Mar 15;139(10):3623-3626. doi: 10.1021/jacs.7b00065. Epub 2017 Mar 6.

10.

Patterning Three-Dimensional Hydrogel Microenvironments Using Hyperbranched Polyglycerols for Independent Control of Mesh Size and Stiffness.

Pedron S, Pritchard AM, Vincil GA, Andrade B, Zimmerman SC, Harley BA.

Biomacromolecules. 2017 Apr 10;18(4):1393-1400. doi: 10.1021/acs.biomac.7b00118. Epub 2017 Mar 9.

11.

Proton transfer dynamics dictate quinone speciation at lipid-modified electrodes.

Tse EC, Barile CJ, Li Y, Zimmerman SC, Hosseini A, Gewirth AA.

Phys Chem Chem Phys. 2017 Mar 8;19(10):7086-7093. doi: 10.1039/c6cp07586j.

PMID:
28225090
12.

Worm-Like Superparamagnetic Nanoparticle Clusters for Enhanced Adhesion and Magnetic Resonance Relaxivity.

Smith CE, Lee J, Seo Y, Clay N, Park J, Shkumatov A, Ernenwein D, Lai MH, Misra S, Sing CE, Andrade B, Zimmerman SC, Kong H.

ACS Appl Mater Interfaces. 2017 Jan 18;9(2):1219-1225. doi: 10.1021/acsami.6b10891. Epub 2017 Jan 6.

PMID:
27989109
13.

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells.

Bai Y, Feng X, Xing H, Xu Y, Kim BK, Baig N, Zhou T, Gewirth AA, Lu Y, Oldfield E, Zimmerman SC.

J Am Chem Soc. 2016 Sep 7;138(35):11077-80. doi: 10.1021/jacs.6b04477. Epub 2016 Aug 26.

PMID:
27529791
14.

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting.

Bai Y, Nguyen L, Song Z, Peng S, Lee J, Zheng N, Kapoor I, Hagler LD, Cai K, Cheng J, Chan HY, Zimmerman SC.

J Am Chem Soc. 2016 Aug 3;138(30):9498-507. doi: 10.1021/jacs.6b03697. Epub 2016 Jul 20.

PMID:
27355522
15.

Supramolecular chemistry at the interface of biology, materials and medicine.

Anslyn EV, Zimmerman SC.

Beilstein J Org Chem. 2016 May 31;12:1101-2. doi: 10.3762/bjoc.12.105. eCollection 2016. No abstract available.

16.

The Flip-Flop Diffusion Mechanism across Lipids in a Hybrid Bilayer Membrane.

Barile CJ, Tse ECM, Li Y, Gewargis JP, Kirchschlager NA, Zimmerman SC, Gewirth AA.

Biophys J. 2016 Jun 7;110(11):2451-2462. doi: 10.1016/j.bpj.2016.04.041.

17.

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.

Luu LM, Nguyen L, Peng S, Lee J, Lee HY, Wong CH, Hergenrother PJ, Chan HY, Zimmerman SC.

ChemMedChem. 2016 Jul 5;11(13):1428-35. doi: 10.1002/cmdc.201600081. Epub 2016 Jun 1.

18.

Proton transfer dynamics control the mechanism of O2 reduction by a non-precious metal electrocatalyst.

Tse EC, Barile CJ, Kirchschlager NA, Li Y, Gewargis JP, Zimmerman SC, Hosseini A, Gewirth AA.

Nat Mater. 2016 Jul;15(7):754-9. doi: 10.1038/nmat4636. Epub 2016 May 2.

PMID:
27135859
19.
20.

Optimizing matching and analysis combinations for estimating causal effects.

Colson KE, Rudolph KE, Zimmerman SC, Goin DE, Stuart EA, Laan Mv, Ahern J.

Sci Rep. 2016 Mar 16;6:23222. doi: 10.1038/srep23222.

21.

A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy.

Zimmerman SC.

Beilstein J Org Chem. 2016 Jan 25;12:125-38. doi: 10.3762/bjoc.12.14. eCollection 2016. Review.

22.

Crosslinked dendronized polyols as a general approach to brighter and more stable fluorophores.

Li Y, Bai Y, Zheng N, Liu Y, Vincil GA, Pedretti BJ, Cheng J, Zimmerman SC.

Chem Commun (Camb). 2016 Mar 7;52(19):3781-4. doi: 10.1039/c5cc09430e.

PMID:
26848548
23.

Photoresponsive molecular switch for regulating transmembrane proton-transfer kinetics.

Li Y, Tse EC, Barile CJ, Gewirth AA, Zimmerman SC.

