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Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals.

Mesquita EC, Hottz ED, Amancio RT, Carneiro AB, Palhinha L, Coelho LE, Grinsztejn B, Zimmerman GA, Rondina MT, Weyrich AS, Bozza PT, Bozza FA.

Sci Rep. 2018 Oct 9;8(1):14999. doi: 10.1038/s41598-018-33403-0.


Integrin αDβ2 (CD11d/CD18) Modulates Leukocyte Accumulation, Pathogen Clearance, and Pyroptosis in Experimental Salmonella Typhimurium Infection.

Nascimento DO, Vieira-de-Abreu A, Arcanjo AF, Bozza PT, Zimmerman GA, Castro-Faria-Neto HC.

Front Immunol. 2018 May 24;9:1128. doi: 10.3389/fimmu.2018.01128. eCollection 2018.


Early Returns in Vascular Inflammation in ARDS.

Middleton EA, Zimmerman GA.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1514-1516. doi: 10.1164/rccm.201804-0670ED. No abstract available.


Amicus or Adversary Revisited: Platelets in Acute Lung Injury and Acute Respiratory Distress Syndrome.

Middleton EA, Rondina MT, Schwertz H, Zimmerman GA.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):18-35. doi: 10.1165/rcmb.2017-0420TR.


Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA-DNA Hybrids.

Schwertz H, Rowley JW, Schumann GG, Thorack U, Campbell RA, Manne BK, Zimmerman GA, Weyrich AS, Rondina MT.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):801-815. doi: 10.1161/ATVBAHA.117.310552. Epub 2018 Jan 4.


Retinoic acid receptor-α regulates synthetic events in human platelets.

Schwertz H, Rowley JW, Zimmerman GA, Weyrich AS, Rondina MT.

J Thromb Haemost. 2017 Dec;15(12):2408-2418. doi: 10.1111/jth.13861. Epub 2017 Nov 1.


Clots Are Potent Triggers of Inflammatory Cell Gene Expression: Indications for Timely Fibrinolysis.

Campbell RA, Vieira-de-Abreu A, Rowley JW, Franks ZG, Manne BK, Rondina MT, Kraiss LW, Majersik JJ, Zimmerman GA, Weyrich AS.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1819-1827. doi: 10.1161/ATVBAHA.117.309794. Epub 2017 Aug 3.


Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue.

Trugilho MRO, Hottz ED, Brunoro GVF, Teixeira-Ferreira A, Carvalho PC, Salazar GA, Zimmerman GA, Bozza FA, Bozza PT, Perales J.

PLoS Pathog. 2017 May 19;13(5):e1006385. doi: 10.1371/journal.ppat.1006385. eCollection 2017 May.


18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury.

Rodrigues RS, Bozza FA, Hanrahan CJ, Wang LM, Wu Q, Hoffman JM, Zimmerman GA, Morton KA.

Nucl Med Biol. 2017 May;48:52-62. doi: 10.1016/j.nucmedbio.2017.01.005. Epub 2017 Jan 17.


Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants.

Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT.

J Thromb Haemost. 2016 Nov;14(11):2230-2240. doi: 10.1111/jth.13500. Epub 2016 Oct 20.


Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation.

Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA.

J Clin Invest. 2016 Oct 3;126(10):3783-3798. doi: 10.1172/JCI83873. Epub 2016 Sep 6.


Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases.

Middleton EA, Weyrich AS, Zimmerman GA.

Physiol Rev. 2016 Oct;96(4):1211-59. doi: 10.1152/physrev.00038.2015. Epub 2016 Aug 3. Review.


Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS).

de Azevedo-Quintanilha IG, Vieira-de-Abreu A, Ferreira AC, Nascimento DO, Siqueira AM, Campbell RA, Teixeira Ferreira TP, Gutierrez TM, Ribeiro GM, E Silva PM, Carvalho AR, Bozza PT, Zimmerman GA, Castro-Faria-Neto HC.

Malar J. 2016 Jul 30;15(1):393. doi: 10.1186/s12936-016-1447-7.