J Am Chem Soc. 2015 Nov 11;137(44):14059-62. doi: 10.1021/jacs.5b10016. Epub 2015 Nov 3.

PMID:
26512414
24.

Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1.

Nguyen L, Luu LM, Peng S, Serrano JF, Chan HY, Zimmerman SC.

J Am Chem Soc. 2015 Nov 11;137(44):14180-9. doi: 10.1021/jacs.5b09266. Epub 2015 Nov 3.

PMID:
26473464
25.

Chemical Control over Cellular Uptake of Organic Nanoparticles by Fine Tuning Surface Functional Groups.

Bai Y, Xing H, Wu P, Feng X, Hwang K, Lee JM, Phang XY, Lu Y, Zimmerman SC.

ACS Nano. 2015 Oct 27;9(10):10227-36. doi: 10.1021/acsnano.5b03909. Epub 2015 Sep 14.

PMID:
26327513
26.

Hydrophilic packaging of iron oxide nanoclusters for highly sensitive imaging.

Smith CE, Ernenwein D, Shkumatov A, Clay NE, Lee J, Melhem M, Misra S, Zimmerman SC, Kong H.

Biomaterials. 2015 Nov;69:184-90. doi: 10.1016/j.biomaterials.2015.07.056. Epub 2015 Aug 4.

27.

Trigger chemistries for better industrial formulations.

Wang HC, Zhang Y, Possanza CM, Zimmerman SC, Cheng J, Moore JS, Harris K, Katz JS.

ACS Appl Mater Interfaces. 2015 Apr 1;7(12):6369-82. doi: 10.1021/acsami.5b00485. Epub 2015 Mar 23. Review.

PMID:
25768973
28.

New frontiers for encapsulation in the chemical industry.

Andrade B, Song Z, Li J, Zimmerman SC, Cheng J, Moore JS, Harris K, Katz JS.

ACS Appl Mater Interfaces. 2015 Apr 1;7(12):6359-68. doi: 10.1021/acsami.5b00484. Epub 2015 Mar 23. Review.

PMID:
25764282
29.

Anion transport through lipids in a hybrid bilayer membrane.

Tse EC, Barile CJ, Gewargis JP, Li Y, Zimmerman SC, Gewirth AA.

Anal Chem. 2015 Feb 17;87(4):2403-9. doi: 10.1021/ac5043544. Epub 2015 Feb 2.

PMID:
25597547
30.

Polymer self-assembly: a web themed issue.

Huang F, O'Reilly R, Zimmerman SC.

Chem Commun (Camb). 2014 Nov 14;50(88):13415-6. doi: 10.1039/c4cc90367f. No abstract available.

PMID:
25255200
31.

Small molecules that target the toxic RNA in myotonic dystrophy type 2.

Nguyen L, Lee J, Wong CH, Zimmerman SC.

ChemMedChem. 2014 Nov;9(11):2455-62. doi: 10.1002/cmdc.201402095. Epub 2014 Jun 17.

32.

Proton switch for modulating oxygen reduction by a copper electrocatalyst embedded in a hybrid bilayer membrane.

Barile CJ, Tse EC, Li Y, Sobyra TB, Zimmerman SC, Hosseini A, Gewirth AA.

Nat Mater. 2014 Jun;13(6):619-23. doi: 10.1038/nmat3974. Epub 2014 May 11.

PMID:
24813418
33.

Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.

Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS, Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HY, Baranger AM, Hergenrother PJ, Zimmerman SC.

J Am Chem Soc. 2014 Apr 30;136(17):6355-61. doi: 10.1021/ja5012146. Epub 2014 Apr 22.

34.

Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1.

Jahromi AH, Fu Y, Miller KA, Nguyen L, Luu LM, Baranger AM, Zimmerman SC.

J Med Chem. 2013 Dec 12;56(23):9471-9481. doi: 10.1021/jm400794z. Epub 2013 Nov 21.

35.

A polymeric fastener can easily functionalize liposome surfaces with gadolinium for enhanced magnetic resonance imaging.

Smith CE, Shkumatov A, Withers SG, Yang B, Glockner JF, Misra S, Roy EJ, Wong CH, Zimmerman SC, Kong H.

ACS Nano. 2013 Nov 26;7(11):9599-610. doi: 10.1021/nn4026228. Epub 2013 Oct 11.

36.

A dendritic single-molecule fluorescent probe that is monovalent, photostable and minimally blinking.

Yang SK, Shi X, Park S, Ha T, Zimmerman SC.

Nat Chem. 2013 Aug;5(8):692-7. doi: 10.1038/nchem.1706. Epub 2013 Jun 30.

37.

Quadruply hydrogen bonding modules as highly selective nanoscale adhesive agents.