Platelet-Monocyte Aggregates and C-Reactive Protein are Associated with VTE in Older Surgical Patients.

Shih L, Kaplan D, Kraiss LW, Casper TC, Pendleton RC, Peters CL, Supiano MA, Zimmerman GA, Weyrich AS, Rondina MT.

Sci Rep. 2016 Jun 7;6:27478. doi: 10.1038/srep27478.


Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets.

Rondina MT, Freitag M, Pluthero FG, Kahr WH, Rowley JW, Kraiss LW, Franks Z, Zimmerman GA, Weyrich AS, Schwertz H.

J Thromb Haemost. 2016 May;14(5):1082-94. doi: 10.1111/jth.13281. Epub 2016 Mar 22.



Araújo CV, Campbell C, Gonçalves-de-Albuquerque CF, Molinaro R, Cody MJ, Yost CC, Bozza PT, Zimmerman GA, Weyrich AS, Castro-Faria-Neto HC, Silva AR.

Shock. 2016 Apr;45(4):393-403. doi: 10.1097/SHK.0000000000000520.


VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock.

Kaplan D, Casper TC, Elliott CG, Men S, Pendleton RC, Kraiss LW, Weyrich AS, Grissom CK, Zimmerman GA, Rondina MT.

Chest. 2015 Nov;148(5):1224-1230. doi: 10.1378/chest.15-0287.


Integrin αDβ2 (CD11d/CD18) is expressed by human circulating and tissue myeloid leukocytes and mediates inflammatory signaling.

Miyazaki Y, Vieira-de-Abreu A, Harris ES, Shah AM, Weyrich AS, Castro-Faria-Neto HC, Zimmerman GA.

PLoS One. 2014 Nov 21;9(11):e112770. doi: 10.1371/journal.pone.0112770. eCollection 2014.


Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue.

Hottz ED, Medeiros-de-Moraes IM, Vieira-de-Abreu A, de Assis EF, Vals-de-Souza R, Castro-Faria-Neto HC, Weyrich AS, Zimmerman GA, Bozza FA, Bozza PT.

J Immunol. 2014 Aug 15;193(4):1864-72. doi: 10.4049/jimmunol.1400091. Epub 2014 Jul 11.


Unraveling the PAF-AH/Lp-PLA2 controversy.

Stafforini DM, Zimmerman GA.

J Lipid Res. 2014 Sep;55(9):1811-4. doi: 10.1194/jlr.E052886. Epub 2014 Jul 9. No abstract available.


Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock.

Rondina MT, Carlisle M, Fraughton T, Brown SM, Miller RR 3rd, Harris ES, Weyrich AS, Zimmerman GA, Supiano MA, Grissom CK.

J Gerontol A Biol Sci Med Sci. 2015 Feb;70(2):225-31. doi: 10.1093/gerona/glu082. Epub 2014 Jun 10.


Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency.

Chen K, Coonrod EM, Kumánovics A, Franks ZF, Durtschi JD, Margraf RL, Wu W, Heikal NM, Augustine NH, Ridge PG, Hill HR, Jorde LB, Weyrich AS, Zimmerman GA, Gundlapalli AV, Bohnsack JF, Voelkerding KV.

Am J Hum Genet. 2013 Nov 7;93(5):812-24. doi: 10.1016/j.ajhg.2013.09.009. Epub 2013 Oct 17.


Reply to Schattner.

Rondina MT, Weyrich AS, Zimmerman GA.

Circ Res. 2013 Oct 12;113(9):e93. doi: 10.1161/CIRCRESAHA.113.302408. No abstract available.


Bacterial clearance is improved in septic mice by platelet-activating factor-acetylhydrolase (PAF-AH) administration.

Teixeira-da-Cunha MG, Gomes RN, Roehrs N, Bozza FA, Prescott SM, Stafforini D, Zimmerman GA, Bozza PT, Castro-Faria-Neto HC.

PLoS One. 2013 Sep 12;8(9):e74567. doi: 10.1371/journal.pone.0074567. eCollection 2013.


Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation.

Hottz ED, Lopes JF, Freitas C, Valls-de-Souza R, Oliveira MF, Bozza MT, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza FA, Bozza PT.

Blood. 2013 Nov 14;122(20):3405-14. doi: 10.1182/blood-2013-05-504449. Epub 2013 Sep 5.


Platelets as cellular effectors of inflammation in vascular diseases.

Rondina MT, Weyrich AS, Zimmerman GA.

Circ Res. 2013 May 24;112(11):1506-19. doi: 10.1161/CIRCRESAHA.113.300512. Review.


Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases.

Hottz ED, Oliveira MF, Nunes PC, Nogueira RM, Valls-de-Souza R, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza PT, Bozza FA.

J Thromb Haemost. 2013 May;11(5):951-62. doi: 10.1111/jth.12178.


Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines.

Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA.

Free Radic Biol Med. 2013 Sep;62:145-156. doi: 10.1016/j.freeradbiomed.2013.01.033. Epub 2013 Feb 16. Review.


Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration.

Franks Z, Campbell RA, Vieira de Abreu A, Holloway JT, Marvin JE, Kraemer BF, Zimmerman GA, Weyrich AS, Rondina MT.

Thromb Haemost. 2013 Apr;109(4):684-95. doi: 10.1160/TH12-08-0543. Epub 2013 Jan 24.


Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria.

Reis PA, Estato V, da Silva TI, d'Avila JC, Siqueira LD, Assis EF, Bozza PT, Bozza FA, Tibiriça EV, Zimmerman GA, Castro-Faria-Neto HC.

PLoS Pathog. 2012 Dec;8(12):e1003099. doi: 10.1371/journal.ppat.1003099. Epub 2012 Dec 27.


Translational control of JunB, an AP-1 transcription factor, in activated human endothelial cells.

Schmid DI, Schwertz H, Jiang H, Campbell RA, Weyrich AS, McIntyre TM, Zimmerman GA, Kraiss LW.

J Cell Biochem. 2013 Jul;114(7):1519-28. doi: 10.1002/jcb.24493.


Bacterial clearance in septic mice is modulated by MCP-1/CCL2 and nitric oxide.

Gomes RN, Teixeira-Cunha MG, Figueiredo RT, Almeida PE, Alves SC, Bozza PT, Bozza FA, Bozza MT, Zimmerman GA, Castro-Faria-Neto HC.

Shock. 2013 Jan;39(1):63-9. doi: 10.1097/SHK.0b013e31827802b5.


Lessons from rare maladies: leukocyte adhesion deficiency syndromes.

Harris ES, Weyrich AS, Zimmerman GA.

Curr Opin Hematol. 2013 Jan;20(1):16-25. doi: 10.1097/MOH.0b013e32835a0091. Review.


(18)F-FDG PET in the evaluation of acuity of deep vein thrombosis.

Rondina MT, Lam UT, Pendleton RC, Kraiss LW, Wanner N, Zimmerman GA, Hoffman JM, Hanrahan C, Boucher K, Christian PE, Butterfield RI, Morton KA.

Clin Nucl Med. 2012 Dec;37(12):1139-45. doi: 10.1097/RLU.0b013e3182638934.


Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets.

Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS.

Blood. 2012 Dec 13;120(25):5014-20. doi: 10.1182/blood-2012-04-420661. Epub 2012 Oct 18.


Platelets in lung biology.

Weyrich AS, Zimmerman GA.

Annu Rev Physiol. 2013;75:569-91. doi: 10.1146/annurev-physiol-030212-183752. Epub 2012 Oct 1. Review.


The acute respiratory distress syndrome.

Matthay MA, Ware LB, Zimmerman GA.

J Clin Invest. 2012 Aug;122(8):2731-40. doi: 10.1172/JCI60331. Epub 2012 Aug 1. Review.


Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses.