Zhang Y, Anderson CA, Zimmerman SC.

Org Lett. 2013 Jul 19;15(14):3506-9. doi: 10.1021/ol401035t. Epub 2013 Jul 1.

PMID:
23815128
38.

Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules.

Haghighat Jahromi A, Honda M, Zimmerman SC, Spies M.

Nucleic Acids Res. 2013 Jul;41(13):6687-97. doi: 10.1093/nar/gkt330. Epub 2013 May 9.

39.

High-affinity DNA base analogs as supramolecular, nanoscale promoters of macroscopic adhesion.

Anderson CA, Jones AR, Briggs EM, Novitsky EJ, Kuykendall DW, Sottos NR, Zimmerman SC.

J Am Chem Soc. 2013 May 15;135(19):7288-95. doi: 10.1021/ja4005283. Epub 2013 May 1.

PMID:
23590235
40.

Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol.

Jeong JH, Schmidt JJ, Kohman RE, Zill AT, DeVolder RJ, Smith CE, Lai MH, Shkumatov A, Jensen TW, Schook LG, Zimmerman SC, Kong H.

J Am Chem Soc. 2013 Jun 19;135(24):8770-3. doi: 10.1021/ja400636d. Epub 2013 Apr 19.

41.

A novel CUG(exp)·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1.

Jahromi AH, Nguyen L, Fu Y, Miller KA, Baranger AM, Zimmerman SC.

ACS Chem Biol. 2013 May 17;8(5):1037-43. doi: 10.1021/cb400046u. Epub 2013 Mar 20.

42.

Polyglycerol-Dendronized Perylenediimides as Stable, Water-Soluble Fluorophores.

Yang SK, Zimmerman SC.

Adv Funct Mater. 2012 Jul 24;22(14):3023-3028. Epub 2012 Apr 17.

43.

Orthogonality in organic, polymer, and supramolecular chemistry: from Merrifield to click chemistry.

Wong CH, Zimmerman SC.

Chem Commun (Camb). 2013 Feb 28;49(17):1679-95. doi: 10.1039/c2cc37316e.

PMID:
23282586
44.

Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.

Wong CH, Richardson SL, Ho YJ, Lucas AM, Tuccinardi T, Baranger AM, Zimmerman SC.

Chembiochem. 2012 Nov 26;13(17):2505-9. doi: 10.1002/cbic.201200602. Epub 2012 Oct 24. No abstract available.

45.

Azobenzene dye-coupled quadruply hydrogen-bonding modules as colorimetric indicators for supramolecular interactions.

Zhang Y, Zimmerman SC.

Beilstein J Org Chem. 2012;8:486-95. doi: 10.3762/bjoc.8.55. Epub 2012 Apr 2.

46.

Top-down synthesis of versatile polyaspartamide linkers for single-step protein conjugation to materials.

Cha C, Jeong JH, Tang X, Zill AT, Prakash YS, Zimmerman SC, Saif TA, Kong H.

Bioconjug Chem. 2011 Dec 21;22(12):2377-82. doi: 10.1021/bc200339s. Epub 2011 Nov 9.

PMID:
22053983
47.

Synthesis of a redox-responsive quadruple hydrogen-bonding unit for applications in supramolecular chemistry.

Li Y, Park T, Quansah JK, Zimmerman SC.

J Am Chem Soc. 2011 Nov 2;133(43):17118-21. doi: 10.1021/ja2069278. Epub 2011 Oct 12.

PMID:
21970558
48.

Selective inhibition of MBNL1-CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2).

Wong CH, Fu Y, Ramisetty SR, Baranger AM, Zimmerman SC.

Nucleic Acids Res. 2011 Nov 1;39(20):8881-90. doi: 10.1093/nar/gkr415. Epub 2011 Jul 18.

49.

Monovalent, clickable, uncharged, water-soluble perylenediimide-cored dendrimers for target-specific fluorescent biolabeling.

Yang SK, Shi X, Park S, Doganay S, Ha T, Zimmerman SC.

J Am Chem Soc. 2011 Jul 6;133(26):9964-7. doi: 10.1021/ja2009136. Epub 2011 Jun 14. Erratum in: J Am Chem Soc. 2011 Aug 24;133(33):13206.

50.

Clickable polyglycerol hyperbranched polymers and their application to gold nanoparticles and acid-labile nanocarriers.

Zill A, Rutz AL, Kohman RE, Alkilany AM, Murphy CJ, Kong H, Zimmerman SC.

Chem Commun (Camb). 2011 Jan 28;47(4):1279-81. doi: 10.1039/c0cc04096g. Epub 2010 Nov 22.

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