Rowley JW, Finn AV, French PA, Jennings LK, Bluestein D, Gross PL, Freedman JE, Steinhubl SR, Zimmerman GA, Becker RC, Dauerman HL, Smyth SS; 2011 Platelet Colloquium Participants.

Circ Cardiovasc Interv. 2012 Apr;5(2):296-304. doi: 10.1161/CIRCINTERVENTIONS.111.965426. Review. No abstract available.


In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1).

Rondina MT, Brewster B, Grissom CK, Zimmerman GA, Kastendieck DH, Harris ES, Weyrich AS.

Chest. 2012 Jun;141(6):1490-1495. doi: 10.1378/chest.11-2860. Epub 2012 Mar 1.


Different mechanisms preserve translation of programmed cell death 8 and JunB in virus-infected endothelial cells.

Jiang H, Schwertz H, Schmid DI, Jones BB, Kriesel J, Martinez ML, Weyrich AS, Zimmerman GA, Kraiss LW.

Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):997-1004. doi: 10.1161/ATVBAHA.112.245324. Epub 2012 Feb 9.


Whole blood flow cytometry measurements of in vivo platelet activation in critically-Ill patients are influenced by variability in blood sampling techniques.

Rondina MT, Grissom CK, Men S, Harris ES, Schwertz H, Zimmerman GA, Weyrich AS.

Thromb Res. 2012 Jun;129(6):729-35. doi: 10.1016/j.thromres.2011.11.031. Epub 2011 Dec 16.


Leukocyte adhesion deficiency-I variant syndrome (LAD-Iv, LAD-III): molecular characterization of the defect in an index family.

Harris ES, Smith TL, Springett GM, Weyrich AS, Zimmerman GA.

Am J Hematol. 2012 Mar;87(3):311-3. doi: 10.1002/ajh.22253. Epub 2011 Dec 3.


Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation.

Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS.

PLoS Pathog. 2011 Nov;7(11):e1002355. doi: 10.1371/journal.ppat.1002355. Epub 2011 Nov 10.


Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum.

Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman GA.

Semin Immunopathol. 2012 Jan;34(1):5-30. doi: 10.1007/s00281-011-0286-4. Epub 2011 Aug 6. Review.


A pilot study utilizing whole body 18 F-FDG-PET/CT as a comprehensive screening strategy for occult malignancy in patients with unprovoked venous thromboembolism.

Rondina MT, Wanner N, Pendleton RC, Kraiss LW, Vinik R, Zimmerman GA, Heilbrun M, Hoffman JM, Morton KA.

Thromb Res. 2012 Jan;129(1):22-7. doi: 10.1016/j.thromres.2011.06.025. Epub 2011 Jul 29.


Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes.

Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS.

Blood. 2011 Oct 6;118(14):e101-11. doi: 10.1182/blood-2011-03-339705. Epub 2011 May 19. Erratum in: Blood. 2014 Jun 12;123(24):3843.


The septic milieu triggers expression of spliced tissue factor mRNA in human platelets.

Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman GA.

J Thromb Haemost. 2011 Apr;9(4):748-58. doi: 10.1111/j.1538-7836.2011.04208.x.


Persistent cognitive impairment after cerebral malaria: models, mechanisms and adjunctive therapies.

Zimmerman GA, Castro-Faria-Neto H.

Expert Rev Anti Infect Ther. 2010 Nov;8(11):1209-12. doi: 10.1586/eri.10.117. No abstract available.


Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy.

Reis PA, Comim CM, Hermani F, Silva B, Barichello T, Portella AC, Gomes FC, Sab IM, Frutuoso VS, Oliveira MF, Bozza PT, Bozza FA, Dal-Pizzol F, Zimmerman GA, Quevedo J, Castro-Faria-Neto HC.

PLoS Pathog. 2010 Jun 24;6(6):e1000963. doi: 10.1371/journal.ppat.1000963.


Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza.

London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY.

Sci Transl Med. 2010 Mar 17;2(23):23ra19. doi: 10.1126/scitranslmed.3000678.

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